Helen Lyon and Evelyn Bowden in a Joint Recital

This is the program for the joint recital of violinist Helen Lyon and pianist Evelyn Bowden. This recital took place on May 26, 1946, in Mitchell Hall

Social entrepreneurship: Entrepreneurship and social value creation

Social entrepreneurship has attracted attention from scholars, policy makers and practitioners in developed and developing countries around the world. Much of the early research was devoted to addressing definitional debates and contextual differences and only recently have scholars turned their attention to investigating the relationship between social value creation and opportunity identification and exploitation. The aim of the chapter is three fold. First, we review the rise to prominence of social entrepreneurship and the principal definitional and contextual debates. Second, we summarize the main research findings concerning social value creation and opportunity identification and exploitation. Finally, we identify ten critical topics for advancing social entrepreneurship knowledge and theory development

Eugene Taylor, Helen Lyon, and Sue Plumlee in a Faculty Recital

This is the program for the faculty recital of pianist Eugene Taylor, violinist Helen Lyon, and harpist Sue Plumlee. This recital took place on May 19, 1957, in the Mitchell Hall Auditorium

Marjorie Stobaugh in a Senior Soprano Recital

This is the program for the senior soprano recital of Marjorie Stobaugh, accompanied by pianist, David Glaze, and violinist, Helen Lyon. The recital was held on February 27, 1968, in Mitchell Hall

A study of the effectiveness of a phonetic and activity approach to the teaching of spelling in grade four,

Includes appendices. Thesis (M.A.)--Boston Universit

Cindy Dvirnak Schultz, George Keck, and Helen Lyon in a Recital

This program is for the joint recital of mezzo-soprano Cindy Dvirnak Schultz, pianist George Keck, and violist Helen Lyon. The recital took place on September 19, 1978, in the Mabee Fine Arts Recital Hall

Faculty Recital

This is the program for the faculty recital featuring the following artists in order of performance: organist Evelyn Bowden; baritone Jimmy Tompkins and pianist George Keck; violinist Helen Lyon and pianist William Bill Trantham; soprano Frances Scott and pianist Roberta Rauch; flutist Ralph Rauch and pianist Roberta Rauch; soprano Mary Shambarger and pianist Virginia Queen; and soprano Frances Scott, flautist Ralph Rauch, and pianist Roberta Rauch. This recital took place on November 2, 1972, in Mitchell Hall Auditorium

Faculty Recital

This is the program for the faculty recital featuring several faculty artists (in order of performance): violinists Helen Lyon and Nancy Umiker, flautist Ralph Rauch, trumpet player James Smith, and cellist Alex Nisbet; trumpet player James Smith, pianist Evelyn Bowden; flautist Ralph Rauch and pianist Virginia Queen; pianist William Bill Trantham and violinist Helen Lyon; and trumpet player James Smith, bassoon player Charles Wesley, and pianist Evelyn Bowden. This recital took place on February 29, 1968, in Mitchell Hall

Faculty Recital

This is the program for the faculty recital featuring violinist Helen Lyon and pianist Cecil Rhea Crawford and duo pianists Evelyn Bowden and Virginia Queen. This recital took place on March 28, 1950, in Mitchell Hall

Rheumatoid arthritis synovial fluid neutrophils drive inflammation through production of chemokines, reactive oxygen species and neutrophil extracellular traps

ABSTRACT Rheumatoid arthritis (RA) is a chronic inflammatory disorder affecting synovial joints. Neutrophils are believed to play an important role in both the initiation and progression of RA, and large numbers of activated neutrophils are found within both synovial fluid (SF) and synovial tissue from RA joints. In this study we analysed paired blood and SF neutrophils from patients with severe, active RA (DAS28> 5.1, n=3) using RNA-seq. 772 genes were significantly different between blood and SF neutrophils. IPA analysis predicted that SF neutrophils had increased expression of chemokines and ROS production, delayed apoptosis, and activation of signalling cascades regulating the production of NETs. This activated phenotype was confirmed experimentally by incubating healthy control neutrophils in cell-free RA SF, which was able to delay apoptosis and induce ROS production in both unprimed and TNF α primed neutrophils (p< 0.05). RA SF significantly increased neutrophil migration through 3mM transwell chambers (p< 0.05) and also increased production of NETs by healthy control neutrophils, including exposure of myeloperoxidase (MPO) and citrullinated histone-H3-positive DNA NETs. IPA analysis predicted NET production was mediated by signalling networks including AKT, RAF1, SRC and NF- κ B. Our results expand the understanding of the molecular changes that take place in the neutrophil transcriptome during migration into inflamed joints in RA, and the altered phenotype in RA SF neutrophils. Specifically, RA SF neutrophils lose their migratory properties, residing within the joint to generate signals that promote joint damage, as well as inflammation via recruitment and activation of both innate and adaptive immune cells. We propose that this activated SF neutrophil phenotype contributes to the chronic inflammation and progressive damage to cartilage and bone observed in patients with RA