Oral contraception and eye disease: findings in two large cohort studies

AIM : To investigate the relation between oral contraceptive use and certain eye diseases. \ud \ud METHODS : Abstraction of the relevant data from the two large British cohort studies of the effects of oral contraception, the Royal College of General Practitioners' (RCGP) Oral Contraception Study and the Oxford-Family Planning Association (Oxford-FPA) Contraceptive Study. Both cohort studies commenced in 1968 and were organised on a national basis. Between them they have accumulated over 850 000 person years of observation involving 63 000 women. \ud \ud RESULTS : The conditions considered in the analysis were conjunctivitis, keratitis, iritis, lacrimal disease, strabismus, cataract, glaucoma, retinal detachment, and retinal vascular lesions. With the exception of retinal vascular lesions, there was no consistent evidence of important increases in risk of eye diseases in users of oral contraception. There was about a twofold increase in the risk of retinal vascular lesions in recent pill users in both studies (statistically significant only in the RCGP study). The increase was not limited to any specific type of lesion and may well reflect diagnostic bias. \ud \ud CONCLUSION : Oral contraceptive use does not appear to increase the risk of eye disease, with the possible exception of retinal vascular lesions. \ud \ud Keywords: oral contraception; eye disease; cohort studie

Self-reported pain severity is associated with a history of coronary heart disease

This study was funded by Arthritis Research UK (grant number: 17292).Peer reviewedPublisher PD

Storage and retrieval of light pulses in atomic media with "slow" and "fast" light

We present experimental evidence that light storage, i.e. the controlled release of a light pulse by an atomic sample dependent on the past presence of a writing pulse, is not restricted to small group velocity media but can also occur in a negative group velocity medium. A simple physical picture applicable to both cases and previous light storage experiments is discussed.Comment: 4 pages, 3 figures, submitted to Physical Review Letter

Precision measurements of s-wave scattering lengths in a two-component Bose-Einstein condensate

We use collective oscillations of a two-component Bose-Einstein condensate (2CBEC) of \Rb atoms prepared in the internal states $\ket{1}\equiv\ket{F=1, m_F=-1}$ and $\ket{2}\equiv\ket{F=2, m_F=1}$ for the precision measurement of the interspecies scattering length $a_{12}$ with a relative uncertainty of $1.6\times 10^{-4}$. We show that in a cigar-shaped trap the three-dimensional (3D) dynamics of a component with a small relative population can be conveniently described by a one-dimensional (1D) Schr\"{o}dinger equation for an effective harmonic oscillator. The frequency of the collective oscillations is defined by the axial trap frequency and the ratio $a_{12}/a_{11}$, where $a_{11}$ is the intra-species scattering length of a highly populated component 1, and is largely decoupled from the scattering length $a_{22}$, the total atom number and loss terms. By fitting numerical simulations of the coupled Gross-Pitaevskii equations to the recorded temporal evolution of the axial width we obtain the value $a_{12}=98.006(16)\,a_0$, where $a_0$ is the Bohr radius. Our reported value is in a reasonable agreement with the theoretical prediction $a_{12}=98.13(10)\,a_0$ but deviates significantly from the previously measured value $a_{12}=97.66\,a_0$ \cite{Mertes07} which is commonly used in the characterisation of spin dynamics in degenerate \Rb atoms. Using Ramsey interferometry of the 2CBEC we measure the scattering length $a_{22}=95.44(7)\,a_0$ which also deviates from the previously reported value $a_{22}=95.0\,a_0$ \cite{Mertes07}. We characterise two-body losses for the component 2 and obtain the loss coefficients ${\gamma_{12}=1.51(18)\times10^{-14} \textrm{cm}^3/\textrm{s}}$ and ${\gamma_{22}=8.1(3)\times10^{-14} \textrm{cm}^3/\textrm{s}}$.Comment: 11 pages, 8 figure

Using variograms to detect and attribute hydrological change

There have been many published studies aiming to identify temporal changes in river flow time series, most of which use monotonic trend tests such as the Mann–Kendall test. Although robust to both the distribution of the data and incomplete records, these tests have important limitations and provide no information as to whether a change in variability mirrors a change in magnitude. This study develops a new method for detecting periods of change in a river flow time series, using temporally shifting variograms (TSVs) based on applying variograms to moving windows in a time series and comparing these to the long-term average variogram, which characterises the temporal dependence structure in the river flow time series. Variogram properties in each moving window can also be related to potential meteorological drivers. The method is applied to 91 UK catchments which were chosen to have minimal anthropogenic influences and good quality data between 1980 and 2012 inclusive. Each of the four variogram parameters (range, sill and two measures of semi-variance) characterise different aspects of the river flow regime, and have a different relationship with the precipitation characteristics. Three variogram parameters (the sill and the two measures of semi-variance) are related to variability (either day-to-day or over the time series) and have the largest correlations with indicators describing the magnitude and variability of precipitation. The fourth (the range) is dependent on the relationship between the river flow on successive days and is most correlated with the length of wet and dry periods. Two prominent periods of change were identified: 1995–2001 and 2004–2012. The first period of change is attributed to an increase in the magnitude of rainfall whilst the second period is attributed to an increase in variability of the rainfall. The study demonstrates that variograms have considerable potential for application in the detection and attribution of temporal variability and change in hydrological systems

Condensate splitting in an asymmetric double well for atom chip based sensors

We report on the adiabatic splitting of a BEC of $^{87}$Rb atoms by an asymmetric double-well potential located above the edge of a perpendicularly magnetized TbGdFeCo film atom chip. By controlling the barrier height and double-well asymmetry the sensitivity of the axial splitting process is investigated through observation of the fractional atom distribution between the left and right wells. This process constitutes a novel sensor for which we infer a single shot sensitivity to gravity fields of $\delta g/g\approx2\times10^{-4}$. From a simple analytic model we propose improvements to chip-based gravity detectors using this demonstrated methodology.Comment: 4 pages, 5 figure

Nullification at Work? A Glimpse from the National Center for State Courts Study of Hung Juries

In recent years, the criminal justice community has become increasingly concerned about the possibility that jury nullification is the underlying motivation for increasing numbers of acquittals and mistrials due to jury deadlock in felony jury trials. In this Article, the authors discuss the inherent difficulty in defining jury nullification and identifying its occurrence in actual trials. They review the evolution in public and legal opinion about the legitimacy of jury nullification and contemporary judicial responses to perceived instances of jury nullification. Finally, the authors examine the possible presence of jury nullification through empirical analysis of data collected from 372 felony jury trials in four state courts. Jurors\u27 opinions about the fairness of the law proved to be related to trial outcomes. However, case characteristics, particularly the strength and credibility of trial evidence, were the strongest predictors of verdicts. The authors conclude that jury nullification is an unlikely factor in the vast majority of felony trials. When juror attitudes about legal fairness do play a role, they most likely do so by affecting how jurors perceive and interpret trial evidence, rather than by leading jurors to intentionally disregard the governing law

Pupillometry, a bioengineering overview

The pupillary control system is examined using a microprocessor based integrative pupillometer. The real time software functions of the microprocessor include: data collection, stimulus generation and area to diameter conversion. Results of an analysis of linear and nonlinear phenomena are presented