Oculomotor fatigue and neuropsychological assessments mirror multiple sclerosis fatigue

Fatigue is a major complaint in MS. Up to now no objective assessment tools have been established which hampers any treatment approach. Previous work has indicated an association of fatigue with cognitive measures of attention. Oculomotor tests have been established in healthy individuals as a read-out of fatigue, and to some extent in MS patients. Based on these observations we compared two groups of MS patients, one with fatigue (n=28) and one without fatigue (n=21) and a group of healthy subjects (n=15) with a stand- ardised computerised measure of alertness and an oculomotor stress test. Patients with fatigue showed highly significant changes of their saccade dynamics as defined by the Main Sequence and Phase Plane plots: They showed slowing of saccades, the characteristical fatigue double peak, and an asymmetrical phase plane. Oculomotor tests differentiated significantly between fatigue and fatigabiliy in our MS patients. They also showed significantly worse performance in the alertness test as well as in the oculomotor task. Significantly slower reaction times were observed for tonic alertness in 2 series without a cue (p=.025 and p=.037) but not in phasic alertness with a cue (p=.24 and p=.34). Performance was influenced by disability as well as by affective state. We conclude, when controlling for disability and depression, saccadic stress tests and alertness tests could be used as an objective read-out for fatigability and fatigue in MS patients

Polarisation properties of Milky-Way-like galaxies

(Abridged) We study the polarisation properties, magnetic field strength, and synchrotron emission scale-height of Milky-Way-like galaxies in comparison with other spiral galaxies. We use our 3D-emission model of the Milky Way Galaxy for viewing the Milky Way from outside at various inclinations as spiral galaxies are observed. When seen edge-on the synchrotron emission from the Milky Way has an exponential scale-height of about 0.74 kpc, which is much smaller than the values obtained from previous models. We find that current analysis methods overestimate the scale-height of synchrotron emission of galaxies by about 10% at an inclination of 80 degree and about 40% at an inclination of 70 degree because of contamination from the disk. The observed RMs for face-on galaxies derived from high-frequency polarisation measurements approximate to the Faraday depths (FDs) when scaled by a factor of two. For edge-on galaxies, the observed RMs are indicative of the orientation of the large-scale magnetic field, but are not well related with the FDs. Assuming energy equipartition between the magnetic field and particles for the Milky Way results in an average magnetic-field strength, which is about two times larger than the intrinsic value for a K factor of 100. The number distribution of the integrated polarisation percentages of a large sample of unresolved Milky-Way-like galaxies peaks at about 4.2% at 4.8 GHz and at about 0.8% at 1.4GHz. Integrated polarisation angles rotated by 90 degree align very well with the position angles of the major axes, implying that unresolved galaxies do not have intrinsic RMs.Comment: 10 pages, 11 figures, accepted for publication in A&

The non-thermal superbubble in IC 10 : the generation of cosmic ray electrons caught in the act

Superbubbles are crucial for stellar feedback, with supposedly high (of the order of 10 per cent) thermalization rates. We combined multiband radio continuum observations from the Very Large Array (VLA) with Effelsberg data to study the non-thermal superbubble (NSB) in IC 10, a starburst dwarf irregular galaxy in the Local Group. Thermal emission was subtracted using a combination of Balmer Hα and VLA 32 GHz continuum maps. The bubble’s nonthermal spectrum between 1.5 and 8.8 GHz displays curvature and can be well fitted with a standard model of an ageing cosmic ray electron population. With a derived equipartition magnetic field strength of 44 ±8 μG, and measuring the radiation energy density from Spitzer MIPS maps as 5±1×10−11 erg cm−3, we determine, based on the spectral curvature, a spectral age of the bubble of 1.0 ± 0.3 Myr. Analysis of the LITTLE THINGS HI data cube shows an expanding HI hole with 100 pc diameter and a dynamical age of 3.8 ± 0.3 Myr, centred to within 16 pc on IC 10 X-1, a massive stellar mass black hole (M > 23 M⊙). The results are consistent with the expected evolution for a superbubble with a few massive stars, where a very energetic event like a Type Ic supernova/hypernova has taken place about 1 Myr ago. We discuss alternatives to this interpretationPeer reviewe

A Role for Judgment Aggregation in Coauthoring Scientific Papers

This paper addresses the problem of judgment aggregation in science. How should scientists decide which propositions to assert in a collaborative document? We distinguish the question of what to write in a collaborative document from the question of collective belief. We argue that recent objections to the application of the formal literature on judgment aggregation to the problem of judgment aggregation in science apply to the latter, not the former question. The formal literature has introduced various desiderata for an aggregation procedure. Proposition-wise majority voting emerges as a procedure that satisfies all desiderata which represent norms of science. An interesting consequence is that not all collaborating scientists need to endorse every proposition asserted in a collaborative document.LKB and RH acknowledge support from the National Science Foundation through Grant SES 1254291. RH also acknowledges support from the Leverhulme Trust and the Isaac Newton Trust through an Early Career Fellowship

GABAergic interneuron diversity and organization are crucial for the generation of human-specific functional neural networks in cerebral organoids

This mini review investigates the importance of GABAergic interneurons for the network function of human-induced pluripotent stem cells (hiPSC)-derived brain organoids. The presented evidence suggests that the abundance, diversity and three-dimensional cortical organization of GABAergic interneurons are the primary elements responsible for the creation of synchronous neuronal firing patterns. Without intricate inhibition, coupled oscillatory patterns cannot reach a sufficient complexity to transfer spatiotemporal information constituting physiological network function. Furthermore, human-specific brain network function seems to be mediated by a more complex and interconnected inhibitory structure that remains developmentally flexible for a longer period when compared to rodents. This suggests that several characteristics of human brain networks cannot be captured by rodent models, emphasizing the need for model systems like organoids that adequately mimic physiological human brain function in vitro

Calibrating the relation of low-frequency radio continuum to star formation rate at 1 kpc scale with LOFAR

9 figures, 6 tables and 17 pages. This paper is part of the LOFAR surveys data release 1 and has been accepted for publication in a special edition of A&A that will appear in Feb 2019, volume 622. The catalogues and images from the data release will be publicly available on lofar-surveys.org upon publication of the journal. Reproduced with permission from Astronomy & Astrophysics. © 2018 ESO.Radio continuum (RC) emission in galaxies allows us to measure star formation rates (SFRs) unaffected by extinction due to dust, of which the low-frequency part is uncontaminated from thermal (free-free) emission. We calibrate the conversion from the spatially resolved 140 MHz RC emission to the SFR surface density ($\Sigma_{\rm SFR}$) at 1 kpc scale. We used recent observations of three galaxies (NGC 3184, 4736, and 5055) from the LOFAR Two-metre Sky Survey (LoTSS), and archival LOw-Frequency ARray (LOFAR) data of NGC 5194. Maps were created with the facet calibration technique and converted to radio $\Sigma_{\rm SFR}$ maps using the Condon relation. We compared these maps with hybrid $\Sigma_{\rm SFR}$ maps from a combination of GALEX far-ultraviolet and Spitzer 24 $\mu\rm m$ data using plots tracing the relation at $1.2\times 1.2$-kpc$^2$ resolution. The RC emission is smoothed with respect to the hybrid $\Sigma_{\rm SFR}$ owing to the transport of cosmic-ray electrons (CREs). This results in a sublinear relation $(\Sigma_{\rm SFR})_{\rm RC} \propto [(\Sigma_{\rm SFR})_{\rm hyb}]^{a}$, where $a=0.59\pm 0.13$ (140 MHz) and $a=0.75\pm 0.10$ (1365 MHz). Both relations have a scatter of $\sigma = 0.3~\rm dex$. If we restrict ourselves to areas of young CREs ($\alpha > -0.65$; $I_\nu \propto \nu^\alpha$), the relation becomes almost linear at both frequencies with $a\approx 0.9$ and a reduced scatter of $\sigma = 0.2~\rm dex$. We then simulate the effect of CRE transport by convolving the hybrid $\Sigma_{\rm SFR}$ maps with a Gaussian kernel until the RC-SFR relation is linearised; CRE transport lengths are $l=1$-5 kpc. Solving the CRE diffusion equation, we find diffusion coefficients of $D=(0.13$-$1.5) \times 10^{28} \rm cm^2\,s^{-1}$ at 1 GeV. A RC-SFR relation at $1.4$ GHz can be exploited to measure SFRs at redshift $z \approx 10$ using $140$ MHz observations.Peer reviewe

The influence of the cluster environment on the large-scale radio continuum emission of 8 Virgo cluster spirals

The influence of the environment on the polarized and total power radio continuum emission of cluster spiral galaxies is investigated. We present deep scaled array VLA 20 and 6 cm observations including polarization of 8 Virgo spiral galaxies. These data are combined with existing optical, HI, and Halpha data. Ram pressure compression leads to sharp edges of the total power distribution at one side of the galactic disk. These edges coincide with HI edges. In edge-on galaxies the extraplanar radio emission can extend further than the HI emission. In the same galaxies asymmetric gradients in the degree of polarization give additional information on the ram pressure wind direction. The local total power emission is not sensitive to the effects of ram pressure. The radio continuum spectrum might flatten in the compressed region only for very strong ram pressure. This implies that neither the local star formation rate nor the turbulent small-scale magnetic field are significantly affected by ram pressure. Ram pressure compression occurs mainly on large scales (>=1 kpc) and is primarily detectable in polarized radio continuum emission.Comment: 16 pages, 10 figures, accepted for publication in A&

GMRT 333 MHz observations of 6 nearby normal galaxies

We report Giant Meterwave Radio Telescope (GMRT) continuum observations of six nearby normal galaxies at 333 MHz. The galaxies are observed with angular resolutions better than ~20" (corresponding to a linear scale of about 0.4 - 1 kpc). These observations are sensitive to all the angular scales of interest, since the resolution of the shortest baseline in GMRT is greater than the angular size of the galaxies. Further, for five of these galaxies we show that at 333 MHz, the mean thermal fraction is less than 5%. Using archival data at about 1 GHz, we estimate the mean thermal fraction to be about 10% at that frequency. We also find that the nonthermal spectral index is generally steeper in regions with low thermal fraction and/or located in the outer parts of the galaxy. In regions of high thermal fraction, the nonthermal spectral index is flatter, and has a narrow distribution peaking at ~ -0.78 with a spread of 0.16, putting stringent constraints on the physical conditions for generation, diffusion and energy losses of cosmic ray electrons at scales of ~ 1 kpc.Comment: 18 pages, 11 figures, Accepted for publication in MNRA

26Al kinematics: superbubbles following the spiral arms? : Constraints from the statistics of star clusters and HI supershells

High energy resolution spectroscopy of the 1.8 MeV radioactive decay line of 26Al with the SPI instrument on board the INTEGRAL satellite has recently revealed that diffuse 26Al has large velocities in comparison to other components of the interstellar medium in the Milky Way. 26Al shows Galactic rotation in the same sense as the stars and other gas tracers, but reaches excess velocities up to 300 km s−1Peer reviewe