Justice System Contact and Health: Do Immigrants Fair Better or Worse than the Native-Born after Arrest, Probation, or Incarceration?

Despite decades of both macro- and micro-level studies showing immigration to be unassociated or negatively linked to crime, research examining the consequences of justice system contact among immigrants has been comparatively underdeveloped. The current study examines whether justice system contact (arrest, probation, and incarceration) is linked to poorer health and, in turn, whether there were differences in how justice system contact is related to immigrant versus native-born health. Using data from multiple waves of the National Longitudinal Study of Adolescent to Adult Health (Add Health), we construct both ordinal and Poisson regression models predicting poor self-rated health and the prevalence of chronic health conditions for both foreign-born and native-born groups, as well as different generations. The findings suggest important differences by nativity, immigrant generation, and type of justice system contact. Despite lower criminality than the native-born, the health of immigrants is deleteriously impacted by some types of justice system contact, especially incarceration, while probation is more strongly linked to poor health among the native-born. Our findings carry implications for the provision of care for individuals with histories of criminal justice involvement, as well as academic research examining the consequences of justice contact and the immigration–crime nexus

Social and behavioral vulnerability, pregnancy, and negative mental health outcomes in the U.S. during the Covid-19 pandemic

The novel coronavirus (Covid-19) pandemic has had a significant impact on the mental health of the general U.S. population. Extant literature has increasingly linked social vulnerabilities, risky behavior, and limited social and psychological resources to the growing mental health crisis during the virus\u27s spread. The purpose of this study was to examine the impact of pertinent social vulnerabilities and subjective risk factors for both men and women on mental health (i.e., depression, anxiety, isolation) with a closer examination of the influence of pregnancy during the pandemic on mental health. The sample included 740,640 respondents participating in the U.S. Covid-19 Trends and Impact Survey that was deployed between February and March 2021. Descriptive statistics and ordinary least squares regression models are presented with a focus on the factors that shape negative mental health outcomes, particularly on the disparities between pregnant and non-pregnant women relative to men, but also subjective/perception factors (e.g., fear/worry) and social vulnerabilities. Results show that pregnant women were at significantly greater risk of negative mental health outcomes at this stage of the pandemic than either men or non-pregnant women. Overall, respondents who were younger, without children in the household, unemployed, worried generally about infection or their finances, or had ever tested positive for Covid were also more likely to report feelings of anxiety, isolation, and depression than their counterparts. Pregnant women may be especially vulnerable to depression, anxiety, and isolation during the pandemic and our findings suggest the importance of developing targeted mental health support for this sub-population

Understanding the Social Science Effect: An Intervention in Life Course Generosity

Does interacting with social science data in early adulthood promote generosity? To investigate this question from a life course development perspective, two distinct samples were drawn for a survey with an embedded experimental design. The first sample is of emerging adult college students (n = 30, median age = 20 years). The second sample is of young adults who were selected to participate based on their prior participation in a nationally representative and longitudinal study (n = 170, median age = 31 years). Toward the end of the survey, participants were randomly selected into a website interaction with either: (a) data on charitable giving, (b) data on social inequality, or (c) data about weather (a control condition). The key outcome of interest is a behavioral measure of generosity: whether participants elected to keep their study incentive or donate their incentive to a charitable organization. The donation decision occurred after the randomly selected website interaction. Interacting with charitable giving data resulted in greater generosity than interacting with weather data, across both samples. Interacting with social inequality data had mixed results. Moreover, emerging adult college students gave at a considerably higher rate overall than the national sample of young adults, net of treatment type. Implications are discussed

Familial Alzheimer's Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis

Mutations in presenilin 1 (PSEN1) or presenilin 2 (PSEN2), the catalytic subunit of γ-secretase, cause familial Alzheimer’s disease (fAD). We hypothesized that mutations in PSEN1 reduce Notch signaling and alter neurogenesis. Expression data from developmental and adult neurogenesis show relative enrichment of Notch and γ-secretase expression in stem cells, whereas expression of APP and β-secretase is enriched in neurons. We observe premature neurogenesis in fAD iPSCs harboring PSEN1 mutations using two orthogonal systems: cortical differentiation in 2D and cerebral organoid generation in 3D. This is partly driven by reduced Notch signaling. We extend these studies to adult hippocampal neurogenesis in mutation-confirmed postmortem tissue. fAD cases show mutation-specific effects and a trend toward reduced abundance of newborn neurons, supporting a premature aging phenotype. Altogether, these results support altered neurogenesis as a result of fAD mutations and suggest that neural stem cell biology is affected in aging and disease

Multifactor dimensionality reduction for graphics processing units enables genome-wide testing of epistasis in sporadic ALS

Motivation: Epistasis, the presence of gene–gene interactions, has been hypothesized to be at the root of many common human diseases, but current genome-wide association studies largely ignore its role. Multifactor dimensionality reduction (MDR) is a powerful model-free method for detecting epistatic relationships between genes, but computational costs have made its application to genome-wide data difficult. Graphics processing units (GPUs), the hardware responsible for rendering computer games, are powerful parallel processors. Using GPUs to run MDR on a genome-wide dataset allows for statistically rigorous testing of epistasis

The Science of College: Navigating the First Year and Beyond

The transition to adulthood is a complex process, and college is pivotal to this experience. "The Science of College" aids entering college students--and the people who support them--in navigating college successfully, with up-to-date recommendations based upon real student situations, sound social science research, and the collective experiences of faculty, lecturers, advisors, and student support staff. The stories captured in this book highlight how the challenges that college students encounter vary in important ways based on demographics and social backgrounds. Despite these varied backgrounds, all students are more likely to have successful college experiences if they invest in their communities. Universities have many resources available, but as this book will show, students need to learn when to access which resources and how best to engage with people serving students. This includes having a better awareness of the different roles held by university faculty and staff, and navigating who to go to for what, based upon understanding their distinct sets of expertise and approaches to support. There is no single template for student success. Yet, this book highlights common issues that many students face and provides science-based advice for how to navigate college. Each topic covered is geared towards the life stage that most college students are in: emerging adulthood. In addition to the student-focused chapters, the book includes appendixes with activities for students, tips for parents, and methods information for faculty. Supplemental website materials suggest classroom activities for instructors who adopt this book within first-year seminars and general education courses

The rapid assembly of an elliptical galaxy of 400 billion solar masses at a redshift of 2.3

Stellar archeology shows that massive elliptical galaxies today formed rapidly about ten billion years ago with star formation rates above several hundreds solar masses per year (M_sun/yr). Their progenitors are likely the sub-millimeter-bright galaxies (SMGs) at redshifts (z) greater than 2. While SMGs' mean molecular gas mass of 5x10^10 M_sun can explain the formation of typical elliptical galaxies, it is inadequate to form ellipticals that already have stellar masses above 2x10^11 M_sun at z ~ 2. Here we report multi-wavelength high-resolution observations of a rare merger of two massive SMGs at z = 2.3. The system is currently forming stars at a tremendous rate of 2,000 M_sun/yr. With a star formation efficiency an order-of-magnitude greater than that of normal galaxies, it will quench the star formation by exhausting the gas reservoir in only ~200 million years. At a projected separation of 19 kiloparsecs, the two massive starbursts are about to merge and form a passive elliptical galaxy with a stellar mass of ~4x10^11 M_sun. Our observations show that gas-rich major galaxy mergers, concurrent with intense star formation, can form the most massive elliptical galaxies by z ~ 1.5.Comment: Appearing in Nature online on May 22 and in print on May 30. Submitted here is the accepted version (including the Supplementary Information), see nature.com for the final versio

Chronic non-specific low back pain - sub-groups or a single mechanism?

Copyright 2008 Wand and O'Connell; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Background: Low back pain is a substantial health problem and has subsequently attracted a considerable amount of research. Clinical trials evaluating the efficacy of a variety of interventions for chronic non-specific low back pain indicate limited effectiveness for most commonly applied interventions and approaches. Discussion: Many clinicians challenge the results of clinical trials as they feel that this lack of effectiveness is at odds with their clinical experience of managing patients with back pain. A common explanation for this discrepancy is the perceived heterogeneity of patients with chronic non-specific low back pain. It is felt that the effects of treatment may be diluted by the application of a single intervention to a complex, heterogeneous group with diverse treatment needs. This argument presupposes that current treatment is effective when applied to the correct patient. An alternative perspective is that the clinical trials are correct and current treatments have limited efficacy. Preoccupation with sub-grouping may stifle engagement with this view and it is important that the sub-grouping paradigm is closely examined. This paper argues that there are numerous problems with the sub-grouping approach and that it may not be an important reason for the disappointing results of clinical trials. We propose instead that current treatment may be ineffective because it has been misdirected. Recent evidence that demonstrates changes within the brain in chronic low back pain sufferers raises the possibility that persistent back pain may be a problem of cortical reorganisation and degeneration. This perspective offers interesting insights into the chronic low back pain experience and suggests alternative models of intervention. Summary: The disappointing results of clinical research are commonly explained by the failure of researchers to adequately attend to sub-grouping of the chronic non-specific low back pain population. Alternatively, current approaches may be ineffective and clinicians and researchers may need to radically rethink the nature of the problem and how it should best be managed