3,419 research outputs found
Madness in Nineteenth-Century Russian Literature: Identity, Self and Other
This thesis explores the connection between madness and identity in nineteenth-century Russian literature, with significant focus on works by Dostoevskii, Tolstoi, Gogol’ and Pushkin. Proposing personhood as comprised of the personal and the social, I argue that discrepancies between these two halves – relating to different types of breakdown in social relations – engender madness in Russian literary works.
Analysing a range of characters through the lens of a variety of identity theories, I argue that duality is projected in three dimensions in these texts. Personal and social selves are opposed in the formation of identity, as are the real and imaginary in the construction of fictional worlds. The duality of sanity and madness straddles both to create an interdependence of self and other across the three spheres.
Examining different types of ‘madness’, including clinical disorders such as mania and spiritual concepts such as holy folly, I argue that the fluidity of insanity in literary protagonists means it can be viewed as a non-alignment with the social other on any plane. I aim to answer the questions of how a disparity between perceptions of reality leads to a definition of madness, and the significance of the role the other plays in the categorisation of ‘the mad’ and ‘the sane’.
This thesis is divided into three main parts, assessing the mad individual in relation to: social system, society, and individuals. The first examines mania and St Petersburg’s social hierarchy, demonstrating how relational identities create a desire for power, and how idealised selves distance an individual from reality. The second addresses group mindsets to explore how fluid definitions of madness are determined according to the social environment within the spheres of the provinces and holy folly. The third investigates epilepsy and depression, highlighting the importance of a loving relationship and morality for sanity
To dam or not to dam : a case study of conflict surrounding the Collinsville Dams and implications for the future
Hydroelectric power is a controversial renewable energy. Adding more renewables to the energy mix is becoming more critical with the onslaught of climate change, while river health and water quality remain a highly pertinent environmental issue. Balancing the need for local renewable energy and environmental concerns is the topic of many cases. This thesis analyzes a case of conflict surrounding the debate of the Collinsville Dams on the Farmington River, which exemplify hurtles in developing a run-of-river hydropower project. Many factors are involved in the process, and the need to look at hydropower projects on existing dam sites is of concern in New England as many dams are up for relicensing. Stakeholders for the Collinsville Dams are interviewed and the perceptions and findings regarding the complexity and hurtles to the project are displayed. If a sustainability science method was utilized for diverse stakeholders to come to an agreement to benefit both the river and the need for renewable energy, future reconciliation of energy, environment, and society may be better addressed. Sustainability science could prove a solution for optimizing the renewable energy benefit of run-of-river hydropower alongside of protecting a watershed and minimizing the impacts. The power relations and lack of transparency among the town, the State Renewable Energy goals, as well as various stakeholders in this case of conflict will be looked into for a greater understanding on the Collinsville Dams
Growing Social Inequalities in Youth Civic Engagement? Evidence from the National Election Study
Social class differences in civic engagement persist for both youth and adults. Although empirical evidence is mixed, several recent social changes pertaining to youth suggest that social inequalities in civic engagement may be growing over time for young people. Using data from the National Election Study, we compared trends for youth and older adults of varying education levels and tested the hypothesis of an increasing educational disparity in youth political participation. Results for voting supported our expectations: declines over time were found for less-educated youth only. Unexpectedly, participation in other political activities for more-educated youth declined more over time compared to other groups. Our findings highlight the need to create equal opportunities for youth civic engagement across social groups
Concert recording 2017-04-09b
[Track 1]. Three concert duets Op. 10, No. 3. Rondo allegro / Friedrich Kuhlau arr. Larry Teal -- [Track 2]. Chanson triste / Henri Duparc -- [Track 3]. Tableaux de Provence. Farandoulo di chatouno [Track 4]. Cansoun per ma mio [Track 5]. La boumiano [Track 6]. Di Alyxcamps l\u27amo souspire [Track 7]. Lou cabridan / Paule Maurice -- [Track 8]. Sonate for oboe and piano. Munter [Track 9]. Sehr langsam -- Lebhaft / Paul Hindemith -- [Track 10]. Quatuor pour Saxophones. Overture - brillante [Track 11]. Doloroso [Track 12]. Spirituoso [Track 13]. Andante - presto / Pierre Max Dubois
Bleomycin increases neutrophil adhesion to human vascular endothelial cells independently of upregulation of ICAM-1 and E-selectin
© 2016 Taylor & Francis. Aim of the Study: Bleomycin-induced lung disease is a serious complication of therapy characterized by alveolar injury, cytokine release, inflammatory cell recruitment, and eventually pulmonary fibrosis. The mechanisms underlying bleomycin-induced pulmonary fibrosis may be relevant to other progressive scarring diseases of the lungs. Pulmonary vascular endothelial cells are critically involved in immune cell extravasation at sites of injury through adhesion molecule expression and cytokine release. We sought to determine the effects of bleomycin on adhesion molecule expression and cytokine release by pulmonary vascular endothelial cells, and their functional relevance to inflammatory cell recruitment. Materials and Methods: The effects of pharmacologically relevant concentrations of bleomycin on adhesion molecule expression and cytokine release by human vascular endothelial cells in vitro were studied by flow cytometry, quantitative polymerase chain reaction, and enzyme-linked immunosorbent assay. A flow chamber model was used to assess the functional consequences on adhesion of flowing human neutrophils to endothelial cell monolayers. Results: Bleomycin increased intercellular adhesion molecule 1 (ICAM-1; CD54), vascular cell adhesion molecule (VCAM-1; CD106), and E-selectin (CD62E) expression, and increased monocyte chemoattractant protein (MCP-1) and interleukin (IL-8) release by endothelial cells. Increases in protein expression were accompanied by increased mRNA transcription. In contrast, there was no direct effect of bleomycin on the profibrotic cytokines transforming growth factor-beta (TGF-β), platelet-derived growth factor-BB (PDGF-BB), or endothelin-1. Under flow conditions, endothelial cells exposed to bleomycin supported increased neutrophil adhesion which was independent of ICAM-1 or E-selectin. Conclusion: Our findings demonstrate that bleomycin promotes endothelial-mediated inflammation and neutrophil adhesion. These mechanisms may contribute to the development of pulmonary fibrosis by supporting immune cell recruitment in the lungs
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