Clear-cell carcinoma of the breast, resembling clear-cell carcinoma of the kidney

The lobular arrangement and the fine vascular network are clearly visible.<p><b>Copyright information:</b></p><p>Taken from "Glycogen-rich clear cell carcinoma of the breast"</p><p>http://www.wjso.com/content/6/1/44</p><p>World Journal of Surgical Oncology 2008;6():44-44.</p><p>Published online 29 Apr 2008</p><p>PMCID:PMC2386120.</p><p></p

PCR Primers for FOXP3 (TC)n amplification.

<p>PCR Primers for FOXP3 (TC)n amplification.</p

Univariate overall survival (OS) analysis.

<p>Univariate overall survival (OS) analysis.</p

Multivariate overall survival (OS) analysis.

<p>Multivariate overall survival (OS) analysis.</p

Multivariate overall survival (OS) analysis with stage correction.

<p>Multivariate overall survival (OS) analysis with stage correction.</p

Univariate relapse free survival (RFS) analysis.

<p>Univariate relapse free survival (RFS) analysis.</p

The LOOV Validated Kaplan-Meier curve based on combined survival risk model.

<p>The LOOCV Kaplan-Meier curves showed that the five-marker OS model (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0040805#pone-0040805-g004" target="_blank">Figure 4A</a>) and the combined model (five-marker + stage model) (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0040805#pone-0040805-g004" target="_blank">Figure 4B</a>) may be used to predict RFS survival data. In each round of LOOCV, the model was built in the training set using the OS information and tested on the left out sample using the RFS information.</p

LOOCV Kaplan-Meier and Time-dependent ROC curves.

<p>A prognostic index for a patient with a specific genotyping profile were calculated as the weighted average (weighted as regression coefficient) of the five-marker genotypes. LOOCV Kaplan-Meier curve (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0040805#pone-0040805-g002" target="_blank">Figure 2</a> A) identified 90 patients (22 deaths) in the low risk group (green line) and 194 (78 deaths) in the high risk group (red line). Time-dependent ROC curves showed that the AUCs at 5 and 7 year were 0.645 and 0.720, respectively (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0040805#pone-0040805-g002" target="_blank">Figure 2B</a>, 7 year survival ROC curve).</p

Kaplan-Meier curves for DRB1*15 for OS and RFS.

<p>The Leave-One-Out Cross Validated (LOOCV) Kaplan-Meier curves to compare DRB1*15 positive (red line) and negative patients (green line) for OS (log rank p value = 0.027) (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0040805#pone-0040805-g001" target="_blank">Figure 1A</a>) and RFS (log rank p value = 0.025) (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0040805#pone-0040805-g001" target="_blank">Figure 1B</a>), respectively.</p

The Kaplan–Meier (KM) plot of RFS by the dichotomized multi-marker score in Arm B (patients treated with one month of interferon-α).

<p>One month pro-inflammatory cytokines (IL2Rα, IL-12p40 and IFN-α) predict one year RFS.</p