Re-evaluation of histological diagnoses of malignant mesothelioma by immunohistochemistry

<p>Abstract</p> <p>Background</p> <p>In order to provide reliable tissue material for malignant mesothelioma (MM) studies, we re-evaluated biopsies and autopsy material from 61 patients with a diagnosis of MM from the period of 1980-2002.</p> <p>Methods</p> <p>Basic positive (Calretinin, EMA, Podoplanin, Mesothelin) and negative (CEA, Ber-Ep4) immunohistochemical (IHC) marker reactions were determined. If needed, more markers were used. Histological diagnoses were made by three pathologists. Survival data were calculated.</p> <p>Results</p> <p>49 cases (80%) were considered being MM by a high degree of likelihood, five more cases possible MM. Of the remaining seven cases, three were diagnosed as adenocarcinoma, three as pleomorphic lung carcinoma, in one peritoneal case a clear entity diagnosis could not be given. One of the possible MM cases and two of the lung carcinoma cases had this already as primary diagnoses, but were registered as MM.</p> <p>With a sensitivity of 100%, Calretinin and CEA were the most reliable single markers. The amount of MM cells with positive immunoreactivity (IR) for Podoplanin and Mesothelin showed most reliable inverse relation to the degree of atypia.</p> <p>In the confirmed MM cases, there had been applied either no IHC or between one and 18 markers.</p> <p>The cases not confirmed by us had either lacked IHC (n = 1), non-specific markers were used (n = 4), IR was different (n = 1), or specific markers had not shown positive IR in the right part of the tumour cells (n = 3).</p> <p>46 of the 49 confirmed and three of the not confirmed cases had been diagnosed by us as most likely MM before IHC was carried out.</p> <p>Conclusions</p> <p>In order to use archival tissue material with an earlier MM diagnosis for studies, histopathological re-evaluation is important. In possible sarcomatous MM cases without any positive IR for positive MM markers, radiology and clinical picture are essential parts of diagnostics. IHC based on a panel of two positive and two negative MM markers has to be adapted to the differential diagnostic needs in each single case. New diagnostic tools and techniques are desirable for cases where IHC and other established methods cannot provide a clear entity diagnosis, and in order to improve MM treatment.</p

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Detta är en konferensrapport från konferensen Barnet i Familjerätten vilken hölls i december 2001. Deltog gjorde domare, familjerättsadvokater och familjerättssekreterare

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PHI THETA KAPPAMembers: William Campbell, Betty Marcovitz, Mava Ciavarella, Kenneth Kluch, Irene Olson, Robert Campbell, and Sharon Glass. Plw~~pOl~~ ~ J-I~ ~PJtSlup Seven members of the graduating sophomore class were selected into the Kappa Omicron chapter of Phi Theta Kappa, national honor society. Receiving this esteemed recognition were Robert and William Campbell, Mava Ciavarella, Sharon Glass, Kenneth Kluch, Betty Marcovitz, and Irene Olson. Membership in Phi Theta Kappa is based on forty-five semester hours of college work. Thirty-six of these must be applicable to an Associate of Arts Degree and at least thirty semester hours must be completed at BJC. The grade average for these forty-five hours must be at least 2.5 (an A being three points). In addition to the required grade average, members must be of good moral character and pleasin~ personality. Mrs. Ruth Gannon, English and Spanish instructor, is local sponsor for the group. 3

Alkoholsamtal med alla blivande föräldrar - utmaning och folkhälsoarbete!

Mödrahälsovården är en viktig arena för reflektion omkring alkohol och föräldraskap. Vissa blivande föräldrapar har senaste året före graviditeten ändrat alkoholvanor men kanske inte reflekterat angående alkoholanvändning tillsammans med små barn. Artikeln visar hur olika blivande föräldrars alkoholvanor samt attityder till alkohol är idag. I artikeln diskuteras också barnens behov vid alkoholism i familjen. Uppgifter om fäders alkoholvanor och alkoholism i familjen/släkten saknas i mödrahälsovårdsjournalen samt registreras ej i medicinska födelseregistret. Därmed försvåras framtida forskning om samband mellan eventuella ”alkoholgener”, alkohol under graviditet och fosterskador. This study descibes how successful information about the harmful effects of alcohol drinking during pregnancy may be delivered. One important finding is that information to both parts in the couple is essential. Key words: Pregnancy and alcohol, intervention, psycho-social support