4,160 research outputs found
Vitamin D3 receptor is highly expressed in Hodgkin's lymphoma
Background: Hodkin s lymphoma is one of the most frequent lymphoma in western world. Despite an overall good prognosis some patients suffer relapsing tumors which are difficult to cure. Over a long period Vitamin D has been shown to be a potential treatment for cancer. Vitamin D acts via the vitamin D receptor, a nuclear receptor, acting as an inducible transcription factor. We aimed to investigate the expression of vitamin D receptor as potential therapeutic target structure in Hodgkin s lymphoma as well as in non Hodgkin s lymphoma.
Methods: We used a panel of 193 formalin fixed tissues of lymphoma cases consisting of 55 cases of Hodgkin s lymphoma and 138 cases on several non Hodgkin s lymphoma entities.
Results: Vitamin D receptor is strongly expressed in Hodgkin s lymphoma, regardless of the subentity with an overall positivity of 80% of all Hodgkin lymphoma cases. In contrast, only about 17% of the analyzed non Hodgkin s lymphoma of B-cell origin showed positivity for vitamin D receptor. Predominant nuclear localization of vitamin D receptor in Hodgkin s lymphoma suggests activated status of the vitamin D receptor.
Conclusions: From this study, we conclude that vitamin D receptor plays a potentially important role in pathogenesis of Hodgkin s lymphoma but not in non Hodgkin s lymphoma. Further investigations of mutational status and functional studies may shed some light in functional relevance of vitamin D receptor signaling in Hodgkin s lymphoma
Variation of discrete spectra for non-selfadjoint perturbations of selfadjoint operators
Let B=A+K where A is a bounded selfadjoint operator and K is an element of
the von Neumann-Schatten ideal S_p with p>1. Let {\lambda_n} denote an
enumeration of the discrete spectrum of B. We show that \sum_n
\dist(\lambda_n, \sigma(A))^p is bounded from above by a constant multiple of
|K|_p^p. We also derive a unitary analog of this estimate and apply it to
obtain new estimates on zero-sets of Cauchy transforms.Comment: Differences to previous version: Extended Introduction, new Section
5, additional references. To appear in Int. Eq. Op. Theor
Global Optimization by Energy Landscape Paving
We introduce a novel heuristic global optimization method, energy landscape
paving (ELP), which combines core ideas from energy surface deformation and
tabu search. In appropriate limits, ELP reduces to existing techniques. The
approach is very general and flexible and is illustrated here on two protein
folding problems. For these examples, the technique gives faster convergence to
the global minimum than previous approaches.Comment: to appear in Phys. Rev. Lett. (2002
Vitamin D3receptor is highly expressed in Hodgkin’s lymphoma
BACKGROUND: Hodgkin lymphoma (HL) is one of the most frequent lymphoma in the western world. Despite a good overall prognosis, some patients suffer relapsing tumors which are difficult to cure. Over a long period Vitamin D has been shown to be a potential treatment for cancer. Vitamin D acts via the vitamin D receptor, a nuclear receptor, acting as an inducible transcription factor. We aimed to investigate the expression of vitamin D receptor as a possible diagnostic marker and potential therapeutic target in HL as well as in B-cell derived non-Hodgkin lymphoma (B-NHL). METHODS: We used a panel of 193 formalin fixed tissues of lymphoma cases consisting of 55 cases of HL and 138 cases on several B-NHL entities. RESULTS: Vitamin D receptor is strongly expressed in tumor cells of HL, regardless of the sub entity with an overall positivity of 80% of all HL cases. In contrast, only about 17% of the analyzed origin-NHL showed positivity for vitamin D receptor. The detection of nuclear localization of vitamin D receptor in the tumor cells of HL suggests activated status of the vitamin D receptor. CONCLUSIONS: Our study suggests VDR as a specific marker for tumor cells of HL, but not of B-NHL subtypes. Further, the observed nuclear localization suggests an activated receptor status in tumor cells of HL. Further investigations of mutational status and functional studies may shed some light in functional relevance of vitamin D receptor signaling in HL
Metropolis simulations of Met-Enkephalin with solvent-accessible area parameterizations
We investigate the solvent-accessible area method by means of Metropolis
simulations of the brain peptide Met-Enkephalin at 300. For the energy
function ECEPP/2 nine atomic solvation parameter (ASP) sets are studied. The
simulations are compared with one another, with simulations with a distance
dependent electrostatic permittivity , and with vacuum
simulations (). Parallel tempering and the biased Metropolis
techniques RM are employed and their performance is evaluated. The measured
observables include energy and dihedral probability densities (pds), integrated
autocorrelation times, and acceptance rates. Two of the ASP sets turn out to be
unsuitable for these simulations. For all other systems selected configurations
are minimized in search of the global energy minima, which are found for the
vacuum and the system, but for none of the ASP models. Other
observables show a remarkable dependence on the ASPs. In particular, we find
three ASP sets for which the autocorrelations at 300K are considerably
smaller than for vacuum simulations.Comment: 10 pages and 8 figure
Mott transitions with partially filled correlated orbitals
We investigate the metal-insulator Mott transition in a generalized version of the periodic Anderson model, in which a band of itinerant non-interacting electrons is hybridrized with a narrow and strongly correlated band. Using the dynamical mean-field theory, we show that the precondition for the Mott transition is that the total filling of the two bands takes an odd integer value. Unlike the conventional portrait of the Mott transition, this condition corresponds to a non-integer filling of the correlated band. For an integer constant occupation of the correlated orbitals the system remains a correlated metal at arbitrary large interaction strength. We picture the transition at a non-integer filling of the correlated orbital as the Mott localization of the singlet states between itinerant and strongly interacting electrons, having occupation of one per lattice site. We show that the Mott transition is of the first order and we characterize the nature of the resulting insulating state with respect to relevant physical parameters, such as the charge-transfer energy
Determining the crystal-field ground state in rare earth Heavy Fermion materials using soft-x-ray absorption spectroscopy
We infer that soft-x-ray absorption spectroscopy is a versatile method for
the determination of the crystal-field ground state symmetry of rare earth
Heavy Fermion systems, complementing neutron scattering. Using realistic and
universal parameters, we provide a theoretical mapping between the polarization
dependence of Ce spectra and the charge distribution of the Ce
states. The experimental resolution can be orders of magnitude larger than the
crystal field splitting itself. To demonstrate the experimental
feasibility of the method, we investigated CePdSi, thereby settling an
existing disagreement about its crystal-field ground state
Non-Fermi liquid behavior with and without quantum criticality in Ce(1-x)Yb(x)CoIn(5)
One of the greatest challenges to Landau's Fermi liquid theory - the standard
theory of metals - is presented by complex materials with strong electronic
correlations. In these materials, non-Fermi liquid transport and thermodynamic
properties are often explained by the presence of a continuous quantum phase
transition which happens at a quantum critical point (QCP). A QCP can be
revealed by applying pressure, magnetic field, or changing the chemical
composition. In the heavy-fermion compound CeCoIn, the QCP is assumed to
play a decisive role in defining the microscopic structure of both normal and
superconducting states. However, the question of whether QCP must be present in
the material's phase diagram to induce non-Fermi liquid behavior and trigger
superconductivity remains open. Here we show that the full suppression of the
field-induced QCP in CeCoIn by doping with Yb has surprisingly little
impact on both unconventional superconductivity and non-Fermi liquid behavior.
This implies that the non-Fermi liquid metallic behavior could be a new state
of matter in its own right rather then a consequence of the underlying quantum
phase transition.Comment: 7 pages, 5 figure
Compact phases of polymers with hydrogen bonding
We propose an off-lattice model for a self-avoiding homopolymer chain with
two different competing attractive interactions, mimicking the hydrophobic
effect and the hydrogen bond formation respectively. By means of Monte Carlo
simulations, we are able to trace out the complete phase diagram for different
values of the relative strength of the two competing interactions. For strong
enough hydrogen bonding, the ground state is a helical conformation, whereas
with decreasing hydrogen bonding strength, helices get eventually destabilized
at low temperature in favor of more compact conformations resembling
-sheets appearing in native structures of proteins. For weaker hydrogen
bonding helices are not thermodynamically relevant anymore.Comment: 5 pages, 3 figures; revised version published in PR
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