The effect of non-linear inertia on dynamic response of asymmetric multi-story buildings

The goal of this paper is to inspect the influence of non-linear inertia on dynamic response of multi-story asymmetric buildings. In this study unlike conventional linear approach, the non-linear inertial terms are considered in the equations of motion. For considering non-linear inertia, the motion equations are derived in local rotary coordinates system. Also, the stiffness and damping parameters are defined in the rotary coordinates system. In the novel approach which is proposed in this paper, the motion equations are different with conventional linear approach. Numerical examples are presented to compare the response of the proposed model and conventional linear model. The modeled building response is derived under harmonic excitation. The results show that if non-linear inertia is considered, the dynamic response of asymmetric multi-story buildings may become different with conventional linear approach

The effect of non-linear inertia on dynamic response of asymmetric multi-story buildings

The goal of this paper is to inspect the influence of non-linear inertia on dynamic response of multi-story asymmetric buildings. In this study unlike conventional linear approach, the non-linear inertial terms are considered in the equations of motion. For considering non-linear inertia, the motion equations are derived in local rotary coordinates system. Also, the stiffness and damping parameters are defined in the rotary coordinates system. In the novel approach which is proposed in this paper, the motion equations are different with conventional linear approach. Numerical examples are presented to compare the response of the proposed model and conventional linear model. The modeled building response is derived under harmonic excitation. The results show that if non-linear inertia is considered, the dynamic response of asymmetric multi-story buildings may become different with conventional linear approach

Exploring new NSM reinforcements for the flexural strengthening of RC beams: experimental and numerical research

Carbon-fiber-reinforced-polymer (CFRP) composite materials applied according to near-surface-mounted (NSM) technique constitute an effective technique for the flexural and shear strengthening of reinforced-concrete (RC) structures. However, the NSM CFRP reinforcement ratio is limited by the thickness of concrete cover of the longitudinal tensile steel bars, and the minimum distance between consecutive CFRPs, below which premature fracture of surrounding concrete occurs due to group effect. Hence, the current study aims to experimentally and numerically evaluate the strengthening potentialities of a novel NSM system (with high CFRP ratio capability) for the flexural strengthening of RC beams. This new system combines externally-bonded-reinforcement (EBR) and NSM techniques in the same application using T-shaped CFRP profiles. The obtained experimental results of the RC beams strengthened with CFRP profiles are presented and discussed with the aim of evaluating the influence of CFRP profile reinforcement ratio on the strengthening efficiency of this technique. A developed 3D finite-element (FE) approach is used to simulate the experimental tests. After demonstrating its good predictive performance, a series of parametric studies is performed to assess the influence of the main material properties, and ratio of bond area to cross sectional area of the CFRP profiles on the efficiency of the proposed system.The first and the last authors acknowledge the support provided by Cutinov QREN project n. 38780 supported by ADI, co-financed by the European Regional Development Fund (FEDER) through the Operational Program COMPETE. The second and the third authors would like to acknowledge the support provided by Mostostal Warszawa S.A. for providing the CFRP T-shaped profiles and for co-funding the research progra

Investigation of the Impacts of Social Capital on Organizational Entrepreneurship in Tehran Municipality

Entrepreneurship is the symbol of endeavor and success in business, and entrepreneurs play a crucial role in economic and social development of communities. Since Organizational Entrepreneurship (OE) contribute to earning stable finance required for administration of urban affairs, it is very important in the case of municipalities. For this reason, this study aims to investigate the role of social capital (SC) in the development of entrepreneurship in Tehran municipality. Research method was descriptive and non-experimental, and required data were collected through 204 questionnaires distributed among managers and experts of the organization. Stratified sampling was used, in which 37 managers and 167 experts participated. Number of male participants was 147, and number of female participants was 57. The mean age of participants was 41 years, and its standard deviation was 0.765. In order to test the research hypothesis, structural equation modeling (SEM) was used. The results of the study showed that social capital and its three dimensions (Cognitive, Relational and Structural dimensions) had positive significant effect on organizational entrepreneurship

The Effects of Natural Clinoptilolite and Nano-Sized Clinoptilolite Supplementation on Lipid Profile, Food Intakes and Body Weight in Rats with Streptozotocin-Induced Diabetes

Purpose: To determine the effect of natural clinoptilolite (CLN) and nano-sized clinoptilolite (NCLN) on lipid profile, food intakes (FI) and weight changes in streptozotocin (STZ) induced diabetic rats. Methods: In this experimental study, 36 rats were randomly divided into two groups: diabetic group which was injected STZ (60 mg/kg BW), and a non-diabetic group. Three days after diabetes induction, each of these groups was randomly divided into 3 subgroups of 6 animals ((1) control, (2) 1%/food CLN, (3) 1%/food NCLN). The animals were supplemented for 28 days, starting three days after STZ administration. At the end of the study, blood was drawn for biochemical assays. The weights and FIs of the rats were measured at the beginning and end of each week. Results: Our findings revealed that there was no significant change in lipid profile, 28 days after administration of STZ in diabetic rats. Low density lipoprotein (LDL) was increased slightly in diabetic rats treated with NCLN without any significant changes in other lipid profile parameters in the other groups. Weight was reduced significantly in diabetic rats. Administration of CLN and NCLN prevented further weight loss in diabetic rats. All groups treated with STZ had higher food intake during the study. Conclusion: Lack of beneficial changes in lipid profile may be attributed to short study duration, insufficient for appearance of lipid abnormalities. Given the partial improvement in weight status and lack of undesirable effects of clinoptilolite supplementation, further research is recommended in subjects with typ1 diabetes mellitus

Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Funding: F Carvalho and E Fernandes acknowledge support from Fundação para a Ciência e a Tecnologia, I.P. (FCT), in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy i4HB; FCT/MCTES through the project UIDB/50006/2020. J Conde acknowledges the European Research Council Starting Grant (ERC-StG-2019-848325). V M Costa acknowledges the grant SFRH/BHD/110001/2015, received by Portuguese national funds through Fundação para a Ciência e Tecnologia (FCT), IP, under the Norma Transitória DL57/2016/CP1334/CT0006.proofepub_ahead_of_prin

The global burden of adolescent and young adult cancer in 2019 : a systematic analysis for the Global Burden of Disease Study 2019

Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. Findings There were 1.19 million (95% UI 1.11-1.28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59.6 [54.5-65.7] per 100 000 person-years) and high-middle SDI countries (53.2 [48.8-57.9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14.2 [12.9-15.6] per 100 000 person-years) and middle SDI (13.6 [12.6-14.8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23.5 million (21.9-25.2) DALYs to the global burden of disease, of which 2.7% (1.9-3.6) came from YLDs and 97.3% (96.4-98.1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe