The treatment of primary tumors of the femur with chemotherapy (if indicated), resection and reconstruction with an endoprosthesis

The treatment protocol of 15 patients with a primary tumor of the femur, including osteosarcoma, malignant fibrous histiocytoma and chondrosar-coma is presented. All patients had been selected for resection and reconstruction with an endoprosthesis. An endoprothesis was implanted in 12 patients. \ud The results of this type of treatment appear to be satisfactory. In eight osteosarcoma cases resection and reconstruction with an endoprosthesis combined with preoperative and postoperative chemotherapy, according to Rosen, were performed. Follow-up in all 15 patients, varying from 1.4 to 6.0 years, showed no evidence of disease in 12 patients. Three patients had died. Function of the involved leg was satisfactory in most cases. \ud The advantage and disadvantages of the use of an endoprosthesis are discussed as well as complications in this series of patients

Quantification of bone involvement in Gaucher disease: MR imaging bone marrow burden score as an alternative to dixon quantitative chemical shift MR imaging - Initial experience

PURPOSE: To develop a semiquantitative magnetic resonance (MR) imaging bone marrow burden (BMB) score with inclusion of both axial and peripheral bone marrow in Gaucher disease as an alternative to MR imaging with the Dixon quantitative chemical shift imaging (QCSI) technique.MATERIALS AND METHODS: Two experienced musculoskeletal radiologists with no experience in evaluating Gaucher disease blindly analyzed MR images of lumbar spines and femora. Interobserver and intraobserver variability were tested. In addition, the BMB score was determined as a parameter to evaluate bone marrow response to enzyme supplementation therapy. Finally, the BMB score was compared with fat fraction measurements obtained with Dixon QCSI. Differences between groups were analyzed by using the nonparametric Mann-Whitney test. A P value of less than .05 was considered to represent significance. Correlation was calculated by using two-tailed nonparametric rank correlation (Spearman ρ).RESULTS: In 30 patients (mean age, 39.3 years; age range, 12–71 years) the mean fat fraction was 0.20 (range, 0.08–0.40). The BMB score range was 3–13 points. A significant correlation was found between the two observers when using BMB (ρ = 0.91, P P P CONCLUSION: BMB is a reproducible semiquantitative scoring system that is easy to use. It combines MR imaging of both axial and peripheral bone marrow and shows a significant correlation with QCSI.FWN – Publicaties zonder aanstelling Universiteit Leide

[Computerised assessment of screening mammograms]

Item does not contain fulltextMore than one million mammograms are performed in the Netherlands each year. Today, these images are all in digital format and processed by various types of software for optimal display during radiological analysis. As a result of continuous quality control on national public health screening for breast cancer, approximately 1000 cases of interval carcinoma and any T2 tumours identified during this screening are re-assessed. The results of these retrospective analyses suggest that there is room for improvement in terms of the reliability of screening mammography without this resulting in an excessive increase of false positive results. Research has shown that the more radiological evaluators are involved, the better the results. Alternatively, a computer can be utilised for detecting abnormalities. Large-scale use of Computer-Assisted Detection (CAD) is already underway in some countries. For this reason, the option of adding CAD to the current practice of double assessment of mammograms could be considered a sensible option for the future

Apparatus and method of navigating an instrument

An apparatus to be used with navigating an instrument in a vascular tree of a patient, comprises a patient's examination table, a C-arm, mounted to which is an X-ray source and an image recorder for registering first X-ray images of the patient, obtained by the use of the X-ray source, and a processing unit connected with the image recorder for processing the images of the first images registered by the image recorder, as well as a monitor optionally connectable with the processing unit for displaying the image, wherein the processing unit is designed for combining the first X-ray images of the patient with second image data relating to at least a portion of the patient's vascular tree, wherein the processing unit is designed for, with respect to an adjustable projection orientation,; deriving a two-dimensional projection image from threedimensional image data concerning the vascular tree of the patient, wherein the projection orientation depends on the information regarding the situation and/or position of the patient's examination table and/or the C-armMechanical, Maritime and Materials Engineerin

Digital mammography in breast cancer screening: a step forward?

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