The verification and national implementation of international instruments for nuclear non-proliferation and security

Os esforços conjuntos internacionais para lidar e mitigar o risco de má utilização nuclear resultaram numa expansão do número de instrumentos que são apelidados de regime nuclear global. Este artigo examina o papel assumido por alguns dos principais instrumentos internacionais na área nuclear, em particular o Tratado de Não-Proliferação Nuclear e a Resolução nº1540 do Conselho de Segurança das Nações Unidas na gestão da proliferação e segurança nuclear. Concretamente, introduz e explica os conceitos de verificação e implementação nacional como importantes componentes dos regimes de controlo nuclear e aborda o papel que estes têm para garantir que os Estados cumprem as suas obrigações internacionais. Examinam-se ainda alguns dos mecanismos de verificação e medidas de implementação nacional desenvolvidas por estes instrumentos e a forma como operam.info:eu-repo/semantics/publishedVersio

The Role of Vigorous and High Intensity Interval Training Physical Activity Counseling in Prenatal Care

Background: Physical activity is becoming a more common component of preventative medicine and patient counseling; however, the prevalence of physical activity counseling and specific social determinants of health have prevented women, namely prenatal patients, from receiving this counseling from their providers1. Physical activity, including high intensity interval training (HIIT), has been shown to be feasible for implementation in patient counseling3 and shown to be safe for pregnant women, even into the third trimester2. We hypothesize that the current percentage of patients, including prenatal patients, being counseled on physical activity is lacking. In addition, we hypothesize the current guidelines and advancements in research on physical activity, including during pregnancy, are not being shared adequately with patients during clinic and hospital visits. This pertains especially to education on the feasibility of execution, safety and benefits of high intensity interval training (HIIT) and vigorous exercise. Methods: In this descriptive study, we will distribute our patient survey at local ob/gyn clinics to assess the current level of patient perceptions of physical activity, physical activity counseling and current level of activity. We will then provide educational materials to the clinics and patients on physical activity, namely HIIT, and reassess patient perceptions and activity levels via survey. Results: Preliminary research shows that the majority of prenatal patients have not been given counseling or education materials on physical activity but are motivated to increase their physical activity and work with providers to do so. Conclusion: Will be presented at the Wayne State Medical Student Research Symposium in February 2022

Examining the Influence of Adoptability, Alignment, and Agility Approaches on the Sustainable Performance of Aviation Industry: An Empirical Investigation of Supply Chain Perspective

In a continuously changing environment, the aviation sector faces the challenge of balancing adaptability to technological changes, alignment with environmental and social considerations, and agility in responding to unforeseen challenges. Keeping in view these challenges this study has explored the impact of the adaptability, alignment, and agility approaches on the sustainable performance of the aviation industry operating in Pakistan. Applying the empirical and quantitative methods the data has been collected from the professionals of the aviation industry supply chain and operations field and assessed the influence of Adoptability, Alignment, and Agility on sustainable performance indicators, including environmental stewardship, social responsibility, and economic viability. The SmartPls, structural equation model (SEM) has been applied to scrutinize the path relationships of variables. Overall the findings reveal a nuanced landscape, and it shows that traditional Adoptability may not directly impact Economic Performance (ECP), but it significantly influences Environmental (ENP), Operational (OPP), and Social Performance (SOP). Therefore, the Agility and Alignment strategies exhibit a consistent positive impact across all performance dimensions and emphasize their pivotal role in fostering holistic sustainability within the aviation sector. This study recommends that the sustainable aviation industry advocates for tailored strategies to address economic sustainability concerns, emphasizing the need for organizations to readjust their approaches. The study also highlights the vibrant nature of the aviation industry, urging continuous monitoring, evaluation, and adaptation of strategies to align with evolving sustainability paradigms. The purpose of this study and its results is to provide valuable insights for industry practitioners, policymakers, and researchers, guiding the development of strategic frameworks to enhance the long-term sustainability of the aviation industry logistics and supply chain management

Early Bubble Continuous Positive Airway Pressure Therapy for Premature Neonates with Respiratory Distress Syndrome

Objective: To determine the outcome of preterm neonates with the early introduction of bubble continuous positive airway pressure (CPAP). Methodology: This observational study was conducted in NICU of Shifa International Hospital, Islamabad from March 2017 to August 2017. Ninety preterm infants were enrolled with a gestational age of 28 to 37 weeks and with the clinical features of Respiratory Distress Syndrome (RDS). Infant variables that were recorded were birth weight, gestational age, and severity of RDS and Fio2 requirement. Bubble CPAP was started at 5cm of water and FiO2 adjusted to maintain SpO2 of 87 to 95%. The SPSS 26 version was used to analyze data. The Chi square test was used, with a P value of <0.05 considered significant. Results: The study included 90 neonates who were clinically diagnosed with RDS. To treat RDS, CPAP was started at the mean age of 5.27 hours of life with a standard deviation of 2.66 hours. 11 out of 90 (11.22%) babies had chest X-ray findings in favor of severe RDS; while X-rays of the remaining 79 (88.78%) showed mild to moderate RDS. Conclusion: CPAP is of valuable importance in low resource countries with a lack of ventilators and provides an adequate and conservative treatment method of mild to moderate RDS for preterm neonates. However, in cases of severe RDS, intubation and mechanical ventilation are often necessary

Oral Soft Tissue Metastasis from Breast Cancer as the Only Primary Source:Systematic Review

Background  Breast cancer is one of the most lethal neoplasms causing death. Oral cavity is the rare site of distant metastasis from breast cancer. Very little research has been conducted to date to analyze breast cancer as the sole primary source of metastasis to the oral soft tissues. The goal of this study was to examine the published cases of oral soft tissue metastasis from breast cancer as the only primary source to date. Methods  An electronic search of the published literature was performed without publication year limitation in PubMed/Medline, Scopus, Google Scholar, Web of Science, Science Direct, Embase, and Research Gate databases, using mesh keywords like ("Breast cancer", OR "Breast carcinoma") AND ("Metastasis" OR "Metastases"), And ("Oral soft tissues" OR "Tongue" OR "Palate" OR "Tonsil" OR "Buccal mucosa" OR "Floor of mouth" OR "Vestibule" OR "Salivary glands"). We also searched all related journals manually. The reference list of all articles was also checked. Results  Our research revealed 88 relevant papers (September 1967-September 2023) with 96 patients in total. The most predominant oral soft tissues involved were salivary glands followed by the gingiva, tonsils, tongue, and buccal mucosa. A total of 23% of patients died with an average survival time of 1 to 15 months. Conclusions  Oral soft tissue metastasis from breast cancer is a rare event and has a bad prognosis. More cases need to be published to raise awareness of these lesions.</p

Oral Soft Tissue Metastasis from Breast Cancer as the Only Primary Source:Systematic Review

Background  Breast cancer is one of the most lethal neoplasms causing death. Oral cavity is the rare site of distant metastasis from breast cancer. Very little research has been conducted to date to analyze breast cancer as the sole primary source of metastasis to the oral soft tissues. The goal of this study was to examine the published cases of oral soft tissue metastasis from breast cancer as the only primary source to date. Methods  An electronic search of the published literature was performed without publication year limitation in PubMed/Medline, Scopus, Google Scholar, Web of Science, Science Direct, Embase, and Research Gate databases, using mesh keywords like ("Breast cancer", OR "Breast carcinoma") AND ("Metastasis" OR "Metastases"), And ("Oral soft tissues" OR "Tongue" OR "Palate" OR "Tonsil" OR "Buccal mucosa" OR "Floor of mouth" OR "Vestibule" OR "Salivary glands"). We also searched all related journals manually. The reference list of all articles was also checked. Results  Our research revealed 88 relevant papers (September 1967-September 2023) with 96 patients in total. The most predominant oral soft tissues involved were salivary glands followed by the gingiva, tonsils, tongue, and buccal mucosa. A total of 23% of patients died with an average survival time of 1 to 15 months. Conclusions  Oral soft tissue metastasis from breast cancer is a rare event and has a bad prognosis. More cases need to be published to raise awareness of these lesions.</p

The prevalence of elongated styloid process in the population of Barcelona: a cross‑sectional study & review of literature

Background: Styloid process (SP) is a cylindrical bony projection that originates from the inferior part of the petrous temporal bone just anteriorly to the stylomastoid foramen. Several nerves, muscles, and ligaments are related closely to the (SP). It is considered elongated when the measurement exceeds 30 mm. The overall prevalence of the styloid process is between 3.3% to 84.4%. The elongation of the styloid process (ESP) is associated with the manifestation of Eagle's Syndrome (ES) which is characterized by various types of pain in the head and neck region such as headache, tinnitus, otalgia, and trigeminal neuralgia. Eagle's syndrome occurs in 4-10.3% of individuals with an elongated styloid process (ESP). The objective of the study is to determine the prevalence of (ESP) in the patients who were treated in the Dental Hospital University of Barcelona (HOUB), to review the literature to spot the light on the different demographic data worldwide. Methods: The archived panoramic image in the University of Barcelona dental Hospital were consecutively retrieved to investigate the prevalence of (ESP). Of all digital panoramic radiographs (OPG), 400 met the inclusion criteria and were furtherly analyzed. The results are correlated with the participant's gender, age, and occurrence. Age is subcategorized into three groups. A chi-square test is used to measure the significant differences and the P-value is set at < 0.05 for the level of significance. Results: Among the included 400, we found 291 demonstrating (ESP). The prevalence of (ESP) which exceeds 30 mm is 72.75%. It is found that the most common morphological type is type 1 which is regarded as the uninterrupted (ESP) regardless of gender and age group. Concerning the calcification pattern, the most prevalent is the partial calcified (ESP) despite genders and age groups. Conclusion: (OPG) is a sufficient tool for the screening of the elongated styloid process. Regarding the prevalence, our results are considered higher than previously reported prevalence in different populations using (OPG) radiography tool. A study on a wider spectrum of the Spanish population is recommended to further investigate the correlation between the elongated styloid process and the occurrence of Eagle's syndrome. Keywords Styloid process, Elongated styloid process, Eagle's syndrome, Panoramic radiograph

Mandibular Third Molar Impaction and Bone Change Distal to the Second Molar: A Panoramic Radiographic Study

Background: The mandibular third molar is the most frequently impacted tooth. An impacted mandibular third molar (IMTM) can have negative consequences on the adjacent mandibular second molar (MSM), such as bone loss. An IMTM can be identified using orthopantomography (OPG). Our objective is to compare changes in bone level distal to the mandibular second molar (MSM) in patients with an extracted IMTM versus non-extracted IMTM using OPG. Methods: In this retrospective case-control study, 160 orthopantomograms (OPGs) of 80 patients who attended Dental Hospital of the University of Barcelona (HOUB) were randomly selected. Participants were stratified into a study group and control group. Results: Males and females experienced bone gain in the study group and bone loss in the control group. However, the difference in bone-level change was not statistically significant regarding gender in the study group. Within the study group, the age group of 29-39 years demonstrated significant (p-value = 0.042) bone gain after extraction compared to other age groups. However, the control group demonstrated bone loss in all age groups in which the difference is not statistically significant (p-value 0.794). Conclusions: Bone improvements distal to the MSM were observed after the extraction of an IMTM compared to when an IMTM was not extracted

CD71+ erythroid cells from neonates born to women with preterm labor regulate cytokine and cellular responses

Neonatal CD71+ erythroid cells are thought to have immunosuppressive functions. Recently, we demonstrated that CD71+ erythroid cells from neonates born to women who underwent spontaneous preterm labor (PTL) are reduced to levels similar to those of term neonates; yet, their functional properties are unknown. Herein, we investigated the functionality of CD71+ erythroid cells from neonates born to women who underwent spontaneous preterm or term labor. CD71+ erythroid cells from neonates born to women who underwent PTL displayed a similar mRNA profile to that of those from term neonates. The direct contact between preterm or term neonatal CD71+ erythroid cells and maternal mononuclear immune cells, but not soluble products from these cells, induced the release of proinflammatory cytokines and a reduction in the release of TGFâ β. Moreover, PTLâ derived neonatal CD71+ erythroid cells (1) modestly altered CD8+ T cell activation; (2) inhibited conventional CD4+ and CD8+ Tâ cell expansion; (3) suppressed the expansion of CD8+ regulatory T cells; (4) regulated cytokine responses mounted by myeloid cells in the presence of a microbial product; and (5) indirectly modulated Tâ cell cytokine responses. In conclusion, neonatal CD71+ erythroid cells regulate neonatal Tâ cell and myeloid responses and their direct contact with maternal mononuclear cells induces a proinflammatory response. These findings provide insight into the biology of neonatal CD71+ erythroid cells during the physiologic and pathologic processes of labor.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142950/1/jlb10051_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142950/2/jlb10051-sup-0003-TableS2.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142950/3/jlb10051-sup-0002-TableS1.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142950/4/jlb10051-sup-0001-Figures.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142950/5/jlb10051.pd