ヒロウ コンパイ ニ イタル シンチョウ タンシュク サイクル ウンドウ ガ カタイ サントウキン ノ シュウシュク トクセイ オヨビ ソンショウ シヒョウ ニ オヨボス エイキョウ

The repeated heel-raiseis a typical stretch-shortening cyc1e (SSC) exercise. The exercise is not only performed in resistance training but also used for evaluating muscular strength in c1inical settings. The present study was undertaken to investigate the effect of repeated heel-raise exercise to a volitional exhaustion on contractile properties of the triceps surae muscle and parameters reflecting muscle injury. Five Healthy university students with no orthopedic disorders served as subjects. Each subject performed two exercises. ln SSC condition，the subjects repeated the SSC exercise every 2 seconds to volitional exhaustion. ln the IS0 condition，they repeated the same number of an isometric exercise as that of the SSC exercise. In the SSC condition，the subjects exhausted after repeating the exercise 28.6 times. At exhaustion，maximal torque developing capacity decreased significantly and the decrease was accompanied by a tendency of a lower median power frequency of the EMG signals. A significantly higher lactate concenlration was also observed. On the other hand，the ISO exercise induced no significant changes in these parameters. In the SSC condition，the decreased maximal torque developing capacity at exhaustion remained one hour and even one day following the exhausting exercise. The circumference of the lower extremity became larger significantly at exhaustion as compared with the pre-exercise values and remained higher one hour and one day after the exercise. The pressure threshold for pain in the medial head of the gastrocnemius muscle and the muscle-tendon junction of the triceps surae muscle became significantly lower compared with pre-exercise value one hour or one day following the exercise. Muscle pain evaluated using visual analog scale f1uctuated and the higher value was observed at exhaustion and one day after SSC exercise. ln the ISO condition，no significant changes in these parameters were observed. The results of the present study indicated that the SSC exercise had more profound effects on contractile properties， myo-electrical signals and injury-related parameters than the ISO exercise. Furthermore, the results suggest that，even in a relatively small number of repetitions，repeated heel-raise, at ypical SSC exercise，induces as light muscle injury

セイカツ ノ QOL オ タカメル コト オ メザシタ ウォーキング ランニング ノ アリカタ ニ カンスル ソウゴウテキ ケンキュウ

A walking and/or running for raising quality of life (QOL) was studied from the face of exercise physiology，exercise biochemistry，sport sociology. Three experiments and a survey were carried out to achieve the purpose. The results were summarized as follows: 1) The running program in the long time was effective in the decrease of body fat percentage， the decrease of body weight as overweight person， and also in the increase of muscular endurance. 2) Appropriate BMI and muscular endurance are important for the marathon race. 3) Accelerometer steps per day did not significantly for correlate to body composition， health-related parameters in blood or serum adipocytokine levels. 4) Each subject ofthe walk exercise must be examined from the coordination ability. 5) A exercise class rises the Self-efficacy(SE)，and the individual group activity is effective to maintain the SE

The Relationship between Peripheral Nerve Conduction Velocity and Ophthalmological Findings in Type 2 Diabetes Patients with Early Diabetic Retinopathy

Purpose. Nerve conduction velocity (NCV) is an indicator of neuronal damage in the distal segment of the peripheral nerves. Here, we determined the association between NCV and other systemic and ocular clinical findings, in type 2 diabetes patients with early diabetic retinopathy (DR). Methods. This study included 42 eyes of 42 type 2 diabetes patients (median age: 54 years) with no DR or with mild nonproliferative DR. Standard statistical techniques were used to determine associations between clinical findings. Results. Sural sensory conduction velocity (SCV) and tibial motor conduction velocity (MCV) were significantly lower in mild nonproliferative DR patients than patients with no DR (P=0.008 and P=0.01, resp.). Furthermore, logistic regression analyses revealed that sural SCV and tibial MCV were independent factors contributing to the presence of mild nonproliferative DR (OR 0.83, P=0.012 and OR 0.69 P=0.02, resp.). Tibial MCV was correlated with choroidal thickness (CT) (P=0.01), and a multiple regression analysis revealed that age, tibial MCV, and carotid intima-media thickness were independent associating factors with CT (P=0.035, P=0.015, and P=0.008, resp.). Conclusions. Our findings suggest that reduced NCV may be closely associated with early DR in type 2 diabetes patients. Thus, reduced nerve conduction is a potential early biomarker of DR

Social robot for older adults with cognitive decline: a preliminary trial

The number of older adults living alone is rapidly increasing. Loneliness in older adults not only degrade their quality of life but also causes troubles such as heavy burden on the medical staff, especially when cognitive decline is present. Social robots could be used in several ways to reduce such problems. As a first step towards this goal, we introduced conversation robots into the homes of older adults with cognitive decline to evaluate the robot’s availability and acceptance during several months. The study involved two steps, one for evaluating the robustness of the proposed robotic system, and the second one to examine the long-term acceptance of social robots by older adults with cognitive decline living alone. Our data shows that after several weeks of human-robot interaction, the participants continued to use the robot and successfully integrated them into their lives. These results open the possibility of further research involving how sustained interaction can be achieved, as well as which factors contributed to the acceptance of the robot

Utilizing portable electroencephalography to screen for pathology of Alzheimer’s disease: a methodological advancement in diagnosis of neurodegenerative diseases

BackgroundThe current biomarker-supported diagnosis of Alzheimer’s disease (AD) is hindered by invasiveness and cost issues. This study aimed to address these challenges by utilizing portable electroencephalography (EEG). We propose a novel, non-invasive, and cost-effective method for identifying AD, using a sample of patients with biomarker-verified AD, to facilitate early and accessible disease screening.MethodsThis study included 35 patients with biomarker-verified AD, confirmed via cerebrospinal fluid sampling, and 35 age- and sex-balanced healthy volunteers (HVs). All participants underwent portable EEG recordings, focusing on 2-minute resting-state EEG epochs with closed eyes state. EEG recordings were transformed into scalogram images, which were analyzed using “vision Transformer(ViT),” a cutting-edge deep learning model, to differentiate patients from HVs.ResultsThe application of ViT to the scalogram images derived from portable EEG data demonstrated a significant capability to distinguish between patients with biomarker-verified AD and HVs. The method achieved an accuracy of 73%, with an area under the receiver operating characteristic curve of 0.80, indicating robust performance in identifying AD pathology using neurophysiological measures.ConclusionsOur findings highlight the potential of portable EEG combined with advanced deep learning techniques as a transformative tool for screening of biomarker-verified AD. This study not only contributes to the neurophysiological understanding of AD but also opens new avenues for the development of accessible and non-invasive diagnostic methods. The proposed approach paves the way for future clinical applications, offering a promising solution to the limitations of advanced diagnostic practices for dementia

結晶化ガラス顆粒の臨床応用

This reports tha development of bioactive glass ceramic particles and evaluates their use inclinical applications. 1. The subjects of the evaluation were 13 impacted teeth, 17 intramaxillary cysts (not including radicular cysts), and 7 atrophic mandibular alveolar ridges. 2. The results were classified into effective, slightly effective, ineffective, and harmful, a very high proportion, 33 or 89.3%,were judged effective or slightly effective. 3. None were evaluated to be harmful, showing the safety of the present material. Among the ineffective cases there were open wounds due to infection, leakage of the supplied material, and fistulation. In cases where inflammation had not disappeared at the supply there were cases where the particles had to be completely removed due to infection, It was determined the that this was not due to the material, but possidly due to the surgical procedures, as there were no further complications in the tretment. 4. From the results reported here, the bioactive glass ceramic material here was found to be useful in the articial bone needed after atrophic mandibular alveolar ridge surgery

Shortcut Approach to 1,4-Diazepine from 3-Pyridylnitrene Intermedietes under Mild Condition

The reaction of nitropyridine derivatives and tributylphosphine (Bu3P) with the existence of nucleophilic solvent gives ring expansion product as diazepines in medium yield. Reaction mechanism subjected the formation of phenylnitrene, followed by intramolecular electrophilic insertion reaction to pyridine ring and subsequent ring enlargement. The intermediate in the reaction confirmed by computational calculation using B3LYP/6-31G* level. The intramolecular insertion reaction of pyridylnitrene is considered suppressed by the low HOMO (-9.932 eV) energy level of pyridine ring compared to that of benzene (-9.653 eV), hence 1,4-diazepine is obtained when employed 3-nitro-2,6-lutidine as starting material. The formation of diazepines was confirmed by the analysis of 1H NMR data. Separation of the product mixture using column chromatography on SiO2 was carried out and found to give expected diazepine along with the reduction product

Evidence of past migration of the ice divide between the Shirase and Sôya drainage basins derived from chemical characteristics of the marginal ice in the Sôya drainage basin, East Antarctica

Ice originating near the inland ice divide of the ice sheet can reappear as marginal ice at the surface near the ice terminal in the ablation area. We have analyzed δ18O values and ion concentrations of the Skallen, Skarvsnes and Hamna terminal ice sections, located along the estuary line in the Sôya drainage basin, East Antarctica. The data suggest that the upper part of the Skallen terminal ice section could have originated from inland precipitation on the Shirase drainage basin during marine isotope stage (MIS) 5e, while the upper part of Skarvsnes and Hamna terminal ice sections could have originated from inland precipitation on the Sôya drainage basin. We calculate past elevation maps for the Antarctic ice sheet using the three-dimensional model, SICOPOLIS. This model suggests that the upstream portion of the Sôya drainage basin during the glacial period (MIS 2, 3 or 4) was located to the northeast of its present location. A flow history is proposed wherein ice from the inland Shirase drainage area flowed over the present ice-divide line from the Shirase to the Sôya drainage basin during the glacial period. The ice in the Sôya drainage basin then flowed to the marginal part of the sheet after the ice divide had assumed its present position

Frequency control in power system using Fuel Cell cogeneration system in Kyushu area

This paper applies a method for reducing frequency fluctuations in power system by using Fuel Cell cogeneration system (FC cogeneration). Frequency fluctuation in power system is used as a feedback signal to a controller of FC cogeneration. In addition, the potential of power system for controlling frequency is estimated from the supply and demand record, and the timing, when power system requires the control from FC cogeneration, is determined. Thus, the effectiveness of the method is analyzed, considering the conditions in Kyushu area. The impact of the proposed method is high since the available capacity for the frequency control in power system is small in the evening. Even if 13.7% of the capacity for regulating frequency which is the pumped storage power generation on 22nd May 2019 is reduced, the FC cogeneration can regulate the frequency in power system