The testing of a hazard potential rating form to evaluate the degree of hazard in industrial operations

M.S.W. N. Cox, Jr

The Evolution of an Internet Market Exchange and Value System: Examples From The Motion Control Industry

This manuscript examines the evolution of internet value systems in the motion control industry. We believe the primary reason behind the inconsistent performance of that industry\u27s adoption of the internet in the supply channel was largely due to poor strategy. Using a the concepts of bias exchanges and game theory it is suggested that intemet strategies such as disintermediation and first-mover advantage were elusive because firms focused too much on technology and not enough on customer value. Lessons for managers and future decisions are offered

Falcon Research in Greenland, 1973

... During the summer of 1972 a research team initiated the first in-depth study of the peregrine falcon (Falco peregrinus) in West Greenland. Eight eyries (nests) of this endangered species were located in an inland sample area of 700 sq. mi. Detailed observations were taken of peregrine breeding behaviour at one eyrie. Seven of the eyries produced young, containing an average of 2.57 young per successful eyrie. This high reproductive rate indicates a healthy population, but analyses of 2 addled eggs revealed high p,p'-DDE as well as polychlorinated biphenyl (PCB) residues and eggshell fragments from 9 eggs showed a 14 per cent decrease in thickness compared with 42 eggs collected in Greenland before the introduction of DDT into the environment. ... The [1973] survey area consisted of 900 sq. mi. (2,330 sq. km.), including ice-cap, lakes, fjords, and other unsuitable habitat totalling about 150 sq. mi. (388 sq. km.). We found 10 occupied peregrine falcon nesting cliffs in the survey area in 1973. ... 9 eyries produced young. Of these 9, 7 were also successful in 1972, while another was occupied throughout the season by an aggressive pair, and at the ninth a lone female mildly defended the cliff. Of the 9 producing eyries in 1973, 1 contained 4 young, 5 contained 3 young each, 2 had 2 young each, and 1 held 1 young. This gives a total of 24 young peregrines and a production rate of 2.4 young per occupied eyrie, or 2.67 young per successful eyrie. These young were counted at advanced ages varying from 2.5 weeks to just before fledging. It is believed that all or almost all fledged. We found 1 occupied eyrie per 90 sq. mi. (233 sq. km.), or 1 successful eyrie per 100 sq. mi. (260 sq. km.). All young were banded with a metal band on the left tarsus and a red plastic band on the right. ... The colour bands signify the beginning of an international peregrine colour banding system established for quick geographical identification of banding locality. During the 2 summers, 9 gyrfalcon nesting cliffs were located in the survey area. We believe that at least 6 of the 9 locations were occupied in 1972. In 1973, 8 of the 9 cliffs were checked. Young were found at 4 sites. A fifth was observed from an aircraft and appeared to be active. Lone adults were observed at 2 other locations. Seven young gyrfalcons were banded out of 10 young found. One nest site was inaccessible and the young were not banded, accounting for the difference in number located and banded. The production rate per producing pair of gyrfalcons was 2.50 young. ... Our sample survey indicates that in 1973, as in 1972, the peregrine falcon reproduced normally in West Greenland. The slightly higher production rate in 1973 can possibly be attributed to warmer temperatures during the nesting period, as the summer of 1972 was unseasonably cool. However, the 1972 data on eggshell thinning and high DDE and PCB residues reveal that this population is precariously balanced, and severe reproductive failure threatens. Analysis of the 1973 addled egg and measurement of the additional eggshell fragments will supplement the 1972 results to provide a larger data base. ..

Peregrine Falcon Survey, West Greenland, 1972

... The main purpose of the 1972 survey was to study a sample area of West Greenland to supply baseline data about peregrine falcons from which future surveys could determine the status and trends of this bird in Greenland. The main part of the study had as its goals: 1) to determine the density, distribution, and reproductive success of nesting peregrines in a sample area; 2) to band all peregrine nestlings found; 3) to determine prey species of the peregrine; 4) to make interspecific observations of peregrines and gyrfalcons; 5) to make detailed observations from a blind of a sample peregrine falcon eyrie; 6) to conduct a small-bird census in the area of the sample eyrie; 7) to make a photographic record in colour slides and movies of the investigations. ... Eight peregrine falcon eyries and 3 gyrfalcon eyries were found in the survey area. In all, 18 nestlings were found in the 8 peregrine eyries. Of the 8 eyries, 1 had no young, but showed signs of occupancy ... and was defended by an aggressive pair of falcons. Of the other 7 eyries where we found hatched young, 1 had 4 young, 4 had 3 young, and 2 had 1 young bird each. Of the total of 18 nestling peregrines, 13 were banded and 5 were fully-fledged, on the wing, and unable to be caught for banding. Of the peregrine nestlings banded, 9 were males and 4 were females. The number of nestlings (18) in the 8 peregrine eyries gave a production rate of 2.25 per eyrie, or 2.57 if an average is taken of the 7 eyries actually producing young. At 1 eyrie a young falcon was found dead (the eyrie with 4 young). We know that at least 8 of the remaining 17 young fledged successfully, but we are uncertain about the success of the others and cannot therefore make a definite statement on fledging ratio. We estimate, however, that the fledging rate of the peregrines in our survey area was at least 2.00 per producing eyrie. The maximum dimensions of our irregularly-shaped survey area were 39 x 34 miles (63 x 55 km). The estimated area of the survey was about 800 sq. mi. (2,072 sq. km), or about 700 sq. mi. (1,800 sq. km) when the surface area of fiords and lakes is excluded. The nesting density of the active, young-producing peregrine eyries (7) was about 1 pair per 100 sq. mi. (260 sq. km). ... At the 3 gyrfalcon (Falco rusticolus) eyries we found 8 nestlings or fully-fledged young, of which we were able to band 3. Peregrines and gyrfalcons (and a rare white-tailed sea eagle, Haliaetus albicilla) are the only avian predators nesting in southern West Greenland, although ravens (Corvus corax) competed for some nesting cliff sites. We collected remains of prey species and pellets at each falcon eyrie. Addled eggs (2) from 2 peregrine eyries were collected for pesticide analysis. Eggshell fragments for thickness determination were gathered at 5 peregrine eyries. ... Peregrine falcons in West Greenland appear to be in a healthy state as evidenced by a high nesting density (1/100 sq. mi.) and a high production rate (2.25/eyrie), especially in light of the unusually severe conditions in West Greenland during the winter and late spring of 1971-72. We found little interspecific competition for prey species between peregrines and gyrfalcons. The gyrfalcon is already nesting in West Greenland before the peregrines arrive from their winter migration to the south. The gyrfalcons could therefore be expected to be aggressive in defence of their nesting cliffs and thereby occupy optimal cliffs. Despite this, all the peregrines we studied occupied high, sheer, and quite optimal nesting cliffs. Gyrfalcons seemed to prefer a nesting site lower down on a cliff face than peregrines, and both falcons preferred high, sheer cliffs with a southern exposure. Ravens were relegated to lower, less desirable (more accessible) cliffs for nesting. We await pesticide analysis of the peregrine falcon eggs and prey species collected, as well as eggshell thickness determination. Before these facts are determined we can say nothing definite about the status of peregrines in Greenland. Nesting density and production, however, suggest that the status of the peregrine is better in Greenland than in other areas of the north. ..

Monoclonal Light Chain–Mesangial Cell Interactions: Early Signaling Events and Subsequent Pathologic Effects

Glomerulopathic monoclonal light chains (G-LC) interact with mesangial cells (MC), resulting in alterations of mesangial homeostasis. Early signaling events control mitogenic activities and cytokine production, which in turn participate in the subsequent pathologic events. Mesangial homeostasis is affected in two very different ways, depending on whether the G-LC is from a patient with light chain deposition disease (LCDD) or light chain–related amyloidosis (AL-Am). In contrast, tubulopathic (T)-LC chains from patients with myeloma cast nephropathy do not significantly interact with MC and result in no alterations in mesangial homeostasis. Therefore, understanding early events in the monoclonal LC–MC interactions is fundamental. MC in culture were exposed to LC obtained and purified from the urine of patients with plasma cell dyscrasias and biopsy-proven renal disease, including LCDD, AL-Am, and myeloma cast nephropathy. Incubation of MC with G-LC, but not T-LC, resulted in cytoskeletal and cell shape changes, activation of platelet-derived growth factor-β (PDGF-β) and its corresponding receptor, cytoplasmic to nuclear migration of c-fos and NF-κβ signals, and production of monocyte chemoattractant protein-1 (MCP-1), as well as increased expression of Ki-67, a proliferation marker. Although NF-κβ activation was directly related to MCP-1 production, c-fos activation regulated proliferative signals and cytoskeletal changes in MC. Amyloidogenic LC were avidly internalized by the MC, whereas LCDD-LC effector targets were located at the MC surface. These cellular events are likely initiated as a result of interactions of the G-LC with yet-uncharacterized MC surface receptors. Dissecting the events taking place when G-LC interact with MC may define potential important targets for selective therapeutic manipulation to ameliorate or prevent the glomerular injury that ensues

The Renouxia files: the richness is out there!

ABSTRACT: In 1989, a gelatinous red alga was reported for the Caribbean, to which no species name, genus, order or even family could be assigned. Renouxia antillana was finally described in 1995 and accomodated in a new order and family (Rhodogorgonales, Rhodogorgonaceae) along with Rhodogorgon ramosissima described six years earlier based on material from reefs in Belize. For more than 20 years, the genus has remained monotypic, with rare reports in the Caribbean and in the Indo-Pacific (from Malaysia to French Polynesia). Recent collections in Egypt resulted in the first record of Renouxia in the Red Sea. DNA sequence analyses indicate that the specimens belong to a new species. The cox1 pairwise distance among the Red Sea specimens is 0.0-0.2%, while the distance between these and the generitype is 7.5 -7.7%. This interspecific nucleotide diversity is as high as the diversity between R. antillana and Rhodenigma contortum (7.2-7.5%), the third species in the family. RbcL pairwise distances are also high (6.7% within Renouxia, and 9.1-9.6% between Renouxia and Rhodenigma), indicating the possibility that the new species belongs to a new genus. Morphological and anatomical studies are underway to formally describe the new taxon.info:eu-repo/semantics/publishedVersio