War and Lombard Street.

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Autocalibration with the Minimum Number of Cameras with Known Pixel Shape

In 3D reconstruction, the recovery of the calibration parameters of the cameras is paramount since it provides metric information about the observed scene, e.g., measures of angles and ratios of distances. Autocalibration enables the estimation of the camera parameters without using a calibration device, but by enforcing simple constraints on the camera parameters. In the absence of information about the internal camera parameters such as the focal length and the principal point, the knowledge of the camera pixel shape is usually the only available constraint. Given a projective reconstruction of a rigid scene, we address the problem of the autocalibration of a minimal set of cameras with known pixel shape and otherwise arbitrarily varying intrinsic and extrinsic parameters. We propose an algorithm that only requires 5 cameras (the theoretical minimum), thus halving the number of cameras required by previous algorithms based on the same constraint. To this purpose, we introduce as our basic geometric tool the six-line conic variety (SLCV), consisting in the set of planes intersecting six given lines of 3D space in points of a conic. We show that the set of solutions of the Euclidean upgrading problem for three cameras with known pixel shape can be parameterized in a computationally efficient way. This parameterization is then used to solve autocalibration from five or more cameras, reducing the three-dimensional search space to a two-dimensional one. We provide experiments with real images showing the good performance of the technique.Comment: 19 pages, 14 figures, 7 tables, J. Math. Imaging Vi

Belimumab : a technological advance for systemic lupus erythematosus patients? Report of a systematic review and meta-analysis

Objectives: To undertake a systematic review and meta-analysis to investigate clinical effectiveness of belimumab for patients with systemic lupus erythematosus (SLE) and antinuclear and/or anti-double-stranded DNA (dsDNA) autoantibodies. Methods: We searched eight electronic databases and reference lists for randomised controlled trials (RCTs) of belimumab against placebo or best supportive care. Quality assessment and random effects meta-analysis were undertaken. Design: A meta-analysis of RCTs. Participants: 2133 SLE patients. Primary and secondary outcome measures: SLE Responder Index (SRI) at week 52. Results: Three double-blind placebo-controlled RCTs (L02, BLISS-52 BLISS-76) investigated 2133 SLE patients. BLISS-52 and BLISS-76 trials recruited patients with antinuclear and/or anti-dsDNA autoantibodies and demonstrated belimumab effectiveness for the SRI at week 52. Ethnicity and geographical location of participants varied considerably between BLISS trials. Although tests for statistical heterogeneity were negative, BLISS-52 results were systematically more favourable for all measured outcomes. Meta-analysis of pooled 52-week SRI BLISS results showed benefit for belimumab (OR 1.63, 95% CI 1.27 to 2.09). By week 76, the primary SRI outcome in BLISS-76 was not statistically significant (OR 1.31, 95% CI 0.919 to 1.855)

Nature versus Nurture: The curved spine of the galaxy cluster X-ray luminosity -- temperature relation

The physical processes that define the spine of the galaxy cluster X-ray luminosity -- temperature (L-T) relation are investigated using a large hydrodynamical simulation of the Universe. This simulation models the same volume and phases as the Millennium Simulation and has a linear extent of 500 h^{-1} Mpc. We demonstrate that mergers typically boost a cluster along but also slightly below the L-T relation. Due to this boost we expect that all of the very brightest clusters will be near the peak of a merger. Objects from near the top of the L-T relation tend to have assembled much of their mass earlier than an average halo of similar final mass. Conversely, objects from the bottom of the relation are often experiencing an ongoing or recent merger.Comment: 8 pages, 7 figures, submitted to MNRA

A PCA-based automated finder for galaxy-scale strong lenses

We present an algorithm using Principal Component Analysis (PCA) to subtract galaxies from imaging data, and also two algorithms to find strong, galaxy-scale gravitational lenses in the resulting residual image. The combined method is optimized to find full or partial Einstein rings. Starting from a pre-selection of potential massive galaxies, we first perform a PCA to build a set of basis vectors. The galaxy images are reconstructed using the PCA basis and subtracted from the data. We then filter the residual image with two different methods. The first uses a curvelet (curved wavelets) filter of the residual images to enhance any curved/ring feature. The resulting image is transformed in polar coordinates, centered on the lens galaxy center. In these coordinates, a ring is turned into a line, allowing us to detect very faint rings by taking advantage of the integrated signal-to-noise in the ring (a line in polar coordinates). The second way of analysing the PCA-subtracted images identifies structures in the residual images and assesses whether they are lensed images according to their orientation, multiplicity and elongation. We apply the two methods to a sample of simulated Einstein rings, as they would be observed with the ESA Euclid satellite in the VIS band. The polar coordinates transform allows us to reach a completeness of 90% and a purity of 86%, as soon as the signal-to-noise integrated in the ring is higher than 30, and almost independent of the size of the Einstein ring. Finally, we show with real data that our PCA-based galaxy subtraction scheme performs better than traditional subtraction based on model fitting to the data. Our algorithm can be developed and improved further using machine learning and dictionary learning methods, which would extend the capabilities of the method to more complex and diverse galaxy shapes

Three manifestations of the pulsed harmonic potential

We consider, in turn, three systems being acted upon by a regularly pulsed harmonic potential (PHP). These are i) a classical particle, ii) a quantum particle, and iii) a directed line. We contrast the mechanics of the first two systems by parameterizing their bands of stability and periodicity. Interesting differences due to quantum fluctuations are examined in detail. The fluctuations of the directed line are calculated in the two cases of a binding PHP, and an unbinding PHP. In the latter case there is a finite maximum line length for a given potential strength.Comment: 34 Revtex pages, with 5 attached figure

Historical Criminology and the Explanatory Power of the Past

To what extent can the past ‘explain’ the present? This deceptively simple question lies at the heart of historical criminology (research which incorporates historical primary sources while addressing present-day debates and practices in the criminal justice field). This article seeks first to categorise the ways in which criminologists have used historical data thus far, arguing that it is most commonly deployed to ‘problematize’ the contemporary rather than to ‘explain’ it. The article then interrogates the reticence of criminologists to attribute explicative power in relation to the present to historical data. Finally, it proposes the adoption of long time-frame historical research methods, outlining three advantages which would accrue from this: the identification and analysis of historical continuities; a more nuanced, shared understanding of micro/macro change over time in relation to criminal justice; and a method for identifying and analysing instances of historical recurrence, particularly in perceptions and discourses around crime and justice

Proton-transfer pathways in the mitochondrial S. cerevisiae cytochrome c oxidase

In cytochrome c oxidase (CytcO) reduction of O2 to water is linked to uptake of eight protons from the negative side of the membrane: four are substrate protons used to form water and four are pumped across the membrane. In bacterial oxidases, the substrate protons are taken up through the K and the D proton pathways, while the pumped protons are transferred through the D pathway. On the basis of studies with CytcO isolated from bovine heart mitochondria, it was suggested that in mitochondrial CytcOs the pumped protons are transferred though a third proton pathway, the H pathway, rather than through the D pathway. Here, we studied these reactions in S. cerevisiae CytcO, which serves as a model of the mammalian counterpart. We analyzed the effect of mutations in the D (Asn99Asp and Ile67Asn) and H pathways (Ser382Ala and Ser458Ala) and investigated the kinetics of electron and proton transfer during the reaction of the reduced CytcO with O2. No effects were observed with the H pathway variants while in the D pathway variants the functional effects were similar to those observed with the R. sphaeroides CytcO. The data indicate that the S. cerevisiae CytcO uses the D pathway for proton uptake and presumably also for proton pumping