Acquiring Articles through Unmediated, User-Initiated Pay-Per-View Transactions: An Assessment of Current Practices

Depressed economic times often lead libraries to consider new practices, including alternatives to the traditional subscription model. This column discusses a pay-per-view (PPV) model for acquiring journal articles whereby a library creates an account with a content provider through which authenticated users can purchase articles at the library’s expense. To gain insight into the current use of this model, the paper draws on both a literature review and the results of a survey assessing the practices of academic libraries with experience acquiring articles through unmediated, user-initiated pay-per-view transactions. The future of the PPV model as well as issues and challenges that it raises are also considered

Spectrophotometric analysis of ternary uranyl systems to replace tri-N-butyl phosphate (TBP) in used fuel reprocessing

In this report, the interaction of monoamide/diamide and monoamide/diglycolamide mixtures with UO2+2 are investigated in pH = 1 methanolic nitric acid media. These monoamides include N,N-dimethylacetamide (DMAA), N,N-diethylacetamide (DEAA), N,N-dibutylacetamide (DBAA) and N,N-dibutylbutanamide (DBBA). N,N,N′N′-tetraethylmalonamide (TEMA) and N,N,N′,N′-tetraethyldiglycolamide (TEDGA), which were chosen as model diamides and diglycolamides, respectively. Complex stability constants for each ligand were modelled using the Stability Quotients Using Absorbance Data program using UV–visible data. Complex stoichiometry of ligand mixtures was determined using Job plots and UV–Vis spectrometry. Monoamides were confirmed to produce only disolvate complexes with UO2+2 in solution. The log10(K) values for monoamides were found to be independent of amine-side chain length, but were slightly dependent on the carbonyl-side chain length. TEDGA was found to produce multiple uranyl complexes in solution. Job plot data indicated that the uranyl cation strongly prefers to bond either only with the monoamide or diamide in ternary monoamide–diamide–UO2 systems. Monoamide–diglycolamide–UO2 systems were more complicated, with Job plot data indicating the potential for multiple ternary species being present is dependent on the monoamide structure

Cognitive behaviour therapy for social anxiety in autism spectrum disorder: A systematic review.

Purpose Individuals who have autism spectrum disorders (ASD) commonly experience anxiety about social interaction and social situations. Cognitive behaviour therapy (CBT) is a recommended treatment for social anxiety (SA) in the non-ASD population. Therapy typically comprises cognitive interventions, imagery-based work and for some individuals, behavioural interventions. Whether these are useful for the ASD population is unclear. Therefore, the purpose of this paper is to undertake a systematic review to summarise research about CBT for SA in ASD. Design/methodology/approach Using a priori criteria, the authors searched for English-language peer-reviewed empirical studies in five databases. The search yielded 1,364 results. Titles, abstracts, and relevant publications were independently screened by two reviewers. Findings Four single case studies met the review inclusion criteria; data were synthesised narratively. Participants (three adults and one child) were diagnosed with ASD and SA. There were commonalities in interventions and techniques used: participants were encouraged to identify and challenge negative thoughts, enter anxiety-provoking social situations, and develop new ways of coping. Unlike CBT for SA in non-ASD individuals, treatment also included social skills interventions. Outcomes were assessed using self- or informant-reports. Improvements in SA, depressive symptoms, social skills, and activity levels were noted. Generalisability of results is hampered, however, by the small number of studies and participants and lack of randomised controlled trial conditions employed. Research limitations/implications Future studies should investigate how beliefs and behaviours indicative of SA can be ameliorated in individuals with ASD. Originality/value This is the first review to synthesise empirical data about CBT for SA in ASD

Warm temperature acclimation impacts metabolism of paralytic shellfish toxins from Alexandrium minutum in commercial oysters

© 2015 John Wiley & Sons Ltd. Species of Alexandrium produce potent neurotoxins termed paralytic shellfish toxins and are expanding their ranges worldwide, concurrent with increases in sea surface temperature. The metabolism of molluscs is temperature dependent, and increases in ocean temperature may influence both the abundance and distribution of Alexandrium and the dynamics of toxin uptake and depuration in shellfish. Here, we conducted a large-scale study of the effect of temperature on the uptake and depuration of paralytic shellfish toxins in three commercial oysters (Saccostrea glomerata and diploid and triploid Crassostrea gigas, n = 252 per species/ploidy level). Oysters were acclimated to two constant temperatures, reflecting current and predicted climate scenarios (22 and 27 °C), and fed a diet including the paralytic shellfish toxin-producing species Alexandrium minutum. While the oysters fed on A. minutum in similar quantities, concentrations of the toxin analogue GTX1,4 were significantly lower in warm-acclimated S. glomerata and diploid C. gigas after 12 days. Following exposure to A. minutum, toxicity of triploid C. gigas was not affected by temperature. Generally, detoxification rates were reduced in warm-acclimated oysters. The routine metabolism of the oysters was not affected by the toxins, but a significant effect was found at a cellular level in diploid C. gigas. The increasing incidences of Alexandrium blooms worldwide are a challenge for shellfish food safety regulation. Our findings indicate that rising ocean temperatures may reduce paralytic shellfish toxin accumulation in two of the three oyster types; however, they may persist for longer periods in oyster tissue

The integration of single case designs in coaching contexts: A commentary for applied sport psychologists

From personal experiences of working with coaches toward the modification of behaviors and psychological constructs that include motivation, enjoyment, and self-confidence, this commentary highlights how the integration of single case designs can enhance the services of sport psychology practitioners. Interventions within golf, soccer, and tennis are outlined, targeting factors pertinent to the coaches, their players or team members, and the development of relationships with parents. Single case designs are posited as enabling the implementation of personal, evidence-based interventions that yield perceptible differences in cognitive, affective, and behavioral responses within athletic populations; factors that enhance and underpin the practitioner-coach relationship

An analysis of Russian equity capital markets

Thesis (S.M.)--Massachusetts Institute of Technology, Sloan School of Management, 2012.Cataloged from PDF version of thesis.Includes bibliographical references (p. [49]-[57]).This paper begins with the assumption that stock market development has a positive and causal relationship with long run economic growth. It thus takes the view that developing the equity market is an important policy objective for the Russian government. Through a series of interviews, data collection and a review of the literature, it is found that the Russian equity market is rather underdeveloped as measured by its liquidity, free float capitalization and industry concentration. In order to stimulate the development of the market, the paper focuses on the attraction of long term capital to sustainably increase the size and liquidity of the market and reduce volatility. A set of viable reforms are suggested to achieve this goal including: 1) the upgrade of market infrastructure primarily through the creation of a Central Settlement Depository and relaxation of prefunding requirements, 2) corporate governance improvements through a reduced government participation, increased board independence and the introduction of a minimum free float requirement and 3) Incentives for the pooling of long term domestic capital, in particular through the diversification of risk using cross-country swaps.by Catherine F. Harwood.S.M

Glucosamine hydrochloride but not chondroitin sulfate prevents cartilage degradation and inflammation induced by interleukin-1α in bovine cartilage explants

Objective Glucosamine hydrochloride (GH) and chondroitin sulfate (CS) are commonly used for the treatment of osteoarthritis (OA). The aim of this study was to assess their effects, alone and in combination, on preventing aggrecan degradation and inflammation in an in vitro model of OA. Design To test the effects of GH and/or CS as a preventative treatment, cartilage explants were pretreated with the compound(s) using concentrations that showed no detrimental effect on chondrocyte viability. Interleukin-1α (IL-1α) was added to induce cartilage degradation, supernatant and explants were analyzed for proteoglycan degradation products, aggrecanase mRNA expression and activity, and for the release of inflammatory markers. Results Following treatment with IL-1α, 2 mg/mL dose of GH pretreatment was associated with a reduction of glycosaminoglycan release, reduced generation of the pathological interglobular domain aggrecan catabolites, decreased mRNA levels of ADAMTS-4 and -5 and reduced activity of ADAMTS-4. In contrast, CS alone did not have a significant effect on IL-1α-induced cartilage degradation and the addition of 0.4 mg/mL CS to 2 mg/mL GH did not further inhibit IL-1α-induced activity. Pretreatment with 2 mg/mL GH also reduced the release of inflammatory markers, prostaglandin E2 and nitric oxide induced by IL-1α while CS did not have a significant effect. Conclusions The results suggest that GH prevents cartilage degradation mediated by aggrecanases ADAMTS-4 and -5, and may also reduce inflammation. This could be part of the mechanisms by which GH is effective in maintaining joint integrity and function, and preventing or delaying early symptoms of OA

A Welcome Proposal to Amend the GMO Legislation of the EU

Is the European Union (EU) regulatory framework for genetically modified organisms (GMOs) adequate for emerging techniques, such as genome editing? This has been discussed extensively for more than 10 years. A recent proposal from The Netherlands offers a way to break the deadlock. Here, we discuss how the proposal would affect examples from public plant researchauthorsversionPeer reviewe

A Record of Antarctic Climate and Ice Sheet History Recovered

Antarctica’s late Cenozoic (the past ~15 million years) climate history is poorly known from direct evidence, owing to its remoteness, an extensive sea ice apron, and an ice sheet cover over the region for the past 34 million years. Consequently, knowledge about the role of Antarctica’s ice sheets in global sea level and climate has relied heavily upon interpretations of oxygen isotope records from deep-sea cores. Whereas these isotopic records have revolutionized our understanding of climate-ice-ocean interactions, questions still remain about the specific role of Antarctic ice sheets in global climate. Such questions can be addressed from geological records at the marine margin of the ice sheets, recovered by drilling from floating ice platforms [e.g., Davey et al., 2001; Harwood et al., 2006; Barrett, 2007]. During the austral summer of 2006–2007, a new Antarctic geological drilling program (ANDRILL) successfully recovered a 1285- meter-long record of climate and ice sheet variability spanning the past 13 million years from beneath the McMurdo Ice Shelf (Figure 1). The cores contain sedimentary rocks deposited by the ice sheets grounded in the sea, and they provide the best direct evidence to date of past Antarctic ice sheet and climate fluctuations for this period of Earth’s history. The new geological evidence is being used to provide direct physical calibrationfor deep-sea isotope records, low-latitude continental margin sea level records, and numerical climate and ice sheet models, especially for times of past global warmth. Such analogs are becoming increasingly important because of the difficulties in predicting the dynamic response of ice sheets to global warming [Vaughan and Athern, 2007]. In this article we summarize the initial results of the ANDRILL program’s first drilling project from the McMurdo Ice Shelf (MIS) site [Naish et al., 2007a, 2007b], with an emphasis on the potential of the record for improving our knowledge of Antarctica’s influence on, and response to, global climate change

Signatures from a merging galaxy cluster and its AGN population : LOFAR observations of Abell 1682

Reproduced with permission from Astronomy & Astrophysics. © 2019 ESOWe present LOFAR data from 110-180 MHz of the merging galaxy cluster Abell 1682, alongside archival optical, radio, and X-ray data. Our images of 6 arcsec in resolution at low frequencies reveal new structures associated with numerous radio galaxies in the cluster. At a resolution of 20 arcsec we see diffuse emission throughout the cluster over hundreds of kiloparsecs, indicating particle acceleration mechanisms are in play as a result of the cluster merger event and powerful active galactic nuclei. We show that a significant part of the cluster emission is from an old radio galaxy with very steep spectrum emission (having a spectral index of α < -2.5). Furthermore, we identify a new region of diffuse steep-spectrum emission (α < -1.1) as a candidate for a radio halo which is co-spatial with the centre of the cluster merger. We suggest its origin as a population of old and mildly relativistic electrons left over from radio galaxies throughout the cluster which have been re-accelerated to higher energies by shocks and turbulence induced by the cluster merger event. We also note the discovery of six new giant radio galaxies in the vicinity of Abell 1682.Peer reviewedFinal Accepted Versio