Four-year outcomes of full-arch fixed dental prostheses using CAD/CAM frameworks : a retrospective review of 15 cases

The aim of this report is to analyze the clinical performance of 20 full-arch implant-supported titanium frameworks using CAD/CAM (Computer-Aided Design and Computer-Aided Manufacturing) technology. One hundred and four implants were placed in 15 patients using a one-stage protocol. After planning the location of all implants via 3-dimensional software (NobleClinician), 4-8 implants were placed in each edentulous arch based on anatomical measurements. Twenty edentulous arches were treated with full arch implant-supported fixed dental prostheses utilizing CAD/CAM milled titanium frameworks . All patients were followed up for 48±4 months. Clinical performance of the implants and restorations were evaluated for implant/prosthesis survival, framework fit, marginal bone levels, and maintenance requirements. One implant was lost during the follow up period, giving an implant survival rate of 99.1%. The average distance from the implant platform to first bone-implant contact was 1.1±0.2 mm from the time of metal-framework try-in to the time of the last recall appointment. None of the prostheses needed a replacement, indicating the prosthesis success rate was 100%. Sixteen occlusal adjustments and 5 broken denture teeth were repaired chairside during the study period. The results of this retrospective clinical report suggest that CAD/CAM milled titanium frameworks using the software and scanner presented in this study fit accurately and can be a viable treatment option to restore edentulous arches

Time-Dependent Thermally-Driven Interfacial Flows in Multilayered Fluid Structures

A computational study of thermally-driven convection in multilayered fluid structures will be performed to examine the effect of interactions among deformable fluid-fluid interfaces on the structure of time-dependent flow in these systems. Multilayered fluid structures in two models configurations will be considered: the differentially heated rectangular cavity with a free surface, and the encapsulated cylindrical liquid bridge. An extension of a numerical method developed as part of our recent NASA Fluid Physics grant will be used to account for finite deformations of fluid-fluid interfaces

Thermocapillary motion of deformable drops

The thermocapillary motion of initially spherical drops/bubbles driven by a constant temperature gradient in an unbounded liquid medium is simulated numerically. Effects of convection of momentum and energy, as well as shape deformations, are addressed. The method used is based on interface tracking on a base cartesian grid, and uses a smeared color or indicator function for the determination of the surface topology. Quad-tree adaptive refinement of the cartesian grid is implemented to enhance the fidelity of the surface tracking. It is shown that convection of energy results in a slowing of the drop, as the isotherms get wrapped around the front of the drop. Shape deformation resulting from inertial effects affect the migration velocity. The physical results obtained are in agreement with the existing literature. Furthermore, remarks are made on the sensitivity of the calculated solutions to the smearing of the fluid properties. Analysis and simulations show that the migration velocity depends very strongly on the smearing of the interfacial force whereas it is rather insensitive to the smearing of other properties, hence the adaptive grid

On the rules for aquatic locomotion

We present unifying rules governing the efficient locomotion of swimming fish and marine mammals. Using scaling and dimensional analysis, supported by new experimental data, we show that efficient locomotion occurs when the values of the Strouhal (St) number St(=f A/U) and A∗(=A/L), two nondimensional numbers that relate forward speed U, tail-beat amplitude A, tail-beat frequency f , and the length of the swimmer L are bound to the tight ranges of 0.2–0.4 and 0.1–0.3, respectively. The tight range of 0.2–0.4 for the St number has previously been associated with optimal thrust generation. We show that the St number alone is insufficient to achieve optimal aquatic locomotion, and an additional condition on A∗ is needed. More importantly, we show that when swimming at minimal power consumption, the Strouhal number of a cruising swimmer is predetermined solely by the shape and drag characteristics of the swimmer. We show that diverse species of fish and cetaceans cruise indeed with the St number and A∗ predicted by our theory. Our findings provide a physical explanation as to why fast aquatic swimmers cruise with a relatively constant tail-beat amplitude of approximately 20% of the body length, and their swimming speed is nearly proportional to their tail-beat frequenc

Перинатология. Настоящее и будущее

На основании обобщения многолетнего собственного опыта автора, данных литературы и результатов работы Московского центра планирования семьи и репродукции освещены актуальные проблемы перинатологии от пренатального периода до постнатальной охраны здоровья плода. Сделано заключение о необходимости и возможности создания стандартов в области лечебных мероприятий и тактики ведения родов при осложнениях.Basing on the generalization of many−year experience as well as the data of the literature and results of the work of Moscow Center for Family Planning and Reproduction, the author features the urgent issues of perinatology from prenatal period to postnatal health protection. The author concludes about the necessity and possibility to create the standards in the field of therapeutic measures and management tactics in complicated delivery

A systematic numerical study of the tidal instability in a rotating triaxial ellipsoid

The full non-linear evolution of the tidal instability is studied numerically in an ellipsoidal fluid domain relevant for planetary cores applications. Our numerical model, based on a finite element method, is first validated by reproducing some known analytical results. This model is then used to address open questions that were up to now inaccessible using theoretical and experimental approaches. Growth rates and mode selection of the instability are systematically studied as a function of the aspect ratio of the ellipsoid and as a function of the inclination of the rotation axis compared to the deformation plane. We also quantify the saturation amplitude of the flow driven by the instability and calculate the viscous dissipation that it causes. This tidal dissipation can be of major importance for some geophysical situations and we thus derive general scaling laws which are applied to typical planetary cores

Implementation of a flexible and modular multiphase framework for the analysis of surface-tension-driven flows based on a LS-VOF approach

The mathematical modelling and numerical simulation of multi-phase flows are both a demanding and highly complex exercise. In typical problems with industrial relevance, the fluids are often in non-isothermal conditions and interfacial phenomena are a relevant part of the problem. A number of effects due to the presence of temperature differences must be adequately taken into account to make the results of numerical simulations consistent and realistic. Moreover, in general, gradients of surface tension at the interface separating two liquids are a source of numerical issues that can delay (and even prevent completely in some circumstances) the convergence of the solution algorithm. Here, we propose a fundamental and concerted approach for the simulation of the typical dynamics resulting from the presence of a dispersed phase in an external matrix in nonisothermal conditions based on the modular computer-aided design, modelling, and simulations capabilities of the OpenFOAM environment. The resulting framework is tested against the migration of a droplet induced by thermocapillary effects in the absence of gravity. The simulations are fully three-dimensional and based on an adaptive mesh refinement (AMR) strategy. We describe in detail the countermeasures taken to circumvent the problematic issues associated with the simulation of this kind of flows

Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Funding: F Carvalho and E Fernandes acknowledge support from Fundação para a Ciência e a Tecnologia, I.P. (FCT), in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy i4HB; FCT/MCTES through the project UIDB/50006/2020. J Conde acknowledges the European Research Council Starting Grant (ERC-StG-2019-848325). V M Costa acknowledges the grant SFRH/BHD/110001/2015, received by Portuguese national funds through Fundação para a Ciência e Tecnologia (FCT), IP, under the Norma Transitória DL57/2016/CP1334/CT0006.proofepub_ahead_of_prin