Mass-Radius Relationships for Solid Exoplanets

We use new interior models of cold planets to investigate the mass-radius relationships of solid exoplanets, considering planets made primarily of iron, silicates, water, and carbon compounds. We find that the mass-radius relationships for cold terrestrial-mass planets of all compositions we considered follow a generic functional form that is not a simple power law: $\log_{10} R_s = k_1 + 1/3 \log_{10}(M_s) - k_2 M_s^{k_3}$ for up to $M_p \approx 20 M_{\oplus}$, where $M_s$ and $R_s$ are scaled mass and radius values. This functional form arises because the common building blocks of solid planets all have equations of state that are well approximated by a modified polytrope of the form $\rho = \rho_0 + c P^n$. We find that highly detailed planet interior models, including temperature structure and phase changes, are not necessary to derive solid exoplanet bulk composition from mass and radius measurements. For solid exoplanets with no substantial atmosphere we have also found that: with 5% fractional uncertainty in planet mass and radius it is possible to distinguish among planets composed predominantly of iron or silicates or water ice but not more detailed compositions; with $\sim$~5% uncertainty water ice planets with $\gtrsim 25$ water by mass may be identified; the minimum plausible planet size for a given mass is that of a pure iron planet; and carbon planet mass-radius relationships overlap with those of silicate and water planets due to similar zero-pressure densities and equations of state. We propose a definition of "super Earths'' based on the clear distinction in radii between planets with significant gas envelopes and those without.Comment: ApJ, in press, 33 pages including 16 figure

It’s Time to Change Our Documentation Philosophy: Writing Better Neurology Notes Without the Burnout

Succinct Clinical Documentation is Vital to Effective Twenty-First-Century Healthcare. Recent Changes in Outpatient and Inpatient Evaluation and Management (E/M) Guidelines Have Allowed Neurology Practices to Make Changes that Reduce the Documentation Burden and Enhance Clinical Note Usability. Despite Favorable Changes in E/M Guidelines, Some Neurology Practices Have Not Moved Quickly to Change their Documentation Philosophy. We Argue in Favor of Changes in the Design, Structure, and Implementation of Clinical Notes that Make Them Shorter Yet Still Information-Rich. a Move from Physician-Centric to Team Documentation Can Reduce Work for Physicians. Changing the Documentation Philosophy from Bigger is Better to Short But Sweet Can Reduce the Documentation Burden, Streamline the Writing and Reading of Clinical Notes, and Enhance their Utility for Medical Decision-Making, Patient Education, Medical Education, and Clinical Research. We Believe that These Changes Can Favorably Affect Physician Well-Being Without Adversely Affecting Reimbursement

A deficit of spatial remapping in constructional apraxia after right-hemisphere stroke

This Article is provided by the Brunel Open Access Publising Fund - Copyright @ 2010 Oxford University PressConstructional apraxia refers to the inability of patients to copy accurately drawings or three-dimensional constructions. It is a common disorder after right parietal stroke, often persisting after initial problems such as visuospatial neglect have resolved. However, there has been very little experimental investigation regarding mechanisms that might contribute to the syndrome. Here, we examined whether a key deficit might be failure to integrate visual information correctly from one fixation to the next. Specifically, we tested whether this deficit might concern remapping of spatial locations across saccades. Right-hemisphere stroke patients with constructional apraxia were compared to patients without constructional problems and neurologically healthy controls. Participants judged whether a pattern shifted position (spatial task) or changed in pattern (non-spatial task) across two saccades, compared to a control condition with an equivalent delay but without intervening eye movements. Patients with constructional apraxia were found to be significantly impaired in position judgements with intervening saccades, particularly when the first saccade of the sequence was to the right. The importance of these remapping deficits in constructional apraxia was confirmed through a highly significant correlation between saccade task performance and constructional impairment on standard neuropsychological tasks. A second study revealed that even single saccades to the right can impair constructional apraxia patients’ perception of location shifts. These data are consistent with the view that rightward eye movements result in loss of remembered spatial information from previous fixations, presumably due to constructional apraxia patients’ damage to the right-hemisphere regions involved in remapping locations across saccades. These findings provide the first evidence for a deficit in remapping visual information across saccades underlying right-hemisphere constructional apraxia.European Commission Marie Curie Intra-European Fellowship (011457 to C.R.) and a Wellcome Trust Senior Fellowship (to M.H.)

Evidence for melt leakage from the Hawaiian plume above the mantle transition zone

Dehydration reactions at the top of the mantle transition zone (MTZ) can stabilize partial melt in a seismic low-velocity layer (LVL), but the seismic effects of temperature, melt and volatile content are difficult to distinguish. We invert P-to-S receiver function phases converted at the top and bottom of a LVL above the MTZ beneath Hawaii. To separate the thermal and melting related seismic anomalies, we carry out over 10 million rock physics inversions. These inversions account for variations arising from the Clapeyron slope of phase transition, bulk solid composition, dihedral angle, and mantle potential temperature. We use two independent seismic constraints to evaluate the temperature and shear wave speed within the LVL. The thermal anomalies reveal the presence of a hot and seismically slow plume stem surrounded by a “halo” of cold and fast mantle material. In contrast to this temperature distribution, the plume stem contains less than 0.5 vol% melt, while the surrounding LVL—within the coverage area—contains up to 1.7 vol% melt, indicating possible lateral transport of the melt. When compared to the melting temperatures of mantle rocks, the temperature within the LVL, calculated from seismic observations of MTZ thickness, suggests that the observed small degrees of melting are sustained by the presence of volatiles such as CO2 and H2O. We estimate the Hawaiian plume loses up to 1.9 Mt/yr H2O and 10.7 Mt/yr CO2 to the LVL, providing a crucial missing flux for global volatile cycles

Evidence of Volatile-Induced Melting in the Northeast Asian Upper Mantle

A seismic low velocity layer (LVL) above the mantle transition zone (MTZ), often thought to be caused by volatile-induced melting, can significantly modulate planetary volatile cycles. In this work, we show that an LVL observed beneath northeast Asia is characterized by small, 0.8 (Formula presented.) 0.5 vol%, average degrees of partial melting. Seismically derived P-T conditions of the LVL indicate that slab-derived (Formula presented.), possibly combined with small amounts of (Formula presented.) O, is necessary to induce melting. Modeling the reactive infiltration instability of the melt in a stationary mantle above a stalled slab, we demonstrate that the volatile-rich melt slowly rises above the stalled slab in the MTZ, with percolation velocities of 200–500 (Formula presented.) m/yr. The melt remains stable within the LVL for this geologically significant period of time, potentially transferring up to 52 Mt/yr of (Formula presented.) from the subducting slab to the mantle for an LVL similar in areal extent ((Formula presented.)) to the northeast Asian LVL. Reaction between the melt channels and the LVL mantle precipitates up to 200 ppmw solid C in localized zones. Using the inferred small melt volume fraction to model trace element abundances and isotopic signatures, we show that interaction between this melt and the surrounding mantle can over the long-term produce rocks bearing a HIMU like geochemical signature

Pore network analysis of Brae Formation sandstone, North Sea

In this work, we apply digital rock physics (DRP) to characterize the pore networks of the Brae Formation sandstones from two different wells in the Miller field area (North Sea, UK). Using X-ray micro-CT scans, we calculate the porosity and permeability and generate pore network models to assess pore shape characteristics. The porous samples are marked by macroporosities ranging from 4.9% to 15.2% with the effective porosities varying from 0 to 14.8%. The samples also contained some microporosity hosted in secondary and accessory mineral phases, varying between 2.6% and 10.7%. Pore network model results for total porosity indicate that the samples have median pore and throat radii ranging from 5.5 μm to 16.8 μm and 6.4 μm–12.9 μm, respectively. The throat length of all samples has a median value ranging between 36.3 μm and 82.4 μm. The ratio between effective porosity and total porosity (φ∗) varies with total porosity (φ) following the exponential relation φ∗ = 0.98 − e− (φ− 0.032)/0.028. Pore network connectivity is established at a porosity of 3% and full communication is achieved at porosities exceeding 10%. Permeability was found to vary with total porosity with an exponent of 3.67. Based on these observations and the results from our models, the connectivity of the pore network has important implications for predicting reservoir performance during large scale subsurface projects such as hydrocarbon production and CO2 storage

Enhancing Dimension-Reduced Scatter Plots with Class and Feature Centroids

Dimension reduction is increasingly applied to high-dimensional biomedical data to improve its interpretability. When datasets are reduced to two dimensions, each observation is assigned an x and y coordinates and is represented as a point on a scatter plot. A significant challenge lies in interpreting the meaning of the x and y axes due to the complexities inherent in dimension reduction. This study addresses this challenge by using the x and y coordinates derived from dimension reduction to calculate class and feature centroids, which can be overlaid onto the scatter plots. This method connects the low-dimension space to the original high-dimensional space. We illustrate the utility of this approach with data derived from the phenotypes of three neurogenetic diseases and demonstrate how the addition of class and feature centroids increases the interpretability of scatter plots.Comment: Submitted to 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Societ

Prognostic factors of head and neck cutaneous squamous cell carcinoma: a systematic review

Background: Head and neck cutaneous squamous cell carcinoma (HNCSCC) is a non-melanoma skin cancer that is mostly caused by solar ultraviolet radiation exposure. While it usually has an excellent prognosis, a subset of patients (5%) develops nodal metastasis and has poor outcomes. The aim of this study was to systematically review the literature and evaluate the prognostic factors of HNCSCC in order to better understand which patients are the most likely to develop metastatic disease. Methods: A comprehensive literature search was performed on PubMed and EMBASE to identify the studies that evaluated the prognostic factors of HNCSCC. Prognostic factors were deemed significant if they had a reported p-value of < 0.05. Proportions of studies that reported a given factor to be statistically significant were calculated for each prognostic factor. Results: The search yielded a total of 958 citations. Forty studies, involving a total of 8535 patients, were included in the final analysis. The pre-operative/clinical prognostic factors with the highest proportion of significance were state of immunosuppression (73.3%) and age (53.3%); while post-operative/pathological prognostic factors of importance were number of lymph nodes involved with carcinoma (70.0%), margins involved with carcinoma (66.7%), and tumor depth (50.0%). Conclusion: This systematic review is aimed to aid physicians in assessing the prognosis of HNCSCC and identifying the subsets of patients that are most susceptible to metastasis. It also suggests that immunosuppressed patients with a high-risk feature on biopsy, such as invasion beyond subcutaneous fat, could possibly benefit from a sentinel lymph node biopsy. Keywords: Carcinoma; Mohs surgery; Sentinel lymph node biopsy; Skin neoplasms; Squamous cell; Squamous cell carcinoma of head and neck