298 research outputs found
Development of Functional Bioengineered Muscle Models and a Novel Micro-Perfusion System.
- Author
- Publication venue
- Publication date
- Field of study
Tissue engineering combines the principles of medical, life science, and engineering fields toward the development of biological substitutes to restore, maintain, or improve tissue function. Previous work has demonstrated the feasibility of bioengineering smooth muscle tissue in vitro; however the contractile properties of bioengineered smooth muscle tissue have not been evaluated. It is imperative that bioengineered tissues have a high degree of functional testing in order to evaluate tissue-specific function as well as suitability for future clinical applications. This research describes the development and functional testing of novel 3-dimensional bioengineered smooth muscle tissues in vitro and the development of a micro-perfusion system to support culture and enhance functionality of bioengineered tissues. All bioengineered tissue models described here were developed utilizing a fibrin biomaterial, which is well-suited for bioengineering contractile tissues. We developed ring-shaped models of rat sphincter and colonic smooth muscle tissue as well as a strip model of human aortic vascular smooth muscle tissue. Functional testing of the contractile properties of bioengineered muscle tissues was accomplished using a custom build force transducer. Bioengineered tissues exhibited striking tissue-specific functionality, which was similar to smooth muscle in vivo, including the generation of spontaneous basal tone and agonist-induced contraction and relaxation, which was calcium-dependent and calcium-independent (respectively). Finally, in order to support the increased metabolic demands of bioengineered tissues, we designed and fabricated a novel micro-perfusion system to promote delivery of a constant supply of oxygenated media to bioengineered tissues. We tested the compatibility of our micro-perfusion system with Bioengineered Heart Muscle (BEHM) and found that the system is capable of supporting viability (mitochondrial activity, total protein, total RNA) and maintaining contractile properties (twitch force, specific force, electrical pacing, and expression of contractile proteins) of bioengineered tissues. In addition, short-term exposure of BEHMs to micro-perfusion resulted in some functional improvement. This research specifically adds to the knowledge base of two critical areas in tissue engineering research: 1) the development of functional bioengineered models, and 2) ancillary technology to support these models. Collectively, this research bridges several scientific and technological gaps in the field of functional tissue engineering.Ph.D.Applied PhysicsUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/58465/1/lhecker_1.pd
Functional Evaluation of Isolated Zebrafish Hearts
- Publication venue
- 'Mary Ann Liebert Inc'
- Publication date
- 01/12/2008
- Field of study
Abstract Traditional working heart preparations, based on the original Langendorff setup, are widely used experimental models that have tremendously advanced the cardiovascular field. However, these systems can be deceivingly complex, requiring the maintenance of pH with CO2, the delivery of oxygenated perfusate, and the need for extensive laboratory equipment. We have examined the feasibility of using isolated zebrafish (Danio rerio) hearts as an experimental model system, in which experimental procedures can be performed in the absence of the traditional requirements and sophisticated setup equipment. Isolated zebrafish hearts exhibited spontaneous contractile activity, could be electrically paced, and were responsive to pharmacologic stimulation with isoproterenol for 1.5 h after in vivo removal. Isolated zebrafish hearts offer a time- and cost-effective alternative to traditional Langendorff/working heart preparation models, and could be used to investigate cardiac function and repair.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63209/1/zeb.2008.0550.pd
NOX Enzymes and Pulmonary Disease
- Author
- Publication venue
- 'Mary Ann Liebert Inc'
- Publication date
- 01/10/2009
- Field of study
Abstract The primary function of the lung is to facilitate the transfer of molecular oxygen (O2; dioxygen) from the atmosphere to the systemic circulation. In addition to its essential role in aerobic metabolism, O2 serves as the physiologic terminal acceptor of electron transfer catalyzed by the NADPH oxidase (NOX) family of oxidoreductases. The evolution of the lungs and circulatory systems in vertebrates was accompanied by increasing diversification of NOX family enzymes, suggesting adaptive roles for NOX-derived reactive oxygen species in normal physiology. However, this adaptation may paradoxically carry detrimental consequences in the setting of overwhelming/persistent environmental stressors, both infectious and noninfectious, and during the process of aging. Here, we review current understanding of NOX enzymes in normal lung physiology and their pathophysiologic roles in a number of pulmonary diseases, including lung infections, acute lung injury, pulmonary arterial hypertension, obstructive lung disorders, fibrotic lung disease, and lung cancer. Antioxid. Redox Signal. 11, 2505-2516.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78108/1/ars.2009.2599.pd
Mitochondrial physiology
- Author
- Aasander Frostner Eleonor
- Abdel-Rahman Engy Ali
- Abdul Karim Norwahidah
- Abumrad Nada A
- Acuna-Castroviejo Dario
- Adiele Reginald C
- Ahn Bumsoo
- Alencar Mayke Bezerra
- Ali Sameh S
- Almeida Angeles
- Alton Lesley
- Alves Marco G
- Amati Francesca
- Amoedo Nivea Dias
- Amorim Ricardo
- Anderson Ethan J
- Andreadou Ioanna
- Antunes Diana
- Arago Marc
- Aral Cenk
- Arandarcikaite Odeta
- Arias-Reyes Christian
- Armand Anne-Sophie
- Arnould Thierry
- Avram Vlad F
- Axelrod Christopher L
- Bailey Damian M
- Bairam Aida
- Bajpeyi Sudip
- Bajzikova Martina
- Bakker Barbara M
- Banni Aml
- Bardal Tora
- Barlow J
- Bastos Sant'Anna Silva Ana Carolina
- Batterson Philip M
- Battino Maurizio
- Bazil Jason N
- Beard Daniel A
- Bednarczyk Piotr
- Beleza Jorge
- Bello Fiona
- Ben-Shachar Dorit
- Bento Guida Jose Freitas
- Bergdahl Andreas
- Berge Rolf K
- Bergmeister Lisa
- Bernardi Paolo
- Berridge Michael V
- Bettinazzi Stefano
- Bishop David J
- Blier Pierre U
- Blindheim Dan Filip
- Boardman Neoma T
- Boersheim Elisabet
- Boetker Hans Erik
- Borchard Sabine
- Boros Mihaly
- Borras Consuelo
- Borutaite Vilma
- Botella Javier
- Bouillaud Frederic
- Bouitbir Jamal
- Boushel Robert C
- Bovard Josh
- Bravo-Sagua Roberto
- Breton Sophie
- Brown David A
- Brown Guy C
- Brown Robert Andrew
- Brozinick Joseph T
- Buettner Garry R
- Burtscher Johannes
- Bustos Matilde
- Calabria Elisa
- Calbet Jose AL
- Calzia Enrico
- Cannon Daniel T
- Cano Sanchez Maria Consolacion
- Canto Alvarez Carles
- Cardinale Daniele A
- Cardoso Luiza HD
- Carvalho Eugenia
- Casado Pinna Marta
- Cassar Samantha
- Castelo Rueda Maria Paulina
- Castilho Roger F
- Cavalcanti-de-Albuquerque Joao Paulo
- Cecatto Cristiane
- Celen Murat C
- Cervinkova Zuzana
- Chabi Beatrice
- Chakrabarti Lisa
- Chakrabarti Sasanka
- Chaurasia Bhagirath
- Chen Quan
- Chicco Adam J
- Chinopoulos Christos
- Chowdhury Subir Kumar
- Cizmarova Beata
- Clementi Emilio
- Coen Paul M
- Cohen Bruce H
- Coker Robert H
- Collin-Chenot Anne
- Coughlan Melinda T
- Coxito Pedro
- Crisostomo Luis
- Crispim Marcell
- Crossland Hannah
- Dahdah Norma Ramon
- Dalgaard Louise T
- Dambrova Maija
- Danhelovska Tereza
- Darveau Charles-A
- Darwin Paula M
- Das Anibh Martin
- Dash Ranjan K
- Davidova Eliska
- Davis Michael S
- Dayanidhi Sudarshan
- De Bem Andreza Fabro
- De Goede Paul
- De Palma Clara
- De Pinto Vito
- Dela Flemming
- Dembinska-Kiec Aldona
- Detraux Damian
- Devaux Yvan
- Di Marcello Marco
- Di Paola Floriana Jessica
- Dias Candida
- Dias Tania R
- Diederich Marc
- Distefano Giovanna
- Djafarzadeh Siamak
- Doermann Niklas
- Doerrier Carolina
- Dong Lan-Feng
- Donnelly Chris
- Drahota Zdenek
- Duarte Filipe Valente
- Dubouchaud Herve
- Duchen Michael R
- Dumas Jean-Francois
- Durham William J
- Dymkowska Dorota
- Dyrstad Sissel E
- Dyson Alex
- Dzialowski Edward M
- Eaton Simon
- Ehinger Johannes K
- Elmer Eskil
- Endlicher Rene
- Engin Ayse Basak
- Escames Germaine
- Evinova Andrea
- Ezrova Zuzana
- Falk Marni J
- Fell David A
- Ferdinandy Peter
- Ferko Miroslav
- Fernandez-Ortiz Marisol
- Fernandez-Vizarra Erika
- Ferreira Julio Cesar B
- Ferreira Rita Maria P
- Ferri Alessandra
- Fessel Joshua Patrick
- Festuccia William T
- Filipovska Aleksandra
- Fisar Zdenek
- Fischer Christine
- Fischer Michael J
- Fisher Gordon
- Fisher Joshua J
- Fontanesi Flavia
- Forbes-Hernandez Tamara Y
- Ford Ellen
- Fornaro Mara
- Fuertes Agudo Marina
- Fulton Montana
- Galina Antonio
- Galkin Alexander
- Gallee Leon
- Galli Gina L J
- Gama Perez Pau
- Gan Zhenji
- Ganetzky Rebecca
- Gao Yun
- Garcia Geovana S
- Garcia-Rivas Gerardo
- Garcia-Roves Pablo Miguel
- Garcia-Souza Luiz F
- Garlid Keith D
- Garrabou Gloria
- Garten Antje
- Gastaldelli Amalia
- Gayen Jiaur
- Genders Amanda J
- Genova Maria Luisa
- Giampieri Francesca
- Giovarelli Matteo
- Glatz Jan FC
- Gnaiger Erich
- Goikoetxea Usandizaga Naroa
- Goncalo Teixeira da Silva Rui
- Goncalves Debora Farina
- Gonzalez- Armenta Jenny L
- Gonzalez-Franquesa Alba
- Gonzalez-Freire Marta
- Gonzalo Hugo
- Goodpaster Bret H
- Gorr Thomas A
- Gourlay Campbell W
- Grams Bente
- Granata Cesare
- Grefte Sander
- Grilo Luis
- Guarch Meritxell Espino
- Gueguen Naig
- Gumeni Sentiljana
- Haas Clarissa
- Haavik Jan
- Hachmo Yafit
- Haendeler Judith
- Haider Markus
- Hajrulahovic Anesa
- Hamann Andrea
- Han Jin
- Han Woo Hyun
- Hancock Chad R
- Hand Steven C
- Handl Jiri
- Hansikova Hana
- Hardee Justin P
- Hargreaves Iain P
- Harper Mary- Ellen
- Harrison David K
- Hassan Hazirah
- Hatokova Zuzana
- Hausenloy Derek J
- Heales Simon JR
- Hecker Matthias
- Heiestad Christina
- Hellgren Kim T
- Henrique Alexandrino
- Hepple Russell T
- Hernansanz- Agustin Pablo
- Hewakapuge Sudinna
- Hickey Anthony J
- Ho Dieu Hien
- Hoehn Kyle L
- Hoel Fredrik
- Holland Olivia J
- Holloway Graham P
- Holzner Lorenz
- Hoppel Charles L
- Hoppel Florian
- Hoppeler Hans
- Houstek Josef
- Huete-Ortega Maria
- Hyrossova Petra
- Iglesias-Gonzalez Javier
- Indiveri Cesare
- Irving Brian A
- Isola Raffaella
- Iyer Shilpa
- Jackson Christopher Benjamin
- Jadiya Pooja
- Jana Prado Fabian
- Jandeleit-Dahm Karin
- Jang David H
- Jang Young Charles
- Janowska Joanna
- Jansen Kirsten M
- Jansen-Duerr Pidder
- Jansone Baiba
- Jarmuszkiewicz Wieslawa
- Jaskiewicz Anna
- Jaspers Richard T
- Jedlicka Jan
- Jerome Estaquier
- Jespersen Nichlas Riise
- Jha Rajan Kumar
- Jones John G
- Joseph Vincent
- Juhasz Laszlo
- Jurczak Michael J
- Jurk Diana
- Jusic Amela
- Kaambre Tuuli
- Kaczor Jan Jacek
- Kainulainen Heikki
- Kampa Rafal Pawel
- Kandel Sunil Mani
- Kane Daniel A
- Kapferer Werner
- Kapnick Senta
- Kappler Lisa
- Karabatsiakis Alexander
- Karavaeva Iuliia
- Karkucinska-Wieckowska Agnieszka
- Kaur Sarbjot
- Keijer Jaap
- Keller Markus A
- Keppner Gloria
- Khamoui Andy V
- Kidere Dita
- Kilbaugh Todd
- Kim Hyoung Kyu
- Kim Julian KS
- Kimoloi Sammy
- Klepinin Aleksandr
- Klepinina Lyudmila
- Klingenspor Martin
- Klocker Helmut
- Kolassa Iris
- Komlodi Timea
- Koopman Werner JH
- Kopitar-Jerala Natasa
- Kowaltowski Alicia J
- Kozlov Andrey V
- Krajcova Adela
- Krako Jakovljevic Nina
- Kristal Bruce S
- Krycer James R
- Kuang Jujiao
- Kucera Otto
- Kuka Janis
- Kwak Hyo Bum
- Kwast Kurt E
- Kwon Oh Sung
- Laasmaa Martin
- Labieniec-Watala Magdalena
- Lagarrigue Sylviane
- Lai Nicola
- Lalic Nebojsa M
- Land John M
- Lane Nick
- Laner Verena
- Lanza Ian R
- Laouafa Sofien
- Laranjinha Joao
- Larsen Steen
- Larsen Terje S
- Lavery Gareth G
- Lazou Antigone
- Ledo Ana Margarida
- Lee Hong Kyu
- Leeuwenburgh Christiaan
- Lehti Maarit
- Lemieux Helene
- Lenaz Giorgio
- Lerfall Joergen
- Li Pingan Andy
- Li Puma Lance
- Liang Liping
- Liepins Edgars
- Lin Chien-Te
- Liu Jiankang
- Lopez Garcia Luis Carlos
- Lucchinetti Eliana
- Ma Tao
- Macedo Maria Paula
- Machado Ivo F
- Maciej Sarah
- MacMillan-Crow Lee Ann
- Magalhaes Jose
- Magri Andrea
- Majtnerova Pavlina
- Makarova Elina
- Makrecka-Kuka Marina
- Malik Afshan N
- Marcouiller Francois
- Marechal Amandine
- Markova Michaela
- Markovic Ivanka
- Martin Daniel S
- Martins Ana Dias
- Martins Joao D
- Maseko Tumisang Edward
- Maull Felicia
- Mazat Jean-Pierre
- McKenna Helen T
- McKenzie Matthew
- McMillan Duncan GG
- McStay Gavin P
- Mendham Amy
- Menze Michael A
- Mercer John R
- Merz Tamara
- Messina Angela
- Meszaros Andras
- Methner Axel
- Michalak Slawomir
- Mila Guasch Maria
- Minuzzi Luciele M
- Misirkic Marjanovic Maja
- Moellering Douglas R
- Moisoi Nicoleta
- Molina Anthony JA
- Montaigne David
- Moore Anthony L
- Moore Christy
- Moreau Kerrie
- Moreira Bruno P
- Moreno-Sanchez Rafael
- Mracek Tomas
- Muccini Anna Maria
- Munro Daniel
- Muntane Jordi
- Muntean Danina M
- Murray Andrew James
- Musiol Eva
- Nabben Miranda
- Nair K Sreekumaran
- Nehlin Jan O
- Nemec Michal
- Nesci Salvatore
- Neufer P Darrell
- Neuzil Jiri
- Neviere Remi
- Newsom Sean A
- Norman Jennifer
- Nozickova Katerina
- Nunes Sara
- Nuoffer Jean-Marc
- O'Brien Katie A
- O'Brien Kristin
- O'Gorman Donal
- Olgar Yusuf
- Oliveira Ben
- Oliveira Jorge
- Oliveira Marcos Tulio
- Oliveira Marcus F
- Oliveira Paulo J
- Oliveira Pedro Fontes
- Olsen Rolf Erik
- Orynbayeva Zulfiya
- Osiewacz Heinz D
- Paez Hector
- Pak Youngmi Kim
- Pallotta Maria Luigia
- Palmeira Carlos
- Parajuli Nirmala
- Passos Joao F
- Passrugger Manuela
- Patel Hemal H
- Pavlova Nadia
- Pavlovic Kasja
- Pecina Petr
- Pedersen Tina M
- Perales Jose Carles
- Pereira da Silva Grilo da Silva Filomena
- Pereira Rita
- Pereira Susana P
- Perez Valencia Juan Alberto
- Perks Kara L
- Pesta Dominik
- Petit Patrice X
- Pettersen Nitschke Ina Katrine
- Pichaud Nicolas
- Pichler Irene
- Piel Sarah
- Pietka Terri A
- Pinho Sonia A
- Pino Maria F
- Pirkmajer Sergej
- Place Nicolas
- Plangger Mario
- Porter Craig
- Porter Richard K
- Preguica Ines
- Prigione Alessandro
- Procaccio Vincent
- Prochownik Edward V
- Prola Alexandre
- Pulinilkunnil Thomas
- Puskarich Michael A
- Puurand Marju
- Radenkovic Filip
- Ramzan Rabia
- Rattan Suresh IS
- Reano Simone
- Reboredo-Rodriguez Patricia
- Rees Bernard B
- Renner-Sattler Kathrin
- Rial Eduardo
- Robinson Matthew M
- Roden Michael
- Rodrigues Ana Sofia
- Rodriguez Enrique
- Rodriguez-Enriquez Sara
- Roesland Gro Vatne
- Rohlena Jakub
- Rolo Anabela Pinto
- Ropelle Eduardo R
- Roshanravan Baback
- Rossignol Rodrigue
- Rossiter Harry B
- Rousar Tomas
- Rubelj Ivica
- Rybacka-Mossakowska Joanna
- Saada Reisch Ann
- Safaei Zahra
- Salin Karine
- Salvadego Desy
- Sandi Carmen
- Saner Nicholas
- Santos Diana
- Sanz Alberto
- Sardao Vilma
- Sarlak Saharnaz
- Sazanov Leonid A
- Scaife Paula
- Scatena Roberto
- Schartner Melanie
- Scheibye-Knudsen Morten
- Schilling Jan M
- Schlattner Uwe
- Schmitt Sabine
- Schneider Gasser Edith Mariane
- Schoenfeld Peter
- Schots Pauke C
- Schulz Rainer
- Schwarzer Christoph
- Scott Graham R
- Selman Colin
- Sendon Pamella Marie
- Shabalina Irina G
- Sharma Pushpa
- Sharma Vipin
- Shevchuk Igor
- Shirazi Reza
- Shiroma Jonathan G
- Siewiera Karolina
- Silber Ariel M
- Silva Ana Maria
- Sims Carrie A
- Singer Dominique
- Singh Brijesh Kumar
- Skolik Robert A
- Smenes Benedikte Therese
- Smith James
- Soares Felix Alexandre Antunes
- Sobotka Ondrej
- Sokolova Inna
- Solesio Maria E
- Soliz Jorge
- Sommer Natascha
- Sonkar Vijay K
- Sova Marina
- Sowton Alice P
- Sparagna Genevieve C
- Sparks Lauren M
- Spinazzi Marco
- Stankova Pavla
- Starr Jonathan
- Stary Creed
- Stefan Eduard
- Stelfa Gundega
- Stepto Nigel K
- Stevanovic Jelena
- Stiban Johnny
- Stier Antoine
- Stocker Roland
- Storder Julie
- Sumbalova Zuzana
- Suomalainen Anu
- Suravajhala Prashanth
- Svalbe Baiba
- Swerdlow Russell H
- Swiniuch Daria
- Szabo Ildiko
- Szewczyk Adam
- Szibor Marten
- Tanaka Masashi
- Tandler Bernard
- Tarnopolsky Mark A
- Tausan Daniel
- Tavernarakis Nektarios
- Teodoro Joao Soeiro
- Tepp Kersti
- Thakkar Himani
- Thapa Maheshwor
- Thyfault John P
- Tomar Dhanendra
- Ton Riccardo
- Torp May-Kristin
- Torres-Quesada Omar
- Towheed Atif
- Treberg Jason R
- Tretter Laszlo
- Trewin Adam J
- Trifunovic Aleksandra
- Trivigno Catherine
- Tronstad Karl Johan
- Trougakos Ioannis P
- Truu Laura
- Tuncay Erkan
- Turan Belma
- Tyrrell Daniel J
- Urban Tomas
- Urner Sofia
- Valentine Joseph Marco
- Van Bergen Nicole J
- Van der Ende Miranda
- Varricchio Frederick
- Vaupel Peter
- Vella Joanna
- Vendelin Marko
- Vercesi Anibal E
- Verdaguer Ignasi Bofill
- Vernerova Andrea
- Victor Victor Manuel
- Vidimce Josif
- Vieira Ligo Teixeira Camila
- Viel Christian
- Vieyra Adalberto
- Vilks Karlis
- Villena Josep A
- Vincent Vinnyfred
- Vinogradov Andrey D
- Viscomi Carlo
- Vitorino Rui Miguel Pinheiro
- Vlachaki Walker Julia
- Vogt Sebastian
- Volani Chiara
- Volska Kristine
- Votion Dominique-Marie
- Vujacic-Mirski Ksenija
- Wagner Brett A
- Ward Marie Louise
- Warnsmann Verena
- Wasserman David H
- Watala Cezary
- Wei Yau-Huei
- Weinberger Klaus M
- Weissig Volkmar
- White Sarah Haverty
- Whitfield Jamie
- Wickert Anika
- Wieckowski Mariusz R
- Wiesner Rudolf J
- Williams Caroline M
- Winwood-Smith Hugh
- Wohlgemuth Stephanie E
- Wohlwend Martin
- Wolff Jonci Nikolai
- Wrutniak-Cabello Chantal
- Wuest Rob CI
- Yokota Takashi
- Zablocki Krzysztof
- Zanon Alessandra
- Zanou Nadege
- Zaugg Kathrin
- Zaugg Michael
- Zdrazilova Lucie
- Zhang Yizhu
- Zhang Yong
- Zikova Alena
- Zischka Hans
- Zorzano Antonio
- Zujovic Tijana
- Zurmanova Jitka
- Zvejniece Liga
- Publication venue
- Publication date
- 01/01/2020
- Field of study
As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery
Mitochondrial physiology
- Author
- >Gonzalez-Francesqua A
- Aasander Frostner Eleonor
- Abdel-Rahman Engy Ali
- Abdul Karim Norwahidah
- Abumrad Nada A
- Acuna-Castroviejo Dario
- Adiele Reginald C
- Ahn Bumsoo
- Alencar MB
- Ali Sameh S
- Almeida Angeles
- Alton Lesley
- Alves Marco G
- Amati Francesca
- Amoedo Nivea Dias
- Amorim Ricardo
- Anderson Ethan J
- Andreadou Ioanna
- Antunes Diana
- Arago Marc
- Aral Cenk
- Arandarcikaite Odeta
- Arias-Reyes Christian
- Armand Anne-Sophie
- Arnould Thierry
- Avram Vlad Florian
- Axelrod Christopher L
- Bailey Damian M
- Bairam Aida
- Bajpeyi Sudip
- Bajzikova Martina
- Bakker Barbara M
- Banni A
- Bardal Tora
- Barlow Jonathan
- Bastos Sant'Anna Silva Ana Carolina
- Batterson Philip
- Battino Maurizio
- Bazil Jason
- Beard Daniel A
- Bednarczyk Piotr
- Beleza Jorge
- Bello Fiona
- Ben-Shachar Dorit
- Bergdahl Andreas
- Berge Rolf K
- Bergmeister Lisa
- Bernardi Paolo
- Berridge Michael V
- Bettinazzi Stefano
- Bishop David
- Blier Pierre U
- Blindheim Dan Filip
- Boardman Neoma T
- Boetker Hans Erik
- Borchard Sabine
- Boros Mihaly
- Borras Consuelo
- Borsheim Elisabet
- Borutaite Vilma
- Botella Javier
- Bouillaud Frederic
- Bouitbir Jamal
- Boushel Robert C
- Bovard Josh
- Bravo-Sagua Roberto
- Breton Sophie
- Brown David A
- Brown Guy C
- Brown Robert A
- Brozinick Joseph T
- Buettner Garry R
- Burtscher Johannes
- Bustos Matilde
- Calabria Elisa
- Calbet Jose A
- Calzia Enrico
- Cannon Daniel T
- Cano Sanchez Maria
- Canto Alvarez Carlos
- Cardinale D
- Cardoso Luiza Helena Daltro
- Carvalho Eugenia
- Casado Pinna Marta
- Cassar Samantha
- Castelo Maria P
- Castilho Roger F
- Cavalcanti-de-Albuquerque Joao Paulo
- Cecatto Cristiane
- Celen Murat C
- Cervinkova Zuzana
- Chabi Beatrice
- Chakrabarti Lisa
- Chakrabarti Sasanka
- Chaurasia Bhagirath
- Chen Qi
- Chicco Adam J
- Chinopoulos Christos
- Chowdhury Subir K
- Cizmarova Beata
- Clementi Emilio
- Coen Paul M
- Cohen Bruce H
- Coker Robert H
- Collin-Chenot Anne
- Coughlan MT
- Coxito Pedro
- Crisostomo Luis
- Crispim Marcell
- Crossland Hannah
- Dahdah Norma
- Dalgaard Louise T
- Dambrova Maija
- Danhelovska Tereza
- Darveau Charles A
- Darwin Paula M
- Das Anibh M
- Dash Ranjan K
- Davidova Eliska
- Davis Michael S
- Dayanidhi Sudarshan
- De Bem Andreza Fabro
- De Goede Paul
- De Palma Clara
- De Pinto Vito
- Dela Flemming
- Dembinska-Kiec Aldona
- Detraux Damien
- Devaux Yvan
- Di Marcello Marco
- Di Paola Floriana Jessica
- Dias Candida
- Dias Tania R
- Diederich Marc
- Distefano Giovanna
- Djafarzadeh Siamak
- Doermann Niklas
- Doerrier Carolina
- Dong Lan-Feng
- Donnelly Chris
- Drahota Zdenek
- Duarte Filipe Valente
- Dubouchaud Herve
- Duchen Michael R
- Dumas Jean-Francois
- Durham William J
- Dymkowska Dorota
- Dyrstad Sissel E
- Dyson Alex
- Dzialowski Edward M
- Eaton Simon
- Ehinger Johannes
- Elmer Eskil
- Endlicher Rene
- Engin Ayse B
- Escames Germaine
- Evinova Andrea
- Ezrova Zuzana
- Falk Marni Joy
- Fell David A
- Ferdinandy Peter
- Ferko Miroslav
- Fernandez-Ortiz Marisol
- Fernandez-Vizarra Erika
- Ferreira Julio Cesar Batista
- Ferreira Rita
- Ferri Alessandra
- Fessel Joshua P
- Festuccia WT
- Filipovska Aleksandra
- Fisar Zdenek
- Fischer Christine
- Fischer Michael
- Fisher Gordon
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- Fontanesi Flavia
- Forbes-Hernandez Tamara Y
- Ford Ellen
- Fornaro Mara
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- Fulton Montana
- Galina Antonio
- Galkin Alexander
- Gallee Leon
- Galli Gina L
- Gama Perez Pau
- Gan Zhenji
- Ganetzky Rebecca
- Gao Yun
- Garcia Geovana S
- Garcia-Rivas Gerardo
- Garcia-Roves Pablo Miguel
- Garcia-Souza Luiz Felipe
- Garlid Keith D
- Garrabou Gloria
- Garten Antje
- Gastaldelli Amalia
- Gayen Jiaur
- Genders Amanda J
- Genova Maria Luisa
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- Goncalo Teixeira da Silva Rui
- Goncalves Debora Farina
- Gonzalez-Armenta Jenny L
- Gonzalez-Freire Marta
- Gonzalo Hugo
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- Gorr Thomas A
- Gourlay Campbell W
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- Hachmo Yafit
- Haendeler Judith
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- Hamann Andrea
- Han Jin
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- Hancock Chad R
- Hand Steven C
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- Henrique Alexandrino
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- Indiveri Cesare
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- Isola Raffaella
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- Jackson Christophe B
- Jadiya Pooja
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- Jandeleit-Dahm K
- Jang David H
- Jang Young C
- Janowska Joanna
- Jansen Kirsten
- Jansen-Duerr Pidder
- Jansone Baiba
- Jarmuszkiewicz Wieslawa
- Jaskiewicz Anna
- Jaspers Richard T
- Jedlicka Jan
- Jerome Estaquier
- Jespersen Nichlas R
- Jha Rajan K
- John G JG
- Joseph Vincent
- Juhasz Laszlo
- Jurczak Michael J
- Jurk Diana
- Jusic Amela
- Kaambre Tuuli
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- Kainulainen Heikki
- Kampa Rafal Pawel
- Kandel Sunil M
- Kane Daniel A
- Kapferer Werner
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- Karabatsiakis Alexander
- Karavaeva Iuliia
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- Kaur Sarbjot
- Keijer Jaap
- Keller Markus A
- Keppner Gloria
- Khamoui Andy V
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- Koopman Werner JH
- Kopitar-Jerala Natasa
- Kowaltowski Alicia J
- Kozlov Andrey V
- Krajcova Adela
- Krako Jakovljevic Nina
- Kristal Bruce S
- Krycer Jamer R
- Kuang Jujiao
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- Land John M
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- Machado Ivo F
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- Magalhaes Jose
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- Malik Afshan N
- Marcouiller Francois
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- Markovic Ivanka
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- Martins Joao D
- Maseko Tumisang Edward
- Maull Felicia
- Mazat Jean Pierre
- McKenna Helen T
- McKenzie Matthew
- McMillan Duncan GG
- McStay Gavin P
- Menndham A
- Menze Michael A
- Mercer John R.
- Merz Tamara
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- Methner Axel
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- Misirkic Marjanovic Maja
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- Moisoi Nicoleta
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- Montaigne David
- Moore Anthony L
- Moore Christy
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- Moreira Bruno P
- Moreno-Sanchez Rafael
- Mracek Tomas
- Muccini Anna Maria
- Munro Daniel
- Muntane Jordi
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- Murray Andrew J
- Musiol Eva
- Nabben Miranda
- Nair K Sreekumaran
- Nehlin Jan O
- Nemec Michal
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- Neufer P Darrell
- Neuzil Jiri
- Neviere Remi
- Newsom Sean A.
- Norman Jennifer
- Nozickova Katerina
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- Nuoffer Jean-Marc
- O'Brien Katie A
- O'Brien Kristin
- O'Gorman Donal
- Olgar Yusuf
- Oliveira Ben
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- Oliveira Paulo J
- Oliveira Pedro F
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- Orynbayeva Zulfiya
- Osiewacz Heinz D
- Paez Hector
- Pak Youngmi K
- Pallotta Maria L
- Palmeira Carlos M
- Parajuli Nirmala
- Passos Joao F
- Passrugger Manuela
- Patel Hemal H
- Pavlova Nadia
- Pavlovic Kasja
- Pecina Petr
- Pedersen Tina M
- Perales Jose Carles
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- Perez Valencia Juan A
- Perks Kara L
- Pesta Dominik
- Petit Patrice X
- Pettersen Ina Katrine Nitschke
- Pichaud Nicolas
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- Pietka Terri A
- Pinho Sonia A
- Pino Maria F
- Pirkmajer Sergej
- Place Nicolas
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- Porter Richard K
- Preguica Ines
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- Procaccio Vincent
- Prochownik Edward V
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- Puskarich Michael A
- Puurand Marju
- Radenkovic Filip
- Ramzan Rabia
- Rattan Suresh IS
- Reano Simone
- Reboredo-Rodriguez Patricia
- Rees Bernard B
- Renner-Sattler Kathrin
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- Robinson Matthew M
- Roden Michael
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- Rohlena Jakub
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- Ropelle Eduardo R
- Roshanravan Baback
- Rossignol Rodrigue
- Rossiter Harry B
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- Sanz Alberto
- Sazanov Leonid A
- Scatena Roberto
- Schartner Melanie
- Scheibye-Knudsen Morten
- Schilling Jan M
- Schlattner Uwe
- Schoenfeld Peter
- Schots Pauke C
- Schulz Rainer
- Schwarzer Christoph
- Scott Graham R
- Selman Colin
- Shabalina Irina G
- Sharma Pushpa
- Sharma Vipin
- Shevchuk Igor
- Shirazi Reza
- Shiroma Jonathan G
- Siewiera Karolina
- Silber Ariel M
- Silva Ana Maria
- Sims Carrie A
- Singer Dominique
- Singh Brijesh Kumar
- Skolik Robert A
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- Smith James
- Soares Félix Alexandre Antunes
- Sobotka Ondrej
- Sokolova Inna
- Solesio Maria E
- Sommer Natascha
- Sonkar Vijay K
- Sowton Alice P
- Sparagna Genevieve C
- Sparks Lauren M
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- Starr Jonathan
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- Stelfa Gundega
- Stepto Nigel K
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- Suravajhala Prashanth
- Svalbe Baiba
- Swerdlow Russel H
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- Szibor Marten
- Tanaka Masashi
- Tandler Bernard
- Tarnopolsky Mark A
- Tausan Daniel
- Tavernarakis Nektarios
- Teodoro J
- Tepp Kersti
- Thakkar Himani
- Thapa Maheshwo
- Thyfault John P
- Tomar Dhanendra
- Ton Riccardo
- Torp May-Kristin
- Towheed Atif
- Tretter Laszlo
- Trewin Adam J
- Trifunovic Aleksandra
- Trivigno Catherine
- Tronstad Karl Johan
- Trougakos Ioannis P
- Truu Laura
- Tuncay Erkan
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- Tyrrell Daniel J
- Urban Tomas
- Urner Sofia
- Valentine Joseph Marco
- Van Bergen Nicole J
- Varricchio Frederick
- Vella Joanna
- Vendelin Marko
- Vercesi Anibal E
- Verdaguer Ignasi Bofill
- Vernerova Andrea
- Victor Victor Manuel
- Vidimce Josif
- Vieira Ligo Teixeira Camila
- Viel Christian
- Vieyra Adalberto
- Vilks Karlis
- Villena Joseph A
- Vincent Vinnyfred
- Vinogradov Andrey D
- Viscomi Carlo
- Vitorino Rui Miguel Pinheiro
- Vogt Sebastian
- Volani Chiara
- Volska Kristine
- Votion Dominique-Marie
- Vujacic-Mirski Ksenija
- Wagner Brett A
- Ward Marie Louise
- Warnsmann Verena
- Wasserman David H
- Watala Cezary
- Wei Yau-Huei
- Weissig Volkmar
- Whitfield Jamie
- Wickert Anika
- Wieckowski Mariusz R
- Wiesner Rudolf J
- Williams Caroline M
- Winwood-Smith Hugh
- Wohlgemuth Stephanie E
- Wohlwend Martin
- Wolff Jonci Nikolai
- Wrutniak-Cabello Chantal
- Wuest Rob C I
- Yokota Takashi
- Zablocki Krzysztof
- Zanon Alessandra
- Zanou Nadege
- Zaugg Kathrin
- Zaugg Michael
- Zdrazilova Lucie
- Zhang Yi Zhu
- Zhang Yong
- Zikova Alena
- Zischka Hans
- Zorzano Antonio
- Zvejniece Liga
- Publication venue
- Oroboros Ecosystem
- Publication date
- 20/05/2020
- Field of study
As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery
Physics case for an LHCb Upgrade II - Opportunities in flavour physics, and beyond, in the HL-LHC era
- Author
- Aaij Roel
- Adeva Bernardo
- Adinolfi Marco
- Aidala Christine Angela
- Ajaltouni Ziad
- Akar Simon
- Albicocco Pietro
- Albrecht Johannes
- Alessio Federico
- Alexander Michael
- Alfonso Albero Alejandro
- Ali Suvayu
- Alkhazov Georgy
- Alvarez Cartelle Paula
- Alves Jr Antonio Augusto
- Amato Sandra
- Amerio Silvia
- Amhis Yasmine
- An Liupan
- Anderlini Lucio
- Andreassi Guido
- Andreotti Mirco
- Andrews Jason
- Appleby Robert
- Archilli Flavio
- Arnau Romeu Joan
- Artamonov Alexander
- Artuso Marina
- Arzymatov Kenenbek
- Aslanides Elie
- Atzeni Michele
- Bachmann Sebastian
- Back John
- Baker Sophie
- Balagura Vladislav
- Baldini Wander
- Baranov Alexander
- Barlow Roger
- Barsuk Sergey
- Barter William
- Baryshnikov Fedor
- Batozskaya Varvara
- Batsukh Baasansuren
- Battista Vincenzo
- Bay Aurelio
- Beddow John
- Bedeschi Franco
- Bediaga Ignacio
- Beiter Andrew
- Bel Lennaert
- Beliy Nikita
- Bellee Violaine
- Belloli Nicoletta
- Belous Konstantin
- Belyaev Ivan
- Ben-Haim Eli
- Bencivenni Giovanni
- Benson Sean
- Beranek Sarah
- Berezhnoy Alexander
- Bernet Roland
- Berninghoff Daniel
- Bertholet Emilie
- Bertolin Alessandro
- Betancourt Christopher
- Betti Federico
- Bettler Marc-Olivier
- Bezshyiko Iaroslava
- Bhasin Srishti
- Bhom Jihyun
- Bifani Simone
- Billoir Pierre
- Birnkraut Alex
- Bizzeti Andrea
- Bjørn Mikkel
- Blago Michele Piero
- Blake Thomas
- Blanc Frederic
- Blusk Steven
- Bobulska Dana
- Bocci Valerio
- Boente Garcia Oscar
- Boettcher Thomas
- Bondar Alexander
- Bondar Nikolay
- Borghi Silvia
- Borisyak Maxim
- Borsato Martino
- Bossu Francesco
- Boubdir Meriem
- Bowcock Themistocles
- Bozzi Concezio
- Braun Svende
- Brodski Michael
- Brodzicka Jolanta
- Brossa Gonzalo Arnau
- Brundu Davide
- Buchanan Emma
- Buonaura Annarita
- Burr Christopher
- Bursche Albert
- Buytaert Jan
- Byczynski Wiktor
- Cadeddu Sandro
- Cai Hao
- Calabrese Roberto
- Calladine Ryan
- Calvi Marta
- Calvo Gomez Miriam
- Camboni Alessandro
- Campana Pierluigi
- Campora Perez Daniel Hugo
- Capriotti Lorenzo
- Carbone Angelo
- Carboni Giovanni
- Cardinale Roberta
- Cardini Alessandro
- Carniti Paolo
- Carson Laurence
- Carvalho Akiba Kazuyoshi
- Casse Gianluigi
- Cassina Lorenzo
- Cattaneo Marco
- Cavallero Giovanni
- Cenci Riccardo
- Chamont David
- Chapman Matthew George
- Charles Matthew
- Charpentier Philippe
- Chatzikonstantinidis Georgios
- Chefdeville Maximilien
- Chekalina Viktoriia
- Chen Chen
- Chen Shanzhen
- Chitic Stefan-Gabriel
- Chobanova Veronika
- Chrzaszcz Marcin
- Chubykin Alexsei
- Ciambrone Paolo
- Cid Vidal Xabier
- Ciezarek Gregory
- Clarke Peter
- Clemencic Marco
- Cliff Harry
- Closier Joel
- Coco Victor
- Coelho Joao A B
- Cogan Julien
- Cogneras Eric
- Cojocariu Lucian
- Collins Paula
- Colombo Tommaso
- Comerma-Montells Albert
- Contu Andrea
- Coombs George
- Coquereau Samuel
- Corti Gloria
- Corvo Marco
- Costa Sobral Cayo Mar
- Couturier Benjamin
- Cowan Greig
- Craik Daniel Charles
- Crocombe Andrew
- Cruz Torres Melissa Maria
- Currie Robert
- D'Ambrosio Carmelo
- d'Argent Philippe
- Da Cunha Marinho Franciole
- Da Silva Cesar Luiz
- Dall'Occo Elena
- Dalseno Jeremy
- Danilina Anna
- Davis Adam
- De Aguiar Francisco Oscar
- De Bruyn Kristof
- De Capua Stefano
- De Cian Michel
- De Miranda Jussara
- De Paula Leandro
- De Serio Marilisa
- De Simone Patrizia
- de Vries Jacco
- Dean Cameron Thomas
- Decamp Daniel
- Del Buono Luigi
- Delaney Blaise
- Dembinski Hans Peter
- Demmer Moritz
- Dendek Adam
- Derkach Denis
- Deschamps Olivier
- Desse Fabrice
- Dettori Francesco
- Dey Biplab
- Di Canto Angelo
- Di Nezza Pasquale
- Didenko Sergey
- Dijkstra Hans
- Dordei Francesca
- Dorigo Mirco
- dos Reis Alberto
- Dosil Suárez Alvaro
- Douglas Lauren
- Dovbnya Anatoliy
- Dreimanis Karlis
- Dufour Laurent
- Dujany Giulio
- Durante Paolo
- Durham John Matthew
- Dutta Deepanwita
- Dzhelyadin Rustem
- Dziewiecki Michal
- Dziurda Agnieszka
- Dzyuba Alexey
- Easo Sajan
- Egede Ulrik
- Egorychev Victor
- Eidelman Semen
- Eisenhardt Stephan
- Eitschberger Ulrich
- Ekelhof Robert
- Eklund Lars
- Ely Scott
- Ene Alexandru
- Escher Stephan
- Esen Sevda
- Evans Timothy
- Falabella Antonio
- Farley Nathanael
- Farry Stephen
- Fazzini Davide
- Färber Christian
- Federici Luca
- Fernandez Declara Placido
- Fernandez Gerard
- Fernandez Prieto Antonio
- Ferrari Fabio
- Ferreira Lopes Lino
- Ferreira Rodrigues Fernando
- Ferro-Luzzi Massimiliano
- Féo Mauricio
- Filippov Sergey
- Fini Rosa Anna
- Fiorini Massimiliano
- Firlej Miroslaw
- Fitzpatrick Conor
- Fiutowski Tomasz
- Fleuret Frederic
- Fontana Marianna
- Fontanelli Flavio
- Forty Roger
- Franco Lima Vinicius
- Frank Markus
- Frei Christoph
- Fu Jinlin
- Funk Wolfgang
- Gabriel Emmy
- Gallas Torreira Abraham
- Galli Domenico
- Gallorini Stefano
- Gambetta Silvia
- Gan Yuyue
- Gandelman Miriam
- Gandini Paolo
- Gao Yuanning
- Garcia Martin Luis Miguel
- Garcia Plana Beatriz
- García Pardiñas Julián
- Garra Tico Jordi
- Garrido Lluis
- Gascon David
- Gaspar Clara
- Gavardi Laura
- Gazzoni Giulio
- Gerick David
- Gersabeck Evelina
- Gersabeck Marco
- Gershon Timothy
- Gerstel Dawid
- Ghez Philippe
- Gianì Sebastiana
- Gibson Valerie
- Girard Olivier Göran
- Giubega Lavinia-Helena
- Gizdov Konstantin
- Gligorov Vladimir
- Golubkov Dmitry
- Golutvin Andrey
- Gomes Alvaro
- Gorelov Igor Vladimirovich
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- Govorkova Ekaterina
- Göbel Carla
- Grabowski Jascha Peter
- Graciani Diaz Ricardo
- Granado Cardoso Luis Alberto
- Graugés Eugeni
- Graverini E
- Graziani Giacomo
- Grecu Alexandru
- Greim Roman
- Griffith Peter
- Grillo Lucia
- Gruber Lukas
- Gruberg Cazon Barak Raimond
- Grünberg Oliver
- Gu Chenxi
- Gushchin Evgeny
- Guz Yury
- Gys Thierry
- Hadavizadeh Thomas
- Hadjivasiliou Christos
- Haefeli Guido
- Haen Christophe
- Haines Susan
- Hamilton Brian
- Han Xiaoxue
- Hancock Thomas Henry
- Hansmann-Menzemer Stephanie
- Harnew Neville
- Harnew Samuel
- Harrison Thomas
- Hasse Christoph
- Hatch Mark
- He Jibo
- Hecker Malte
- Heinicke Kevin
- Heister Arno
- Hennessy Karol
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- Heß Miriam
- Hicheur Adlène
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- Hill Donal
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- Hopchev Plamen Hristov
- Hu Wenhua
- Huang Wenqian
- Huard Zachary
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- Humair Thibaud
- Hushchyn Mikhail
- Hutchcroft David
- Hynds Daniel
- Ibis Philipp
- Idzik Marek
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- Ivshin Kuzma
- Jacobsson Richard
- Jalocha Pawel
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- John Malcolm
- Johnson Daniel
- Jones Christopher
- Joram Christian
- Jost Beat
- Jurik Nathan
- Kandybei Sergii
- Karacson Matthias
- Kariuki James Mwangi
- Karodia Sarah
- Kazeev Nikita
- Kecke Matthieu
- Keizer Floris
- Kelsey Matthew
- Kenzie Matthew
- Ketel Tjeerd
- Khairullin Egor
- Khanji Basem
- Khurewathanakul Chitsanu
- Kim Kyung Eun
- Kirn Thomas
- Klaver Suzanne
- Klimaszewski Konrad
- Klimkovich Tatsiana
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- Kolpin Michael
- Kopecna Renata
- Koppenburg Patrick
- Kostiuk Igor
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- Kreps Michal
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- Kudryavtsev Vasily
- Kuonen Axel Kevin
- Kvaratskheliya Tengiz
- Lacarrere Daniel
- Lafferty George
- Lai Adriano
- Lancierini Davide
- Lanfranchi Gaia
- Langenbruch Christoph
- Latham Thomas
- Lazzeroni Cristina
- Le Gac Renaud
- Lefèvre Regis
- Leflat Alexander
- Lefrançois Jacques
- Lemaitre Florian
- Leroy Olivier
- Lesiak Tadeusz
- Leverington Blake
- Li Pei-Rong
- Li Tenglin
- Li Zhuoming
- Liang Xixin
- Likhomanenko Tatiana
- Lindner Rolf
- Lionetto Federica
- Lisovskyi Vitalii
- Liu Xuesong
- Loh David
- Loi Angelo
- Longstaff Iain
- Lopes Jose
- Lovell George Holger
- Lucchesi Donatella
- Lucio Martinez Miriam
- Lupato Anna
- Luppi Eleonora
- Lupton Oliver
- Lusiani Alberto
- Lyu Xiao-Rui
- Machefert Frederic
- Maciuc Florin
- Macko Vladimir
- Mackowiak Patrick
- Maddrell-Mander Samuel
- Maev Oleg
- Maguire Kevin
- Maisuzenko Dmitrii
- Majewski Maciej Witold
- Malde Sneha
- Malecki Bartosz
- Malinin Alexander
- Maltsev Timofei
- Manca Giulia
- Mancinelli Giampiero
- Marangotto Daniele
- Maratas Jan
- Marchand Jean François
- Marconi Umberto
- Marin Benito Carla
- Marinangeli Matthieu
- Marino Pietro
- Marks Jörg
- Marshall Phillip John
- Martellotti Giuseppe
- Martin Morgan
- Martinelli Maurizio
- Martinez Santos Diego
- Martinez Vidal Fernando
- Massafferri André
- Materok Marcel
- Matev Rosen
- Mathad Abhijit
- Mathe Zoltan
- Matteuzzi Clara
- Mauri Andrea
- Maurice Emilie
- Maurin Brice
- Mazurov Alexander
- McCann Michael
- McNab Andrew
- McNulty Ronan
- Mead James Vincent
- Meadows Brian
- Meaux Cedric
- Meier Frank
- Meinert Nis
- Melnychuk Dmytro
- Merk Marcel
- Merli Andrea
- Michielin Emanuele
- Milanes Diego Alejandro
- Millard Edward James
- Minard Marie-Noelle
- Minzoni Luca
- Mitzel Dominik Stefan
- Mogini Andrea
- Molina Rodriguez Josue
- Mombächer Titus
- Monroy Igancio Alberto
- Monteil Stephane
- Morandin Mauro
- Morello Gianfranco
- Morello Michael Joseph
- Morgunova Olga
- Moron Jakub
- Morris Adam Benjamin
- Mountain Raymond
- Mödden Antje
- Muheim Franz
- Mulder Mick
- Murphy Colm Harold
- Murray Donal
- Müller Dominik
- Müller Janine
- Müller Katharina
- Müller Vanessa
- Naik Paras
- Nakada Tatsuya
- Nandakumar Raja
- Nandi Anita
- Nanut Tara
- Nasteva Irina
- Needham Matthew
- Neri Nicola
- Neubert Sebastian
- Neufeld Niko
- Neuner Max
- Nguyen Thi Dung
- Nguyen-Mau Chung
- Nieswand Simon
- Niet Ramon
- Nikitin Nikolay
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- Vorobyev Vitaly
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- Wang Mengzhen
- Wang Yilong
- Wang Zhenzi
- Ward David
- Wark Heather Mckenzie
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- Whitehead Mark
- Wicht Jean
- Wilkinson Guy
- Wilkinson Michael
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- Williams Mike
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- Wimberley Jack
- Winn Michael Andreas
- Wishahi Julian
- Wislicki Wojciech
- Witek Mariusz
- Wormser Guy
- Wotton Stephen
- Wyllie Kenneth
- Xiao Dong
- Xie Yuehong
- Xu Ao
- Xu Menglin
- Xu Qingnian
- Xu Zehua
- Xu Zhirui
- Yang Zhenwei
- Yang Zishuo
- Yao Yuezhe
- Yeomans Lauren Emma
- Yin Hang
- Yu Jiesheng
- Yuan Xuhao
- Yushchenko Oleg
- Zarebski Kristian Alexander
- Zavertyaev Mikhail
- Zhang Dongliang
- Zhang Liming
- Zhang Wen Chao
- Zhang Yanxi
- Zhelezov Alexey
- Zheng Yangheng
- Zhu Xianglei
- Zhukov Valery
- Zonneveld Jennifer Brigitta
- Zucchelli Stefano
- Publication venue
- Publication date
- 01/01/2018
- Field of study
The LHCb Upgrade II will fully exploit the flavour-physics opportunities of the HL-LHC, and study additional physics topics that take advantage of the forward acceptance of the LHCb spectrometer. The LHCb Upgrade I will begin operation in 2020. Consolidation will occur, and modest enhancements of the Upgrade I detector will be installed, in Long Shutdown 3 of the LHC (2025) and these are discussed here. The main Upgrade II detector will be installed in long shutdown 4 of the LHC (2030) and will build on the strengths of the current LHCb experiment and the Upgrade I. It will operate at a luminosity up to 2×1034
cm−2s−1, ten times that of the Upgrade I detector. New detector components will improve the intrinsic performance of the experiment in certain key areas. An Expression Of Interest proposing Upgrade II was submitted in February 2017. The physics case for the Upgrade II is presented here in more depth. CP-violating phases will be measured with precisions unattainable at any other envisaged facility. The experiment will probe b → sl+l−and b → dl+l− transitions in both muon and electron decays in modes not accessible at Upgrade I. Minimal flavour violation will be tested with a precision measurement of the ratio of B(B0 → μ+μ−)/B(Bs → μ+μ−). Probing charm CP violation at the 10−5 level may result in its long sought discovery. Major advances in hadron spectroscopy will be possible, which will be powerful probes of low energy QCD. Upgrade II potentially will have the highest sensitivity of all the LHC experiments on the Higgs to charm-quark couplings. Generically, the new physics mass scale probed, for fixed couplings, will almost double compared with the pre-HL-LHC era; this extended reach for flavour physics is similar to that which would be achieved by the HE-LHC proposal for the energy frontier
LHCb upgrade software and computing : technical design report
- Author
- Aaij Roel
- Adeva Bernardo
- Adinolfi Marco
- Aidala Christine Angela
- Ajaltouni Ziad
- Akar Simon
- Albicocco Pietro
- Albrecht Johannes
- Alessio Federico
- Alexander Michael
- Alfonso Albero Alejandro
- Ali Suvayu
- Alkhazov Georgy
- Alvarez Cartelle Paula
- Alves Jr Antonio Augusto
- Amato Sandra
- Amerio Silvia
- Amhis Yasmine
- An Liupan
- Anderlini Lucio
- Andreassi Guido
- Andreotti Mirco
- Andrews Jason
- Appleby Robert
- Archilli Flavio
- Arnau Romeu Joan
- Artamonov Alexander
- Artuso Marina
- Arzymatov Kenenbek
- Aslanides Elie
- Atzeni Michele
- Bachmann Sebastian
- Back John
- Baker Sophie
- Balagura Vladislav
- Baldini Wander
- Baranov Alexander
- Barlow Roger
- Barsuk Sergey
- Barter William
- Baryshnikov Fedor
- Batozskaya Varvara
- Batsukh Baasansuren
- Battista Vincenzo
- Bay Aurelio
- Beddow John
- Bedeschi Franco
- Bediaga Ignacio
- Beiter Andrew
- Bel Lennaert
- Beliy Nikita
- Bellee Violaine
- Belloli Nicoletta
- Belous Konstantin
- Belyaev Ivan
- Ben-Haim Eli
- Bencivenni Giovanni
- Benson Sean
- Beranek Sarah
- Berezhnoy Alexander
- Bernet Roland
- Berninghoff Daniel
- Bertholet Emilie
- Bertolin Alessandro
- Betancourt Christopher
- Betti Federico
- Bettler Marc-Olivier
- Bezshyiko Iaroslava
- Bhasin Srishti
- Bhom Jihyun
- Bifani Simone
- Billoir Pierre
- Birnkraut Alex
- Bizzeti Andrea
- Bjørn Mikkel
- Blago Michele Piero
- Blake Thomas
- Blanc Frederic
- Blusk Steven
- Bobulska Dana
- Bocci Valerio
- Boente Garcia Oscar
- Boettcher Thomas
- Bondar Alexander
- Bondar Nikolay
- Borghi Silvia
- Borisyak Maxim
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- Brodski Michael
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- Cadeddu Sandro
- Cai Hao
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- Calladine Ryan
- Calvi Marta
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- Campora Perez Daniel Hugo
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- Owen Patrick
- Oyanguren Maria Aranzazu
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- Palano Antimo
- Palutan Matteo
- Panshin Gennady
- Papanestis Antonios
- Pappagallo Marco
- Pappalardo Luciano
- Parker William
- Parkes Christopher
- Passaleva Giovanni
- Pastore Alessandra
- Patel Mitesh
- Patrignani Claudia
- Pearce Alex
- Pellegrino Antonio
- Penso Gianni
- Pepe Altarelli Monica
- Perazzini Stefano
- Pereima Dmitrii
- Perret Pascal
- Pescatore Luca
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- Petrolini Alessandro
- Petrov Aleksandr
- Petrucci Stefano
- Petruzzo Marco
- Pietrzyk Boleslaw
- Pietrzyk Guillaume
- Pikies Malgorzata
- Pili Martina
- Pinci Davide
- Pinzino Jacopo
- Pisani Flavio
- Piucci Alessio
- Placinta Vlad-Mihai
- Playfer Stephen
- Plews Jonathan
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- Pugatch Valery
- Puig Navarro Albert
- Pullen Hannah Louise
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- Qian Wenbin
- Qin Jia-Jia
- Quagliani Renato
- Quintana Boris
- Rachwal Bartlomiej
- Rademacker Jonas
- Rama Matteo
- Ramos Pernas Miguel
- Rangel Murilo
- Ratnikov Fedor
- Raven Gerhard
- Ravonel Salzgeber Melody
- Reboud Meril
- Redi Federico
- Reichert Stefanie
- Reiss Florian
- Remon Alepuz Clara
- Ren Zan
- Renaudin Victor
- Ricciardi Stefania
- Richards Sophie
- Rinnert Kurt
- Robbe Patrick
- Robert Arnaud
- Rodrigues Ana Barbara
- Rodrigues Eduardo
- Rodriguez Lopez Jairo Alexis
- Roehrken Markus
- Rogozhnikov Alexey
- Roiser Stefan
- Rollings Alexandra Paige
- Romanovskiy Vladimir
- Romero Vidal Antonio
- Rotondo Marcello
- Rudolph Matthew Scott
- Ruf Thomas
- Ruiz Vidal Joan
- Saborido Silva Juan Jose
- Sagidova Naylya
- Saitta Biagio
- Salustino Guimaraes Valdir
- Sanchez Gras Cristina
- Sanchez Mayordomo Carlos
- Sanmartin Sedes Brais
- Santacesaria Roberta
- Santamarina Rios Cibran
- Santimaria Marco
- Santovetti Emanuele
- Sarpis Gediminas
- Sarti Alessio
- Satriano Celestina
- Satta Alessia
- Saur Miroslav
- Savrina Darya
- Schael Stefan
- Schellenberg Margarete
- Schiller Manuel
- Schindler Heinrich
- Schmelling Michael
- Schmelzer Timon
- Schmidt Burkhard
- Schneider Olivier
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- Schreiner HF
- Schubiger Maxime
- Schune Marie Helene
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- Sciubba Adalberto
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- Sepulveda Eduardo Enrique
- Sergi Antonino
- Serra Nicola
- Serrano Justine
- Sestini Lorenzo
- Seuthe Alex
- Seyfert Paul
- Shapkin Mikhail
- Shcheglov Yury
- Shears Tara
- Shekhtman Lev
- Shevchenko Vladimir
- Shmanin Evgenii
- Siddi Benedetto Gianluca
- Silva Coutinho Rafael
- Silva de Oliveira Luiz Gustavo
- Simi Gabriele
- Simone Saverio
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- Sun Jiayin
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- Swientek Krzysztof
- Syropoulos Vasileios
- Szumlak Tomasz
- Szymanski Maciej Pawel
- T'Jampens Stephane
- Tang Zhipeng
- Tayduganov Andrey
- Tekampe Tobias
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- Teubert Frederic
- Thomas Eric
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- Vagnoni Vincenzo
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- van Herwijnen Eric
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- Vazquez Regueiro Pablo
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- Vieira Daniel
- Vieites Diaz Maria
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- Vitkovskiy Arseniy
- Vitti Marcela
- Volkov Vladimir
- Vollhardt Achim
- Voneki Balazs
- Vorobyev Alexey
- Vorobyev Vitaly
- Waldi Roland
- Walsh John
- Wang Jianchun
- Wang Mengzhen
- Wang Yilong
- Wang Zhenzi
- Ward David
- Wark Heather Mckenzie
- Watson Nigel
- Websdale David
- Weiden Andreas
- Weisser Constantin
- Whitehead Mark
- Wicht Jean
- Wilkinson Guy
- Wilkinson Michael
- Williams Ifan
- Williams Mark Richard James
- Williams Mike
- Williams Timothy
- Wilson Fergus
- Wimberley Jack
- Winn Michael Andreas
- Wishahi Julian
- Wislicki Wojciech
- Witek Mariusz
- Wormser Guy
- Wotton Stephen
- Wyllie Kenneth
- Xiao Dong
- Xie Yuehong
- Xu Ao
- Xu Menglin
- Xu Qingnian
- Xu Zehua
- Xu Zhirui
- Yang Zhenwei
- Yang Zishuo
- Yao Yuezhe
- Yeomans Lauren Emma
- Yin Hang
- Yu Jiesheng
- Yuan Xuhao
- Yushchenko Oleg
- Zarebski Kristian Alexander
- Zavertyaev Mikhail
- Zhang Dongliang
- Zhang Liming
- Zhang Wen Chao
- Zhang Yanxi
- Zhelezov Alexey
- Zheng Yangheng
- Zhu Xianglei
- Zhukov Valery
- Zonneveld Jennifer Brigitta
- Zucchelli Stefano
- Publication venue
- Publication date
- 01/01/2018
- Field of study
This document reports the Research and Development activities that are carried out in the software and computing domains in view of the upgrade of the LHCb experiment. The implementation of a full software trigger implies major changes in the core software framework, in the event data model, and in the reconstruction algorithms. The increase of the data volumes for both real and simulated datasets requires a corresponding scaling of the distributed computing infrastructure. An implementation plan in both domains is presented, together with a risk assessment analysis
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
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- Aladna Abdallah
- Alali Mahmoud
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- Aljiffry Murad
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- Alkhalifa Elmustafa
- Alkhatib Sondos
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- Allan Anna
- Almarshad Felwa
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- Almiqlash Bushray
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- Alnsour Abed Alfattah Mahmoud
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- Ekwen Gerald
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- El Assaad Hadi
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- El-Boghdadly Kariem
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- El-Kassas Mohamed
- Elagili Ahmed
- Elahi Zain
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- Elbahnasawy Mohamed
- Elbe Peter
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- Elebute Olumide
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- Elnour Moheyaldien Ahmed Elamin
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- Elshahawy Mahmoud Abdelaziz Mohamed
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- Mahečić Tina Tomić
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- Manjula S.
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- Martins Claudia Pinto
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- Martínez Daniel Fernández
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- Mayer Horacio F.
- Mayo-Yáñez Miguel
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- Mbodi Langanani
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- McPherson Duncan
- Meara John G.
- Meead Adullah
- Mehraj Asif
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- Mengesha Mengistu G.
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- Wolfenden John W. D.
- Wong Benjamin Ngie Xiong
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- Wong Ho Ying Flora
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- Wormald Justin
- Wright Deborah
- Wright Joshua
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- Yanowsky-Reyes Guillermo
- Yassin Abubaker
- Yates Elizabeth
- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
Mechanisms and consequences of oxidative stress in lung disease: therapeutic implications for an aging populace
- Publication venue
- 'American Physiological Society'
- Publication date
- Field of study
Development of a three-dimensional physiological model of the internal anal sphincter bioengineered in vitro from isolated smooth muscle cells
- Publication venue
- 'American Physiological Society'
- Publication date
- Field of study
- …