Ayurvedic management for Shleshmiki Yoni Vyapada w.s.r to Vaginal Candidiasis

Shleshmiki Yoni Vyapada is one among the 20 Yonivyapada described in Ayurvedic classics. In this condition the female experiences itching, white unctuous discharge per vaginum, dull pain. According to Acharya Charaka the woman appears pale. Vaginal Candidiasis is a very common condition having similar signs and symptoms. About 70-75 % of the female population experiences vaginal candidiasis at least once in their lifetime. Ayurvedic Acharyas have advised various treatment methods which are being practiced since ancient times and have shown effective results in such conditions. Sthanika Chikitsa has been advised in such conditions along with oral medications which give a systemic effect correcting the imbalance of Doshas, thus further preventing the progression of the disease and also treating it

Ayurvedic management for Prasamsini w.s.r to 1st and 2nd degree Genital Prolapse

Prasamsini Yonivyapad is one among the 20 Yonivyapad described by Acharya Sushruta as a condition in which any irritation to the Yoni causes its prolapse. This condition can be correlated with primary and secondary uterine prolapse.[1] While dealing with the condition of genital prolapse surgical interventions cannot be always undertaken or in some cases they can also be avoided. Conservative measures can be advised in such cases. For example, it is a great mistake to advice immediate operative treatment for prolapse in a young women following childbirth as there is always a possibility of recurrence. Besides these women rapidly improve if well-directed conservative measures are adopted.[2] Also, in females for whom surgery is contra-indicated or is hazardous on account of some medical disorders or in case of post-operative risk of vault prolapse or reoccurrence conservative treatment can be undertaken. Ayurvedic Acharyas have advised various treatment methods which are being practiced since ancient times and have shown effective results in many such cases of prolapse. These procedures give strength to the tissues removing laxity which is the basic defect in this condition. Along, with oral medications which give a systematic effect correcting the imbalance of Dosha, thus further preventing the progression of the disease

Identification of Technical Solutions to Improve Primary Education: A Real-Life Application

Quality Function Deployment (QFD) is a meticulous procedure of translating consumers’ needs and demands into appropriate solutions. The application of QFD has been expanded, leaving no definite boundary for its potential use, to almost every field of life. It helps   identify not only the needs and demands of a certain matter but also helps find out the solutions of those matters along with assigning them the priorities. Primary education enjoys the fundamental role and provides the foundation for further upbringing of children with respect to their educational, social, intellectual, cultural, emotional and physical proficiencies. This research article is aimed at exploring the Voices of Parents, (VOPs) (parent’s needs and demands) regarding their children’s educational requirements at primary school level. This objective is achieved by identifying significant VOPs and then converting these into Technical Solution for better and high quality of education.  With the help of QFD methodology, a real-life case study has been conducted to identify VOPS their technical solutions, then the order of these technical solutions is determined and, finally, suggestions are made about which technical solution is the most important and which one is the least. The findings provide a guide line for primary school stakeholder to identify problems and their solutions for better standard and quality of education

The Semi-Classical Regime for Dark Matter Self-Interactions

Many particle physics models for dark matter self-interactions - motivated to address long-standing challenges to the collisionless cold dark matter paradigm - fall within the semi-classical regime, with interaction potentials that are long-range compared to the de Broglie wavelength for dark matter particles. In this work, we present a quantum mechanical derivation and new analytic formulas for the semi-classical momentum transfer and viscosity cross sections for self-interactions mediated by a Yukawa potential. Our results include the leading quantum corrections beyond the classical limit and allow for both distinguishable and identical dark matter particles. Our formulas supersede the well-known formulas for the momentum transfer cross section obtained from the classical scattering problem, which are often used in phenomenological studies of self-interacting dark matter. Together with previous approximation formulas for the cross section in the quantum regime, our new results allow for nearly complete analytic coverage of the parameter space for self-interactions with a Yukawa potential. We also discuss the phenomenological implications of our results and provide a new velocity-averaging procedure for constraining velocity-dependent self-interactions. Our results have been implemented in the newly released code CLASSICS.Comment: 25 pages + appendices, 8 figures + 1 table, CLASSICS code to calculate self-interaction cross sections available at https://github.com/kahlhoefer/CLASSICS. v2: updated to reflect published versio

New bounds on light millicharged particles from the tip of the red-giant branch

Stellar energy loss is a sensitive probe of light, weakly coupled dark sectors, including ones containing millicharged particles (MCPs). The emission of MCPs can affect stellar evolution, and therefore can alter the observed properties of stellar populations. In this work, we improve upon the accuracy of existing stellar limits on MCPs by self-consistently modelling (1) the MCP emission rate, accounting for all relevant in-medium effects and production channels, and (2) the evolution of stellar interiors (including backreactions from MCP emission) using the MESA stellar evolution code. We find MCP emission leads to significant brightening of the tip of the red-giant branch. Based on photometric observations of 15 globular clusters whose bolometric magnitudes are inferred using parallaxes from Gaia astrometry, we obtain robust bounds on the existence of MCPs with masses below 100 keV.Comment: 12 pages, 8 figure

Diagnostic concordance and discordance in digital pathology : a systematic review and meta-analysis

Background – Digital pathology (DP) has the potential to fundamentally change the way that histopathology is practiced, by streamlining the workflow, increasing efficiency, improving diagnostic accuracy and facilitating the platform for implementation of artificial intelligence-based computerassisted diagnostics. Although the barriers to wider adoption of digital pathology have been multifactorial, limited evidence of reliability has been a significant contributor. A meta-analysis to demonstrate the combined accuracy and reliability of DP is still lacking in the literature. Objectives – We aimed to review the published literature on the diagnostic use of DP and to synthesise a statistically pooled evidence on safety and reliability of DP for routine diagnosis (primary and secondary) in the context of validation process. Methods – A comprehensive literature search was conducted through PubMed, Medline, EMBASE, Cochrane Library and Google Scholar for studies published between 2013 and August 2019. The search protocol identified all studies comparing DP with light microscopy (LM) reporting for diagnostic purposes, predominantly including H&E stained slides. Random-effects meta-analysis was used to pool evidence from the studies. Results – Twenty five studies were deemed eligible to be included in the review which examined a total of 10,410 histology samples (average sample size 176). For overall concordance (clinical concordance) the agreement percentage was 98.3% (95% Confidence interval: 97.4 – 98.9) across 24 studies. A total of 546 major discordances were reported across 25 studies. Over half (57%) of these were related to assessment of nuclear atypia, grading of dysplasia and malignancy. These were followed by challenging diagnoses (26%) and identification of small objects (16%). Conclusion - The results of this meta-analysis indicate equivalent performance of DP in comparison to LM for routine diagnosis. Furthermore, the results provide valuable information concerning the areas of diagnostic discrepancy which may warrant particular attention in the transition to DP

Neurological disorders in HIV:Hope despite challenges

INTRODUCTION: Human Immunodeficiency virus (HIV) is a virus that causes several diseases by attacking the human immune system. It is transmitted by contact with certain bodily fluids of an infected person, most commonly during unprotected sex, through sharing needles, or from mother to baby during pregnancy, birth or breastfeeding. The central nervous system is not spared from this virus, as HIV has been shown to induce several neurological disorders. However most neurological pathologies (such as dementia, infections, meningitis, and neuropathy) rarely show until late stages, in this case, after the patients develop acquired immunodeficiency syndrome (AIDS). This article aims to review the neurological disorders in the HIV population and the attempts initiated to limit the disease. METHODOLOGY: Data were collected from medical journals published on PubMed, Ovid MEDLINE, Science Direct and Embase bibliographical databases with a predefined search strategy. All articles considering neurological disorders associated with HIV were considered. RESULTS: To date, the pathogenesis of HIV‐associated neurological complications remains poorly elucidated; thus, imposing a hindrance and limitations on the treatment options. Nevertheless, some studies have reported alterations in dendritic spine as the causative agent for developing brain damage. CONCLUSION: HIV remains one of the most serious global health challenges, with neurological manifestations imposing a major concern among patients with HIV. Despite the availability and efficacy of antiretroviral therapies, yet, the risk of developing neurological complications remains relatively high among patients with HIV. Thus, the 2030 HIV vision must focus on further preventive measures to protect HIV patients from developing such neurological complications