A rare case of isoniazid induced sideroblastic anemia

Sideroblastic anemia is a rare cause of anemia. Most of it accounts for the genetic cause, while drug induced is still uncommon. Our patient, a 20 year old female, is a known case of right frontal tuberculoma on ATT presented with complaints of generalized weakness and loss of appetite. On evaluation, she was found to have severe anemia and bone marrow studies confirmed it to be sideroblastic anemia. On revisiting the history, it was noted that she was not taking pyridoxine supplements as advised along with antitubercular drugs. Our patient is one among the few documented cases of Isoniazid induced sideroblastic anemia.This case needs attention because it is a preventable cause of anemia and the clinicians need to be aware about the compliance of the patient with the supplementary drugs.

Magnetotransport properties of individual InAs nanowires

We probe the magnetotransport properties of individual InAs nanowires in a field effect transistor geometry. In the low magnetic field regime we observe magnetoresistance that is well described by the weak localization (WL) description in diffusive conductors. The weak localization correction is modified to weak anti-localization (WAL) as the gate voltage is increased. We show that the gate voltage can be used to tune the phase coherence length ($l_\phi$) and spin-orbit length ($l_{so}$) by a factor of $\sim$ 2. In the high field and low temperature regime we observe the mobility of devices can be modified significantly as a function of magnetic field. We argue that the role of skipping orbits and the nature of surface scattering is essential in understanding high field magnetotransport in nanowires

Investigating large-scale brain dynamics using field potential recordings: Analysis and interpretation

New technologies to record electrical activity from the brain on a massive scale offer tremendous opportunities for discovery. Electrical measurements of large-scale brain dynamics, termed field potentials, are especially important to understanding and treating the human brain. Here, our goal is to provide best practices on how field potential recordings (EEG, MEG, ECoG and LFP) can be analyzed to identify large-scale brain dynamics, and to highlight critical issues and limitations of interpretation in current work. We focus our discussion of analyses around the broad themes of activation, correlation, communication and coding. We provide best-practice recommendations for the analyses and interpretations using a forward model and an inverse model. The forward model describes how field potentials are generated by the activity of populations of neurons. The inverse model describes how to infer the activity of populations of neurons from field potential recordings. A recurring theme is the challenge of understanding how field potentials reflect neuronal population activity given the complexity of the underlying brain systems

An assessment of surgical outcome with the influencing factors of horizontal strabismus surgery

Background: Influencing factors of conventional horizontal surgery for surgical outcome has not been assessed in Nepal. Aims and Objective: To assess the pre-operative factors that influences the surgical outcome of horizontal strabismus surgery. Materials and Methods: The medical records of 68 patients who underwent their first horizontal strabismus surgery at Lumbini Eye Institute from 1st January to 30th December 2015 were retrospectively reviewed. The collected clinical data included diagnosis, age group, visual acuity, binocular function, extraocular motility and pre and postoperative deviation. The success of surgery was defined by eye deviation less than 10 prism diopters (PD) at 6 weeks after operation. The influencing factors for surgical success (diagnosis, age group, visual acuity, binocular function, and angle deviations) were analyzed using chi square test and Mann-Whitney - U test, where ever appropriate. Results: Out of 113 patients who underwent strabismus surgery during the year, 68 patients were enrolled in the study. Majority of the patients (27, 39.7%) were >9 years of age and 52.9% were female. Thirty seven patients (54.4%) were esotropic whereas, 31 were exotropic. Preoperatively, angle of deviation ranged from 20 to 90 PD with binocular vision present in 57.4% cases. Overall, success was seen in 26 patients (38.2%). Pre-operative angle of deviation and binocular vision had statistical significance with surgical success (p = 0.012 and 0.026 respectively). Conclusion: Larger angle of deviation and poor binocular vision at presentation has higher failure rate for horizontal strabismus surgery

Performance evaluation of quality protein maize genotypes across various maize production agro ecologies of Nepal

To identify superior quality protein maize genotypes for grain yield under different agro climatic conditions of terai and hill districts in Nepal, the coordinated varietal trials (CVT) were conducted at Dailekh, Doti, Salyan, Lumle and Pakhribas in 2013 and Salyan, Pakhribas and Kabre in 2014 during summer season and coordinated farmer’s field trials (CFFT) at Surkhet and Dailekh in 2013 and Salyan, Pakhribas and Khumaltar in 2014 during summer season. The experiment was carried out using randomized complete block design with three replications for CVT and CFFT. Across the locations and years the superior genotypes found under CVT were S01SIYQ, S01SIWQ-2 and Poshilo Makai-1 where as S99TLYQ-HG-AB, S99TLYQ-B and Poshilo Makai-1 were found superior genotypes under CFFT. The superior genotypes derived from CFFT will be promoted further for similar environments across the country

Performance evaluation of quality protein maize genotypes across various maize production agro ecologies of Nepal

ABSTRACT To identify superior quality protein maize genotypes for grain yield under different agro climatic conditions of terai and hill districts in Nepal, the coordinated varietal trials (CVT) were conducted at Dailekh, Doti, Salyan, Lumle and Pakhribas in 2013 and Salyan, Pakhribas and Kabre in 2014 during summer season and coordinated farmer's field trials (CFFT) at Surkhet and Dailekh in 2013 and Salyan, Pakhribas and Khumaltar in 2014 during summer season. The experiment was carried out using randomized complete block design with three replications for CVT and CFFT. Across the locations and years the superior genotypes found under CVT were S01SIYQ, S01SIWQ-2 and Poshilo Makai-1 where as S99TLYQ-HG-AB, S99TLYQ-B and Poshilo Makai-1 were found superior genotypes under CFFT. The superior genotypes derived from CFFT will be promoted further for similar environments across the country