Experiences with a gravity-assisted valve in hydrocephalic children. Clinical article.

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IKT 16: A composite supernova remnant in the Small Magellanic Cloud

Aims. IKT 16 is an X-ray and radio-faint supernova remnant (SNR) in the Small Magellanic Cloud (SMC). A previous X-ray study of this SNR found a hard X-ray source near its centre. Using all available archival and proprietary XMM-Newton data, alongside new multi-frequency radio-continuum surveys and optical observations at Hα and forbidden [SII] and [OIII] lines, we aim to constrain the properties of the SNR and discover the nature of the hard source within. Methods. We combine XMM-Newton datasets to produce the highest quality X-ray image of IKT 16 to date. We use this, in combination with radio and optical images, to conduct a multi-wavelength morphological analysis of the remnant. We extract separate spectra from the SNR and the bright source near its centre, and conduct spectral fitting of both regions. Results. We find IKT 16 to have a radius of 37 ± 3 pc, with the bright source located 8 ± 2 pc from the centre. This is the largest known SNR in the SMC. The large size of the remnant suggests it is likely in the Sedov-adiabatic phase of evolution. Using a Sedov model to fit the SNR spectrum, we find an electron temperature kT of 1.03 ± 0.12 keV and an age of 14700 yr. The absorption found requires the remnant to be located deep within the SMC. The bright source is fit with a power law with index Γ = 1.58 ± 0.07, and is associated with diffuse radio emission extending towards the centre of the SNR. We argue that this source is likely to be the neutron star remnant of the supernova explosion, and infer its transverse kick velocity to be 580 ± 100 km s -1. The X-ray and radio properties of this source strongly favour a pulsar wind nebula (PWN) origin. © 2011 ESO

New radio continuum study of the Large Magellanic Cloud Supernova Remnant N49

International audienceWe present new Australia Telescope Compact Array (ATCA) radio observations toward N49, one of the brightest extragalactic Supernova remnants (SNRs) located in the Large Magellanic Cloud. Our new and archival ATCA radio observations were analysed along with $Chandra$ X-ray data. These observations show a prominent `bullet' shaped feature beyond the southwestern boundary of the SNR. Both X-ray morphology and radio polarisation analysis support a physical connection of this feature to the SNR. The 'bullet' feature's apparent velocity is estimated at $\sim$1300 km s$^{-1}$, based on its distance ($\sim$10 pc) from the remnant's geometric centre and estimated age ($\sim$7600 yrs). we estimated the radio spectral index, $\alpha= -0.55 \pm 0.03$ which is typical of middle-age SNRs. Polarisation maps created for N49 show low to moderate levels of mean fractional polarisation estimated at 7$\pm$1% and 10$\pm$1% for 5.5 and 9 GHz, respectively. These values are noticeably larger than found in previous studies. Moreover, the mean value for the Faraday rotation of SNR N49 from combining CABB data is 212$\pm$65 rad m$^{-2}$ and the maximum value of RM is 591$\pm$103 rad m$^{-2}$

Radio continuum sources behind the Large Magellanic Cloud

We present a comprehensive multifrequency catalogue of radio sources behind the Large Magellanic Cloud (LMC) between 0.2 and 20 GHz, gathered from a combination of new and legacy radio continuum surveys. This catalogue covers an area of ∼144 deg(2) at angular resolutions from 45 arcsec to ∼3 arcmin. We find 6434 discrete radio sources in total, of which 3789 are detected at two or more radio frequencies. We estimate the median spectral index (α; where S(v) ∼ ν(α)) of α = −0.89 and mean of −0.88 ± 0.48 for 3636 sources detected exclusively at two frequencies (0.843 and 1.384 GHz) with similar resolution [full width at half-maximum (FWHM) ∼40–45 arcsec]. The large frequency range of the surveys makes it an effective tool to investigate Gigahertz Peak Spectrum (GPS), Compact Steep Spectrum (CSS), and Infrared Faint Radio Source (IFRS) populations within our sample. We find 10 GPS candidates with peak frequencies near 5 GHz, from which we estimate their linear size. 1866 sources from our catalogue are CSS candidates with α  < −0.8. We found six candidates for High Frequency Peaker (HFP) sources, whose radio fluxes peak above 5 GHz and no sources with unconstrained peaks and α  > 0.5. We found optical counterparts for 343 of the radio continuum sources, of which 128 have a redshift measurement. Finally, we investigate the population of 123 IFRSs found in this study.M D Filipović … G. Rowell … et al

Radio-continuum study of MCSNR J0536–7038 (DEM L249)

We present a detailed radio-continuum study on Australia Telescope Compact Array (ATCA) observations of Large Magellanic Cloud (LMC) supernova remnant (SNR), MCSNR J0536-7038. This Type Ia SNR follows a horseshoe morphology, with a size 32 pc $\times$ 32 pc (1-pc uncertainty in each direction). It exhibits a radio spectrum $\alpha=-0.52\pm0.07$ between $\lambda = 73$ and 6 cm. We report detections of regions showing moderately high fractional polarisation at 6 cm, with a peak value of 71$\pm$25% and a mean fractional polarisation of 35$\pm$8%. We also estimate an average rotation measure across the remnant of -237 rad m$^{-2}$. The intrinsic magnetic field appears to be uniformly distributed, extending in the direction of the two brightened limbs of the remnant.Comment: Accepted for publication in Astrophysics and Space Scienc

Vorapaxar in the secondary prevention of atherothrombotic events

Item does not contain fulltextBACKGROUND: Thrombin potently activates platelets through the protease-activated receptor PAR-1. Vorapaxar is a novel antiplatelet agent that selectively inhibits the cellular actions of thrombin through antagonism of PAR-1. METHODS: We randomly assigned 26,449 patients who had a history of myocardial infarction, ischemic stroke, or peripheral arterial disease to receive vorapaxar (2.5 mg daily) or matching placebo and followed them for a median of 30 months. The primary efficacy end point was the composite of death from cardiovascular causes, myocardial infarction, or stroke. After 2 years, the data and safety monitoring board recommended discontinuation of the study treatment in patients with a history of stroke owing to the risk of intracranial hemorrhage. RESULTS: At 3 years, the primary end point had occurred in 1028 patients (9.3%) in the vorapaxar group and in 1176 patients (10.5%) in the placebo group (hazard ratio for the vorapaxar group, 0.87; 95% confidence interval [CI], 0.80 to 0.94; P<0.001). Cardiovascular death, myocardial infarction, stroke, or recurrent ischemia leading to revascularization occurred in 1259 patients (11.2%) in the vorapaxar group and 1417 patients (12.4%) in the placebo group (hazard ratio, 0.88; 95% CI, 0.82 to 0.95; P=0.001). Moderate or severe bleeding occurred in 4.2% of patients who received vorapaxar and 2.5% of those who received placebo (hazard ratio, 1.66; 95% CI, 1.43 to 1.93; P<0.001). There was an increase in the rate of intracranial hemorrhage in the vorapaxar group (1.0%, vs. 0.5% in the placebo group; P<0.001). CONCLUSIONS: Inhibition of PAR-1 with vorapaxar reduced the risk of cardiovascular death or ischemic events in patients with stable atherosclerosis who were receiving standard therapy. However, it increased the risk of moderate or severe bleeding, including intracranial hemorrhage. (Funded by Merck; TRA 2P-TIMI 50 ClinicalTrials.gov number, NCT00526474.)