Comparison of results from individual component algorithms: four examples.

<p>Comparison of results from individual component algorithms: four examples.</p

The standard procedure for data derivation.

<p>The standard procedure for data derivation.</p

Data sources’ characteristics^*.

<p>Data sources’ characteristics^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0160648#t001fn001" target="_blank">*</a>}.</p

Impact of extracted component algorithms on total case population identified in each participating data source through the application of the relevant recommended composite algorithm.

<p>Impact of extracted component algorithms on total case population identified in each participating data source through the application of the relevant recommended composite algorithm.</p

Component algorithms description.

<p>Component algorithms description.</p

Recommended composite algorithms: age band-specific percentages of subjects identified on the relevant total study population.

<p>PPV: Positive Predictive Value.</p

COVID-19 Host Genetics Initiative. A first update on mapping the human genetic architecture of COVID-19

The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity.</p