The Other 20 Cents Isn’t Worth It: The Inadequacy of Title VII’s Anti-Retaliation Framework

This Article examines the framework for resolving Title VII retaliation disputes through the lens of gender pay disparity and proposes that the current framework is inadequate. The Article begins by illustrating the issue and the impact of retaliatory conduct in the workplace through the stories of two female workers. It also explains the Title VII retaliation standard and explores the process for filing and pursuing an anti-retaliation claim under this framework. Ultimately, the current framework is inadequate for two reasons. First, it does little to discourage retaliatory conduct by employers or co-workers because what amounts to “retaliation” under the law is under-inclusive and difficult to prove. Second, the employment relationship is among the most important in American society, but instead of seeking to salvage it, the current litigation-driven anti-retaliation framework destroys it. Consequently, the Article proposes an alternative dispute resolution method for solving retaliation disputes and provides examples from the transformative mediation and ombudsman models

Diagnosis and management of eosinophilic asthma: a US perspective.

Eosinophilic asthma is now recognized as an important subphenotype of asthma based on the pattern of inflammatory cellular infiltrate in the airway. Eosinophilic asthma can be associated with increased asthma severity, atopy, late-onset disease, and steroid refractoriness. Induced sputum cell count is the gold standard for identifying eosinophilic inflammation in asthma although several noninvasive biomarkers, including fractional exhaled nitric oxide and periostin, are emerging as potential surrogates. As novel therapies and biologic agents become increasingly available, there is an increased need for specific phenotype-directed treatment strategies. Greater recognition and understanding of the unique immunopathology of this asthma phenotype has important implications for management of the disease and the potential to improve patient outcomes. The present review provides a summary of the clinical features, pathogenesis, diagnosis, and management of eosinophilic asthma

Type 2 Innate Lymphoid Cells in Allergic Disease.

Type II innate lymphoid cells (ILC2) are a novel population of lineage-negative cells that produce high levels of Th2 cytokines IL-5 and IL-13. ILC2 are found in human respiratory and gastrointestinal tissue as well as in skin. Studies from mouse models of asthma and atopic dermatitis suggest a role for ILC2 in promoting allergic inflammation. The epithelial cytokines IL-25, IL-33, and TSLP, as well as the lipid mediator leukotriene D4, have been shown to potently activate ILC2 under specific conditions and supporting the notion that many separate pathways in allergic disease may result in stimulation of ILC2. Ongoing investigations are required to better characterize the relative contribution of ILC2 in allergic inflammation as well as mechanisms by which other cell types including conventional T cells regulate ILC2 survival, proliferation, and cytokine production. Importantly, therapeutic strategies to target ILC2 may reduce allergic inflammation in afflicted individuals. This review summarizes the development, surface marker profile, cytokine production, and upstream regulation of ILC2, and focuses on the role of ILC2 in common allergic diseases

RADIC Voice Authentication: Replay Attack Detection using Image Classification for Voice Authentication Systems

Systems like Google Home, Alexa, and Siri that use voice-based authentication to verify their users’ identities are vulnerable to voice replay attacks. These attacks gain unauthorized access to voice-controlled devices or systems by replaying recordings of passphrases and voice commands. This shows the necessity to develop more resilient voice-based authentication systems that can detect voice replay attacks. This thesis implements a system that detects voice-based replay attacks by using deep learning and image classification of voice spectrograms to differentiate between live and recorded speech. Tests of this system indicate that the approach represents a promising direction for detecting voice-based replay attacks

Are Coloring Books Really Just for Kids? Investigating Possible Effects of Specific Pattern Coloring on Conceptual, Physiological and Behavioral Aspects of Anxiety

This study examined the role of specific pattern coloring, such as coloring books for adults, on conceptual, behavioral and physiological measures of anxiety. Undergraduate female students (n = 8) had ECG electrodes and a respiration belt attached and completed the State Trait Anxiety Inventory (STAI) at five time points; at baseline, after an initial autobiographical anxiety induction, following a passive relaxation condition, after a repeat induction and then after a coloring condition. The participants were randomly split into a control and experimental group; the control group free colored while the experimental group colored in a mandala pattern. Participants had the option of coloring before bed to test the effect of coloring on sleep onset latency. The electrodes and respiration belt measured heart rate and respiratory sinus arrhythmia (RSA) data and MATLAB transformed the raw data to produce heart rate variability (HRV) values. The self-report data indicated that the manipulation did not induce anxiety and that there was no reduction in anxiety after the coloring conditions. Physiological data indicated that the manipulation successfully induced anxiety, however, there was no significant reduction in anxiety. Although the results of this study were not significant, they suggest that with a larger sample size, it would be possible to see an effect of specific pattern coloring on the reduction of anxiety

Unruly Periods: Reproductive Futurities and the Rhetorics of Menstruation

“Unruly Periods: Reproductive Temporalities and the Rhetorics of Menstruations” argues that dominant rhetorics of shame and regulation around menstruation work to maintain strict reproductive temporalities that uphold heteropatriarchal norms. Specifically, I draw upon scholarship in queer studies and disability rhetorics to assert that sexual health texts (such as puberty books), menstrual care products (pads and tampons), and technologies of menstruation (period-tracking apps) function as a form of chronobiolitics—a teleological force that seeks to reinforce bodily normalcy. In doing so, these rhetorics of menstruation deny or elide the embodied experiences of diverse, queer, and disabled menstruators, limiting reproductive possibilities. Reproductive justice scholarship and activism began with the work of women of color, so this dissertation foregrounds their voices. Additionally, the dissertation explores my involvement with the Period Project, a local activist organization in Greenville, SC, and Period, a digital activist community, two groups that ground their activism in the affective, embodied experiences of the menstruators they aim to help. The Period Project works to incorporate menstrual activism and rhetoric within the paradigm of reproductive justice and offer feminist and digital rhetoricians a model for analyzing affective activism

Blue-Collar Backroads

The photographer discusses work in Blue-Collar Backroads, a Master of Fine Arts thesis exhibit held at downtown Tipton Gallery from February 1st through February 18th, 2022. The exhibit consists of 17 archival inkjet prints selected from the artist’s two-year exploration of rural backroads as a vehicle for creating images. Using aesthetic traditions of large-format film photography, the photographer poses questions of identity, place, memory, and the intentional pursuit of meditative practices in art. Non-photographic influences are listed, including Claire Wellesley-Smith and Elizabeth Catte. Photographic influences include Joel Sternfeld, Rachel Boillot, William Christenberry, and Mike Smith. A catalog of the exhibit is included at the end of this thesis

Characterisation of cardiac structure and function in late adolescence and modification by adiposity and other cardiovascular risk factors

Cardiovascular disease remains one of the leading causes of death worldwide. However, a large proportion of research in the field focuses primarily on middle- to old- age, by which time much damage to the heart and vascular system has been incurred. The rationale for this research was to gain a clearer picture of cardiovascular health in late adolescence, prior to the onset of adulthood. In this thesis I characterise the cardiac structure and function of individuals from the ALSPAC cohort (average age 17.7 years) through analysing M-Mode, two dimensional and Doppler echocardiographic measures and haemodynamic, biochemical and anthropometric measures. Adiposity, sex and genetic predisposition are considered as key exposures which impact a range of cardiovascular outcomes. I consider the relationships of fat mass and lean mass with cardiovascular outcomes and the ways in which left ventricular mass indexation is affected by adiposity, lean mass, height and body surface area. I then discuss the roles which particular haemodynamic and biochemical biomarkers have in mediating associations between fat mass and left ventricular structural and functional outcomes. Finally I consider the influence which genes associated with body mass index have on key cardiovascular measures, including cardiac structural and functional measures. Adiposity has a direct and detrimental effect on cardiovascular health. My findings provide insights into the way in which adiposity affects the development of an adverse cardiometabolic phenotype from a comparatively young age and also have interesting implications for future research. Furthermore, they serve as another important reminder of the need for adiposity to be monitored throughout the life course

Using Social-Emotional Learning to Help Behavioral Problems

This Capstone Project focused on Social-Emotional Learning (SEL) to help manage behavioral problems that students may face. A class of 25 fourth-grade students attending a public K-5 school participated in this Capstone Project. SEL teachings were condensed into a four-week lesson plan which focused on various skills, catered to help this class’ specific deficits. To match the students’ needs, the lessons were designed to promote positive participation and raise self-esteem so students feel comfortable sharing out during discussions. The students learned what perseverance and encouragement meant to them and participated in activities relating to these skills. By the end of the four weeks, students showed a higher rate of participation in classroom discussions. SEL is a valuable tool that all educators should learn because it allows them to give their students the necessary tools they need to succeed both in and out of school

Exploring communication and collective behaviour between spatially organised inorganic protocell communities

A living system profoundly relies on mass, information and energy interactions through cell-cell and cell-environment networks. As a step towards understanding such interactions, it is beneficial to design and create bottom-up artificial living systems from non-living components, with a specific focus on synergistic interactivity between artificial cells (protocells) and their local environment. Although there are several routes for fabricating protocellular systems, we recognise key challenges associated with a) developing protocellular models with high levels of organisational tunability, b) achieving cell-environment bilateral communication, and c) realising autonomous self-assembly and regulation of protocell systems. The aim of this thesis is thus to review some matrix-based and matrix-free methods of inorganic protocell (colloidosome) 3D-spatial organisation, as judicious system designs capable of cell-cell and cell-environment communication, collective behaviours, and dynamic self-assembly, in close relation with local environments.The first experimental chapter details assembly of colloidosomes within hydrogel or coacervate-based matrices. A droplet microfluidic technique is employed as a novel method for encapsulating segregated colloidosome colonies within alginate hydrogel microspheres. The technique exploits high tunability for customisable size, ratio, microscale geometry, and 3D-patterning parameters. Benefiting from the versatility associated with such matrix-based systems, the second experimental chapter develops 3D-organised colloidosomes for collective signalling and emergent behaviours. Notably, spatially segregated colonies show proximity-mediated chemical communication with increased kinetics compared to analogous homogenous arrangements. This proximity-enhanced colloidosome signalling is exploited, alongside segregated ionic/covalent crosslinking transitions in the environment, to obtain simultaneous structural degradation and resilience of hydrogel hemispheres as a programmable mechanism for protocell ejection. Colloidosomes are also employed as simple signalling hotspots within coacervate-matrix systems. The final experimental chapter aims to re-imagine colloidosome organisation into a matrix-free system, capable of dynamic self-assembly and self-sorting via electrostatically-active membrane appendages. Alginate-coated and chitosan-coated colloidosomes are either co-assembled or self-sorted, in response to varied pH environments. Again, these systems are highly coordinated with their environment and as such, can be spatially pattered according to temporal pH changes through endogenous enzyme catalysis. Furthermore, a spatiotemporal effect on the rate of colloidosome communication in the presence of a hostile guest molecule is demonstrated. <br/