29 research outputs found
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi Hasan M.
- Al Jabbary Ahmed S.
- Albaiceta Guillermo M.
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain U.
- Allan Russell M.
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G.
- Altaf Wahid
- Alvarez António M.
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Abdellatif Benslama Mourad
- An Youzhong
- Andersen Finn H.
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo M.
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana M.
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E.
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio C.
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie M.
- Barberet Guillaume
- Baron Rebecca M.
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa M.
- Barros Nelson C.
- Batra Hitesh
- Battle Ceri E.
- Bauer Philippe R.
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu H.
- Beegle Scott H.
- Beitler Jeremy R.
- Bellani Giacomo
- Bellani Giacomo
- Beloncle Francois
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien L.
- Bettini Lisandro R.
- Beuret Pascal
- Bezzi Marco G.
- Bhardwaj Vallish K.
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Biondi Rodrigo S.
- Biscione Roberto R.
- Bisso Mariano Carboni
- Black Colin S.
- Blakeman Thomas C.
- Bolon Stefan
- Borello Silvina A.
- Borotto Erika E.
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria J.
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M.
- Briquet Anais
- Brito Vania A.
- Brizuela Matias
- Brochard Laurent
- Brochard Laurent
- Broman Lars M.
- Brown Samuel M.
- Browne Troy S.
- Bruhn Alejandro R.
- Brunettini Barbara
- Bruns Monique M.
- Buensuseso Juan A.
- Bugedo Guillermo
- Buise Marc P.
- Bulpa Pierre A.
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew J.
- Burtin Philippe
- Buzancais Gautier
- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis P.
- Careless Jon P.
- Carpentier Dorothée
- Carreño Nicolás G.
- Carteaux Guillaume
- Casalena Paolo
- Casement Jonathan
- Castro Alejandro G.
- Castro Silvia
- Catorze Nuno T.
- Cazorla-Barranquero Francisca G.
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria I.
- Cervantes Mavy Ramirez
- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon K.
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng Meisy Perez
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna E.
- Claraco-Vega Luis M.
- Clarkson Kevin
- Clarkson Kevin P.
- Claverias Laura
- Cohen Jason E.
- Cole Jade M.
- Collins Daniel V.
- Collyer Thomas
- Colombo Riccardo
- Combaux Daniele M.
- Combes Alain
- Cooper Raphael
- Coppadoro Andrea
- Corneci Dan E.
- Cortegiani Andrea
- Cortez Cesar A.
- Coxo Cristina M.
- Cracchiolo Andrea N.
- Cranshaw Julius H.
- Crapelli Giulia
- Crouch Daniel R.
- Crova Philippe J.
- Csabi Peter
- Curley Gerard
- Curto Elena Gallego
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin C. dric
- Daviaud Fabrice
- Davies Kyle G.
- Dawson Heidi
- de Cima-Iglesias Sara
- de Gordoa Laura Ortiz-Ruiz
- de Haro Candelaria
- de Pablo Raul
- de Prost Nicolas
- Dean Michael N.
- Declercq Pierre-Louis M.
- Dector Dulce
- Dector Dulce M.
- Deicas Alberto
- del Carmen Lorente Maria
- Dellamonica Jean
- Dellera Christian
- Delsing Angela
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane Tarek
- Depuydt P.
- Depuydt Pieter
- Derman Suleyman S.
- di Tomasso Nora N.
- di Yu D.
- Diaz-Rodriguez Esther
- Dive Alain M.
- Dixit Subhal B.
- Do Vale Fernandes Antero
- Dolva Merete S.
- Donnelly Adrian
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- Doyen Denis
- Dres Martin
- Dreyer Kyle R.
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- Dupont Herve
- Duranteau Jacques
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- Ebeid Alejandro
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- Gelée Bruno
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- Glietsch Rita
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- Gonz Á Lez Raquel Montiel
- Gonzalez Daniel R.
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- Hashida Tomoaki
- He Zhenyang
- Hedlund Lars
- Heidari Farshad
- Heines Serge J.
- Helleberg Johan
- Henderson Galen
- Herbrecht Jean-Etienne
- Hermosa Cecilia
- Hessell Robert J.
- Heunks Leo M.
- Higashijima Ushio
- Hirata Akira
- Holzgraefe Bernhard
- Honda Hiroyuki
- Honrubia Teresa
- Hopf Hans-Bernd F.
- Hopkins Phil
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- Zani Gianluca
- Zantua Kim S.
- Zazu Alan
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Hervé O.
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao H.
- Zhu Wei H.
- Zogheib Elie H.
- Ñamendys-Silva Silvio A.
- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe
Таксономическое положениеVicia faba L. в родеVicia L. и некоторые соображения о происхождении этого культурного вида
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- Publication venue
- 'Springer Science and Business Media LLC'
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- Field of study
Comparative Physicochemical and Biological Characterisation of the Similar Biological Medicinal Product Teriparatide and Its Reference Medicinal Product
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Immunocompromised patients with acute respiratory distress syndrome : Secondary analysis of the LUNG SAFE database
- Author
- Abad R.D.
- Abe Toshikazu
- Abroug Fekri
- Adams J.C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguirre Janet S
- Aguirre-Bermeo Hernan
- Aisa T.M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi H.M.
- Al Jabbary A.S.
- Albaiceta G.M.
- Albarrak M.M.
- Albiero Daniela
- Alda R.S.
- Alejandro Risso V.
- Alexander P.
- Alfonso Alec A.Tallet
- Algaba Á.
- Aliaga Felipe A.
- Alisasis A.U.
- Allan R.M.
- Allue R.M.
- Almekhlafi G.
- Alonso J.G.
- Altaf Wahid
- Alvarez A.M.
- Alvarez Javier
- Amin P.
- Amir Fahd
- Amor M.
- An Youzhong
- Andersen F.H.
- Andoh Kohkichi
- Andruszkiewicz P.
- Aneman Anders
- Antonelli Massimo
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Y.M.
- Araujo A.M.
- Arizmendi A.
- Arnal Jean-Michel
- Artiga M.J.D.
- Artigas A.
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E.
- Azad Raman
- Azevedo L.C.
- Baboi Loredana
- Badie Julio C.
- Bailey Irene M.
- Bailey M.B.
- Bajwa E.
- Balkhi H.
- Baltus Thomas
- Banner-Goodspeed V.M.
- Barberet Guillaume
- Baron Rebecca M
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros F.M.
- Barros N.C.
- Batra H.
- Battle C.E.
- Bauer P.R.
- Beck Eduardo
- Beck O.
- Bedreag O.H.
- Beegle S.H.
- Beitler J.R.
- Bellani Giacomo
- Beloncle François
- Benslama A.
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz.
- Besset Sebastien L.
- Bettini Lisandro R.
- Beuret Pascal
- Bezzi Marco G.
- Bhardwaj Vallish K.
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Binti Pengiran Haji Ismail Dayangku Hajah Maizatul Aiman
- Biondi Rodrigo S.
- Biscione Roberto R.
- Bisso Mariano Carboni
- Black Colin S.
- Blakeman T.C.
- Blanco J.
- Bolon S.
- Borello Silvana A.
- Borotto Erika E.
- Botteri Marco
- Bouchoucha Slaheddiine
- Boukhazna Messabi
- Bouw M.J.
- Boyd O.
- Bramall J.
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M.
- Briquet Anais
- Brito V.A.
- Brizuela Matias
- Broman Lars M.
- Brown S.M.
- Browne T.S.
- Bruhn Alejandro R.
- Brunettini Barbara
- Bruns M.M.
- Buensuseso J.A.
- Bugedo G.
- Buise M.P.
- Bulpa Pierre Alain
- Bumbasierevic V.
- Bumbasirevic Vesna
- Burtenshaw A.J.
- Burtin Philippe
- Buzancais Gautier
- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz C.
- Cardonnet Luis P.
- Careless J.P.
- Carpentier Dorothée
- Carreño Nicolás G.
- Carteaux Guillaume
- Casalena Paolo
- Casement J.
- Castro A.G.
- Castro S.
- Catorze N.T.
- Cazorla-Barranquero F.G.
- Ceniceros-Barros A.
- Cereijo E.
- Cerny V.
- Cerrato Valeria I.
- Cervantes M.R.
- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman R.
- Chau S.K.
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng M.P.
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry S.
- Christiansen Aage
- Cimic N.
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna E.
- Claraco-Vega L.M.
- Clarkson Kevin P.
- Claverias Laura
- Cohen J.E.
- Cole J.M.
- Collins Daniel V.
- Collyer T.
- Colombo Ricardo
- Combaux Daniele M.
- Combes Alain
- Conti S.
- Cooper R.
- Coppadoro Andrea
- Corneci D.E.
- Cortegiani Andrea
- Cortez Cesar A.
- Coxo C.M.
- Cracchiolo Andrea N.
- Cranshaw J.H.
- Crapelli Giulia
- Crouch D.R.
- Crova Philippe J.
- Csabi P.
- Curley Gerard
- Curto Elena Gallego
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric.
- Daubin Cédric
- Daviaud Fabrice
- Davies Kyle G.
- Dawson H.
- de Cima-Iglesias S.
- de Gordoa L.O.R.
- de Haro C.
- de Pablo R.
- de Prost Nicolas
- Dean M.N.
- Declercq Pierre-Louis M.
- Dector D.
- Dector D.M.
- Deicas A.
- Dellamonica Jean
- Dellera Christian
- Delsing A.
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane T.
- Depuydt Pieter
- Derman Suleyman S.
- Di Tomasso Nora N.
- Di Yu D.
- Diaz-Rodriguez Esther
- Dive Alain M.
- Dixit Subhal B.
- do Vale Fernandes A.
- Dolva M.S.
- Donnelly A.
- Dowling A.T.
- Doyen Denis
- Dres Martin
- Dreyer K.R.
- Dunne Eimhin S.
- Dupont Herve
- Duranteau Jacques
- Dwyer Rory
- Démpair G.
- Ebeid A.
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- Elisabet Garcia M.
- Elkhayari M.
- Ellis Helen E.
- Elmasri M.
- Erbabacan Emre
- Eriksson Karin E.
- Estenssoro Elisa
- Esteve F.
- Estilita J.M.
- Estrella C.R.
- Ezzouine Hanane
- Fan E.
- Fartoukh Muriel
- Farías Pamela A.
- Fawkes Danielle A.
- Ferguson Andrew
- Ferguson Niall D.
- Fernandez Adriana M.
- Fernandez Ruben O.
- Fierro J.M.
- Floris Leda
- Follin Arnaud
- Fontenele Danielle C.
- Formenti Paolo
- Forteza Catalina
- Fossali Tommaso
- Foti Giuseppe
- Franco N.
- Francois Guy M.
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- Frati Elena
- Frendl Gyorgy
- Frigyik A.D.
- Fusari Maurizio
- Futami Satoru
- Gally Josette
- Ganesan Deeban
- Gao Yuan N.
- Gao Yuan N.
- Garcia Patricio H.
- Gazenkampf A.A.
- Gelée Bruno
- George F.G.
- Ghazi Mohammed
- Gianinetto Hernan
- Giarratano Antonino
- Gillis S.
- Girgin Nermin Kelebek
- Gjedsted Jakob
- Glietsch Rita
- Goldgran-Toledano Dany
- Goligher Ewan C.
- Gomaa D.
- Gomes R.M.
- Gomez Pablo E.
- Gomez-Flores S.S.
- Gonzalez D.R.
- Gonzalez M.
- González R.M.
- González-Salamanca Ángela
- Gonçalves Claudio H.
- Goodson Jennifer C
- Gordo F.
- Gosselin R.J.
- Goubaux Bernard
- Grasselli Giacomo
- Graziani Romano
- Gregoretti Cesare
- Grelon Fabien
- Griffin Ruth
- Grigoriev E.
- Grijalba C.Q.
- Grissom C.K.
- Gritsan A.I.
- Grubissich Nicolas
- Gueret R.M.
- Gurjar Mohan
- Guttormsen A.B.
- Guérin Claude
- Gómez P.R.A.
- Hacking D.J.
- Haddad Youssef
- Hadfield Dan
- Hagan S.J.
- Han Hui
- Han Yi
- Hang Ai Y.
- Hanlon Gabrielle C.
- Harasawa Tomofumi
- Harrois Anatole
- Hashemian Seyed Mohammadreza
- Hashida Tomoaki
- He Z.
- Hedlund Lars
- Heidari Farshad
- Heines S.J.
- Helleberg Johan
- Henderson Galen
- Herbrecht Jean-Etienne.
- Hermosa C.
- Hessell R.J.
- Heunks L.M.
- Higashijima Ushio
- Hirata Akira
- Holzgraefe Bernhard
- Honda Hiroyuki
- Honrubia T.
- Hopf Hans-Bernd F.
- Hopkins Phil
- Hormis Anil P.
- Hou Peter C.
- Hou Sen-Kuang
- Hraiech Sami
- Hua Ma X.
- Huang Qing Q.
- Huang Xiao B.
- Huerta Francisco P.
- Huff N.G.
- Humphreys Sally K.
- Hunt A.
- Hurtado J.
- Hutchison R.A.
- Hutton Paula J.
- Ibañez-Santacruz M.
- Ichikado Kazuya
- Ilutovich Santiago
- Imai Hiroshi
- Imma Vallverdu P.
- Imperio M.C.
- Insaurralde Carolina S.
- Inskip Deborah M.
- Ioannou N.
- Iotti Giorgio A.
- Irvine Donald A
- Ismail D.
- Ismail Mehvish
- Ito Fumihito
- Izawa Masayo
- Jaafar Rola F.
- Jakubowska K.
- Jamaati Hamidreza
- Jarquin-Badiola Y.D.
- Jassal Mandeep
- Javeed Areej
- Jha Rajeev R.
- Jiang Liangyan
- Jibaja M.
- Jimenez Antonio G.
- Jochmans Sébasien
- Jog Sameer A.
- Jovanovic Bojan
- Judy C.
- Jurado M.T.
- Kadaba Varsha
- Kajtor I.
- Kakar Vivek
- Kalaitzis Evangelos
- Kalkoff M.
- Kamel G.
- Kameyama Yoshinobu
- Kamoun Salma
- Kander Thomas
- Kannan Santhana G.
- Kashiwa Yozo
- Kedelv Hans
- Kennedy Barry
- Khebbeb Samy
- Kheir F.
- Kheir F.M.
- Kimura Hiroyasu
- Kiourtzieva Ellada V.
- Kitch B.T.
- Knapman Karl M.
- Knoll Jenny
- Knowles Serena
- Kol Mark R.
- Kong Jing
- Koyama Kansuke
- Krabler Jens
- Krstevski Amanda
- Kulkarni S.
- Kumar Alek
- Kurahashi K.
- Kusumoto Kohei
- Laake Jon Henrik
- Labarca Eduardo F.
- Laffey John G.
- Lamb K.D.
- Lanspa M.J.
- Larsson A.
- Larsson Niklas
- Lebbinck Herve
- Lee J.
- Leemann-Refondini Corinne
- Lemiale Virginie
- Lemus J.S.
- Leon Yoshido H.H.
- Li Bin
- Li Qingdong
- Li Qiong J.
- Li Wenwen
- Li Xiao L.
- Li Xinyu
- Li Yimin
- Li Yuan Y.
- Li-Xin Zhou
- Liew Kong Y.
- Ling Long L.
- Liu Haitao
- Liu Jian
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- Liu Ling
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- Loiacono Flavia A.
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- Lora Pilar
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- Losada E.P.
- Lovazzano Pablo
- Lu Weihua
- Lu Yuanhua
- Luis Palazon Sanchez Eugenio
- Luo Xiaoming
- Lynch Joan M.
- López-Messa J.B.
- Maazouzi W.
- Macfadyen R.
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- Madotto Fabiana
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- Magret Monica
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- Marin Julien
- Marin M.C.
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- Massa Eleni V.
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- Persson Linnea
- Pesenti Antonio
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- Roser T.P.
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- Rugonfalvi Szabolcs
- Ruiz S.R.
- Ruiz-Aguilar A.L.
- Rylander ChristianC.
- Ryosuke Sekine
- Sabelnikovs Olegs
- Sable Safal D.
- Saenz María G.
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- Schlichting A.B.
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- Seven Aylin
- Shah Bhagyesh
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- Staudinger Thomas
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- Strauch U.
- Sula Hektor
- Sun Renhua
- Surbatovic Maja
- Suzuki Hiroyuki
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- Treanor Nuala
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- Trinidad O.A.
- Tulaimat A.
- Twohey Linda
- Uchiyama Akinori
- Ueda Takeshi
- Ueno Keiko
- Umbrello Michele
- Universitat Autònoma de Barcelona
- Unnikrishnan Rammesh
- Uppalapati A.
- Van Haren Frank
- Van Wezel H.M.
- Vargas Monica P.
- Vascotto Ettore R.
- Vasquez Daniela N.
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- Veljovic Milic
- Venti Aaron
- Vercueil Andre
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- Vinzio Mauricio
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- Wittebole Xavier
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- Wrathall D.W.
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- Xin-Hua Qiang
- Xu Yinghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
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- Yeatts D.J.
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
- Yuste L.J.
- Zacharas Giannis A.
- Zacharowski Kai D.
- Zani Gianluca
- Zantua K.S.
- Zazu Alan
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Hervé O.
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao H.
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao H.
- Zhu Wei H.
- Zogheib Elie
- Zumaran Aguilar Ronald
- Ñamendys-Silva S.A.
- ünal Necmettin
- Publication venue
- Publication date
- 01/01/2018
- Field of study
The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiogenic shock were their most common risk factors for ARDS. Hospital mortality was higher in immunocompromised than in immunocompetent patients (52.4% vs 36.2%; p < 0.0001), despite similar severity of ARDS. Decisions regarding limiting life-sustaining measures were significantly more frequent in immunocompromised patients (27.1% vs 18.6%; p < 0.0001). Use of noninvasive ventilation (NIV) as first-line treatment was higher in immunocompromised patients (20.9% vs 15.9%; p = 0.0048), and immunodeficiency remained independently associated with the use of NIV after adjustment for confounders. Forty-eight percent of the patients treated with NIV were intubated, and their mortality was not different from that of the patients invasively ventilated ab initio. Conclusions: Immunosuppression is frequent in patients with ARDS, and infections are the main risk factors for ARDS in these immunocompromised patients. Their management differs from that of immunocompetent patients, particularly the greater use of NIV as first-line ventilation strategy. Compared with immunocompetent subjects, they have higher mortality regardless of ARDS severity as well as a higher frequency of limitation of life-sustaining measures. Nonetheless, nearly half of these patients survive to hospital discharge. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
Immunocompromised patients with acute respiratory distress syndrome: Secondary analysis of the LUNG SAFE database
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat
- Aisiku Imo
- Ajetunmobi Olaitan
- Aker Mustafa
- Akyol Onat
- Al Dorzi Hasan M.
- Al Jabbary Ahmed
- Albaiceta Guillermo
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Alfonso Alec A. Tallet
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain
- Allan Russell
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier
- Altaf Wahid
- Alvarez António
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Mourad
- An Youzhong
- Andersen Finn
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- Yu Rongguo
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- Zani Gianluca
- Zantua Kim
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- Zender Hervé
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao
- Zhu Wei H.
- Zogheib Elie
- Ñamendys-Silva Silvio A.
- ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiogenic shock were their most common risk factors for ARDS. Hospital mortality was higher in immunocompromised than in immunocompetent patients (52.4% vs 36.2%; p < 0.0001), despite similar severity of ARDS. Decisions regarding limiting life-sustaining measures were significantly more frequent in immunocompromised patients (27.1% vs 18.6%; p < 0.0001). Use of noninvasive ventilation (NIV) as first-line treatment was higher in immunocompromised patients (20.9% vs 15.9%; p = 0.0048), and immunodeficiency remained independently associated with the use of NIV after adjustment for confounders. Forty-eight percent of the patients treated with NIV were intubated, and their mortality was not different from that of the patients invasively ventilated ab initio. Conclusions: Immunosuppression is frequent in patients with ARDS, and infections are the main risk factors for ARDS in these immunocompromised patients. Their management differs from that of immunocompetent patients, particularly the greater use of NIV as first-line ventilation strategy. Compared with immunocompetent subjects, they have higher mortality regardless of ARDS severity as well as a higher frequency of limitation of life-sustaining measures. Nonetheless, nearly half of these patients survive to hospital discharge. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
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- A Kretzschmar
- A Kühne
- A Lipsmeier
- A Lipsmeier
- A Schlüter
- A Siemsen
- A Wissenschaften
- Akademie der Pädagogischen Wissenschaften u. a.
- Alt Robert
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- Anweisung zur Ausbildung auf Teilgebieten von Ausbildungsberufen vom 5. Oktober
- Anweisung zur Berufsausbildung der aus den Hilfsschulen entlassenen Jugendlichen vom 10. Februar
- Anweisung über die Grundlagenfächer in der sozialistischen Berufsbildung vom 15. Dezember
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- Hohm Werner (Ltg. d. Autorenkollektivs)
- I Grund
- I Risch
- I Spittmann-Rühle
- I Wilke
- Industriegewerkschaft Metall
- Industriegewerkschaft Metall
- J Bernhard
- J Bethgenhagen
- J Heimchen
- J Kuhnert
- J Mönch
- J Riedel
- J Riemer
- J Wissing
- Jahn Horst
- K Achtel
- K Becker
- K Belwe
- K Belwe
- K Bücher
- K Große
- K Heinze
- K Offe
- K Schurbaum
- K Steinitz
- K Zander
- K Zander
- Kell Adolf
- Knauer Arnold
- Knoll Joachim
- Kuhrt Willi
- Kuratorium der Deutschen Wirtschaft für Berufsbildung
- L Klingberg
- Langen Eva-Maria
- Leschinsky Achim
- Lexikon der Wirtschaft
- Lexikon der Wirtschaft. Arbeit
- Lorenz Peter
- M Baethge
- M Frackmann
- M Kipp
- M Kirsten
- M Lötsch
- M Messing
- M Schecker
- M Stengel
- Mannschatz Eberhard
- Menschik. Jutta
- Ministerrat der Deutschen Demokratischen Republik. Ministerium für Volksbildung
- Ministerrat der Deutschen Demokratischen Republik. Ministerium für Volksbildung
- Nowitzki Heinz
- O Anweiler
- O Monsheimer
- OE Walter
- P Blonskij
- P Brokmeier
- P Lorenz
- P Oestreich
- P Storz
- P Ziertmann
- Pogodda Gerhard
- Pogodda Gerhard
- R Brämer
- R Brämer
- R Fuchs
- R Inhaltsbestimmung
- R Nissler
- R Weidig
- R Zeh
- Riedel
- S Baske
- S Baske
- S Berufsbildung
- S Eßbach
- S Republik
- S Statistik
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- S Thyssen
- S Tuschke
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- Schanz Arthur
- Siemon Günter (Ltg.)
- Siemon Günter (Ltg.), Csongär, G.
- Sontheimer Kurt
- Staatssekretariat für Berufsbildung
- Staatssekretariat für Berufsbildung
- T Dresden
- Thalheim Karl, C.
- Thalheim Karl,C.
- U Forbriger
- U Müllges
- V Protokoll
- Voigt Dieter
- W Bleck
- W Bloy
- W Fdgb
- W Fuchs
- W Gerth
- W Gewande
- W Gewande
- W Greinen
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- W Kuhrt
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- W Lemm
- W Lempert
- W Mergner
- W Peper
- W Thomas
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1990
- Field of study
MVA Vectors Expressing Conserved Influenza Proteins Protect Mice against Lethal Challenge with H5N1, H9N2 and H7N1 Viruses
- Author
- A Endo
- A Hashem
- A Hessel
- A Hessel
- A Reber
- A Vitelli
- AC Boyd
- Andreas Pilz
- Annett Hessel
- AT Heiny
- B Schafer
- Birgit Schäfer
- Brian A. Crowe
- BS Shim
- C Dreyfus
- C Verheust
- CE Gomez
- CE Mullarkey
- D Corti
- D Liu
- D Zhou
- Daniel Portsmouth
- DC Ekiert
- F Scheiflinger
- Falko G. Falkner
- G Bommakanti
- G Sutter
- G Zhao
- G Zhao
- Gary P. Kobinger
- GE Price
- GE Price
- GF Rimmelzwaan
- H Chang
- H Sagawa
- Helga Savidis-Dacho
- HH Bui
- I Kosik
- J Mayrhofer
- JB Ulmer
- JB Ulmer
- JH Kreijtz
- JH Kreijtz
- JH Kreijtz
- JH Kreijtz
- JM Song
- JN Brewoo
- K Subbarao
- KJ Jakeman
- KK McKinstry
- KK McKinstry
- LS Wyatt
- M Kundi
- M Schotsaert
- MF Pascutti
- Michael G. Schwendinger
- MT Kheiri
- MW LaMere
- N Pica
- NB Marshall
- NJ Cox
- O Dienz
- O Kistner
- P. Noel Barrett
- PJ Lillie
- PS Ricci
- R Gao
- RB Couch
- RJ Amato
- RO Donis
- S Neirynck
- S Sridhar
- SL Epstein
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- SM Tompkins
- Sogue Coulibaly
- T Lambe
- Thomas R. Kreil
- TK Berthoud
- TM Wilkinson
- VA Slepushkin
- W Fiers
- W Wang
- W Wodal
- WK Joklik
- Y Watanabe
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Zitierte Literatur
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- A Buttlar
- A Chandler
- A Dick
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- A Maihofer
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- Barthelmes Jürgen/Feil, Christine/Furtner-Kallmünzer, Maria
- Becker-Schmidt
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- BMBF
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- Bruchhagen
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- Dokumentation der 5
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- Faulstich-Wieland Hannelore/Güting, Damaris
- Faulstich-Wieland Hannelore/Horstkemper
- Faulstich-Wieland Hannelore/Nyssen. Elke
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- Feministische Erneuerung von Wissenschaft und Kunst
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- Fleßner Heike/Kriszio, Marianne/Kurth, Rita/Potts, Lydia
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- Frauen und Wissenschaft. Beiträge zur Berliner Sommeruniversität für Frauen
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- Hartmann Jutta/Holzkamp, Christine
- Heublein Ulrich/Sommer, Dieter
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- Hornung Ursula/Gümen, Sedef/Weilandt, Sabine (Hg.)
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- Kompetenzzentrum (Hg.)
- L Rose
- Lehnert
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- M Friese
- M Friese
- M Hildegard
- M Krill
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- M Mead
- M Meuser
- MA Kreienbaum
- Macha Hildegard/Klinkhammer, Monika/Gehlert, Siegmund
- Maher Frances A./Tetreault, Mary Kay Thompson
- Mayer Christine/Krüger, Helga/Rabe-Kleberg, Ursula/Schütte
- Metz-Göckel Sigrid/Müller, Ursula
- Meyer Dorit/Ginsheim, Gabriele von
- Mit der Genderperspektive Weiterbildung gestalten
- Mittelalter bis zur Aufklärung
- Müller-Heisrath Angelika/Kückmann-Metschies, Hedwig
- Neue Wege zur Gestaltung der koedukativen Schule. Reflexive Koedukation als Element der Schulentwicklung. Landesinstitut für Schule und Weiterbildung
- P Bourdieu
- P Villa
- P Villa
- P Villa
- Patai Daphne/Koertge, Noretta
- Programm Forschungs¬politik
- Projekt Frauengrundstudium
- R Gildemeister
- R Haberkorn
- R Klees-Möller
- R Kroll
- R Kurth
- Rauschenbach Thomas/Huber, Andreas/Kleifgen, Beate/Züchner, Ivo/Fuchs, Kirsten/Grunert, Cathleen/Krüger, Heinz-Hermann/Rostampour, Parviz/Seeling, Claudia
- Rohrmann Tim/Thoma, Peter
- S Harding
- S Hark
- S Hirschauer
- S Kade
- S Keuneke
- S Metz-Göckel
- S Metz-Göckel
- S Wenk
- S Wesely
- Schmidt Renate-Berenike/Schetschke, Michael
- Schuster Marilyn/Dyne, Susan Van
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- Steenbuck Gisela/Bruchhagen, Verena
- Stephan Inge/Braun, Christina von
- T Rohrmann
- Terhart Ewald/Czerwenka, Kurt/Ehrich, Karin/Jordan, Frank/Schmidt, Hans Joachim
- Thies Wiltrud/Röhner, Charlotte
- U Behrens
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- Verband der Schweizerischen Studentinnenschaften (Hg.)
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- W Ernst
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
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- Field of study
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- A Garlichs
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- A Giddens
- A Groeben
- A Grundschule
- A Hinz
- A Honneth
- A Honneth
- A Kaiser
- A Klocke
- A Knauf
- A Möckel
- A Pehnke
- A Prengel
- A Prengel
- A Prengel
- A Regenbogen
- A Sander
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- A Wenzel
- A Wenzel
- A Winkler
- Akademie der Pädagogischen Wissenschaften/Institute für Bildungsforschung und Erziehungswissenschaften (Hg.)
- Albers Sven/Hameyer, Uwe/Schusdziarra, Gisela (Hg.)
- Altrichter Herbert/Posch, Peter
- Amlung Ulrich/Haubfleisch, Dietmar/Link, Jörg-W./Schmitt, Hanno (Hg.)
- B Friebertshäuser
- B Friedrich
- B Kohnen
- B Müller
- B Nicolas
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- B Paetzold
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- Beck
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- CF Graumann
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- D Baacke
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- Drewek Peter/Horn, Klaus-Peter/Kersting, Christa/Tenorth, Heinz Elmar
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- DW Winnicott
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- E Purmann
- E Riegel
- E Röbe
- E Rösner
- E Schuchardt
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- E Schwarz
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- E Terhart
- E Teufel
- E Wittmann
- E Zeißig
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- ER Huber
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- H Wocken
- HA Horn
- Haarmann
- Hacke Axel/Sowa
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- Hartmann Waltraut/Neugebauer
- HB Brügelmann
- HE Tenorth
- Heinzel Friederike/Weber, Isolde/Scheer
- Hennig Claudius/Knödler, Uwe
- Hessisches Institut für Bildungsplanung und Schulentwicklung
- Hetzner Renate/Stoellger, Norbert
- Heyer Peter/Preuß-Lausitz, Ulf/Zielke
- Heyting Frieda/Tenorth, Heinz-Elmar (Hg.)
- HG Roßbach
- HG Steiner
- Hildeschmidt Anne/Sander
- HJ Apel
- HJ Apel
- HJ Lambrich
- HJ Röbe
- HJ Röbe
- Horkheimer Max/Adorno,Theodor W
- Horstkemper Marianne/Zimmermann, Peter (Hg.)
- HRB Becher
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- I Beck
- I Goffmann
- I Lichtenstein-Rother
- I Mann
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- K Hurrelmann
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- K Ingenkamp
- K Ingenkamp
- K Lewin
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- K Mollenhauer
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- Kaufmann-Huber
- KB Günther
- Kegler Ulrike/Prengel, Annedore
- Kellmer-Pringle
- Kelly
- KH Nave
- Kiesel Doron/von Lüpke, Hans
- KJ Tillmann
- Knörzer Wolfgang/Grass
- Knörzer Wolfgang/Grass, Karl
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- Korch Sylvia/Stuchlik, Ellen
- Kornmann Reimer/Klingele, Christoph
- Krapp Andreas/Mandl
- Krapp Andreas/Mandl, Heinz
- Krappmann Lothar/Oswald, Hans
- Krohn Wolfgang/Küppers, Günter (Hg.)
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- L Blumenstock
- L Duncker
- L Friedeburg
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- L Kemmler
- L Montada
- L Rademacher
- Leuzinger-Bohleber M./Garlichs, Ariane
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- M Bildung
- M Buber
- M Dehn
- M Foucault
- M Foucault
- M Fölling-Albers
- M Göhlich
- M Jay
- M Krecker
- M Krug
- M Krüger-Potratz
- M Polzin
- M Ulich
- M Ulich
- M Verlinden
- M Wagenschein
- M Winschermann
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- Meyer-Drawe
- MF Bildung
- Ministerium für Jugend
- Müller Max/Halder
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- N Bennett
- N Fraser
- Nickel Horst
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- NRW Bildungskommission
- Nunner-Winkler
- O Dann
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- Pekrun H./Fend
- Pekrun Reinhard/Helmke
- Peter-Koop
- PP Morrison
- Prengel Annedore/van der Voort, Dörte
- Preuss-Lausitz
- Priebe Hiltrud/Röbe, Edeltraud
- Purmann Ernst/Peter, Dietmar
- R Fatke
- R Huschke-Rhein
- R Keck
- R Kornmann
- R Kornmann
- R Laging
- R Meier
- R Portmann
- R Portmann
- R Portmann
- R Stahringer
- R Sterzenbach
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- R Wild
- R Wimmer
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- RB Meiers
- RC Cohn
- Reese-Schäfer
- Reiser Helmut/Lotz, Walter
- Roth
- Rother
- RW Keck
- Röber-Sickmeyer
- Röhner Charlotte/Skischus, Gabriele/Thies
- S Bernfeld
- S Bundesamt
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- S Bönisch
- S Hebenstreit
- Sandfuchs Uwe/Stange, E. M./Kost, S
- Scheerer-Neumann Gerheid/Petrow, Olga
- Schifler Horst/Winkeler
- Schley Wilfried/Köbberling
- Schlömerkemper Jörg/Winkel, Klaus
- Schmitt Hanno/Link, Jörg W./Tosch
- Schneider Wolfgang/Stefanek, Jan/Dotzler, Hans
- Schoeler Udo/Winter
- Schreier
- Sekretariat der Ständigen Konferenz der Kultusminister der Länder in der Bundesrepublik Deutschland
- Sekretariat der Ständigen Konferenz der Kultusminister der Länder in der Bundesrepublik Deutschland
- Speck-Hamdan
- Stadler Michael/Kruse, Peter
- Steiner-Khamsi
- T Knauf
- T Orlick
- T Schulze
- T Schulze
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- Thurn Susanne/Tillmann, Klaus-Jürgen
- Treinies Gerhard/Einsiedler, Wolfgang
- TW Adorno
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- U Beck
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- U Bronfenbrenner
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- U Carle
- U Carle
- U Carle
- U Drews
- U Drews
- U Drews
- U Gerhard
- U Guzzoni
- U Guzzoni
- U Herrmann
- U Herrmann
- U Jürgens
- U Preuss-Lausitz
- U Preuss-Lausitz
- U Preuss-Lausitz
- U Puritz
- U Sandfuchs
- U Sandfuchs
- U Sandfuchs
- U Sandfuchs
- UBG Beck
- Uhle R./Hoffmann, D. (Hg.)
- V Moser
- V Popp
- Valtin R./Naegele, I. (Hg.)
- Valtin Renate/Postmann, Rosemarie (Hg.)
- Valtin Renate/Sander, Alfred/Reinartz, Anton (Hg.)
- W Einsiedler
- W Einsiedler
- W Einsiedler
- W Einsiedler
- W Einsiedler
- W Flitner
- W Heitmeyer
- W Keim
- W Klafki
- W Klafki
- W Klafki
- W Marotzki
- W Metzger
- W Metzger
- W Rauer
- W Reese-Schäfer
- W Schmid
- W Sünkel
- W Tietze
- W Wallrabenstein
- W Wallrabenstein
- W Welsch
- W Wittenbruch
- W Wittenbruch
- Weigert Hildegund/Weigert
- Weigert Hildegund/Weigert
- Z Bauman
- Z Bauman
- Z Bauman
- Zeil-Fahlbusch
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1999
- Field of study
Таксономия и эволюци я культурных растени й: обзор литературы за 1975–1977 гг.
- Author
- A. A. Filatenko
- A. A. Jušev
- A. B. L. Stemler
- A. Belea
- A. C. Zeven
- A. D. Rotman
- A. Fouzdar
- A. J. B. Fuentealba
- A. J. Kupzow
- A. M. Tarlakovskaja
- A. S. Dariev
- A. Terpo
- A. V. Bogdan
- B. C. Stone
- B. L. Johnson
- B. L. Johnson
- B. R. Baum
- B. R. Baum
- B. V. Ford-Lloyd
- C. M. Rick
- C. M. Rick
- C. M. Rick
- C. M. Rick
- Ch. B. Heiser
- Chin-Ling Wang
- D. E. Giannasi
- D. G. Krishnappa
- D. J. Banks
- E. Small
- E. Small
- F. M. Sacks
- F. R. Fosberg
- F. Tahbaz
- G. C. G. Argent
- G. K. Koval
- G. Ladizinsky
- G. Ladizinsky
- G. Ladizinsky
- G. Ladizinsky
- G. Ladizinsky
- G. Ladizinsky
- H. Brücher
- H. Brücher
- H. Brücher
- H. Brücher
- H. F. Neubauer
- H. G. Wilkes
- H. Kihara
- H. W. Debor
- Harald Ohle
- Helga I. Schäfer
- Hu Shiu Ying
- I. S. Kapanadze
- J. C. Gray
- J. Cullen
- J. Dvořák
- J. G. Hawkes
- J. G. Waines
- J. M. J. Wet de
- J. M. J. Wet de
- J. N. Brunken
- J. N. Brunken
- J. P. Moss
- J. R. Harlan
- J. R. Harlan
- J. R. Harlan
- J. Smartt
- J. T. Williams
- Joachim Kruse
- Jürgen Schultze-Motel
- K. Chen
- K. E. Denford
- K. Hammer
- K. Hammer
- K. Kuckuck
- K. M. Rawal
- K. M. Rawal
- K. W. Hilu
- K. W. Hilu
- Karl Hammer
- L. F. Randolph
- M. A. Veselovskaja
- M. D. Bennett
- M. P. Nayar
- N. D. Mitchell
- N. Degraeve
- N. Kawashima
- N. P. Ivanov
- P. A. Fryxell
- P. A. Gandiljan
- P. A. Gandiljan
- P. A. Thompson
- P. C. Mangelsdorf
- P. Chandravadana
- P. Grun
- P. M. Žukovskij
- P. M. Žukovskij
- Peter Hanelt
- R. A. Udačin
- R. B. Demina
- R. Fritsch
- R. K. Basu
- R. M. Harley
- R. W. Scora
- Reinhard Fritsch
- S. M. Lawani
- S.-T. Chang
- T. Hymowitz
- T. Načev
- T. Yabuno
- T. Yamazaki
- Th. W. Whitaker
- V. D. Kobyljanskij
- V. G. Konarev
- V. K. Dulin
- V. N. Vorošilov
- V. V. Ponomarenko
- W. C. Galinat
- W. H. Eshbaugh
- Y. Shechter
- Z. Afzal-Rafii
- Ė. F. Migušova
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study