Prevalence of Parental refusal rate and its associated factors in routine immunization by using WHO Vaccine Hesitancy tool: A Cross sectional study at district Bannu, KP, Pakistan

Objective To determine the parents refusal rate, associated factors and the perceptions of refusal parents in routine immunization by using “WHO SAGE Working Group on Vaccine Hesitancy survey tool”. Material and Methods A cross sectional survey was conducted by using multi stage cluster sampling at the remote district Bannu Khyber Pakhtunkhwa Province, Pakistan from March 2019 to July 2019.A WHO validated questionaire was used. Our outcome variable was “Ever refusal from routine immunization (yes/No)”.logistic regression was run for association and multi regression was applied to see counfounders. Result Out of total 610 parents, the refusal rate was 170(27.9%).Mostly the mother of the children has no education 145(85.3%,P 0.03).Mother has no mobile but the father has 152(89.4%, p=<.001) higher frequency to have mobile. The refusal rate was high in those having secure food 88(51.8%) as compare to minimal 62(36.5%) and highly insecure food 20(11.8%,P=<.05).On multivariate logistic regression, those father who were employee (adjusted OR = 0.59; 95% CI 0.37 to 0.94; p = 0.02) and having higher education (adjusted OR = 0.21; 95% CI 0.08 to 0.50; p=<.001) were less likely to refuse to vaccinate their children while in contrast those having highly insecure food were more likely to refuse (adjusted OR = 2.2; 95% CI 1.0 to 0.50; p = 0.04) as compare to minimal insecure food (adjusted OR = 1.6; 95% CI 1.0 to 2.5; p = 0.02). Conclusion Refusal rate among parents was very high while those parents who’s can’t read or write and with no education, having mobile phone, unemployment and secure food were more to be associated with refusal

A case report and brief literature review of Klippel-Tr&amp;eacute;naunay syndrome

Madan Gopal Choudhary, Zia Ul Haq, Ram Narayan Sehra, Chandra Kumar ChaharDepartment of Paediatrics, Sardar Patel Medical College and P.B.M Hospital, Rajasthan, IndiaAbstract: Klippel-Tr&amp;eacute;naunay syndrome is a rare disorder characterized by the triad of vascular malformations, venous varicosities, and bone and soft-tissue hypertrophy. We present a case of Klippel-Tr&amp;eacute;naunay syndrome with limb hypertrophy, port-wine stains, angiokeratoma, and venous varicosities in the limbs.Keywords: Klippel-Tr&amp;eacute;naunay syndrome, sporadic, venous varicosities, port-wine stain, angiokeratom

Nano-biotechnology: a new approach to treat and prevent malaria

Khaista Rahman,1,* Shahid Ullah Khan,2,* Shah Fahad,2,3 Ming Xian Chang,4,5 Aqleem Abbas,6 Wasim Ullah Khan,7 Lutfur Rahman,8 Zaheer Ul Haq,9 Ghulam Nabi,4,5 Dilfaraz Khan10 1College of Animal Sciences/State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China; 2College of Plant Sciences and Technology/National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China; 3Department of Agriculture, The University of Swabi, Khyber Pakhtunkhwa, Anbar, Pakistan; 4State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, the Chinese Academy of Sciences, Wuhan 430072, Hubei, China; 5University of the Chinese Academy of Sciences, Shijingshan District, Beijing, China; 6Provincial Key Lab of Plant Pathology of Hubei Province, Huazhong Agricultural University, Hongshan District, Wuhan 430070, China; 7School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou, China; 8Molecular Systematics &amp; Applied Ethno Botany Lab (MoSEL), Department of Biotechnology, Quaid I Azam University, Islamabad, Pakistan; 9School of Chemistry and Chemical Engineering, Shanghai Jiao tong University, Shanghai, China; 10Institute of Chemical Sciences, Gomal University, Dera Ismail Khan, Pakistan *These authors contributed equally to this work Abstract: Malaria, the exterminator of ~1.5 to 2.7 million human lives yearly, is a notorious disease known throughout the world. The eradication of this disease is difficult and a challenge to scientists. Vector elimination and effective chemotherapy for the patients are key tactics to be used in the fight against malaria. However, drug resistance and environmental and social concerns are the main hurdles in this fight against malaria. Overcoming these limitations is the major challenge for the 21st-century malarial researchers. Adapting the principles of nano-biotechnology to both vector control and patient therapy is the only solution to the problem. Several compounds such as lipids, proteins, nucleic acid and metallic nanoparticles (NPs) have been successfully used for the control of this lethal malaria disease. Other useful natural reagents such as microbes and their products, carbohydrates, vitamins, plant extracts and biodegradable polymers, are also used to control this disease. Among these particles, the plant-based particles such as leaf, root, stem, latex, and seed give the best antagonistic response against malaria. In the present review, we describe certain efforts related to the control, prevention and treatment of malaria. We hope that this review will open new doors for malarial research. Keywords: malaria, vectors, chemotherapy, drug resistance, nano-biotechnolog

First-principles study of structural, electronic and thermoelectric properties of nidoped Bi2 Se3

Direct conversion of waste heat to electrical energy could address present energy challenges. Bi2 Se3 is one of few thermoelectric materials known to operate at room temperature. Comprehensive analysis using density functional theory was conducted to explore the effect of nickel doping on structural, electronic, and thermoelectric properties of Bi2 Se3 . Local density approximation (LDA) was used with an addition of spin-orbit coupling (SOC) and van der Waals interaction scheme consideration. Analysis of the effect of SOC was elaborated. It was found that nickel has changed the crystal structure of Bi2 Se3 . Nickel has also changed band structure and density of state that alter the thermoelectric performance. The decreased band gap has decreased the thermopower. However, it gives advantages to the improvement of electrical conductivity. Higher electrical conductivity has risen thermal conductivity. Despite the decreased thermopower and increased thermal conductivity, the higher electrical conductivity has improved the overall thermoelectric performance of Bi2 Se3 when nickel is introduced

Enhanced mechanism of thermoelectric performance of Bi2Se3 using density functional theory

Good thermoelectric performance is being sought to face major problems related to energy, especially in the concern of the usage of energy on environmental impact. In this work, we investigate the underlying mechanism to enhance the thermoelectric performance of bismuth selenide (Bi2Se3) by employing density functional theory (DFT) followed by the Boltzmann transport equation under relaxation time approximation. The structural, electronic, and thermoelectric properties were calculated and analyzed. From the analysis of combined results of thermoelectric properties and electronic properties as the function of the Fermi level, we found that the power factor of Bi2Se3 is improved by increasing electrical conductivity that contributed by the large density of states and light effective mass of charge carriers. The figure of merit, on the other hand, is enhanced by increasing Seebeck coefficient that contributed by heavy effective mass and decreasing thermal conductivity that contributed by low density of states. We also found that both power factor and figure of merit can be improved through n-type doping at 300 K and p-type doping at higher temperature (400 K and 500 K)

Path Relinking for a Constrained Simulation-Optimization Team Scheduling Problem Arising in Hydroinformatics

We apply Path Relinking to a real life constrained optimization problem concerning the scheduling of technicians due to activate on site devices located on a water distribution network in case of a contamination event, in order to reduce the amount of consumed contaminated water. Teams travel on the road network when moving from one device to the next, as in the Multiple Traveling Salesperson Problem. The objective, however, is not minimizing travel time but the minimization of consumed contaminated water. This is computed through a computationally demanding simulation given the devices activation times. We propose alternative Path Relinking search strategies exploiting time-based and precedence-based neighborhoods, and evaluate the improvement gained by coupling Path Relinking with state of the art, previously developed, hybrid Genetic Algorithms. Experimental results on a real network are provided to support the efficacy of the methodology