EFFECT OF ORAL CLONIDINE AND ORAL GABAPENTINE AS PREMEDICATION ON HEMODYNAMIC STRESS RESPONSES DURING LARYNGOSCOPY AND TRACHEAL INTUBATION AND DURATION OF POST OPERATIVE ANALGESIA

Introduction: Direct laryngoscopy and passage of endotracheal tube are noxious stimuli that can provoke stress response in cardiovascular, respiratory and other physiological systems. This study was planned to evaluate the effect of oral Gabapentin and oral clonidine on laryngoscopic stress response and postoperative pain relief. Methods: 90 patients between the age group 18 to 60 years belonging to ASA class I and II scheduled for lower abdominal surgeries were devided into three groups. Each patient was given 0.2mg inj. Glycopyrolate i.m and oral tab. Clonidine 0.2mg (group C) or oral tab. Gabapentine 900mg (group G) or oral tab. vitamine C (group P) 30 min before surgery. Results: Oral Clonidine (0.2 mg) when given in premedication provided better attenuation of hemodynamic stress response to laryngoscopy and tracheal intubation compared to oral Gabapentine (900 mg), where hypertensive response was fairly obtunded, but not the tachycardiac response. Conclusion: Oral Clonidine has better response over tachycardia than Gabapentine, whereas Gabapentine is superior to clonidine for post-operative analgesia

Diastereoselective formation of 2-aryl-3-arenesulfonyl 4-ethyl-1,3-oxazolidines: an X-ray crystallographic and 1H NMR study

N-Arylsulfonamides of (R)- and (S)-2-amino-1-butanol, on condensation with aromatic aldehydes produced diastereomerically pure 2-aryl-3-arenesulfonyl 4-ethyl-1,3-oxazolidines. The absolute configurations of one enantiomeric pair have been determined from two fully refined X-ray structures, supplemented by nmr data

The type 2 diabetes and insulin-resistance locus near IRS1 is a determinant of HDL cholesterol and triglycerides levels among diabetic subjects

Objective: SNP rs2943641 near the insulin receptor substrate 1 (IRS1) gene has been found to be associated with type 2 diabetes (T2D) and insulin-resistance in genome-wide association studies. We investigated whether this SNP is associated with cardiovascular risk factors and coronary artery disease (CAD) among diabetic individuals. Methods: SNP rs2943641 was typed in 2133 White T2D subjects and tested for association with BMI, serum HDL cholesterol and triglycerides, hypertension history, and CAD risk. Results: HDL cholesterol decreased by 1 mg/dl (p = 0.004) and serum triglycerides increased by 6 mg/dl (p = 0.016) for each copy of the insulin-resistance allele. Despite these effects, no association was found with increased CAD risk (OR = 1.00, 95% CI 0.88-1.13). Conclusions: The insulin-resistance and T2D locus near the IRS1 gene is a determinant of lower HDL cholesterol among T2D subjects. However, this effect is small and does not translate into a detectable increase in CAD risk in this population. (C) 2011 Elsevier Ireland Ltd. All rights reserved