The Impact of Chronic Liver Diseases on the Level of Heart-Type Fatty Acid-Binding Protein (H-FABP) Concentrations

Objectives: Heart-type fatty acid binding-protein (H-FABP) has been reported to be a potential novel biochemical marker for the early diagnosis of acute myocardial infarction (AMI). The presence of H-FABP in the liver has not been reported. The aim of this study was to compare the effect of chronic liver diseases on the level of H-FABP concentrations. Methods: The effects of chronic liver diseases including infective hepatitis and cirrhosis on the concentration of H-FABP was studied in a small group of patients (n=10, mean age ±SD = 58.33 ± 7.19 years). The serum concentrations of the following markers were measured: H-FABP, alanine aminotransferase (ALT) and bilirubin and compared with a reference control group (20 healthy blood donors, mean age ±SD = 63.8 ±8.01). Results: The serum concentrations of these markers in the control group as compared to patients with chronic liver disease were as follows (mean ± SD): H-FABP = 6.86 ±2.21 µg/L versus 6.44 ±3.06 µg/L (p = NS); ALT = 29.8 ±14.7 U/L versus ALT = 198.67 ±122.89 U/L (p < 0.0005) and bilirubin = 9.6 ±4.0 µmol/L versus bilirubin = 100.89 ±87.85 µmol/L (p < 0.0001). Conclusion: These data illustrate clearly that there is no significant interference with the normal concentration of H-FABP in the presence of liver diseases, despite the significant elevation of liver enzymes and proteins. These data may support a useful role of H-FABP for the diagnosis of myocardial injury in patients with liver diseases

Emergent Universe in the Braneworld Scenario

According to Padmanabhan's proposal, the difference between the surface degrees of freedom and the bulk degrees of freedom in a region of space may result in the acceleration of Universe expansion through the relation $\Delta V/\Delta t = N_{\rm sur}-N_{\rm bulk}$ where $N_{\rm bulk}$ and $N_{\rm sur}$ are referred to the degrees of freedom related to the matter and energy content inside the bulk and surface area, respectively \cite{Pad1}. In this paper, we study the dynamical effect of the extrinsic geometrical embedding of an arbitrary four dimensional brane in a higher dimensional bulk space and investigate the corresponding degrees of freedom. Considering the modification of Friedmann equations arising from a general braneworld scenario, we obtain a correction term in Padmanabhan's relation, denoting the number of degrees of freedom related to the extrinsic geometry of the brane embedded in higher dimensional spacetime as $\Delta V /\Delta t=N_{\rm sur}-N_{\rm bulk}-N_{\rm extr}$ where $N_{\rm extr}$ is referred to the degree of freedom related to the extrinsic geometry of the brane while $N_{\rm sur}$ and $N_{\rm bulk}$ are as well as before. Finally, we study the validity of the first and second laws of thermodynamics for this general braneworld scenario in the state of thermal equilibrium and in the presence of confined matter fields to the brane with the induced geometric matter fields.Comment: 16 pages, Major revisio

Graph Symmetry Detection and Canonical Labeling: Differences and Synergies

Symmetries of combinatorial objects are known to complicate search algorithms, but such obstacles can often be removed by detecting symmetries early and discarding symmetric subproblems. Canonical labeling of combinatorial objects facilitates easy equivalence checking through quick matching. All existing canonical labeling software also finds symmetries, but the fastest symmetry-finding software does not perform canonical labeling. In this work, we contrast the two problems and dissect typical algorithms to identify their similarities and differences. We then develop a novel approach to canonical labeling where symmetries are found first and then used to speed up the canonical labeling algorithms. Empirical results show that this approach outperforms state-of-the-art canonical labelers.Comment: 15 pages, 10 figures, 1 table, Turing-10

Coxsackie B2 Virus Infection Causing Multiorgan Failure and Cardiogenic Shock in a 42-Year-Old Man

Infections from coxsackie B2 viruses often cause viral myocarditis and, only rarely, multisystem organ impairment. We present the unusual case of a 42-year-old man in whom coxsackie B2 virus infection caused multiorgan infection, necessitating distal pancreatectomy, splenectomy, renal dialysis, and venoarterial extracorporeal membrane oxygenation with mechanical ventilation. In addition, the patient had a rapid-eye-movement sleep-related conduction abnormality that caused frequent sinus pauses of longer than 10 s, presumably due to myocarditis from the coxsackievirus infection. He recovered after permanent pacemaker placement and was discharged from the hospital. We discuss our aggressive supportive care and the few other reports of multiorgan impairment from coxsackieviruses

Economic Reforms in Indonesia after the 1997/98 Economic Crisis

This paper reviews the experience of undertaking reforms in Indonesia after the economic crisis 1997/98, focusing on the reforms made under the last two presidents : Megawati and Susilo Bambang Yudhoyono. The review leads the paper to draw some lessons from the experience. Among other, the role of IMF in disciplining the policy direction, and hence the reforms, is quite evident. This is in the light of dramatic change in the political economy of decision-making process after the crisis, where the power was shifted from the president to the government. The paper also finds that one important constraint for delivering a successful reform is nationalistic ideology which strongly opposes the mechanism for moving towards more efficient market. Meanwhile, in practical terms, the change in political architecture seems to have contributed to the coordination problems across the governmental agencies and ministries, which leads to slow progress in the policy implementation.Indonesia, Organisation of government, IMF