39 research outputs found
Airworthiness Compliance Verification Method Based on Simulation of Complex System
AbstractA study is conducted on a new airworthiness compliance verification method based on pilot-aircraft-environment complex system simulation. Verification scenarios are established by “block diagram” method based on airworthiness criteria. A pilot-aircraft-environment complex model is set up and a virtual flight testing method based on connection of MATLAB/Simulink and Flightgear is proposed. Special researches are conducted on the modeling of pilot manipulation stochastic parameters and manipulation in critical situation. Unfavorable flight factors of certain scenario are analyzed, and reliability modeling of important system is researched. A distribution function of small probability event and the theory on risk probability measurement are studied. Nonlinear function is used to depict the relationship between the cumulative probability and the extremum of the critical parameter. A synthetic evaluation model is set up, modified genetic algorithm (MGA) is applied to ascertaining the distribution parameter in the model, and a more reasonable result is obtained. A clause about vehicle control functions (VCFs) verification in MIL-HDBK-516B is selected as an example to validate the practicability of the method
DETRs with Hybrid Matching
One-to-one set matching is a key design for DETR to establish its end-to-end
capability, so that object detection does not require a hand-crafted NMS
(non-maximum suppression) to remove duplicate detections. This end-to-end
signature is important for the versatility of DETR, and it has been generalized
to broader vision tasks. However, we note that there are few queries assigned
as positive samples and the one-to-one set matching significantly reduces the
training efficacy of positive samples. We propose a simple yet effective method
based on a hybrid matching scheme that combines the original one-to-one
matching branch with an auxiliary one-to-many matching branch during training.
Our hybrid strategy has been shown to significantly improve accuracy. In
inference, only the original one-to-one match branch is used, thus maintaining
the end-to-end merit and the same inference efficiency of DETR. The method is
named H-DETR, and it shows that a wide range of representative DETR methods can
be consistently improved across a wide range of visual tasks, including
DeformableDETR, PETRv2, PETR, and TransTrack, among others. The code is
available at: https://github.com/HDETRComment: CVPR 2023. The code is available at: https://github.com/HDET
Effective noninvasive zygosity determination by maternal plasma target region sequencing
Background: Currently very few noninvasive molecular genetic approaches are available to determine zygosity for twin pregnancies in clinical laboratories. This study aimed to develop a novel method to determine zygosity by using maternal plasma target region sequencing. Methods: We constructed a statistic model to calculate the possibility of each zygosity type using likelihood ratios (Li) and empirical dynamic thresholds targeting at 4,524 single nucleotide polymorphisms (SNPs) loci on 22 autosomes. Then two dizygotic (DZ) twin pregnancies, two monozygotic (MZ) twin pregnancies and two singletons were recruited to evaluate the performance of our novel method. Finally we estimated the sensitivity and specificity of the model in silico under different cell-free fetal DNA (cff-DNA) concentration and sequence depth. Results/Conclusions: We obtained 8.90 Gbp sequencing data on average for six clinical samples. Two samples were classified as DZ with L values of 1.891 and 1.554, higher than the dynamic DZ cut-off values of 1.162 and 1.172, respectively. Another two samples were judged as MZ with 0.763 and 0.784 of L values, lower than the MZ cut-off values of 0.903 and 0.918. And the rest two singleton samples were regarded as MZ twins, with L values of 0.639 and 0.757, lower than the MZ cut-off values of 0.921 and 0.799. In silico, the estimated sensitivity of our noninvasive zygosity determination was 99.90% under 10% total cff-DNA concentration with 2 Gbp sequence data. As the cff-DNA concentration increased to 15%, the specificity was as high as 97% with 3.50 Gbp sequence data, much higher than 80% with 10% cff-DNA concentration. Significance: This study presents the feasibility to noninvasively determine zygosity of twin pregnancy using target region sequencing, and illustrates the sensitivity and specificity under various detecting condition. Our method can act as an alternative approach for zygosity determination of twin pregnancies in clinical practice.Multidisciplinary SciencesSCI(E)2ARTICLE6null
Where is VALDO? VAscular Lesions Detection and segmentatiOn challenge at MICCAI 2021
Imaging markers of cerebral small vessel disease provide valuable information on brain health, but their manual assessment is time-consuming and hampered by substantial intra- and interrater variability. Automated rating may benefit biomedical research, as well as clinical assessment, but diagnostic reliability of existing algorithms is unknown. Here, we present the results of the VAscular Lesions DetectiOn and Segmentation (Where is VALDO?) challenge that was run as a satellite event at the international conference on Medical Image Computing and Computer Aided Intervention (MICCAI) 2021. This challenge aimed to promote the development of methods for automated detection and segmentation of small and sparse imaging markers of cerebral small vessel disease, namely enlarged perivascular spaces (EPVS) (Task 1), cerebral microbleeds (Task 2) and lacunes of presumed vascular origin (Task 3) while leveraging weak and noisy labels. Overall, 12 teams participated in the challenge proposing solutions for one or more tasks (4 for Task 1-EPVS, 9 for Task 2-Microbleeds and 6 for Task 3-Lacunes). Multi-cohort data was used in both training and evaluation. Results showed a large variability in performance both across teams and across tasks, with promising results notably for Task 1-EPVS and Task 2-Microbleeds and not practically useful results yet for Task 3-Lacunes. It also highlighted the performance inconsistency across cases that may deter use at an individual level, while still proving useful at a population level
Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamoxifen resistance through cancer-associated fibroblast-derived fibronectin and β1-integrin signaling pathway in tumor cells
Lyapunov Based Estimation of Flight Stability Boundary under Icing Conditions
Current fight boundary of the envelope protection in icing conditions is usually defined by the critical values of state parameters; however, such method does not take the interrelationship of each parameter and the effect of the external disturbance into consideration. This paper proposes constructing the stability boundary of the aircraft in icing conditions through analyzing the region of attraction (ROA) around the equilibrium point. Nonlinear icing effect model is proposed according to existing wind tunnel test results. On this basis, the iced polynomial short period model can be deduced further to obtain the stability boundary under icing conditions using ROA analysis. Simulation results for a series of icing severity demonstrate that, regardless of the icing severity, the boundary of the calculated ROA can be treated as an estimation of the stability boundary around an equilibrium point. The proposed methodology is believed to be a promising way for ROA analysis and stability boundary construction of the aircraft in icing conditions, and it will provide theoretical support for multiple boundary protection of icing tolerant flight
Numerical and Experimental Investigations on Reducing Particle Accumulation for SCR-deNOx Facilities
Selective catalytic reduction (SCR) is widely used to remove nitrogen oxides (NOx) in the flue gas of coal-fired power plants. The accumulation of ash particles inside the SCR-deNOx facility will increase the risk of catalyst deactivation or even damage. This paper presents the numerical and experimental investigations on the particle dispersal approach for the SCR-deNOx facility of a 1000 MW coal-fired power plant. The accumulation of different-sized particles is evaluated based on computational fluid dynamics (CFD) simulations. To prevent particles from accumulation, an optimized triangular deflector is proposed and attempts are made to find out the optimal installing position of the deflector. For the π-type SCR-deNOx facilities, the particle accumulation predominantly occurred on one side of the catalysts’ entrance, which corresponds to the inner side of the wedge-shaped turning. It is indicated that particles larger than 8.8 × 10−2 mm are responsible for the significant accumulation. The triangular deflector is proved to be an effective way to reduce particle accumulation and is found most efficient when it is installed at the high-speed area of the vertical duct. Flow model test (FMT) is carried out to validate the dispersal effect for the particle with relatively large sizes and the optimal installing position of the triangular deflector
Flight safety warning of iced aircraft based on reachability analysis and fuzzy inference
A flight safety warning method based on reachability analysis and fuzzy inference is proposed against aircraft icing. A nonlinear model of iced aircraft with uncertainty is proposed based on the existing research results on the effects of icing and the uncertainty in icing detection. To deal with the uncertainty caused by icing, reachability analysis is used to estimate the safe flight envelope of iced aircraft. On this basis, fuzzy inference is employed for flight safety warning which can be used to enhance the pilot’s situational awareness in icing encounters. Simulations of the GTM (Generic Transport Model) aircraft show that, the proposed method has the potential to further increase the flight crew awareness about the risk of losing control in flight under icing
Optimal Design of a Tower Type SCR-deNOx Facility for a 1000 MW Coal-Fired Power Plant Based on CFD Simulation and FMT Validation
Selective catalytic reduction (SCR) is one of the most efficient methods to reduce NOx emissions from coal-fired power plants. This paper deals with an optimal design tower type SCR-deNOx facility for a 1000 MW coal-fired power plant. Combined with computational fluid dynamics (CFD), the configuration of the baffles geometry was studied with spatial constraints. Flow field was regulated at the ammonia injection grid (AIG) with the dual aim of reducing difficulties in implementing the non-uniformed ammonia (NH3) injection strategy and achieving a more homogeneous distribution at the catalyst entrance. A flow model test (FMT) was carried out at a laboratory scale to verify the design results. The results of the flow model test are in good agreement with the computational fluid dynamics. It is indicated that small-sized baffles are recommended for installation at the upstream side of the facility as the optimal design and ability to regulate the flow field at the ammonia injection grid makes it an effective way to deal with spatial constraints. This paper provides a good reference for optimizing the tower type SCR-deNOx facilities with spatial constraints