The Ethical Challenge of Digital Bioarchaeological Data

Introduction to the Special Issue: Digital Bioarchaeology: New Dimensions, New Methods, New Ethics

Which Bone to Pick: Creation, Curation, and Dissemination of Online 3D Digital Bioarchaeological Data

A fluorescence of shape-capture technologies at many different scales, including synchrotron, CT, micro/nano-CT, laser scanning, and photogrammetry, has led to a proliferation of digital data in bioarchaeology. The question remains how these new 3D datasets, alongside traditional bioarchaeological data, can be disseminated, and what ethical concerns are raised by trying to bring a sensitive topic into the ‘Open Access’ era. A survey of current resources and policies suggest the need for establishing best-practice standards. This paper outlines a sample of current resources, alongside modes of access and dissemination strategies to develop a picture of online Digital Bioarchaeological Data (DBD) use

Evidence of different climatic adaptation strategies in humans and non-human primates

To understand human evolution it is critical to clarify which adaptations enabled our colonisation of novel ecological niches. For any species climate is a fundamental source of environmental stress during range expansion. Mammalian climatic adaptations include changes in size and shape reflected in skeletal dimensions and humans fit general primate ecogeographic patterns. It remains unclear however, whether there are also comparable amounts of adaptation in humans, which has implications for understanding the relative importance of biological/behavioural mechanisms in human evolution. We compare cranial variation between prehistoric human populations from throughout Japan and ecologically comparable groups of macaques. We compare amounts of intraspecific variation and covariation between cranial shape and ecological variables. Given equal rates and sufficient time for adaptation for both groups, human conservation of non-human primate adaptation should result in comparable variation and patterns of covariation in both species. In fact, we find similar amounts of intraspecific variation in both species, but no covariation between shape and climate in humans, contrasting with strong covariation in macaques. The lack of covariation in humans may suggest a disconnect in climatic adaptation strategies from other primates. We suggest this is due to the importance of human behavioural adaptations, which act as a buffer from climatic stress and were likely key to our evolutionary success

Transcript of WAC 8 Digital Bioarchaeological Ethics Panel Discussion, 29 August 2016 and Resolution on Ethical Use of Digital Bioarchaeological Data

This is the transcript of the panel discussion held at the close of the WAC 8 Digital Bioarchaeological Ethics Panel. Given the rapid pace of emerging technology that allows for the creation of digital bioarchaeological data, including representations of 3d shapes, the panel was convened to discuss common issues and dilemmas that arise from the introduction of new ways of creating, visualizing, storing, and disseminating data derived from human remains. The discussants represent expertise in bioarchaeology, forensic anthropology/archaeology, and palaeoanthropology and have experience in different sectors covering museums, collections management, medical, legal, bioarchaeological and anthropological research. The discussion covers the advantages of creating ‘virtual’ bodies using digital bioarchaeological data, and also the many potential hurdles in creating, using, and sharing this data. Finally, the text of the resolution submitted by the panel to the World Archaeological Congress and adopted at the 8th Annual Meeting is reproduced in full

Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery

<p>Abstract</p> <p>Background</p> <p>In the National Emphysema Treatment Trial (NETT), marked variability in response to lung volume reduction surgery (LVRS) was observed. We sought to identify genetic differences which may explain some of this variability.</p> <p>Methods</p> <p>In 203 subjects from the NETT Genetics Ancillary Study, four outcome measures were used to define response to LVRS at six months: modified BODE index, post-bronchodilator FEV₁, maximum work achieved on a cardiopulmonary exercise test, and University of California, San Diego shortness of breath questionnaire. Sixty-four single nucleotide polymorphisms (SNPs) were genotyped in five genes previously shown to be associated with chronic obstructive pulmonary disease susceptibility, exercise capacity, or emphysema distribution.</p> <p>Results</p> <p>A SNP upstream from glutathione S-transferase pi (<it>GSTP1</it>; p = 0.003) and a coding SNP in microsomal epoxide hydrolase (<it>EPHX1</it>; p = 0.02) were each associated with change in BODE score. These effects appeared to be strongest in patients in the non-upper lobe predominant, low exercise subgroup. A promoter SNP in <it>EPHX1 </it>was associated with change in BODE score (p = 0.008), with the strongest effects in patients with upper lobe predominant emphysema and low exercise capacity. One additional SNP in <it>GSTP1 </it>and three additional SNPs in <it>EPHX1 </it>were associated (p < 0.05) with additional LVRS outcomes. None of these SNP effects were seen in 166 patients randomized to medical therapy.</p> <p>Conclusion</p> <p>Genetic variants in <it>GSTP1 </it>and <it>EPHX1</it>, two genes encoding xenobiotic metabolizing enzymes, were predictive of response to LVRS. These polymorphisms may identify patients most likely to benefit from LVRS.</p

The genetics of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease caused by the interaction of genetic susceptibility and environmental influences. There is increasing evidence that genes link to disease pathogenesis and heterogeneity by causing variation in protease anti-protease systems, defence against oxidative stress and inflammation. The main methods of genomic research for complex disease traits are described, together with the genes implicated in COPD thus far, their roles in disease causation and the future for this area of investigation

The complete genome sequence of Corynebacterium pseudotuberculosis FRC41 isolated from a 12-year-old girl with necrotizing lymphadenitis reveals insights into gene-regulatory networks contributing to virulence

Trost E, Ott L, Schneider J, et al. The complete genome sequence of Corynebacterium pseudotuberculosis FRC41 isolated from a 12-year-old girl with necrotizing lymphadenitis reveals insights into gene-regulatory networks contributing to virulence. BMC Genomics. 2010;11(1): 728

Mediterranean households, British colonial statistics and Greek insular landscapes: insights from nineteenth-century Antikythera

This article addresses a 250-year episode of human colonisation, community growth and subsequent decline on the small Greek island of Antikythera (ad 1770 to present), focusing on rich documentary sources from four decades of British rule in the early nineteenth century. In particular, a series of nominal censuses and accompanying agricultural statistics can be combined with intensive landscape archaeological survey evidence to explore evidence for changing nineteenth-century households, household economies, and how these are manifest across an entire physical landscape. We also contextualise this well-recorded, most recent historical episode within the island's deeper population history stretching back at least seven millennia