Broadening of H2_2O rotational lines by collision with He atoms at low temperature

We report pressure broadening coefficients for the 21 electric-dipole transitions between the eight lowest rotational levels of ortho-H$_2$O and para-H$_2$O molecules by collisions with He at temperatures from 20 to 120 K. These coefficients are derived from recently published experimental state-to-state rate coefficients for H$_2$O:He inelastic collisions, plus an elastic contribution from close coupling calculations. The resulting coefficients are compared to the available experimental data. Mostly due to the elastic contribution, the pressure broadening coefficients differ much from line to line, and increase markedly at low temperature. The present results are meant as a guide for future experiments and astrophysical observations.Comment: 2 figures, 2 table

Tau Phosphorylation, Aggregation, and Cell Toxicity

Protein aggregation takes place in many neurodegenerative disorders. However, there is a controversy about the possible toxicity of these protein aggregates. In this review, this controversy is discussed, focussing on the tau aggregation that takes place in those disorders known as tauopathies

Co-evolutionnary network approach to cultural dynamics controlled by intolerance

Starting from Axelrod's model of cultural dissemination, we introduce a rewiring probability, enabling agents to cut the links with their unfriendly neighbors if their cultural similarity is below a tolerance parameter. For low values of tolerance, rewiring promotes the convergence to a frozen monocultural state. However, intermediate tolerance values prevent rewiring once the network is fragmented, resulting in a multicultural society even for values of initial cultural diversity in which the original Axelrod model reaches globalization

Effects of trapping site on the spectroscopy of 1P1 excited group 12 metal atoms in rare gas matrices

A molecular dynamics deposition model has been used to simulate the growth of rare gas matrices doped with atoms of the group 12 elements zinc, cadmium and mercury. This study investigates the sites occupied by Zn, Cd and Hg metal atoms when isolated in the solid rare gases. To probe the results, the resonance 1 P 1-1 S 0 transitions of the matrix-isolated metal atoms were calculated and compared with the recorded spectra of the M/RG solids. The theoretical spectroscopy obtained in this work was generated using the molecular dynamics with quantum transitions method. In Ne matrices the metal atoms preferably occupy tetra- and hexa-vacancy sites while in the case of Xe matrices, only the single vacancy site is formed. For Ar and Kr matrices Zn but especially Cd can be trapped in tetra- and hexa-vacancy sites in addition to single-vacancy sites, while Hg atoms show exclusive occupancy in single vacancy sites.Fil: Lara Moreno, M.. Universidad de La Habana; Cuba. Instituto Superior de Tecnologías y Ciencias Aplicadas.; Cuba. Université de Bordeaux; Francia. Centre National de la Recherche Scientifique; FranciaFil: Alvarez Hernández, J.. Universidad de La Habana; Cuba. Instituto Superior de Tecnologías y Ciencias Aplicadas.; Cuba. University of Rochester. Department of Chemistry; Estados UnidosFil: Negrín Yuvero, Lázaro Hassiel. Universidad de La Habana; Cuba. Instituto Superior de Tecnologías y Ciencias Aplicadas.; Cuba. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: McCaffrey, J. G.. National University of Ireland. Maynooth University. Department of Chemistry; IrlandaFil: Rojas Lorenzo, G.. Universidad de La Habana; Cuba. Instituto Superior de Tecnologías y Ciencias Aplicadas.; Cub

Determinación del contenido de cobre y leucocito en sangre de bovinos con papilomatosis tratado con cobre mas un acivador inmunológico

The research was carried out at the Hungria farm located 25 km from Concordia, Jinotega department, where a comparative descriptive study was applied with the objective of determining the content of serum copper and leukocytes in the blood of bovines treated with copper earrings subjected to six weeks of treatment, the study groups were divided into two, a group of nine animals treated with a tag and nine animals without applying a tag, considered a control or reference group to compare independent samples. The variables evaluated were the concentration of ceruplasmin oxidase (serum copper), % of neutrophils, % of lymphocytes, % monocytes, % of eosinophils and recurrence of papillomatous warts, which underwent a t-test analysis for related samples and independent samples using the SPSS version 20 statistical system, showing that the ceruplasmin oxidase variable for animals treated with copper earring showed a significant difference p˃0.05 compared to before and after treatment, as in the test analysis for independent samples in animals treated with earring and without earring there was a significant difference p˃0.05, instead the variables % of lymphocytes, monocytes and eosinophils did not show a significant difference p˃0.05, concluding that the animals treated with copper earring suffered a change from hypocuprosis to normocupremia according to the means reflected in the descriptive analysis , instead the leukocytes underwent transformation it is pathological, as is the case with an increase in monocytes and a decrease in eosinophils and neutrophils.  La investigación se realizó en la finca Hungría ubicada a 25 km de la Concordia departamento de Jinotega , donde se aplicó un estudio descriptivo comparativo con el objetivo de determinar el contenido de cobre sérico y leucocitos en sangre de bovinos tratados con arete de cobre sometidos a seis semanas de tratamiento , los grupos de estudio fueron divididos en dos, un grupo de nueve animales tratados con arete y nueve animales sin aplicar arete considerados grupo testigo o de referencia para comparar muestras independientes. Las variables evaluadas fueron la concentración de ceruplasmínaoxidasa(cobre sérico) , % de neutrófilos, % de linfocitos, % monocitos , % de eosinofilos y recidiva de verrugas papilomatosas, lo cual se les realizó un análisis de prueba t para muestras relacionadas y muestras independientes mediante el sistema estadístico SPSS versión 20, demostrando que la variable ceruplasmina oxidasa para animales tratados con arete de cobre mostro diferencia significativa p˃0.05 respecto antes y después del tratamiento, al igual en el análisis de prueba  para muestras independientes en animales tratados con arete y sin arete hubo diferencia significativa p˃0.05 , en cambio las variables % de linfocitos ,monocitos y eosinofilos no mostraron diferencia significativa p˃0.05,llegando a la conclusión que los animales tratados con arete de cobre sufrieron un cambio de hipocuprosis a una normocupremia según las medias reflejadas en el análisis descriptivo,en cambio los leucocitos sufrieron transformaciones patológicas como es el caso en el incremento de monocitos y disminución de eosinofilos y neutrófilos

Restoration of the immune function as a complementary strategy to treat Chronic Lymphocytic Leukemia effectively

Chronic Lymphocytic Leukemia (CLL) is a hematological malignancy characterized by uncontrolled proliferation of B-cells and severe immune dysfunction. Chemo(immuno)therapies (CIT) have traditionally aimed to reduce tumor burden without fully understanding their effects on the immune system. As a consequence, CIT are usually associated with higher risk of infections, secondary neoplasms and autoimmune disorders. A better understanding of the biology of the disease has led to the development of therapeutic strategies which not only act against malignant B-cells but also reactivate and enhance the patient's own anti-tumor immune response. Here, we review the current understanding of the underlying interplay between the malignant cells and non-malignant immune cells that may promote tumor survival and proliferation. In addition, we review the available evidence on how different treatment options for CLL including CIT regimens, small molecular inhibitors (i.e, BTK inhibitors, PI3K inhibitors, BCL-2 inhibitors) and T-cell therapies, affect the immune system and their clinical consequences. Finally, we propose that a dual therapeutic approach, acting directly against malignant B-cells and restoring the immune function is clinically relevant and should be considered when developing future strategies to treat patients with CLL

Porous Titanium surfaces to control bacteria growth: mechanical properties and sulfonated polyetheretherketone coating as antibiofounling approaches

Here, titanium porous substrates were fabricated by a space holder technique. The relationship between microstructural characteristics (pore equivalent diameter, mean free-path between pores, roughness and contact surface), mechanical properties (Young’s modulus, yield strength and dynamic micro-hardness) and bacterial behavior are discussed. The bacterial strains evaluated are often found on dental implants: Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. The colony-forming units increased with the size of the spacer for both types of studied strains. An antibiofouling synthetic coating based on a sulfonated polyetheretherketone polymer revealed an effective chemical surface modification for inhibiting MRSA adhesion and growth. These findings collectively suggest that porous titanium implants designed with a pore size of 100–200 µm can be considered most suitable, assuring the best biomechanical and bifunctional anti-bacterial properties.University of Seville VI Plan Propio de Investigación y Transferencia—US 2018, I.3A

Biotecnología de inoculación de árboles de importancia forestal con hongos ectomicorrízicos comestibles

México se considera un país megadiverso ya que cuenta con aproximadamente 10% de la diversidad terrestre del planet