The pineal gland - a synopsis of present knowledge with particular emphasis on its possible role in control of gonadtrophin function

No Abstrac

The diversity effect in inductive reasoning depends on sampling assumptions

A key phenomenon in inductive reasoning is the diversity effect, whereby a novel property is more likely to be generalized when it is shared by an evidence sample composed of diverse instances than a sample composed of similar instances. We outline a Bayesian model and an experimental study that show that the diversity effect depends on the assumption that samples of evidence were selected by a helpful agent (strong sampling). Inductive arguments with premises containing either diverse or nondiverse evidence samples were presented under different sampling conditions, where instructions and filler items indicated that the samples were selected intentionally (strong sampling) or randomly (weak sampling). A robust diversity effect was found under strong sampling, but was attenuated under weak sampling. As predicted by our Bayesian model, the largest effect of sampling was on arguments with nondiverse evidence, where strong sampling led to more restricted generalization than weak sampling. These results show that the characteristics of evidence that are deemed relevant to an inductive reasoning problem depend on beliefs about how the evidence was generated.Brett K. Hayes, Danielle J. Navarro, Rachel G. Stephens, Keith Ransom, Natali Dilevsk

Factor XIIIA-expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking

Lung cancer is the leading cause of cancer-related deaths worldwide, and lung squamous carcinomas (LUSC) represent about 30% of cases. Molecular aberrations in lung adenocarcinomas have allowed for effective targeted treatments, but corresponding therapeutic advances in LUSC have not materialized. However, immune checkpoint inhibitors in sub-populations of LUSC patients have led to exciting responses. Using computational analyses of The Cancer Genome Atlas, we identified a subset of LUSC tumors characterized by dense infiltration of inflammatory monocytes (IMs) and poor survival. With novel, immunocompetent metastasis models, we demonstrated that tumor cell derived CCL2-mediated recruitment of IMs is necessary and sufficient for LUSC metastasis. Pharmacologic inhibition of IM recruitment had substantial anti-metastatic effects. Notably, we show that IMs highly express Factor XIIIA, which promotes fibrin cross-linking to create a scaffold for LUSC cell invasion and metastases. Consistently, human LUSC samples containing extensive cross-linked fibrin in the microenvironment correlated with poor survival

Dalit identity in urban Pokhara, Nepal

Urban migration by Nepalese Dalits has not only provided them with social, economic and educational opportunities, but also the possibility of escaping traditional caste-based discrimination. However, despite making the most of opportunities provided by the city, Dalits have not been able to pursue their political agenda to the extent of other ethnic communities. This study in the city of Pokhara, Nepal, explored Dalit identity using two rounds of focus group discussions involving a total of 23 individuals drawn from a range of Dalit caste groups with a variety of livelihoods. The results describe the caste-based discrimination experienced by the participants and the different strategies they employ to either reinvent themselves by changing names; or embracing their caste-heritage and taking advantage of affirmative action programmes. Whilst urban migration can provide some relief from discrimination, the study reveals that caste still remains prominent in the lives of Dalits in Pokhara. The paper argues that Dalit unity and elimination of intra-Dalit caste-based discrimination are needed in order to institutionalise their citizenship rights in post conflict Nepal

Using behavior-analytic implicit tests to assess sexual interests among normal and sex-offender populations

The development of implicit tests for measuring biases and behavioral predispositions is a recent development within psychology. While such tests are usually researched within a social-cognitive paradigm, behavioral researchers have also begun to view these tests as potential tests of conditioning histories, including in the sexual domain. The objective of this paper is to illustrate the utility of a behavioral approach to implicit testing and means by which implicit tests can be built to the standards of behavioral psychologists. Research findings illustrating the short history of implicit testing within the experimental analysis of behavior are reviewed. Relevant parallel and overlapping research findings from the field of social cognition and on the Implicit Association Test are also outlined. New preliminary data obtained with both normal and sex offender populations are described in order to illustrate how behavior-analytically conceived implicit tests may have potential as investigative tools for assessing histories of sexual arousal conditioning and derived stimulus associations. It is concluded that popular implicit tests are likely sensitive to conditioned and derived stimulus associations in the history of the test-taker rather than 'unconscious cognitions', per se

Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as a target for cancer immunotherapy. However, anti-CD25 antibodies have displayed limited activity against established tumors. We demonstrated that CD25 expression is largely restricted to tumor-infiltrating Treg cells in mice and humans. While existing anti-CD25 antibodies were observed to deplete Treg cells in the periphery, upregulation of the inhibitory Fc gamma receptor (FcγR) IIb at the tumor site prevented intra-tumoral Treg cell depletion, which may underlie the lack of anti-tumor activity previously observed in pre-clinical models. Use of an anti-CD25 antibody with enhanced binding to activating FcγRs led to effective depletion of tumor-infiltrating Treg cells, increased effector to Treg cell ratios, and improved control of established tumors. Combination with anti-programmed cell death protein-1 antibodies promoted complete tumor rejection, demonstrating the relevance of CD25 as a therapeutic target and promising substrate for future combination approaches in immune-oncology

Artificial neural network for ecological-economic zoning as a tool for spatial planning

O objetivo deste trabalho foi analisar informações socioambientais por meio de rede neural artificial-mapa auto-organizável (RNA-SOM), para fornecer subsídio ao zoneamento ecológico econômico (ZEE) como instrumento para diminuir a subjetividade do processo. A área de estudo compreende 16 municípios do Nordeste Paraense, expressivos no desenvolvimento agropecuário do estado. O tratamento dos dados envolveu três etapas: preparação dos dados em ambiente de sistema de informação geográfica (SIG); processamento matemático (RNA-SOM) dos dados; e visualização e interpretação dos resultados dos processamentos, o que permitiu o ordenamento territorial do Nordeste Paraense. Os resultados compreenderam 13 classes, reagrupadas de acordo com critérios de similaridade de comportamento em quatro categorias, que representam os principais eixos de sustentabilidade propostos para o Estado do Pará, a partir do ZEE existente. A metodologia proposta permite individualizar zonas na região que o ZEE não havia definido, principalmente em razão da maior possibilidade de conjugar e integrar um grande número de variáveis físicas, sociais e econômicas por meio do SOM.The objective of this work was to analyze social and environmental information through an artificial neural network-self-organizing map (ANN-SOM), in order to provide subsidy to ecologicaleconomic zoning (EEZ) as a tool to reduce the subjectivity of the process. The study area comprises 16 municipalities in the northeast of the state of Pará, Brazil, representative of the agricultural development in the state. Data processing involved three steps: preparation of the data in a geographic information system (GIS) environment; mathematical processing (ANN-SOM) of the data; and visualization and interpretation of the processing results, allowing the spatial planning of northeastern Pará. The results comprised 13 classes, regrouped according to behavioral similarity criteria into four categories, which represent the main areas of sustainability proposed for the state of Pará, according to existing EEZ. The proposed methodology allows individualizing areas in the region that EEZ had not defined, mainly due to the greater possibility of combining and integrating a large number of physical, social, and economic variables through the SOM

Search for gravitational waves from Scorpius X-1 in the second Advanced LIGO observing run with an improved hidden Markov model

We present results from a semicoherent search for continuous gravitational waves from the low-mass x-ray binary Scorpius X-1, using a hidden Markov model (HMM) to track spin wandering. This search improves on previous HMM-based searches of LIGO data by using an improved frequency domain matched filter, the J-statistic, and by analyzing data from Advanced LIGO's second observing run. In the frequency range searched, from 60 to 650 Hz, we find no evidence of gravitational radiation. At 194.6 Hz, the most sensitive search frequency, we report an upper limit on gravitational wave strain (at 95% confidence) of h095%=3.47×10-25 when marginalizing over source inclination angle. This is the most sensitive search for Scorpius X-1, to date, that is specifically designed to be robust in the presence of spin wandering. © 2019 American Physical Society

Erratum: "A Gravitational-wave Measurement of the Hubble Constant Following the Second Observing Run of Advanced LIGO and Virgo" (2021, ApJ, 909, 218)

[no abstract available

Searches for lepton-flavour-violating decays of the Higgs boson in s=13\sqrt{s}=13 TeV pp\mathit{pp} collisions with the ATLAS detector

This Letter presents direct searches for lepton flavour violation in Higgs boson decays, H → eτ and H → μτ , performed with the ATLAS detector at the LHC. The searches are based on a data sample of proton–proton collisions at a centre-of-mass energy √s = 13 TeV, corresponding to an integrated luminosity of 36.1 fb−1. No significant excess is observed above the expected background from Standard Model processes. The observed (median expected) 95% confidence-level upper limits on the leptonflavour-violating branching ratios are 0.47% (0.34+0.13−0.10%) and 0.28% (0.37+0.14−0.10%) for H → eτ and H → μτ , respectively.publishedVersio