Developing a relationship between static Young’s modulus and seismic parameters

Mechanical properties of petroleum reservoirs can be determined via static techniques based on laboratory triaxial tests under reservoir conditions. Dynamic approaches represent an alternative in cases where such static laboratory data are unavailable. Dynamic elastic properties are calculated using ultrasonic wave measurements in the laboratory or in situ well logging. Different relationships have been proposed to estimate static properties from dynamic ones based on the available data from a particular reservoir. However, these relationships are often reservoir-specific, making them inadequate for general seismic inversion purposes. This research proposes a method for developing relationships between seismic parameters and static Young’s modulus in carbonate reservoirs by integrating ultrasonic measurements, well logging data, and rock mechanic tests. A multistage triaxial test simulating the reservoir conditions was used to fully control the stress and strain during the geomechanical experiments. Static Young’s modulus was cross-correlated with a broad spectrum of seismic parameters that can be extracted from seismic inversion (e.g., acoustic impedance, shear impedance, Lambda–rho, and mu–rho). Separate analytic relationships were proposed to convert dynamic Young’s modulus and seismic parameters into static Young’s modulus. Analysis of variance was used to evaluate the results and study the applicability and reliability of the obtained relationships. Furthermore, the reliability of the obtained relationships was successfully confirmed by well logging data and blind well analysis. The proposed methodology can be used to predict rock behavior for geomechanical and structural modeling

Hypoxic Culture Conditions as a Solution for Mesenchymal Stem Cell Based Regenerative Therapy

Cell-based regenerative therapies, based on in vitro propagation of stem cells, offer tremendous hope to many individuals suffering from degenerative diseases that were previously deemed untreatable. Due to the self-renewal capacity, multilineage potential, and immunosuppressive property, mesenchymal stem cells (MSCs) are considered as an attractive source of stem cells for regenerative therapies. However, poor growth kinetics, early senescence, and genetic instability during in vitro expansion and poor engraftment after transplantation are considered to be among the major disadvantages of MSC-based regenerative therapies. A number of complex inter- and intracellular interactive signaling systems control growth, multiplication, and differentiation of MSCs in their niche. Common laboratory conditions for stem cell culture involve ambient O2 concentration (20%) in contrast to their niche where they usually reside in 2–9% O2. Notably, O2 plays an important role in maintaining stem cell fate in terms of proliferation and differentiation, by regulating hypoxia-inducible factor-1 (HIF-1) mediated expression of different genes. This paper aims to describe and compare the role of normoxia (20% O2) and hypoxia (2–9% O2) on the biology of MSCs. Finally it is concluded that a hypoxic environment can greatly improve growth kinetics, genetic stability, and expression of chemokine receptors during in vitro expansion and eventually can increase efficiency of MSC-based regenerative therapies

Learning to extrapolate using continued fractions: Predicting the critical temperature of superconductor materials

In Artificial Intelligence we often seek to identify an unknown target function of many variables $y=f(\mathbf{x})$ giving a limited set of instances $S=\{(\mathbf{x^{(i)}},y^{(i)})\}$ with $\mathbf{x^{(i)}} \in D$ where $D$ is a domain of interest. We refer to $S$ as the training set and the final quest is to identify the mathematical model that approximates this target function for new $\mathbf{x}$; with the set $T=\{ \mathbf{x^{(j)}} \} \subset D$ with $T \neq S$ (i.e. thus testing the model generalisation). However, for some applications, the main interest is approximating well the unknown function on a larger domain $D'$ that contains $D$. In cases involving the design of new structures, for instance, we may be interested in maximizing $f$; thus, the model derived from $S$ alone should also generalize well in $D'$ for samples with values of $y$ larger than the largest observed in $S$. In that sense, the AI system would provide important information that could guide the design process, e.g., using the learned model as a surrogate function to design new lab experiments. We introduce a method for multivariate regression based on iterative fitting of a continued fraction by incorporating additive spline models. We compared it with established methods such as AdaBoost, Kernel Ridge, Linear Regression, Lasso Lars, Linear Support Vector Regression, Multi-Layer Perceptrons, Random Forests, Stochastic Gradient Descent and XGBoost. We tested the performance on the important problem of predicting the critical temperature of superconductors based on physical-chemical characteristics.Comment: Submitted to IEEE Transactions on Artificial Intelligence (TAI

Effect of brine-CO2 fracture flow on velocity and electrical resistivity of naturally fractured tight sandstones

Fracture networks inside geological CO2 storage reservoirs can serve as primary fluid flow conduit, particularly in low-permeability formations. While some experiments focused on the geophysical properties of brine- and CO2-saturated rocks during matrix flow, geophysical monitoring of fracture flow when CO2 displaces brine inside the fracture seems to be overlooked. We have conducted laboratory geophysical monitoring of fluid flow in a naturally fractured tight sandstone during brine and liquid CO2 injection. For the experiment, the low-porosity, low-permeability naturally fractured core sample from the Triassic De Geerdalen Formation was acquired from the Longyearbyen CO2 storage pilot at Svalbard, Norway. Stress-dependence, hysteresis and the influence of fluid-rock interactions on fracture permeability were investigated. The results suggest that in addition to stress level and pore pressure, mobility and fluid type can affect fracture permeability during loading and unloading cycles. Moreover, the fluid-rock interaction may impact volumetric strain and consequently fracture permeability through swelling and dry out during water and CO2 injection, respectively. Acoustic velocity and electrical resistivity were measured continuously in the axial direction and three radial levels. Geophysical monitoring of fracture flow revealed that the axial P-wave velocity and axial electrical resistivity are more sensitive to saturation change than the axial S-wave, radial P-wave, and radial resistivity measurements when CO2 was displacing brine, and the matrix flow was negligible. The marginal decreases of acoustic velocity (maximum 1.6% for axial Vp) compared to 11% increase in axial electrical resistivity suggest that in the case of dominant fracture flow within the fractured tight reservoirs, the use of electrical resistivity methods have a clear advantage compared to seismic methods to monitor CO2 plume. The knowledge learned from such experiments can be useful for monitoring geological CO2 storage where the primary fluid flow conduit is fracture network.acceptedVersio

Spawning season and size at first sexual maturity of freshwater mussel Lamellidens marginalis (Lamarck, 1819) in the Brahmaputra River, Bangladesh

Spawning season and size at first sexual maturity of Freshwater mussel Lamellidens marginalis was studied from the specimens collected from Brahmaputra River, Mymensingh district, Bangladesh from July 2015 to June 2016. The present study has investigated sex ratios, gamogenetic cycle, condition index, and size at first sexual maturity by means of standard histological procedures. The results indicated no significant difference in the overall sex ratio (M: F = 1:1.3). The qualitative analysis of gonad developmental stages has provided confirmation of the presence of a yearly reproductive cycle characterized by prolonged gonadal activity. The highest percentages of ripe gonads were observed in July for males (77.78%) and August for females (53.85%). The spawning activity was highest in October for males (50%) and November for females (83.33%). Furthermore, ripening and spawning stages in different shell lengths ranged from 58–63 to 88–93 mm for both sexes. The findings from the qualitative observation of gonad developmental stages, a single annual spawning peak observed between October and November. A statistically significant correlation was detected between the average condition index of male and female. Males reached sexual maturity at smaller standard length (SL50 = 63.25 mm) compared to females (SL50 = 72.10 mm SL). Acquired knowledge regarding the present state and distinctive gonad developmental characteristics of L. marginalis will aid fisheries management professionals and conservation biologist in the effective management of this particular species of mussels in the waters of Bangladesh

Coronavirus disease 2019 and future pandemics: Impacts on livestock health and production and possible mitigation measures

The World Health Organization declared coronavirus disease 2019 (COVID-19) a pandemic on March 11, 2020. COVID-19, the current global health emergency, is wreaking havoc on human health systems and, to a lesser degree, on animals globally. The outbreak has continued since the first report of COVID-19 in China in December 2019, and the second and third waves of the outbreak have already begun in several countries. COVID-19 is expected to have adverse effects on crop production, food security, integrated pest control, tourism, the car industry, and other sectors of the global economy. COVID-19 induces a range of effects in livestock that is reflected economically since human health and livelihood are intertwined with animal health. We summarize the potentially harmful effects of COVID-19 on livestock and possible mitigation steps in response to this global outbreak. Mitigation of the negative effects of COVID-19 and future pandemics on livestock requires the implementation of current guidelines

International manufacturing and trade in colistin, its implications in colistin resistance and One Health global policies: a microbiological, economic, and anthropological study

Background The emergence of colistin-resistant Enterobacterales is a global public health concern, yet colistin is still widely used in animals that are used for food as treatment, metaphylaxis, prophylaxis, and growth promotion. Herein, we investigate the effect of colistin-resistant Enterobacterales in Pakistan, global trade of colistin, colistin use at the farm level, and relevant socioeconomic factors. Methods We conducted a microbiological, economic, and anthropological study of colistin-resistant Escherichia coli in humans, animals, and the environment and international trade and knowledge of colistin in Pakistan, Bangladesh, Nigeria, China, India, and Viet Nam. We collected backyard poultry cloacal swabs, commercial broiler cloacal swabs, cattle and buffalo rectal swabs, human rectal swabs, wild bird droppings, cattle and buffalo meat, sewage water, poultry flies, chicken meat, and canal water from 131 sites across Faisalabad, Pakistan, to be tested for mcr-1-positive and mcr-3-positive Escherichia coli. We recruited new patients admitted to Allied Hospital, Faisalabad, Pakistan, with abdominal pain and diarrhoea for rectal swabs. Patients with dysentery and those who were already on antibiotic treatment were excluded. Data for colistin trade between 2017 and 2020, including importation, manufacturing, and usage, were accessed from online databases and government sources in Pakistan, Bangladesh, and Nigeria. We recruited participants from poultry farms and veterinary drug stores in Pakistan and Nigeria to be interviewed using a structured questionnaire. International manufacturing, import, and export data; value analysis; and trade routes of colistin pharmaceutical raw material (PRM), feed additive, and finished pharmaceutical products (FPPs) were accessed from 2017–21 export data sets. Findings We collected 1131 samples between May 12, 2018, and July 1, 2019: backyard poultry cloacal swabs (n=100), commercial broiler cloacal swabs (n=102), cattle and buffalo rectal swabs (n=188), human rectal swabs (n=200), wild bird droppings (n=100), cattle and buffalo meat (n=100), sewage water (n=90), poultry flies (n=100), chicken meat (n=100), and canal water (n=51). We recruited 200 inpatients at Allied Hospital, Faisalabad, Pakistan, between Nov 15, 2018, and Dec 14, 2018, for rectal swabs. We recruited 21 participants between Jan 1, 2020, and Dec 31, 2020, from poultry farms and drug stores in Pakistan and Nigeria to be interviewed. 75 (7%) of 1131 samples contained mcr-1-positive E coli, including wild bird droppings (25 [25%] of 100), commercial broiler cloacal swabs (17 [17%] of 100), backyard poultry cloacal swabs (one [1%] of 100), chicken meat (13 [13%] of 100), cattle and buffalo meat (two [2%] of 100), poultry flies (eight [8%] of 100), sewage water (six [7%] of 90), and human rectal swabs (three [2%] of 200). During 2017–20, Pakistan imported 275·5 tonnes (68·9 tonnes per year, 95% CI 41·2–96·6) of colistin as PRM, all sourced from China, 701·9 tonnes (175·5 tonnes per year, 140·9–210·1) of colistin as feed additives from China and Viet Nam, and 63·0 tonnes (15·8 tonnes per year, 10·4–21·1) of colistin as FPPs from various countries in Asia and Europe. For Bangladesh and Nigeria, colistin PRM and FPPs were imported from China and Europe. Colistin knowledge and usage practices in Pakistan and Nigeria were unsatisfactory in terms of understanding of the effects on human medicine and usage other than for treatment purposes. China is the major manufacturer of PRM and feed additive colistin and exported a total of 2664·8 tonnes (666·2 tonnes per year, 95% CI 262·1 to 1070·2) of PRM and 2570·2 tonnes (642·6 tonnes per year, –89·4 to 1374·5) of feed additive in 1330 shipments during 2018–21 to 21 countries. Interpretation Regardless of 193 countries signing the UN agreement to tackle antimicrobial resistance, trading of colistin as PRM, FPPs, and feed additive or growth promoter in low-income and middle-income countries continues unabated. Robust national and international laws are urgently required to mitigate the international trade of this antimicrobial listed on WHO Critically Important Antimicrobials for Human Medicine

Clinical Profile and Management of Oral Cancer Patients in a Tertiary Care Hospital in Bangladesh

Introduction: Oral cavity cancer is the 11th most common cancer worldwide, and the incidence rate of lip & oral cavity cancer in Bangladesh in 2020 was 8.9%. The National Institute of Cancer Research and Hospital (NICRH) is a specialized hospital for cancer patient care where all treatment modalities are available. This study was conducted in the faciomaxillary surgical oncology department (FMSO) to see the patient profile and management of oral cancer patients at NIRCH. Materials and methods: This observational study was carried out from January 2017 to December 2020 with hitopathologically proven oral cancer patients. Data of outdoor patients were collected from the OPD and tumor board registers, and indoor patient’s data were collected from the discharge register. Relevant variables were included in the data collection, such as epidemiological features (age, sex) and clinicopathological data (primary site of tumor, disease pattern, TNM staging, presentation status, management of patients by tumor board decision, and surgical management). Collected data were summarized and analyzed by statistical package for the social science SPSS (version 24.0) and results were presented in table, chart, and graph form. Results: A total of 6869 patients were enrolled in the study, where 55% were female and 45% were male, with a male to female ratio of 0.82:1. Buccal mucosa was the most common site (44%) followed by lower gingivo-buccal sulcus (21%). Eighty-eight percent of the total cases were squamous cell carcinoma. Early-stage lesions were only 6% whereas advanced-stage lesions were 94%. Among preoperative patients, 1992 (29%) were operable and 4877 (71%) were inoperable. The tumor board decided nearly 50% of patients for chemo-radiation, 10% for surgery and radiotherapy each. Among the operable patients, only 244 (20%) were operated on in our department in a four-year period. Conclusion: It is evident from this study that most of the patients present in the advanced stage illustrate the necessity for the inclusion of oral health care in primary health care by the government for early detection of oral cancer in Bangladesh