Experiment of Diffuse Reflection Laser Ranging to Space Debris and Data Analysis

Space debris has been posing a serious threat to human space activities and is needed to be measured and cataloged. As a new technology of space target surveillance, the measurement accuracy of DRLR (Diffuse Reflection Laser Ranging) is much higher than that of microwave radar and electro-optical measurement. Based on laser ranging data of space debris from DRLR system collected at SHAO (Shanghai Astronomical Observatory) in March-April 2013, the characteristics and precision of the laser ranging data are analyzed and its applications in OD (Orbit Determination) of space debris are discussed in this paper, which is implemented for the first time in China. The experiment indicates that the precision of laser ranging data can reach 39cm-228cm. When the data is sufficient enough (4 arcs of 3 days), the orbit accuracy of space debris can be up to 50m.Comment: 11 pages, 8 figure

Comparison of efficacy and safety of three different drugs combined with radiotherapy in the treatment of patients with advanced pancreatic cancer

Purpose: To investigate the clinical efficacy and safety of three different drugs combined with radiotherapy, viz, apatinib mesylate combined radiotherapy (group A), gemcitabine combined oxaliplatin (group B), and Huachansu capsules combined radiotherapy (group C)] in advanced pancreatic cancer patients. Methods: A total of 174 patients with advanced pancreatic cancer treated in Yantai Qishan Hospital, Yantai, China from June 2015 to December 2016 were randomly and evenly divided into groups A, B, and C. The incidence of adverse reactions during treatment, immune reaction, efficacy, quality of life, and survival were compared among the three groups after four courses of treatment. Results: Compared with groups B and C, the incidence of nausea and vomiting was higher in group A (p < 0.05), but the incidence of other adverse events was not significantly different (p > 0.05). Group A showed higher response rate and disease control rate, higher CD4+, CD4+/CD8+ levels and QOL scores, as well as lower CD8+ level in peripheral blood after treatment than groups B and C (p < 0.05). Group A also exhibited longer median OS and median PFS, and higher 2-year survival than groups B and C (p < 0.05). Conclusion: Among the three different drug treatments combined with radiotherapy, apatinib mesylate combined radiotherapy enhanced efficacy and quality of life, and lengthen the survival time of advanced pancreatic cancer patients. However, additional clinical trials are required to validate these findings

Isoliquiritigenin inhibits the survival of diffuse large B-cell lymphoma cells by regulating Akt/mTOR signaling pathway

Purpose: To investigate the effect of isoliquiritigenin (ISL) on diffuse large B-cell lymphoma (DLBCL) cells and its underlying mechanism of action.Methods: The DLBCL cell line OCI-Ly19 was used in this study. Cell proliferation was measured by MTT assay. Apoptosis was evaluated using flow cytometry. Phosphorylation of Akt and mTOR was assessed using Western blotting.Results: DLBCL cell proliferation was suppressed by ISL in a concentration-dependent manner. The number of apoptotic cells increased following ISL treatment in a concentration-dependent manner (p < 0.05). ISL treatment also stopped the cell cycle at the G1 phase in a concentration-dependent manner. Western blot analysis indicated that there was no significant Akt and mTOR expression in cells treated with 10, 20, or 50 μM ISL (p < 0.05). However, Akt and mTOR phosphorylation was upregulated following treatment with 10, 20, or 50 μM ISL in a concentration-dependent manner (p < 0.05).Conclusion: The results demonstrate that ISL inhibits DLBCL cell proliferation and promotes cell apoptosis by blocking the cell cycle transition from the G1 to S phase, which is mediated by the inactivation of the Akt/mTOR signaling pathway. Keywords: Isoliquiritigenin, Cell survival, Diffuse large B-cell lymphoma, Akt/mTOR signaling pathwa

S-4-Chloro­phenyl 9,10-dihydro­acridine-9-carbothio­ate

In tricyclic fragment of the title mol­ecule, C20H14ClNOS, the central 1,4-dihydro­pyridine ring adopts a boat conformation while the two benzene rings form a dihedral angle of 17.38 (5)°. In the crystal structure, weak inter­molecular N—H⋯O hydrogen bonds link the mol­ecules into chains propagating along the b axis

Involvement of C6-volatiles in quality formation of herbal medicine: A case study in Astragalus membranaceus var. mongholicus

In this study, the effects of exogenous C6-volatiles on Astragalus membranaceus var. mongholicus growth and secondary metabolism were explored. Five-week old seedlings of A. membranaceus var. mongholicus were exposed to different concentrations of soil-borne hexanal (10, 50, 100 μM) twice/week for 4 weeks. Non-treated plants serve as control. Growth, bioactive compounds and gene expression were measured by conventional and “omic” approaches. The results demonstrated: (1) all doses of hexanal significantly decreased chlorophyll a/b contents; (2) 10 and 100 μM hexanal significantly decreased the shoot length while 50 μM hexanal kept the value at the same level as it was in the control; (3) 50 μM hexanal effectively enhanced the contents of bioactive compounds in roots and the others had no obvious effect; (4) 50 μM hexanal induced more dysregulated metabolites in leaves than in roots, especially those associated with lipid metabolism; (5) expression of unigenes annotaed as “plant-pathogen interaction”, “secondary metabolism” and “lipid metabolism” were largely induced as well as those classified into multiple growth and defense signaling pathways. Taken together, C6-volatiles can serve as potential elicitors for quality formation of herbal medicines. The online version of this article (doi: 10.5073/JABFQ.2017.090.027) contains supplementary files