Capacitance-Based Sensor with Layered Carbon-Fiber Reinforced Polymer and Titania-Filled Epoxy

Advances in intelligent infrastructure can be achieved through the use of novel materials for increased system-level efficiency and multifunctionality. Carbon Fiber-Reinforced Polymer (CFRP) has been widely used in strengthening, rehabilitating, and retrofitting of existing structures because of its speed of deployment, low maintenance requirement, and high strength-to-weight ratio. In this work, the authors propose a novel method to augment CFRP with self-sensing capabilities. The sensor consists of two CFRP layers separated by a titania-filled epoxy dielectric layer, therefore forming a parallel plate capacitor. Sensing capability can be achieved through variations in the sensor’s capacitance provoked by strain, therefore providing an additional function that could be leveraged for structural health monitoring and structural health management purposes. Comprehensive testing, including (1) sensing properties on sensors with and without titania-doped epoxy and (2) electromechanical test on tension specimens subjected to both static and dynamic loading, was conducted. The test results show that doping the titania filler within the epoxy matrix can improve the sensor’s sensitivity. The gauge factor is 0.92 under static load and decreases with the increasing frequency up to 1 Hz. Therefore, it can be concluded that CFRP can be used as a self-sensing sensor without affecting its mechanical properties

Patients’ experience of recurrent/metastatic head and neck squamous cell carcinoma and their perspective on the EORTC QLQC30 and QLQ-H&N35 questionnaires: a qualitative study

Abstract Background Head and neck squamous cell carcinoma (HNSCC) and its associated treatments may affect all aspects of patients’ health-related quality of life (HRQoL). Although the EORTC QLQ-H&N35 is regularly administered to patients with HNSCC, there is a paucity of studies re-assessing the conceptual relevance of this patient-reported outcome (PRO) measure from a patient perspective. Furthermore, the content validity of the EORTC QLQ-C30 has not been widely documented in patients with recurrent and/or metastatic HNSCC. The objectives of this study were to understand patients’ experiences of recurrent/metastatic HNSCC and its treatments, and to evaluate the conceptual relevance and acceptability of the EORTC QLQ-C30 and QLQ-H&N35 from a patient perspective for use in clinical trials. Methods A literature review and clinician interviews were conducted to inform in-depth semi-structured telephone interviews with US patients who had received treatment for recurrent and/or metastatic HNSCC in the preceding 12 months. Interview transcripts were analysed thematically using ATLAS.ti v7; patient quotes were coded to identify concepts and themes to develop a conceptual model of HNSCC experience. Results Fourteen patients were interviewed (71% male, aged 35–84 years). Patients reported few symptoms pre-diagnosis including neck lump/swelling (n = 7/14, 50%) and/or difficulty swallowing (n = 3/14, 21%). Treatments generally comprised surgery and chemotherapy and/or radiotherapy. A number of side effects from all treatments were reported. Numbness, difficulty speaking and pain were the most reported side effects of surgery (n = 4/8, 50%); weight loss and fatigue were the most reported side effects of chemotherapy and/or radiotherapy (n = 8/13, 61%). All side effects negatively impacted patients’ HRQoL. Patients generally found the QLQ-C30 and QLQ H&N35 content to be understandable and conceptually relevant; excessive mucous production and neuropathic symptoms were among the suggested additions. Conclusions HNSCC and its diverse symptoms and treatments have a negative impact on many aspects of patients’ lives. A number of reported symptoms including difficulty speaking and swallowing, localised pain and fatigue may be important for treatment benefit evaluation in clinical trials from a patient perspective. The QLQ-C30 and QLQ-H&N35 are generally relevant and suitable for use in clinical trials. However, some items could be amended/added to ensure conceptual comprehensiveness of these measures

Impacts of the COVID-19 pandemic on access to HIV and reproductive health care among women living with HIV (WLHIV) in Western Kenya: A mixed methods analysis

Results: We analyzed 1,402 surveys and 15 in-depth interviews. Many (32%) CL participants reported greater difficulty refilling medications and a minority (14%) reported greater difficulty accessing HIV care during the pandemic. Most (99%) Opt4Mamas participants reported no difficulty refilling medications or accessing HIV/pregnancy care. Among the CL participants, older women were less likely (aOR = 0.95, 95% CI: 0.92–0.98) and women with more children were more likely (aOR = 1.13, 95% CI: 1.00–1.28) to report difficulty refilling medications. Only 2% of CL participants reported greater difficulty managing FP and most (95%) reported no change in likelihood of using FP or desire to get pregnant. Qualitative analysis revealed three major themes: (1) adverse organizational/economic implications of the pandemic, (2) increased importance of pregnancy prevention during the pandemic, and (3) fear of contracting COVID-19

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication

Reconciliation and peace-building in post-genocide societies : A structured focused comparison in Rwanda and Cambodia

This study aims to explore the effectiveness of reconciliation in post-genocide peace building. Peace activists believe that reconciliation is necessary after a post-war conflict to ensure regeneration and lasting peace. Past research has shown that there are successful and failed cases when implementing reconciliation mechanism, however there is a lack of understanding why some models of reconciliation have succeeded, while others have failed, an aspect that is not fully explored. Therefore this study aims to explore how reconciliation is approached and implemented across different contexts, Rwanda and Cambodia, so as to understand why it brings success or failure in these contexts. The results are analyzed with the help of John Paul Lederach’s four components for reconciliation, justice, truth, mercy and peace, and compared the generated results with the previous research. The main results show that reconciliation has failed in Cambodia and Rwanda. In accordance with John Paul Lederach’s theory, there is a hindrance towards reconciliation in Cambodia because of lack of Justice and Truth as the main concepts and is identified as a structural dimension. In the case of Rwanda, there is a lack of Mercy and Truth and is identified as a relational dimension

Behind the corner lurks the danger : A quantitative study of social trust and the connection between the fear of being subjected to crime among students on the campus area in Växjö

This study aims to explain the phenomenon of fear of crime among students at the Linnaeus University campus area in Växjö. More precisely, the study deals with social trust between people, and the connection between trust and the fear of being subjected to crime. In recurrent national surveys, the results have shown that about one-third of the population in Sweden is largely concerned about being subjected to crime. Our hypothesis is that low interpersonal trust and low trust in social institutions creates anxiety and fear of it’s and society's well-being, which increases the fear of being subjected to crime. In multiple linear regression analyzes, we investigate whether there is any connection between trust and fear of being subjected to crime. The results are analyzed with the help of Anthony Giddens and Ulrich Beck and compared with results generated in previous research. The main result shows that connections exist, but it is not so strong and further studies are required in the area. The respondents feel confident in people in general, and rely on the institutions of society, but at the same time are concerned about everyday crime, going out alone late at night in the campus area and over sexual harassment aimed at women

Detection of Conferences Attendies from Interactions Can We Know if Our Colleague Attend a Given Conference?

International audienceIn this paper, we propose to apply pragma-linguistics and Natural Language Processing (NLP) techniques, in order to isolate researchers interests and their intention to attend a given conference, journey, colloquium, seminar, ... This type of work can be applied in a laboratory or a research group. That help, for instance, to organize meetings in a conference, to ask proceedings and papers

A stand-alone multi-scent olfactory display with a sliding scent switching Mechanism

Here we report on the design, construction, and testing of a multi-scent olfactory display that is intended as promotional tool for smell-related events. Our system used off-the-shelf spray bottles for scent generation, with a control and actuation system constructed around it. The spray bottle is actuated using a solenoid valve, combined with a fan to help deliver the aroma to the user. Scent switching is achieved by sliding the spray bottles on a fixed rail. A step motor is then used to select scents accurately. The final unit can release up to four different scents and testing results show that the unit can be controlled for scent delivery at a range of firing rates