A survey of the techniques of football line play in selected colleges

It was the purpose of this study (1) to determine the importance of techniques of line play in college football; and (2) to note by comparative analysis the viewpoints of leading authorities now in the coaching profession, and those of noted football authors

An induced-fit model for asymmetric organocatalytic reactions: a case study of the activation of olefins via chiral Brønsted acid catalysts

We elucidate the stereo-controlling factors of the asymmetric intramolecular hydroalkoxylation of terminal olefins catalyzed by bulky Brønsted acids [Science 2018, 359 (6383), 1501–1505] using high-level electronic structure methods. The catalyst–substrate interaction is described using a dispersion-driven induced-fit model, in which the conformational changes of the catalyst and of the substrate in the transition states are governed to a large extent by London dispersion forces. The distortion energy of the catalyst is dominated by the change in the intramolecular dispersion interactions, while intermolecular catalyst–substrate dispersion interactions are the major stabilizing contribution in the transition state. This model provides a new general framework in which to discuss the stereoselectivity of transformations catalyzed by such confined organocatalysts

Consulting with young people to inform systematic reviews: an example from a review on the effects of schools on health

Background: There has been increasing interest in involving the public in systematic reviews to help ensure the review is focused on issues that are important and relevant to them. Case examples of this involvement are rare, especially for reviews focused on children and young people. Objective: This study aims to describe the process and outcome of consulting with young people in a review of the effects of school environment interventions on children and young people’s health. Young people’s perspectives were sought alongside the perspectives of teachers, policy-makers and academics to determine the scope and priorities for review. Methods: Consultations were conducted with a pre-existing group of young people brought together to advise on public health research. Their views were sought at three stages: 1) at the beginning when general views relating to the policy problem under study were elicited; 2) half-way through when views on the map of identified evidence were sought; and 3) near the end when the review results were presented and discussed. Face to face to consultation methods were used, supplemented with online social networking for young people to continue discussion. Findings: Each consultation stage helped shape the review process. For example, the first and second consultations helped researchers understand the policy problem in its current context and informed the development of inclusion criteria for priority review areas. Face to face consultation was better at engaging young people but social networking gave the review team greater flexibility to elicit further views when unanticipated issues arose needing immediate input. Conclusion: Consulting with young people alongside other stakeholders added considerable value to the review, especially in terms of helping the review team to prioritise in a relevant and meaningful way. The use of a pre-existing group facilitated engagement, but the use of social networking requires further evaluation

Bone metastases mimicking Complex Regional Pain Syndrome I: a case report

INTRODUCTION: Since there are no valid tools available for the diagnosis of Complex Regional Pain Syndrome I, exclusion of other underlying conditions plays an important role in the diagnostic process. CASE PRESENTATION: A 77-year-old Caucasian man was referred with painful swelling and dysfunction of the right knee. Based on the history and clinical presentation, the referring physician assumed a case of Complex Regional Pain Syndrome I. However, after careful evaluation of the differential diagnosis, a metastatic urothelial carcinoma was diagnosed. CONCLUSION: Even if the clinical picture resembles Complex Regional Pain Syndrome I, the differential diagnosis must be evaluated carefully

A phase II study of capecitabine and oxalplatin combination chemotherapy in patients with inoperable adenocarcinoma of the gall bladder or biliary tract

Background: Advanced biliary tract carcinomas are associated with a poor prognosis, and palliative chemotherapy has only modest benefit. This multi-centre phase II study was conducted to determine the efficacy of capecitabine in combination with oxaliplatin in patients with inoperable gall bladder or biliary tract cancer. Methods: This was a Phase II, non-randomised, two-stage Simon design, multi-centre study. Ethics approval was sought and obtained by the North West MREC, and then locally by the West Glasgow Hospitals Research Ethics Com mittee. Eligible patients with inoperable locally advanced or metastatic adenocarcinoma of the gall bladder or biliary tract and with adequate performance status, haematologic, renal, and hepatic function were treated with capecit abine (1000 mg/m2 po, twice daily, days 1–14) and oxaliplatin (130 mg/m2 i.v., day 1) every 3 weeks for up to six cycles. The primary objective of the study was to determine the objective tumour response rates (complete and partial). The secondary objectives included assessment of toxicity, progression-free survival, and overall survival. Results: Forty-three patients were recruited between July 2003 and December 2005. The regimen was well tolerated with no grade 3/4 neutropenia or thrombocytopenia. Grade 3/4 sensory neuropathy was observed in six patients. Two-thirds of patients received their chemotherapy without any dose delays. Overall response rate was 23.8 % (95 % CI 12.05–39.5 %). Stable disease was observed in a further 13 patients (31 %) and progressive disease observed in 12 (28.6 %) of patients. The median progression-free survival was 4.6 months (95 % CI 2.8–6.4 months; Fig. 1) and the median overall survival 7.9 months (95 % CI 5.3–10.4 months; Fig. 2). Conclusion: Capecitabine combined with oxaliplatin has a lower disease control and shorter overall survival than the combination of cisplatin with gemcitabine which has subsequently become the standard of care in this disease. How ever, capecitabine in combination with oxaliplatin does have modest activity in this disease, and can be considered as an alternative treatment option for patients in whom cisplatin and/or gemcitabine are contra-indicated

Move More, Sit Less: Applying the Physical Activity Guidelines for Americans to Extension Programs

Extension enhances the lives of Americans by translating research-based information related to existing needs into programming that is practical and accessible to the general public. Evidence clearly indicates that physical activity is correlated to positive health outcomes, but despite this conclusion, the majority of Americans do not meet the recommendations for physical activity. The 2nd Edition of the Physical Activity Guidelines for Americans provides guidance for Extension professionals to implement physical activity interventions. We recommend training and technical assistance strategies based on the Interactive Systems Framework to integrate physical activity promotion into all Extension areas

Self-dual Ginzburg-Landau vortices in a disk

We study the properties of the Ginzburg-Laundau model in the self-dual point for a two-dimensional finite system . By a numerical calculation we analyze the solutions of the Euler-Lagrange equations for a cylindrically symmetric ansatz. We also study the self-dual equations for this case. We find that the minimal energy configurations are not given by the Bogomol'nyi equations but by solutions to the Euler Lagrange ones. With a simple approximation scheme we reproduce the result of the numerical calculation.Comment: 8 pages, 4 figures, RevTex macro

Mechanical robustness of HL-LHC collimator designs

Two new absorbing materials were developed as collimator inserts to fulfil the requirements of HL-LHC higher brightness beams: molybdenum-carbide graphite (MoGr) and copper-diamond (CuCD). These materials were tested under intense beam impacts at CERN HiRadMat facility in 2015, when full jaw prototypes were irradiated. Additional tests in HiRadMat were performed in 2017 on another series of material samples, including also improved grades of MoGr and CuCD, and different coating solutions. This paper summarizes the main results of the two experiments, with a main focus on the behaviour of the novel composite blocks, the metallic housing, as well as the cooling circuit. The experimental campaign confirmed the final choice for the materials and the design solutions for HL-LHC collimators, and constituted a unique chance of benchmarking numerical models. In particular, the tests validated the selection of MoGr for primary and secondary collimators, and CuCD as a valid solution for robust tertiary collimators

Dynamics of viscoelastic membranes

We determine both the in-plane and out-of-plane dynamics of viscoelastic membranes separating two viscous fluids in order to understand microrheological studies of such membranes. We demonstrate the general viscoelastic signatures in the dynamics of shear, bending, and compression modes. We also find a screening of the otherwise two-dimensional character of the response to point forces due to the presence of solvent. Finally, we show that there is a linear, hydrodynamic coupling between the in-plane compression modes of the membrane and the out-of-plane bending modes in the case where the membrane separates two different fluids or environments