Present and Future: Crosstalks Between Polycystic Ovary Syndrome and Gut Metabolites Relating to Gut Microbiota

Polycystic ovary syndrome (PCOS) is a common disease, affecting 8%–13% of the females of reproductive age, thereby compromising their fertility and long-term health. However, the pathogenesis of PCOS is still unclear. It is not only a reproductive endocrine disease, dominated by hyperandrogenemia, but also is accompanied by different degrees of metabolic abnormalities and insulin resistance. With a deeper understanding of its pathogenesis, more small metabolic molecules, such as bile acids, amino acids, and short-chain fatty acids, have been reported to be involved in the pathological process of PCOS. Recently, the critical role of gut microbiota in metabolism has been focused on. The gut microbiota-related metabolic pathways can significantly affect inflammation levels, insulin signaling, glucose metabolism, lipid metabolism, and hormonal secretions. Although the abnormalities in gut microbiota and metabolites might not be the initial factors of PCOS, they may have a significant role in the pathological process of PCOS. The dysbiosis of gut microbiota and disturbance of gut metabolites can affect the progression of PCOS. Meanwhile, PCOS itself can adversely affect the function of gut, thereby contributing to the aggravation of the disease. Inhibiting this vicious cycle might alleviate the symptoms of PCOS. However, the role of gut microbiota in PCOS has not been fully explored yet. This review aims to summarize the potential effects and modulative mechanisms of the gut metabolites on PCOS and suggests its potential intervention targets, thus providing more possible treatment options for PCOS in the future

Toxicity of microplastics and nanoplastics: invisible killers of female fertility and offspring health

Microplastics (MPs) and nanoplastics (NPs) are emergent pollutants, which have sparked widespread concern. They can infiltrate the body via ingestion, inhalation, and cutaneous contact. As such, there is a general worry that MPs/NPs may have an impact on human health in addition to the environmental issues they engender. The threat of MPs/NPs to the liver, gastrointestinal system, and inflammatory levels have been thoroughly documented in the previous research. With the detection of MPs/NPs in fetal compartment and the prevalence of infertility, an increasing number of studies have put an emphasis on their reproductive toxicity in female. Moreover, MPs/NPs have the potential to interact with other contaminants, thus enhancing or diminishing the combined toxicity. This review summarizes the deleterious effects of MPs/NPs and co-exposure with other pollutants on female throughout the reproduction period of various species, spanning from reproductive failure to cross-generational developmental disorders in progenies. Although these impacts may not be directly extrapolated to humans, they do provide a framework for evaluating the potential mechanisms underlying the reproductive toxicity of MPs/NPs

Numerical Simulation of Steel-Reinforced Reactive Powder Concrete Beam Based on Bond-Slip

In this study, based on the concrete damaged plasticity (CDP) model in the ABAQUS software, various plastic damage factor calculation methods were introduced to obtain CDP parameters suitable for reactive powder concrete (RPC) materials. Combined with the existing tests for the bending performance of steel-reinforced RPC beams, the CDP parameters of the RPC material were input into ABAQUS to establish a finite element model considering the bond and slip between the steel and RPC for numerical simulation. The load-deflection curve obtained by the simulation was compared with the measured curve in the experiment. The results indicated that on the basis of the experimentally measured RPC material eigenvalue parameters, combined with the appropriate RPC constitutive relationship and the calculation method of the plastic damage factor, the numerical simulation results considering the bond-slip were in good agreement with the experimental results with a deviation of less than 10%. Thus, it is recommended to select a gentle compressive stress-strain curve in the descending section, an approximate strengthening model of the tensile stress-strain curve, and to use the energy loss method and Sidoroff’s energy equivalence principle to calculate the RPC plastic damage parameters

Temperature Field and Gradient Effect of a Steel-Concrete Composite Box Girder Bridge

To study the effect of the temperature field and gradient of a steel-concrete composite box girder bridge, a 5 × 35 continuous composite box girder bridge is used as the research object. The temperature measuring point is set by selecting a typical cross section, and the temperature change data are measured. The temperature field of the different positions in the composite box girder bridge is studied, the global and local temperature differences are compared, and the law of temperature distribution and the main factors affecting the temperature field are formulated. The most unfavourable expression function of the vertical temperature gradient of the section is simulated using the measured data, the existing standard temperature gradient mode is compared, the finite element model of the bridge is established, and the influence of the actual temperature gradient mode on the stress and deformation of the composite girder is further analysed. The conclusions show that the temperature differences of different azimuth sections and the local temperature differences between the steel and concrete joint parts of the steel-concrete composite box girder bridge are not significant. The temperature gradient heating and cooling model fitted by the measured temperature field can be used as a reference for the structural design of similar local bridges

Vertical Gradient Temperature Difference of the Main Arch with Single Pipe Section in Tibet Based on Statistical Analysis

A 75 m long experimental arch with a 1.6 m diameter was constructed in Tibet for a one-year test to determine the most unfavourable vertical temperature difference for a single pipe in the main arch of a concrete-filled steel tube arch bridge. Actual temperature observation data were used to analyse the vertical temperature difference in the single circular pipe arch rib using statistical methods. The standard value for the vertical temperature difference in the single pipe under a return period of 50 years was calculated. The results showed that the influence range of the vertical gradient temperature was 25 cm. The vertical temperature difference followed a lognormal distribution, and the standard values of the positive temperature difference at the upper and lower ends of the single pipe were 16 and 10°C, respectively; the standard values of the negative temperature difference at the upper and lower ends of the single pipe were both -8°C under a return period of 50 years. These results are considerably different from the values specified in the current Chinese code. These could serve as references for calculations involving arch bridges in Tibet with single circular pipes in the main arches

Quantitative liquid storage by billiards‐like droplet collision on surfaces with patterned wettability

Abstract There has been significant interest in researching droplet transport behavior on composite wetting surfaces. However, current research is primarily focused on modifying individual droplets and lacks an in‐depth investigation into high‐precision droplet storage. This study introduces a “billiard ball” droplet transport and storage platform (TSP) with differentiated areas. Within this platform, the volume of droplets stored in the area reaches a consistent threshold through droplet “scrambling,” inspired by the water‐gathering behavior of spiders. The TSP involves connecting two regions of different sizes using a three‐dimensional stepped wedge angle structure. However, this connection is not seamless, leaving a 2‐mm gap between the regions. This gap is intentionally designed to enable continuous droplet transfer while preventing any static migration. Through systematic experimental and simulation analysis, we investigated the influence of superhydrophilic pattern structures and parameters on quantitative droplet storage. We established a functional relationship between the pattern area and the stored volume, and analyzed the intrinsic mechanism of droplet collision separation. This enabled us to achieve on‐demand quantitative droplet storage and autonomize the storage process. The “billiard ball” droplet transport–storage platform proposed in this study holds promising applications in the fields of biomedical and organic chemistry

Electrolytic Manganese Residue-Modified Asphalt Performance Test and Micromechanism Analysis

The aim of this paper is to study the feasibility of using an electrolytic manganese residue (EMR) as modified asphalt. In this paper, after grinding the electrolytic manganese residue (EMR) into asphalt, the electrolytic manganese residue- (EMR-) modified asphalt was prepared with different mix ratios. The three major indicators of the modified asphalt were studied, and its modification mechanism was studied by differential scanning calorimetry, infrared spectroscopy, and atomic force microscopy. The adhesion force, surface energy, and dissipation energy of the asphalt before and after modification were analyzed by a force curve. The results show that the surface energy of the electrolytic manganese residue (EMR) is increased after grinding, the high temperature performance of the asphalt is improved, and the temperature sensitivity of the asphalt is decreased; however, the low-temperature performance is not improved obviously. When the powder oil ratio is 9%, the comprehensive performance of the asphalt is the best. The results of the infrared spectrum analysis show that the mixture of the electrolytic manganese residue (EMR) and asphalt does not produce new functional groups, and thus, the preparation method is a physical modification method. The differential scanning calorimetry (DSC) results show that the electrolytic manganese residue (EMR) can enhance the high-temperature stability of asphalt. It is found that the stability and antideformation ability of the modified asphalt improved

A Z-axis Quartz Cross-fork Micromachined Gyroscope Based on Shear Stress Detection

Here we propose a novel quartz micromachined gyroscope. The sensor has a simple cross-fork structure in the x-y plane of quartz crystal. Shear stress rather than normal stress is utilized to sense Coriolis’ force generated by the input angular rate signal. Compared to traditional quartz gyroscopes, which have two separate sense electrodes on each sidewall, there is only one electrode on each sidewall of the sense beam. As a result, the fabrication of the electrodes is simplified and the structure can be easily miniaturized. In order to increase sensitivity, a pair of proof masses is attached to the ends of the drive beam, and the sense beam has a tapered design. The structure is etched from a z-cut quartz wafer and the electrodes are realized by direct evaporation using the aperture mask method. The drive mode frequency of the prototype is 13.38 kHz, and the quality factor is approximately 1,000 in air. Therefore, the gyroscope can work properly without a vacuum package. The measurement ability of the shear stress detection design scheme is validated by the Coriolis’ force test. The performance of the sensor is characterized on a precision rate table using a specially designed readout circuit. The experimentally obtained scale factor is 1.45 mV/°/s and the nonlinearity is 3.6% in range of ±200 °/s

A Z-axis Quartz Cross-fork Micromachined Gyroscope Based on Shear Stress Detection

Here we propose a novel quartz micromachined gyroscope. The sensor has a simple cross-fork structure in the x-y plane of quartz crystal. Shear stress rather than normal stress is utilized to sense Coriolis’ force generated by the input angular rate signal. Compared to traditional quartz gyroscopes, which have two separate sense electrodes on each sidewall, there is only one electrode on each sidewall of the sense beam. As a result, the fabrication of the electrodes is simplified and the structure can be easily miniaturized. In order to increase sensitivity, a pair of proof masses is attached to the ends of the drive beam, and the sense beam has a tapered design. The structure is etched from a z-cut quartz wafer and the electrodes are realized by direct evaporation using the aperture mask method. The drive mode frequency of the prototype is 13.38 kHz, and the quality factor is approximately 1,000 in air. Therefore, the gyroscope can work properly without a vacuum package. The measurement ability of the shear stress detection design scheme is validated by the Coriolis’ force test. The performance of the sensor is characterized on a precision rate table using a specially designed readout circuit. The experimentally obtained scale factor is 1.45 mV/°/s and the nonlinearity is 3.6% in range of ±200 °/s