The importance of interactive chemistry for stratosphere–troposphere–coupling

Recent observational and modeling studies suggest that stratospheric ozone depletion not only influences the surface climate in the Southern Hemisphere (SH), but also impacts Northern Hemisphere (NH) spring, which implies a strong interaction between dynamics and chemistry. Here, we systematically analyze the importance of interactive chemistry with respect to the representation of stratosphere–troposphere coupling and in particular the effects on NH surface climate during the recent past. We use the interactive and specified chemistry version of NCAR's Whole Atmosphere Community Climate Model coupled to an ocean model to investigate differences in the mean state of the NH stratosphere as well as in stratospheric extreme events, namely sudden stratospheric warmings (SSWs), and their surface impacts. To be able to focus on differences that arise from two-way interactions between chemistry and dynamics in the model, the specified chemistry model version uses a time-evolving, model-consistent ozone field generated by the interactive chemistry model version. We also test the effects of zonally symmetric versus asymmetric prescribed ozone, evaluating the importance of ozone waves in the representation of stratospheric mean state and variability. The interactive chemistry simulation is characterized by a significantly stronger and colder polar night jet (PNJ) during spring when ozone depletion becomes important. We identify a negative feedback between lower stratospheric ozone and atmospheric dynamics during the breakdown of the stratospheric polar vortex in the NH, which contributes to the different characteristics of the PNJ between the simulations. Not only the mean state, but also stratospheric variability is better represented in the interactive chemistry simulation, which shows a more realistic distribution of SSWs as well as a more persistent surface impact afterwards compared with the simulation where the feedback between chemistry and dynamics is switched off. We hypothesize that this is also related to the feedback between ozone and dynamics via the intrusion of ozone-rich air into polar latitudes during SSWs. The results from the zonally asymmetric ozone simulation are closer to the interactive chemistry simulations, implying that under a model-consistent ozone forcing, a three-dimensional (3-D) representation of the prescribed ozone field is desirable. This suggests that a 3-D ozone forcing, as recommended for the upcoming CMIP6 simulations, has the potential to improve the representation of stratospheric dynamics and chemistry. Our findings underline the importance of the representation of interactive chemistry and its feedback on the stratospheric mean state and variability not only in the SH but also in the NH during the recent past

The turnover number for band 3-mediated sulfate transport in phosphatidylcholine bilayers

AbstractThe anion transport system of the human erythrocyte membrane was reconstituted in unilamellar phosphatidylcholine vesicles, and a vesicle subpopulation of a narrow size distribution was isolated from the sample by gel filtration. In this subpopulation, the turnover number of the transport protein (the band 3 protein) for sulfate transport was determined. It was found that, in the reconstituted system, the protein transports sulfate 5–10-times faster than in the human erythrocyte membrane

Lenalidomide in the context of complex karyotype or interrupted treatment: case reviews of del(5q)MDS patients with unexpected responses

Lenalidomide has particular activity in patients with transfusion-dependent del(5q) myelodysplastic syndromes (MDS), but mechanistic information is limited regarding the relationship between erythroid and cytogenetic responses. We reviewed medical records from three distinct subgroups of del(5q) MDS patients who had unexpected effects with lenalidomide treatment: 1. two patients with complex karyotypes who achieved both cytogenetic remissions and transfusion independence; 2. two patients with 5q- syndrome who took lenalidomide for less than 12 weeks but remained transfusion independent for 15+ months still displaying del(5q) metaphases after 6 and 12 months; and 3. one patient who was a non-responder on lenalidomide during treatment but became transfusion independent for 13+ months after discontinuation. All but the latter patient in this series had reduction of affected metaphases, suggesting that erythroid responses might be mediated by result from partial or complete suppression of the malignant clone, either directly or indirectly through modulation of the bone marrow microenvironment. These clinical observations illustrate the heterogeneity of del(5q)MDS pathogenesis and the diversity of lenalidomide responses within this patient subset

High-intensity interval training for overweight adolescents: program acceptance of a media supported intervention and changes in body composition

High-intensity interval training (HIIT) consists of short intervals of exercise at high intensity intermitted by intervals of lower intensity and is associated with improvement of body composition and metabolic health in adults. Studies in overweight adolescents are scarce. We conducted a randomized controlled trial in overweight adolescents to compare acceptance and attendance of HIIT with or without weekly motivational encouragement through text messages and access to a study website. HIIT was offered for six months (including summer vacation) twice a week (60 min/session). Participation rates were continuously assessed and acceptance was measured. Clinical parameters were assessed at baseline and after six months. Twenty-eight adolescents participated in this study (age 15.5 +/- 1.4; 54% female). The standard deviation score for body mass index over all participants was 2.33 at baseline and decreased by 0.026 (95% CI - 0.048 to 0.10) units, p = 0.49. Waist to height ratio was 0.596 at baseline and decreased by 0.013 (95% CI 0.0025 to 0.024), p = 0.023. Participation within the first two months ranged from 65% to 75%, but fell to 15% within the last three months. Attendance in the intervention group was 14% (95% CI - 8 to 37), p = 0.18, higher than the control group. Overall program content was rated as \"good\" by participants, although high drop-out rates were observed. Summer months constitute a serious problem regarding attendance. The use of media support has to be assessed further in appropriately powered trials

The Importance of a Properly Represented Stratosphere for Northern Hemisphere Surface Variability in the Atmosphere and the Ocean

Major sudden stratospheric warmings (SSWs) are extreme events during boreal winter, which not only impact tropospheric weather up to three months but also can influence oceanic variability through wind stress and heat flux anomalies. In the North Atlantic region, SSWs have the potential to modulate deep convection in the Labrador Sea and thereby the strength of the Atlantic meridional overturning circulation. The impact of SSWs on the Northern Hemisphere surface climate is investigated in two coupled climate models: a stratosphere-resolving (high top) and a non-stratosphere-resolving (low top) model. In both configurations, a robust link between SSWs and a negative NAO is detected, which leads to shallower-than-normal North Atlantic mixed layer depth. The frequency of SSWs and the persistence of this link is better captured in the high-top model. Significant differences occur over the Pacific region, where an unrealistically persistent Aleutian low is observed in the low-top configuration. An overrepresentation of SSWs during El Nino conditions in the low-top model is the main cause for this artifact. Our results underline the importance of a proper representation of the stratosphere in a coupled climate model for a consistent surface response in both the atmosphere and the ocean, which, among others, may have implications for oceanic deep convection in the subpolar North Atlantic

Mehr Unterrichtspraxis in die Lehramtsausbildung! Das FOCUS-Videoportal als digitales Lehr-Lern-Medium

Unterrichtsrelevante Kompetenzen wie die professionelle Wahrnehmung können durch die Analyse von Unterrichtsvideos gefördert werden. Hierfür benötigte Fallbeispiele werden im FOCUS-Videoportal bereitgestellt. In diesem Beitrag wird untersucht, inwieweit das Videoportal benutzungsfreundlich ist und sich zur Förderung der professionellen Wahrnehmung eignet. Es wurden 339 Studierende befragt. Die Ergebnisse zeugen von einer generellen Zufriedenheit mit dem inhaltlichen Angebot, der Benutzungsfreundlichkeit und der ästhetischen Umsetzung des Videoportals. Zudem konnte durch die bereitgestellten Videotrainings das Kompetenzerleben hinsichtlich der professionellen Wahrnehmung gefördert werden