Ectopic lipid storage in non-alcoholic fatty liver disease is not mediated by impaired mitochondrial oxidative capacity in skeletal muscle

Background and Aims. Simple clinical algorithms including the Fatty Liver Index (FLI) and Lipid Accumulation Product (LAP) have been developed as a surrogate marker for Non-Alcoholic Fatty Liver Disease (NAFLD). These algorithms have been constructed using ultrasonography, a semi-quantitative method. This study aimed to validate FLI and LAP as measures of hepatic steatosis, as measured quantitatively by proton magnetic resonance spectroscopy (1H-MRS). Methods. Data were collected from 168 patients with NAFLD and 168 controls who had undergone clinical, biochemical and anthropometric assessment in the course of research studies. Values of FLI and LAP were determined, and assessed both as predictors of the presence of hepatic steatosis (liver fat >5.5 %) and of actual liver fat content, as measured by 1H MRS. The discriminative ability of FLI and LAP was estimated using the area under the Receiver Operator Characteristic curve (AUROC). Since FLI can also be interpreted as a predictive probability of hepatic steatosis, we assessed how well calibrated it was in our cohort. Linear regression with prediction intervals was used to assess the ability of FLI and LAP to predict liver fat content. Results. FLI and LAP discriminated between patients with and without hepatic steatosis with an AUROC of 0.79 (IQR= 0.74, 0.84) and 0.78 (IQR= 0.72, 0.83), although quantitative prediction of liver fat content was unsuccessful. Additionally, the algorithms accurately matched the observed percentages of patients with hepatic steatosis in our cohort. Conclusions. FLI and LAP may be used clinically, and for metabolic and epidemiological research, to identify patients with hepatic steatosis, but not as surrogates for liver fat content

Seismic reliability analysis and estimation of multilevel response modification factor for steel diagrid structural systems

Diagrid systems are emerging as one of the structurally efficient and architecturally aesthetic solutions for tall buildings. Despite the fact that such systems are increasingly used in modern construction, current literature lacks detailed information regarding their structural behaviour and seismic design parameters to ensure satisfactory performance under different earthquake intensity levels. This study aims to assess the seismic reliability of diagrid structural systems and develop more efficient performance-based design methodologies. Demand and supply response modification factors are calculated for 16, 24 and 32-storey buildings with diagrid structural systems using 65° diagrid angle and designed in compliance with current standards under a set of 12 spectrum compatible earthquakes. The results are then used to develop a novel multi-level response modification factor (R-Factor) for diagrid structural systems as a function of site seismicity and acceptable damage level. Subsequently, comprehensive seismic reliability analyses are conducted to assess the seismic performance of the selected structures under intensity levels corresponding to DBE and MCE hazard levels (earthquake scenarios with return periods of 475 and 2475 years, respectively). In general, results of this study demonstrate acceptable seismic performance and reliability of steel diagrid systems. It is shown that even using an R-Factor equal to 4 in the seismic design process could ensure that diagrid structures remain in a performance level higher than Life Safety (LS) for both DBE and MCE hazard levels. Multi-level response modification factors proposed in this study can be directly used in performance-based design of diagrid structures to satisfy different performance targets under any seismic hazard level

Deep solidarity: Broadening the basis of transformation

Across the globe, conditions of labour are worsening, providing both challenges and opportunities. As labour is one of the places where the intersectionality of race, ethnicity, gender, sexuality, and class is always at work, new models of resistance are created here as well. Deep solidarity describes what happens when the 99% who have to work for a living (including people who are excluded from the job market) realise what they have in common, in order to employ their differences productively in the struggle. In this article, a theologian and a labour and community organiser work together showing how the Abrahamic religious traditions and developments in the world of labour help us to shape deeper forms of solidarity