Origin, evolution and present thermal state of the moon

The relative absence of lunar volcanism in the last 3 b.y. and the Apollo 15 heat flow measurement suggest that present-day temperatures in the moon are approximately steady state to depths of 100 km. An exponential distribution of heat sources with depth is scaled by equating the surface heat flow to the integrated heat production of this exterior shell. Presumed present-day interior temperatures and the present-day surface heat flow of 30 ergs/cm2-sec are obtained. The estimated homogeneous concentrations of U, the chemistry of the lunar surface material and inferences to modest depth, and the short accretion time of the moon necessary to provide large-scale differentiation at 4.6 AE suggest that the moon had its origin in the rapid accretion of compounds first condensing from the protoplanetary nebula. The present thermal state of the moon may involve at least some partial melting through all the lunar interior deeper than 200 km. Such a thermal configuration is inconsistent neither with temperatures inferred from electrical conductivity studies nor with the nonhydrostatic shape of the moon

Metamorphism, argon depletion, heat flow and stress on the Alpine fault

The Alpine fault of New Zealand is a major continental transform fault which was uplifted on its southeast side 4 to 11 km within the last 5 m.y. This uplift has exposed the Haast schists, which were metamorphosed from the adjacent Torlesse graywackes. The Haast schists increase in metamorphic grade from prehnite-pumpellyite facies 9-12 km from the fault through the chlorite and biotite zones of the greenschist facies to the garnet-oligoclase zone amphibolite facies within 4 km of the fault. These metamorphic zone boundaries are subparallel to the fault for 350 km along the strike. The K-Ar and Rb-Sr ages of the schists increase with distance from the fault: from 4 m.y. within 3 km of the fault to approximately 110 m.y. 20 km from the fault. Field relations show that the source of heat that produced the argon depletion aureole was the fault itself

Implications of an Elastic Analysis of In Situ Stress Measurements Near the San Andreas Fault

Twenty-nine measurements of in situ stress obtained with the hydraulic fracturing technique near Palmdale, California, are the basis of an elastic analysis of the state of stress in the Mojave Desert adjacent to the San Andreas fault. The measurements were made at depths extending from 80 to 849 m and at distances from the fault between 2 and 34 km. The elastic solution indicates a state of deviatoric stress typical for continents in that the inferred depth gradient of the maximum shear stress is about 7.9 MPa/km. Extrapolation yields an average shear stress in the upper 14 km of the crust of about 56 MPa, a result that is higher than estimates of the average shear stress on the San Andreas fault based on the analysis of heat flow data. This finding is consistent, however, with estimates offault strength based on laboratory determinations of the coefficient of friction for samples of San Andreas fault gouge if the regional state of deviatoric stress is limited by the strength of the fault zone. If so, then the coefficient of friction of the San Andreas fault zone inferred from the stress field results is about 0.45. The state of stress does not appear to vary systematically with distance from the San Andreas fault although considerable localized variation is observed. The observations suggest an upper bound of about 0.1 MPa/km for the horizontal gradient of the maximum shear stress in the direction perpendicular to the San Andreas fault, a result that implies a corresponding limit of about 1.4 MPa on the shear traction applied to the base of the seismogenic layer. Finally, we demonstrate the potential application of in situ stress data to the direct assessment of accumulated slip, which could be released in a large earthquake. We show that on the basis of a model involving a locked fault, extending to about 22 km, the total fault slip below the locked portion is less than 13 m. A more comprehensive set of stress data could permit the estimation of an even lower bound

Cytotoxicity and Dentin Permeability of Carbamide Peroxide and Hydrogen Peroxide Vital Bleaching Materials, in vitro

There has been recent concern about the inadvertent exposure of dentin with patent tubules as well as gingiva to bleaching systems containing 10-15% carbamide peroxide or 2-10% hydrogen peroxide for more than a few minutes. The aims of the present study were: (1) to determine the cytotoxicity of dilutions of hydrogen peroxide in cell culture; (2) to measure hydrogen peroxide diffusion from bleaching agents through dentin in vitro; and (3) to determine the risk of hydrogen peroxide-induced cytotoxicity from exposure of dentin to these vital bleaching agents. The 50% inhibitory dose (ID50) of hydrogen peroxide to succinyl dehydrogenase activity in cultured cells was found to be 0.58 mmol/L after 1 h. All bleaching materials demonstrated diffusion of hydrogen peroxide through dentin in an "in vitro pulp chamber" device. The one- and six-hour diffusates of all bleaching agents through 0.5-mm dentin exceeded the ID50 in monolayer cultures. Inhibition of succinyl dehydrogenase activity corresponded to the amount of hydrogen peroxide that can rapidly diffuse through dentin in vitro and reach concentrations which are toxic to cultured cells in less than 1 h.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66707/2/10.1177_00220345930720051501.pd

Hilltop Curvature Increases With the Square Root of Erosion Rate

This is the pre-peer reviewed version of the following article: Gabet, E. J., Mudd, S. M., Wood, R. W., Grieve, S. W. D., Binnie, S. A., & Dunai, T. J. (2021). Hilltop curvature increases with the square root of erosion rate. Journal of Geophysical Research: Earth Surface, 126, e2020JF005858. https://doi.org/10.1029/2020JF005858, which has been published in final form at https://doi.org/10.1029/2020JF005858. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions

Clinical Effects of Electromagnetic Stimulation as an Adjunct to Periodontal Therapy

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141604/1/jper0046.pd

On the Complexity of Case-Based Planning

We analyze the computational complexity of problems related to case-based planning: planning when a plan for a similar instance is known, and planning from a library of plans. We prove that planning from a single case has the same complexity than generative planning (i.e., planning "from scratch"); using an extended definition of cases, complexity is reduced if the domain stored in the case is similar to the one to search plans for. Planning from a library of cases is shown to have the same complexity. In both cases, the complexity of planning remains, in the worst case, PSPACE-complete

The effect of cell monolayer density on the cytotoxicity metal ions which are released from dental alloys

The effect of cell density (number of cells per unit area of a monolayer culture) on the in vitro cytotoxicity of metal ions which are known to be released from dental materials was investigated. The effects of cell density (1) may explain previous discrepancies in in vitro tests, (2) may be important in wound healing where cell density changes over time, and (3) may help clarify the mechanisms of cytotoxicity of metal ions. Balb/c 3T3 fibroblasts were plated at cell densities ranging from 10,000-80,000 cells/cm2 and were exposed to 8 concentrations of 10 different metal ions. After 24 h, the succinic dehydrogenase activity and DNA synthesis were measured to quantify the cytotoxic effect. Higher cell densities markedly reduced the sensitivity of these fibroblasts to all metal ions except Al+3 and Zn+2, but the magnitude of the reduction was metal dependent. In addition, the DNA synthesis was inhibited more than the succinic dehydrogenase activity for all metal ions except Zn+2. The unique effect of cell density on each metal ion supported the hypothesis that the effect was not simply caused by a dilution of the number of metal ions per cell. Given these results, the effect of cell density should be carefully selected in in vitro cytotoxicity tests.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/30808/1/0000466.pd

Precision of and new methods for testing in vitro alloy cytotoxicity

Previous studies have utilized in vitro alloy cytotoxicity tests to evaluate dental casting alloys. The purposes of this study were to: (1) evaluate the precision of the optical density and visual tests previously used, (2) evaluate a new test measuring absorbance of solubilized formazan dyes, and (3) test the correlation between these tests for cytotoxicity. Balb/c 3T3 cells were plated in 24-well culture trays at 25,000 cells/cm2 around ten types of dental casting alloy (six samples/alloy) and incubated for 72 h. Cells were histochemically stained with MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide) succinate for 2 h, then fixed, washed, and dried. Toxicity was measured by optical densitometer (OD) scanning, visual assessment, and 560-nm absorbance of DMSO-solubilized dyes. Measurements of rings of inhibition were not used, because they did not provide precise data, and correlated poorly with the other methods. The results were analyzed by ANOVA, Tukey intervals, and coefficients of variation (CV's). MTT required shorter incubation times for adequate staining, allowed for solubilization of the monolayers, and was less expensive than NBT (2,2'-di-p-nitro-phenyl-5,5'-diphenyl-3,3'-dimethoxy-[3,3'-dimethoxy-4,4'-biphenylene] ditetrazolium chloride). Results showed that all three methods ranked alloy toxicities similarly (p = 0.05). The solubilization method was most discriminating due to lower CV's. Correlation between densitometer and solubilization methods was excellent (R2 = 0.96). Between-experiment CV's were generally less than 20%, and often less than 10%. Between-sample CV;s were generally less than 20%. CV's were consistently lower for the solubilization method. Thus, all methods were repeatable and correlated well, but the solubilization method was more precise and discriminating.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/30285/1/0000687.pd