Evidence-based policing: from effectiveness to cost-effectiveness

Recent years have seen the development of quantitative studies into policing effectiveness, in particular, the ‘evidence based policing’ movement which has encouraged the use of randomized control trials in the UK and the USA. Despite their significance, such studies remain narrowly based in terms of their take-up by academic institutions and police forces. This article charts the rise of evidence-based policing and considers whether it could be taken a step further, by developing consideration of police effectiveness into that of cost-effectiveness. The use of ‘Quality Adjusted Life Years’ (QALY) methodology in the UK in the arena of drugs approval for use by the National Health Service, is considered as a model which might be transferable to policing. It is concluded that there are substantial similarities. Providing that the improvements sought are realistic, there is real potential for the cost-effectiveness of policing methods to be assessed

Te Puni Rumaki – Strengthening Māori medium initial teacher education

The delivery of initial teacher education for Māori medium contexts in Aotearoa seeks to support the revitalization of the indigenous language and practices in collaboration with the current education system. This presentation introduces a research project begun early in 2013 with providers, student teachers, schools and communities involved in respective Māori medium programmes. This research project has a "positive output approach" where fundamental elements to the success of these various programmes are shared. The wide range of Māori medium initial teacher education settings is investigated. Consequences from the research findings will also be discussed

Enhanced Public Defense Improves Pretrial Outcomes and Reduces Racial Disparities

Numerous jurisdictions are working to reform pretrial processes to reduce or eliminate money bail and decrease pretrial detention. Although reforms such as the abandonment of bail schedules or adoption of actuarial risk assessment tools have been widely enacted, the role of defense counsel in the pretrial process has received less attention.This Article considers an approach to pretrial reform focused on improving the quality of defense counsel. In Philadelphia, a substantial fraction of people facing criminal charges are detained following rapid preliminary hearings where initial release conditions are set by bail magistrates operating with limited information. Beginning in 2017, the Defender Association of Philadelphia implemented a pilot program wherein “bail advocates” interviewed defendants shortly after arrest to collect individualized information that could be used to more effectively argue for pretrial release.Using administrative data covering nearly 100,000 criminal cases and a quasi-experimental research design that exploits the random shuffling of arraignment shifts covered by advocates during the pilot, we measure the causal impacts of the advocates on pretrial release, failure to appear, case outcomes, and future crime. Bail advocates did not reduce detention rates (at least on average) but did substantially reduce clients’ likelihood of bail violation (-64%) and future arrest (- 26%). Bail advocates also reduce racial disparities in pretrial detention. Interviews with prosecutors, defenders, and bail advocates suggest that these impacts likely represent both better understanding of defendant risk and needs by magistrates and a better sense of procedural justice by defendants.These results suggest that bail advocates might achieve a key objective desired by proponents of risk assessment tools—the provision of better information to pretrial decisionmakers—without triggering comparable concerns. A workable solution to the problem of improving pretrial outcomes may lie with an old mainstay of the criminal process—the defense attorney

Studies in predictor display technique Final report

Predictor display technique for manual altitude control, and automatic pitch axis performanc

Operational risk, omissions and liability in policing

Recent decades have seen the sensitisation of UK society towards harm and policing ‘failures’ become increasingly significant. This paper is intended to stimulate thought and debate by analysing some consequences of these developments. It reviews literature in relation to risk-taking in UK operational policing, identifying increased criminal and disciplinary liability, particularly in respect of alleged omissions. Hindsight is found to be a potentially powerful influence. The article concludes that it is unlikely that public culture will be changed readily. However, police and other bodies should be able to reach a common approach towards operational risk, omissions and hindsight

Growth-induced mass flows in fungal networks

Cord-forming fungi form extensive networks that continuously adapt to maintain an efficient transport system. As osmotically driven water uptake is often distal from the tips, and aqueous fluids are incompressible, we propose that growth induces mass flows across the mycelium, whether or not there are intrahyphal concentration gradients. We imaged the temporal evolution of networks formed by Phanerochaete velutina, and at each stage calculated the unique set of currents that account for the observed changes in cord volume, while minimising the work required to overcome viscous drag. Predicted speeds were in reasonable agreement with experimental data, and the pressure gradients needed to produce these flows are small. Furthermore, cords that were predicted to carry fast-moving or large currents were significantly more likely to increase in size than cords with slow-moving or small currents. The incompressibility of the fluids within fungi means there is a rapid global response to local fluid movements. Hence velocity of fluid flow is a local signal that conveys quasi-global information about the role of a cord within the mycelium. We suggest that fluid incompressibility and the coupling of growth and mass flow are critical physical features that enable the development of efficient, adaptive, biological transport networks.Comment: To be published in PRSB. 20 pages, plus 8 pages of supplementary information, and 3 page bibliograph

Nivolumab-induced fulminant diabetic ketoacidosis followed by thyroiditis

Five days following the 3rd cycle of nivolumab, a monoclonal antibody, which acts as immune checkpoint inhibitor against the programmed cell death protein-1, for metastatic lung adenocarcinoma, a 56-year-old woman presented at the hospital critically ill. On admission, she had severe diabetic ketoacidosis (DKA), as evidenced by venous glucose of 47 mmol/L, blood ketones of 7.5 mmol/L, pH of 6.95 and bicarbonate of 6.6 mmol/L. She has had no personal or family history of diabetes mellitus (DM), while random venous glucose, measured 1 week prior to hospitalisation, was 6.1 mmol/L. On admission, her HbA1c was 8.2% and anti-GAD antibodies were 12 kIU/L (0–5 kU/L), while islet cell antibodies and serum C-peptide were undetectable. Nivolumab was recommenced without the development of other immune-mediated phenomena until 6 months later, when she developed hypothyroidism with TSH 18 U/L and low free T4. She remains insulin dependent and has required levothyroxine replacement, while she has maintained good radiological and clinical response to immunotherapy. This case is notable for the rapidity of onset and profound nature of DKA at presentation, which occurred two months following commencement of immunotherapy. Despite the association of nivolumab with immune-mediated endocrinopathies, only a very small number of patients developing type 1 DM has been reported to date. Patients should be closely monitored for hyperglycaemia and thyroid dysfunction prior to and periodically during immunotherapy

A V-Diagram for the Design of Integrated Health Management for Unmanned Aerial Systems

Designing Integrated Vehicle Health Management (IVHM) for Unmanned Aerial Systems (UAS) is inherently complex. UAS are a system of systems (SoS) and IVHM is a product-service, thus the designer has to take into account many factors, such as: the design of the other systems of the UAS (e.g. engines, structure, communications), the split of functions between elements of the UAS, the intended operation/mission of the UAS, the cost verses benefit of monitoring a system/component/part, different techniques for monitoring the health of the UAS, optimizing the health of the fleet and not just the individual UAS, amongst others. The design of IVHM cannot sit alongside, or after, the design of UAS, but itself be integrated into the overall design to maximize IVHM’s potential. Many different methods exist to help design complex products and manage the process. One method used is the V-diagram which is based on three concepts: decomposition & definition; integration & testing; and verification & validation. This paper adapts the V-diagram so that it can be used for designing IVHM for UAS. The adapted v-diagram splits into different tracks for the different system elements of the UAS and responses to health states (decomposition and definition). These tracks are then combined into an overall IVHM provision for the UAS (integration and testing), which can be verified and validated. The stages of the adapted V-diagram can easily be aligned with the stages of the V-diagram being used to design the UAS bringing the design of the IVHM in step with the overall design process. The adapted V-diagram also allows the design IVHM for a UAS to be broken down in to smaller tasks which can be assigned to people/teams with the relevant competencies. The adapted V-diagram could also be used to design IVHM for other SoS and other vehicles or products

Dengue Virus and Autophagy

Several independent groups have published that autophagy is required for optimal RNA replication of dengue virus (DENV). Initially, it was postulated that autophagosomes might play a structural role in replication complex formation. However, cryo-EM tomography of DENV replication complexes showed that DENV replicates on endoplasmic reticulum (ER) cisternae invaginations and not on classical autophagosomes. Recently, it was reported that autophagy plays an indirect role in DENV replication by modulating cellular lipid metabolism. DENV-induced autophagosomes deplete cellular triglycerides that are stored in lipid droplets, leading to increased β-oxidation and energy production. This is the first example of a virus triggering autophagy to modulate cellular physiology. In this review, we summarize these data and discuss new questions and implications for autophagy during DENV replication