Can loss-of-function prion-related diseases exist?

Discovery of mutations of the PrnP gene without typical plaque formation and the characterization of two prion receptors led us to postulate a new class of prion-related disease: 'loss of function'.Ludwig Inst Canc Res, BR-01509010 São Paulo, BrazilUNIFESP, Dept Psychiat, BR-01509010 São Paulo, BrazilUNIFESP, Dept Psychiat, BR-01509010 São Paulo, BrazilWeb of Scienc

Aislamiento, cultivo e identificación de microorganismos ambientales a partir de muestras naturales

Se emplearán muestras naturales (agua, suelo, sedimentos de ríos o lagos, heces, etc.) a partir de las cuales se aislaran microrganismos cultivables, principalmente bacterias, mediante el empleo de medios selectivos. Posteriormente se procederá a la identificación por características morfológicas y patrones fisiológicos particulares.Fil: Moreno, Julio Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Planta Piloto de Procesos Industriales Microbiológicos (i); Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; ArgentinaFil: Albarracín, Virginia Helena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Planta Piloto de Procesos Industriales Microbiológicos (i); Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentin

Gestão do SUS : interfederativa e participativa

Trata sobre o federalismo e a política de saúde no Brasil, bem como a relação entre participação social e o SUS. Comenta sobre as fragilidade e desafios da participação socia

Auditoria Contínua - o Futuro da Auditoria no Contexto dos Enterprise Resource Planning

Os sistemas de informação empresarias, Enterprise Resource Planning (ERP), conjuntamente com as recentes tecnologias de negócios da era digital, tem levado a profundas mudanças no sistema de informação contabilístico. Neste contexto, a auditoria tradicional transforma-se com a realidade da auditoria contínua. O objetivo deste estudo é compreender e demonstrar o processo de evolução da auditoria tradicional para a auditoria contínua com o aparecimento dos sistemas de informação empresariais ERP´s. Esta investigação é do tipo exploratório-descritiva, de natureza qualitativa e realizada através de revisão da literatura. Os principais resultados demonstram, entre outros aspetos, a auditoriacontínua como o futuro da auditoria tradicional

Multi-stage Biomarker Models for Progression Estimation in Alzheimer’s Disease

The estimation of disease progression in Alzheimer’s disease (AD) based on a vector of quantitative biomarkers is of high interest to clinicians, patients, and biomedical researchers alike. In this work, quantile regression is employed to learn statistical models describing the evolution of such biomarkers. Two separate models are constructed using (1) subjects that progress from a cognitively normal (CN) stage to mild cognitive impairment (MCI) and (2) subjects that progress from MCI to AD during the observation window of a longitudinal study. These models are then automatically combined to develop a multi-stage disease progression model for the whole disease course. A probabilistic approach is derived to estimate the current disease progress (DP) and the disease progression rate (DPR) of a given individual by fitting any acquired biomarkers to these models. A particular strength of this method is that it is applicable even if individual biomarker measurements are missing for the subject. Employing cognitive scores and image-based biomarkers, the presented method is used to estimate DP and DPR for subjects from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Further, the potential use of these values as features for different classification tasks is demonstrated. For example, accuracy of 64% is reached for CN vs. MCI vs. AD classification

Electronic and structural distortions in graphene induced by carbon vacancies and boron doping

We present an ab initio study on the structural and electronic distortions of modified graphene by creation of vacancies, inclusion of boron atoms, and the coexistence of both, by means of thermodynamics and band structure calculations. In the case of coexistence of boron atoms and vacancy, the modified graphene presents spin polarization only when B atoms locate far from vacancy. Thus, when a boron atom fills single- and di-vacancies, it suppresses the spin polarization of the charge density. In particular when B atoms fill a di-vacancy a new type of rearrangement occurs, where a stable BC4 unit is formed inducing important out of plane distortions to graphene. All these findings suggest that new chemical modifications to graphene and new type of vacancies can be used for interesting applications such as sensor and chemical labeling.Comment: 22 pages, 9 figures and 3 table

Simulation of Aldehyde Emissions from an Ethanol Fueled Spark Ignition Engine and Comparison with FTIR Measurements

This paper presents a mathematical model that calculates aldehyde emissions in the exhaust of a spark ignition engine fueled with ethanol. The numerical model for aldehyde emissions was developed using FORTRAN software, with the input data obtained from a dedicated engine cycle simulation software, AVL BOOST. The model calculates formaldehyde and acetaldehyde emissions, formed from the partial oxidation of methane, ethane and unburned ethanol. The calculated values were compared with experimental data obtained by Fourier Transform Infrared Spectroscopy (FTIR). The experiments were performed with a mid-size sedan powered by a 1.4-liter spark ignition engine on a chassis dynamometer. In general, the results demonstrate that the concentrations of aldehydes and the source elements increased with engine speed and exhaust gas temperature. A reasonable agreement between simulated and measured values was achieved