12 research outputs found
Quickscan opbrengsten en efficiëntie in de gangbare en biologische akkerbouw, melkveehouderij , varkenshouderij en pluimveehouderij : deelstudie van project ‘Duurzame Eiwitvoorziening’
De centrale onderzoeksvraag van onderhavige studie is als volgt geformuleerd: “Wat zijn de gemiddelde verschillen in gewasopbrengsten en in dierlijke productie (kg per ha per jaar) tussen gangbare en biologische landbouw, en waardoor worden deze verschillen veroorzaakt?” Het blijkt niet eenvoudig te zijn om een zuivere vergelijking te maken, omdat er verschillen zijn in soorten en – variëteiten, in bouwplannen en voorvruchten, in doelstellingen en in bedrijfssystemen tussen biologische en gangbare landbouw. Een vergelijking tussen opbrengsten en efficiëntie van biologische en gangbare landbouw kan daarom gekarakteriseerd worden als een vergelijking tussen appels en peren
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Epstein-Barr virus: clinical and epidemiological revisits and genetic basis of oncogenesis
Epstein-Barr virus (EBV) is classified as a member in the order herpesvirales, family herpesviridae, subfamily gammaherpesvirinae and the genus lymphocytovirus. The virus is an exclusively human pathogen and thus also termed as human herpesvirus 4 (HHV4). It was the first oncogenic virus recognized and has been incriminated in the causation of tumors of both lymphatic and epithelial nature. It was reported in some previous studies that 95% of the population worldwide are serologically positive to the virus. Clinically, EBV primary infection is almost silent, persisting as a life-long asymptomatic latent infection in B cells although it may be responsible for a transient clinical syndrome called infectious mononucleosis. Following reactivation of the virus from latency due to immunocompromised status, EBV was found to be associated with several tumors. EBV linked to oncogenesis as detected in lymphoid tumors such as Burkitt's lymphoma (BL), Hodgkin's disease (HD), post-transplant lymphoproliferative disorders (PTLD) and T-cell lymphomas (e.g. Peripheral T-cell lymphomas; PTCL and Anaplastic large cell lymphomas; ALCL). It is also linked to epithelial tumors such as nasopharyngeal carcinoma (NPC), gastric carcinomas and oral hairy leukoplakia (OHL). In vitro, EBV many studies have demonstrated its ability to transform B cells into lymphoblastoid cell lines (LCLs). Despite these malignancies showing different clinical and epidemiological patterns when studied, genetic studies have suggested that these EBV- associated transformations were characterized generally by low level of virus gene expression with only the latent virus proteins (LVPs) upregulated in both tumors and LCLs. In this review, we summarize some clinical and epidemiological features of EBV- associated tumors. We also discuss how EBV latent genes may lead to oncogenesis in the different clinical malignancie