Some recent radio talks.

Light land development in the South - By A. S. WILD, Assistant Superintendent of Wheat Farming, Department of Agriculture. It is only since World War II ended that successful large scale development of light land near the south coast of this State has been undertaken, although the many millions of acres of treeless plain country throughout the agricultural areas have, for many years, presented a challenge to the pioneering ability of Western Australians. The use of hormones in viticulture - By L. T. JONES, Senior Plant Research Officer The discovery and proper use of plant hormones, or as they are more accurately termed, growth-regulating: substances, probably represents the greatest contribution which science has made to agriculture in the past few decades. It was the discovery by Kogl in 1934 that indole acetic acid was an active growth substance which led rapidly to the preparation and testing of large numbers of compounds of similar chemical structure and among these were found many substances which were very potent and also comparatively cheap to produce. Recent trends in viticulture in Western Australia - By W. R. JAMIESON, Viticulturist, Department of Agriculture, Perth Today I want to talk very briefly about some of the more recent trends in viticulture in this State. The commercial production of grapevines is centred mainly around the Swan Valley and as most of the suitable vineyard land in this area has been planted, growers are exploring avenues to increase the returns per acre. Methods of irrigation - By G. GAUNTLETT, Assistant Officer-in-Charge, Irrigation The success of an irrigation scheme depends on several factors. Important among these is the choice and design of the method to be adopted. There are two methods of irrigation, viz., surface and spray irrigation. Canker disease of Red-flowered gum - By W. P. CASS SMITH, B.Sc. (Agric), Government Plant Pathologist Of the many beautiful native plants in Western Australia, few are esteemed more than the red-flowered gum known botanically as Eucalyptus flcifolia. This shapely tree commences blossoming about Christmas time—and provides a magnificent display for several weeks—the blossom shades varying from dark red to pink. Why many beans grow crooked - By M. HARDIE, Vegetable Instructor Sometimes in the process of growing a crop, bean growers find a number of pods which, instead of being long and straight and suitable for marketing, are crooked or bent and quite unsuitable for sale unless beans are in very short supply. It is not unusual for a small number of pods to be affected in this way, generally at the tail-end of the crop, but occasionally the percentage may be high. When this happens the grower is often at a loss to account for his failure to grow a marketable crop. To the best of his ability he has followed methods which normally return a crop of first-grade pods and yet for some reason, his crop is an unpayable one and he is anxious to ascertain the cause. Salt land programme for Autumn - By T. C. STONEMAN, Adviser, Soil Conservation Service Now that summer is over and winter approaches, the time has come to decide what you\u27ll do with that salt problem on your farm. What you SHOULD do, will depend on how severely the area is affected. To make quite clear how the recommendations made by the Department of Agriculture can be applied I will deal with each degree of severity in turn. Orchard cover crops - By J. CRIPPS, Horticultural Adviser The sowing of a cover crop is one of those routine operations which the orchardist often undertakes without much thought, but it is an operation worthy of consideration. Lupin seed - By B. J. QUINLIVAN, B.Sc. (Agric), Botanist, Weeds and Seeds Branch The three types of lupins which we grow in this State are the New Zealand, the W.A. blue, and the yellow lupin. The first two types are very common, the New Zealand lupin being grown mainly in the South-West, while the W.A. lupin is grown over extensive areas of the central and northern wheatbelt, particularly on the sandier types of soil. Cereal rye will grow on wind-eroded areas - By G. H. BURVILL, Chief Plant Research Officer. Travelling around the wheatbelt, one often sees areas of sandy soil quite bare, A due to wind erosion. Surface soil blown from these patches has built up against fences, or as mounds in the nearby scrub. Many of the eroded places are quite small— perhaps less than an acre or only a few acres. But some are large, with one to three hundred acres of bare yellow sand. As much as two feet of soil has been blown from big areas. Autumn-winter feeding for the fat lamb flock - By N. DAVENPORT, Senior Adviser, Meat Production The autumn-winter period is the most important part of the year for the fat lamb crop from a feed point of view. It is important not only from the aspect of the wellbeing of the sheep, but also of the pasture. Pasture plants are living things, too, and they also require consideration and care for their development. When a new season pasture is kept hard grazed in those critical first few weeks of growth it cannot carry as many sheep over the season as one which is lightly stocked during that time. Plant diseases in the home garden - By W. P. CASS-SMITH, B.Sc. (Agric), Government Plant Pathologist Recently many home-gardeners have complained that plantings of vegetables or ornamentals are making unthrifty growth, in spite of liberal waterings and fertilisation. These symptoms are commonly caused by root-knot eelworm, a pest which has unfortunately become very widespread in the sandy soils adjacent to Perth, and in many other parts of this State. This eelworm parasite attacks the roots of many kinds of plants causing them to rot and to develop bead-like swellings or galls. As a result, the intake of plant food and water is restricted and stunting of the above-ground parts occurs. Principles of commercial beekeeping - By R. S. COLEMAN, R.D.A., Government Apiculturist We have many queries from small beekeepers, and from people who have never opened a hive, on how to break into full-time beekeeping. So it was thought that you would like to know just what are the principles of successful bee farming. Grasshoppers and locusts - By C. F. H. JENKINS, M.A., Government Entomologist Grasshoppers and locusts are among the most ancient enemies of mankind for they figured prominently in Biblical times, and periodically throughout the ages have devastated crops in all parts of the world. Acetonaemia in dairy cattle - By P. M. A. HARWOOD, M.R.C.V.S., Veterinary Officer Acetonaemia, more correctly known as ketosis is a metabolic disease. Unlike infectious diseases such as tuberculosis or mastitis, which are caused by microbes, metabolic diseases result from an upset in the normal bodily processes. Molybdenum for subterranean clover - By T. C. DUNNE, B.Sc. (Agric), Ph.D. (Calif.), Chief Plant Nutrition and Research Officer Subterranean clover is undoubtedly the most important pasture species in this State. Because it is a legume, it can make excellent growth on soils with a low nitrogen content. The nitrogen it needs is, of course, provided by bacteria which inhabit the nodules found on its roots. These bacteria provide nitrogen by taking it from the air and converting it to a form which can be used by the clover. However, it is now known that the bacteria can use the nitrogen of the air only if enough molybdenum is available to them. Cobalt deficiency in sheep and cattle - By C. R. TOOP, B.V.SC, Chief Veterinary Officer With the establishment of group settlements at Denmark after the first world war, it was observed that young cattle, although running on lush pastures, developed systems of unthriftness and wasting and usually died. Research conducted of Filmer and Underwood later revealed that this condition was caused by a deficiency of cobalt and that it could be cured and prevented by addition of this mineral to the diet. Cobalt deficiency has since been met with other parts of the State and was recently diagnosed in sheep at Mount Manypeaks

Carbon fiber masculinity: Disability and surfaces of homosociality

In this paper I am concerned with instances in which carbon fiber extends performances of masculinity that are attached to particular kinds of hegemonic male bodies. In examining carbon fiber as a prosthetic form of masculinity, I advance three main arguments. Firstly, carbon fiber can be a site of the supersession of disability that is affected through masculinized technology. Disability can be ‘overcome’ through carbon fiber. Disability is often culturally coded as feminine (Pedersen, 2001; Meeuf, 2009; Garland-Thompson 1997). Building on this cultural construction of disability as feminine, in and as a technology of masculine homosociality (Sedgwick, 1985), carbon fiber reproduced disability as feminine when carbon fiber prosthetic lower legs allowed Oscar Pistorius to compete in the non-disabled Olympic games. Secondly, I argue that carbon fiber can be a homosocial surface; that is, carbon fiber becomes both a surface extension of the self and a third party mediator in homosocial relationships, a surface that facilitates intimacy between men in ways that devalue femininity in both male and female bodies. I examine surfaces as material extensions of subjectivity, and carbon fiber surfaces as vectors of the cultural economies of masculine competition to which I refer. Thirdly, the case of Oscar Pistorius is exemplary of the masculinization of carbon fire, and the associated binding of a psychic attitude of misogyny and power to a form of violent and competitive masculine subjectivity. In this article I explore the affects, economies and surfaces of what I call ‘carbon fiber masculinity’ and discusses Pistorius’ use of carbon fiber, homosociality and misogyny as forms of protest masculinity through which he unconsciously attempted to recuperate his gendered identity from emasculating discourses of disability

Population genomic analysis of Aegilops tauschii identifies targets for bread wheat improvement

Aegilops tauschii, the diploid wild progenitor of the D subgenome of bread wheat, is a reservoir of genetic diversity for improving bread wheat performance and environmental resilience. Here we sequenced 242 Ae. tauschii accessions and compared them to the wheat D subgenome to characterize genomic diversity. We found that a rare lineage of Ae. tauschii geographically restricted to present-day Georgia contributed to the wheat D subgenome in the independent hybridizations that gave rise to modern bread wheat. Through k-mer-based association mapping, we identified discrete genomic regions with candidate genes for disease and pest resistance and demonstrated their functional transfer into wheat by transgenesis and wide crossing, including the generation of a library of hexaploids incorporating diverse Ae. tauschii genomes. Exploiting the genomic diversity of the Ae. tauschii ancestral diploid genome permits rapid trait discovery and functional genetic validation in a hexaploid background amenable to breeding.Kumar Gaurav ... Scott A. Boden ... et al

Raining in MKW 3 s: a Chandra-MUSE analysis of X-Ray cold filaments around 3CR 318.1

High Energy Astrophysic

New insights into the genetic etiology of Alzheimer's disease and related dementias.

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

Integrated biostratigraphy and carbon isotope stratigraphy for the Upper Cretaceous Kanguk Formation of the High Arctic Sverdrup Basin, Canada

Considerable Late Cretaceous research has focused on Cenomanian to Turonian organic carbon-rich deposits associated with oceanic anoxic event (OAE) 2. Less is known about changing paleoceanographic conditions after this event, especially in the Arctic region. The Upper Cretaceous Kanguk Formation, composed of organic-rich shale and mudstone deposited in the Sverdrup Basin of the Canadian Arctic Archipelago, was investigated at two localities on Ellesmere Island, Canada. This study provides an Upper Cretaceous stratigraphic framework for the Arctic region by integrating chemostratigraphic, lithologic, and benthic foraminiferal biostratigraphic data. The potential influence of global transgressive- regressive cycles and positive carbon isotope excursions in the Turonian to lower Campanian were recognized in the Kanguk Formation at both sites by utilizing carbon isotope stratigraphy-based correlation to carbon isotope reference records. The presence and absence of OAE 2 at the Kanguk Formation base in distal and proximal settings, respectively, demonstrate the diachroneity of the lithological boundary between the Kanguk Formation and the underlying Hassel Formation. Two foraminiferal biostratigraphic zones are proposed and correlate to assemblages across the Arctic region: the Turonian to late Santonian Evolutinella boundaryensis zone and the late Santonian to Campanian Verneuilinoides bearpawensis-Glaphyrammina spirocompressa zone. The biostratigraphic zonal ages are constrained by correlations to chemostratigraphic data. This research refines the stratigraphic framework for the Upper Cretaceous of Arctic Canada, improves our understanding of the paleoenvironmental dynamics of the Late Cretaceous Polar Sea in relation to global transgressive-regressive cycles and OAEs, and can be utilized to understand relative timing and gaps in the sedimentary record

Consultation and Communication Skills

When taking a medical history, effective communication is one of the best ways to obtain information from a patient; at the same time, facilitate a patient centred approach. This chapter explores consultation/communication skills within a diagnostic framework. It first gives a brief overview of the aims of the consultation and the benefits of facilitating a patient centred approach. The chapter further includes barriers to communication. Within the medical literature, consultation models and communication skills models are words that are used interchangeably to describe the process that is used when gaining a medical history. Many models incorporate more than one model to integrate both the doctor's and the patient's perspective. This includes the following: the medical model; and the patient's agenda. The success of any consultation will depend on how well the healthcare practitioner and patient communicate with each other and some healthcare professionals are much better natural communicators than others