Considering Men, the Evolving Discourse on Masculinities: Reflections on Masculinities: Violences, Variations, and Visions

It has been twenty-five or so years since scholars first took up the mantle of critically examining masculinities in what are now considered classic works by Jack Sawyer, Joe Pleck and Harry Brod. These scholars made persuasive arguments for considering men in the equation of understanding gender. Drawing on a feminist analysis they called into question the perception that biology explains all and that the oppression of women was a de-facto result of how men and women are made, either by God or by nature. Today there is little support for the early essentialist arguments. Men, it turns out, do have a gender that is more than the sum of their physical parts. Indeed, how boys become men and the meanings society associates with masculinity are not only constructed, but highly regulated, broadly interpreted, and situationally located

Rapidly Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in NSCLC Cell Lines through De-Repression of FGFR2 and FGFR3 Expression

Despite initial and sometimes dramatic responses of specific NSCLC tumors to EGFR TKIs, nearly all will develop resistance and relapse. Gene expression analysis of NSCLC cell lines treated with the EGFR TKI, gefitinib, revealed increased levels of FGFR2 and FGFR3 mRNA. Analysis of gefitinib action on a larger panel of NSCLC cell lines verified that FGFR2 and FGFR3 expression is increased at the mRNA and protein level in NSCLC cell lines in which the EGFR is dominant for growth signaling, but not in cell lines where EGFR signaling is absent. A luciferase reporter containing 2.5 kilobases of fgfr2 5′ flanking sequence was activated after gefitinib treatment, indicating transcriptional regulation as a contributing mechanism controlling increased FGFR2 expression. Induction of FGFR2 and FGFR3 protein as well as fgfr2-luc activity was also observed with Erbitux, an EGFR-specific monoclonal antibody. Moreover, inhibitors of c-Src and MEK stimulated fgfr2-luc activity to a similar degree as gefitinib, suggesting that these pathways may mediate EGFR-dependent repression of FGFR2 and FGFR3. Importantly, our studies demonstrate that EGFR TKI-induced FGFR2 and FGFR3 are capable of mediating FGF2 and FGF7 stimulated ERK activation as well as FGF-stimulated transformed growth in the setting of EGFR TKIs. In conclusion, this study highlights EGFR TKI-induced FGFR2 and FGFR3 signaling as a novel and rapid mechanism of acquired resistance to EGFR TKIs and suggests that treatment of NSCLC patients with combinations of EGFR and FGFR specific TKIs may be a strategy to enhance efficacy of single EGFR inhibitors

Analysis of Mutant Platelet-derived Growth Factor Receptors Expressed in PC12 Cells Identifies Signals Governing Sodium Channel Induction during Neuronal Differentiation.

The mechanisms governing neuronal differentiation, including the signals underlying the induction of voltage-dependent sodium (Na+) channel expression by neurotrophic factors, which occurs independent of Ras activity, are not well understood. Therefore, Na+ channel induction was analyzed in sublines of PC12 cells stably expressing platelet-derived growth factor (PDGF) beta receptors with mutations that eliminate activation of specific signalling molecules. Mutations eliminating activation of phosphatidylinositol 3-kinase (PI3K), phospholipase C gamma (PLC gamma), the GTPase-activating protein (GAP), and Syp phosphatase failed to diminish the induction of type II Na+ channel alpha-subunit mRNA and functional Na+ channel expression by PDGF, as determined by RNase protection assays and whole-cell patch clamp recording. However, mutation of juxtamembrane tyrosines that bind members of the Src family of kinases upon receptor activation inhibited the induction of functional Na+ channels while leaving the induction of type II alpha-subunit mRNA intact. Mutation of juxtamembrane tyrosines in combination with mutations eliminating activation of PI3K, PLC gamma, GAP, and Syp abolished the induction of type II alpha-subunit mRNA, suggesting that at least partially redundant signaling mechanisms mediate this induction. The differential effects of the receptor mutations on Na+ channel expression did not reflect global changes in receptor signaling capabilities, as in all of the mutant receptors analyzed, the induction of c-fos and transin mRNAs still occurred. The results reveal an important role for the Src family in the induction of Na+ channel expression and highlight the multiplicity and combinatorial nature of the signaling mechanisms governing neuronal differentiation

Implementation of PhotoZ under Astro-WISE - A photometric redshift code for large datasets

We describe the implementation of the PhotoZ code in the framework of the Astro-WISE package and as part of the Photometric Classification Server of the PanSTARRS pipeline. Both systems allow the automatic measurement of photometric redshifts for the millions of objects being observed in the PanSTARRS project or expected to be observed by future surveys like KIDS, DES or EUCLID.Comment: Accepted for publication in topical issue of Experimental Astronomy on Astro-WISE information system, references update

Master plan: new state university in East Central Florida.

The preliminary master plan for what would become the University of Central Florida. It consists of drawings and overlays for building placement, pedestrian and vehicle traffic, and the locations of the various colleges.https://stars.library.ucf.edu/floridaheritage/1051/thumbnail.jp

Efficient intra- and inter-night linking of asteroid detections using kd-trees

The Panoramic Survey Telescope And Rapid Response System (Pan-STARRS) under development at the University of Hawaii's Institute for Astronomy is creating the first fully automated end-to-end Moving Object Processing System (MOPS) in the world. It will be capable of identifying detections of moving objects in our solar system and linking those detections within and between nights, attributing those detections to known objects, calculating initial and differentially-corrected orbits for linked detections, precovering detections when they exist, and orbit identification. Here we describe new kd-tree and variable-tree algorithms that allow fast, efficient, scalable linking of intra and inter-night detections. Using a pseudo-realistic simulation of the Pan-STARRS survey strategy incorporating weather, astrometric accuracy and false detections we have achieved nearly 100% efficiency and accuracy for intra-night linking and nearly 100% efficiency for inter-night linking within a lunation. At realistic sky-plane densities for both real and false detections the intra-night linking of detections into `tracks' currently has an accuracy of 0.3%. Successful tests of the MOPS on real source detections from the Spacewatch asteroid survey indicate that the MOPS is capable of identifying asteroids in real data.Comment: Accepted to Icaru

The Pan-STARRS Moving Object Processing System

We describe the Pan-STARRS Moving Object Processing System (MOPS), a modern software package that produces automatic asteroid discoveries and identifications from catalogs of transient detections from next-generation astronomical survey telescopes. MOPS achieves > 99.5% efficiency in producing orbits from a synthetic but realistic population of asteroids whose measurements were simulated for a Pan-STARRS4-class telescope. Additionally, using a non-physical grid population, we demonstrate that MOPS can detect populations of currently unknown objects such as interstellar asteroids. MOPS has been adapted successfully to the prototype Pan-STARRS1 telescope despite differences in expected false detection rates, fill-factor loss and relatively sparse observing cadence compared to a hypothetical Pan-STARRS4 telescope and survey. MOPS remains >99.5% efficient at detecting objects on a single night but drops to 80% efficiency at producing orbits for objects detected on multiple nights. This loss is primarily due to configurable MOPS processing limits that are not yet tuned for the Pan-STARRS1 mission. The core MOPS software package is the product of more than 15 person-years of software development and incorporates countless additional years of effort in third-party software to perform lower-level functions such as spatial searching or orbit determination. We describe the high-level design of MOPS and essential subcomponents, the suitability of MOPS for other survey programs, and suggest a road map for future MOPS development.Comment: 57 Pages, 26 Figures, 13 Table

Observational and Dynamical Characterization of Main-Belt Comet P/2010 R2 (La Sagra)

We present observations of comet-like main-belt object P/2010 R2 (La Sagra) obtained by Pan-STARRS 1 and the Faulkes Telescope-North on Haleakala in Hawaii, the University of Hawaii 2.2 m, Gemini-North, and Keck I telescopes on Mauna Kea, the Danish 1.54 m telescope at La Silla, and the Isaac Newton Telescope on La Palma. An antisolar dust tail is observed from August 2010 through February 2011, while a dust trail aligned with the object's orbit plane is also observed from December 2010 through August 2011. Assuming typical phase darkening behavior, P/La Sagra is seen to increase in brightness by >1 mag between August 2010 and December 2010, suggesting that dust production is ongoing over this period. These results strongly suggest that the observed activity is cometary in nature (i.e., driven by the sublimation of volatile material), and that P/La Sagra is therefore the most recent main-belt comet to be discovered. We find an approximate absolute magnitude for the nucleus of H_R=17.9+/-0.2 mag, corresponding to a nucleus radius of ~0.7 km, assuming an albedo of p=0.05. Using optical spectroscopy, we find no evidence of sublimation products (i.e., gas emission), finding an upper limit CN production rate of Q_CN<6x10^23 mol/s, from which we infer an H2O production rate of Q_H2O<10^26 mol/s. Numerical simulations indicate that P/La Sagra is dynamically stable for >100 Myr, suggesting that it is likely native to its current location and that its composition is likely representative of other objects in the same region of the main belt, though the relatively close proximity of the 13:6 mean-motion resonance with Jupiter and the (3,-2,-1) three-body mean-motion resonance with Jupiter and Saturn mean that dynamical instability on larger timescales cannot be ruled out.Comment: 23 pages, 13 figures, accepted for publication in A

Ultra-Luminous Supernovae as a New Probe of the Interstellar Medium in Distant Galaxies

We present the Pan-STARRS1 discovery and light curves, and follow-up MMT and Gemini spectroscopy of an ultra-luminous supernova (ULSN; dubbed PS1-11bam) at a redshift of z = 1.566 with a peak brightness of MUV ≈ −22.3 mag. PS1-11bam is one of the highest redshift spectroscopically-confirmed SNe known to date. The spectrum is characterized by broad absorption features typical of previous ULSNe (e.g., C II, Si III), and by strong and narrow Mg II and Fe II absorption lines from the interstellar medium (ISM) of the host galaxy, confirmed by an [O II]λ3727 emission line at the same redshift. The equivalent widths of the Fe IIλ2600 and Mg IIλ2803 lines are in the top quartile of the quasar intervening absorption system distribution, but are weaker than those of gamma-ray burst intrinsic absorbers (i.e., GRB host galaxies). We also detect the host galaxy in pre-explosion Pan-STARRS1 data and find that its UV spectral energy distribution is best fit with a young stellar population age of τ∗ ≈ 15 − 45 Myr and a stellar mass of M∗ ≈ (1.1 − 2.6) × 109 M⊙ (for Z = 0.05 − 1 Z⊙). The star formation rate inferred from the UV continuum and [O II]λ3727 emission line is ≈ 10 M⊙ yr−1, higher than in any previous ULSN host. PS1-11bam provides the first direct demonstration that ULSNe can serve as probes of the interstellar medium in distant galaxies. At the present, the depth and red sensitivity of PS1 are uniquely suited to finding such events at cosmologically interesting redshifts (z ∼ 1 − 2); the future combination of LSST and 30-m class telescopes promises to extend this technique to z ∼ 4.Astronom

Sn 2010ay Is a Luminous and Broad-Lined Type Ic Supernova Within a Low-Metallicity Host Galaxy

We report on our serendipitous pre-discovery detection and detailed follow-up of the broad-lined Type Ic supernova (SN) 2010ay at z = 0.067 imaged by the Pan-STARRS1 3π survey just ∼ 4 days after explosion. The SN had a peak luminosity, MR ≈ −20.2 mag, significantly more luminous than known GRB-SNe and one of the most luminous SNe Ib/c ever discovered. The absorption velocity of SN 2010ay is vSi ≈ 19 × 103 km s−1 at ∼ 40 days after explosion, 2 − 5 times higher than other broad-lined SNe and similar to the GRB-SN 2010bh at comparable epochs. Moreover, the velocity declines ∼ 2 times slower than other SNe Ic-BL and GRB-SNe. Assuming that the optical emission is powered by radioactive decay, the peak magnitude implies the synthesis of an unusually large mass of 56Ni, MNi = 0.9 M⊙. Modeling of the light-curve points to a total ejecta mass, Mej ≈ 4.7M⊙, and total kinetic energy, EK ≈ 11 × 1051 ergs. The ratio of MNi to Mej is ∼ 2 times as large for SN 2010ay as typical GRB-SNe and may suggest an additional energy reservoir. The metallicity (log(O/H)PP04 + 12 = 8.19) of the explosion site within the host galaxy places SN 2010ay in the low-metallicity regime populated by GRB-SNe, and ∼ 0.5(0.2) dex lower than that typically measured for the host environments of normal (broad-lined) Ic supernovae. We constrain any gammaray emission with Eγ . 6 × 1048 erg (25-150 keV) and our deep radio follow-up observations with the Expanded Very Large Array rule out relativistic ejecta with energy, E & 1048 erg. We therefore rule out the association of a relativistic outflow like those which accompanied SN 1998bw and traditional long-duration GRBs, but place less-stringent constraints on a weak afterglow like that seen from XRF 060218. These observations challenge the importance of progenitor metallicity for the production of a GRB, and suggest that other parameters also play a key role.Astronom