125 research outputs found
Π Π°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΡΠ±ΠΎΡΠΊΠΈ ΠΈ ΡΠ²Π°ΡΠΊΠΈ ΡΡΡΠΊΠΎΠ²ΠΎΠ³ΠΎ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ ΡΡΡΠ±Π°-Π»ΠΈΡΡ ΠΈΠ· Π½ΠΈΠ·ΠΊΠΎΠ»Π΅Π³ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΡΡΠ°Π»ΠΈ
Π‘ΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠ΅ Π²ΠΈΠ΄Π° ΡΡΡΠ±Π°-Π»ΠΈΡΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΠ΄Π½ΠΈΠΌ ΠΈΠ· ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΡΡ
ΡΠΈΠΏΠΎΠ² ΡΠ²Π°ΡΠ½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ. Π ΠΏΡΠΈΠΌΠ΅ΡΡ, ΠΎΠ½ΠΎ ΡΠ°ΡΡΠΎ ΠΏΡΠΈΠΌΠ΅Π½ΡΠ΅ΡΡΡ ΠΏΡΠΈ ΠΈΠ·Π³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΠΈ ΠΌΠ΅ΡΠ°Π»Π»ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΊΠΎΠ»ΠΎΠ½Π½ ΠΈ Π½Π΅ΡΡΡΠΈΡ
ΠΎΠΏΠΎΡ ΠΊΠ°ΡΠΊΠ°ΡΠΎΠ² Π·Π΄Π°Π½ΠΈΠΉ.
ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π½ΠΈΠ·ΠΊΠΎΠ»Π΅Π³ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΡΠ°Π»Π΅ΠΉ Π²Π·Π°ΠΌΠ΅Π½ ΡΠ³Π»Π΅ΡΠΎΠ΄ΠΈΡΡΡΡ
ΠΏΡΠΈ ΠΈΠ·Π³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΠΈ Π΄Π°Π½Π½ΡΡ
ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΉ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°Π΅Ρ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠ΅ΠΌΠΊΠΎΡΡΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΏΠΎΠ²ΡΡΠΈΡΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ ΠΏΡΠΎΡΠ½ΠΎΡΡΠ½ΡΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ.
Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ β ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΡΠ±ΠΎΡΠΊΠΈ ΠΈ ΡΠ²Π°ΡΠΊΠΈ ΡΡΡΠΊΠΎΠ²ΠΎΠ³ΠΎ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ ΡΡΡΠ±Π°-Π»ΠΈΡΡ ΠΈΠ· ΡΡΠ°Π»ΠΈ 09Π2Π‘.
Π ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΡΠ°Π±ΠΎΡΡ Π±ΡΠ» Π²ΡΠ±ΡΠ°Π½ ΡΠΏΠΎΡΠΎΠ± ΡΠ²Π°ΡΠΊΠΈ, ΡΠ²Π°ΡΠΎΡΠ½ΠΎΠ΅ ΠΎΠ±ΠΎΡΡΠ΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ ΡΠ²Π°ΡΠΎΡΠ½ΡΠ΅ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ. ΠΡΠΎΠΈΠ·Π²Π΅Π΄Π΅Π½Ρ ΡΠ°ΡΡΠ΅ΡΡ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² ΡΠ΅ΠΆΠΈΠΌΠ° ΡΠ²Π°ΡΠΊΠΈ, ΡΠ°ΡΡΡΠΈΡΠ°Π½Ρ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΡΠ΅ Π³Π΅ΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΡΠ²Π°, Π° ΡΠ°ΠΊΠΆΠ΅ Π΅Π³ΠΎ ΠΎΠΆΠΈΠ΄Π°Π΅ΠΌΡΠΉ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠΎΡΡΠ°Π².Pipe-to-sheet joint is one of common welded joints. For example it is used to make of metal columns and load-bearing supports of building frames.
The use of low alloy steels instead of carbon steels in the manufacture of metal structures reduces metal consumption and allows to increase the strength characteristics of joint.
Purpose of the work is development of fitting up and welding technology of a butt pipe-to-sheet joint steel 09G2S.
In the progress, a welding method, welding equipment and welding materials were selected. The parameters of the welding mode, geometric characteristics and chemical composition are calculated
Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor
As a sensor of polyaromatic chemicals the aryl hydrocarbon receptor (AhR)
exerts an important role in immune regulation besides its requirement for
xenobiotic metabolism. Transcriptional activation of AhR target genes is
counterregulated by the AhR repressor (AhRR) but the exact function of the
AhRR in vivo is currently unknown. We here show that the AhRR is predominantly
expressed in immune cells of the skin and intestine, different from other AhR
target genes. Whereas AhRR antagonizes the anti-inflammatory function of the
AhR in the context of systemic endotoxin shock, AhR and AhRR act in concert to
dampen intestinal inflammation. Specifically, AhRR contributes to the
maintenance of colonic intraepithelial lymphocytes and prevents excessive IL-
1Ξ² production and Th17/Tc17 differentiation. In contrast, the AhRR enhances
IFN-Ξ³-production by effector T cells in the inflamed gut. Our findings
highlight the physiologic importance of cell-type specific balancing of
AhR/AhRR expression in response to microbial, nutritional and other
environmental stimuli
Expression Profiling of CYP1B1 in Oral Squamous Cell Carcinoma: Counterintuitive Downregulation in Tumors
Oral Squamous Cell Carcinoma (OSCC) has a very flagitious treatment regime. A prodrug approach is thought to aid in targeting chemotherapy. CYP1B1, a member of cytochrome P450 family, has been implicated in chemical carcinogenesis. There exists a general accordance that this protein is overexpressed in a variety of cancers, making it an ideal candidate for a prodrug therapy. The activation of the prodrug facilitated by CYP1B1 would enable the targeting of chemotherapy to tumor tissues in which CYP1B1 is specifically overexpressed as a result reducing the non-specific side effects that the current chemotherapy elicits. This study was aimed at validating the use of CYP1B1 as a target for the prodrug therapy in OSCC. The expression profile of CYP1B1 was analysed in a panel of 51 OSCC tumors, their corresponding normal tissues, an epithelial dysplasia lesion and its matched normal tissue by qRT-PCR, Western blotting and Immunohistochemistry. CYP1B1 was found to be downregulated in 77.78% (28/36) tumor tissues in comparison to their corresponding normal tissues as well as in the epithelial dysplasia lesion compared to its matched normal tissue at the transcriptional level, and in 92.86% (26/28) of tumor tissues at the protein level. This report therefore clearly demonstrates the downregulation of CYP1B1 at the transcriptional and translational levels in tumor tissues in comparison to their corresponding normal tissues. These observations indicate that caution should be observed as this therapy may not be applicable universally to all cancers and also suggest the possibility of a prophylactic therapy for oral cancer
Regulation of constitutive and inducible AHR signaling : complex interactions involving the AHR repressorstar
Author Posting. Β© Elsevier B.V., 2009. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Biochemical Pharmacology 77(2009): 485-497, doi:10.1016/j.bcp.2008.09.016.The AHR is well known for regulating responses to an array of environmental chemicals.
A growing body of evidence supports the hypothesis that the AHR also plays perhaps an even
more important role in modulating critical aspects of cell function including cell growth, death,
and migration. As these and other important AHR activities continue to be elucidated, it becomes
apparent that attention now must be directed towards the mechanisms through which the AHR
itself is regulated. Here, we review what is known of and what biological outcomes have been
attributed to the AHR repressor (AHRR), an evolutionarily conserved bHLH-PAS protein that
inhibits both xenobiotic-induced and constitutively active AHR transcriptional activity in
multiple species. We discuss the structure and evolution of the AHRR and the dominant
paradigm of a xenobiotic-inducible negative feedback loop comprised of AHR-mediated
transcriptional up-regulation of AHRR and the subsequent AHRR-mediated suppression of AHR
activity. We highlight the role of the AHRR in limiting AHR activity in the absence of
xenobiotic AHR ligands and the important contribution of constitutively repressive AHRR to
cancer biology. In this context, we also suggest a new hypothesis proposing that, under some
circumstances, constitutively active AHR may repress AHRR transcription, resulting in unbridled
AHR activity. We also review the predominant hypotheses on the molecular mechanisms
through which AHRR inhibits AHR as well as novel mechanisms through which the AHRR may
exert AHR-independent effects. Collectively, this discussion emphasizes the importance of this
understudied bHLH-PAS protein in tissue development, normal cell biology, xenobiotic
responsiveness, and AHR-regulated malignancy.Supported by P01-ES11624 (D.H.S.), ArtBeCAUSE (D.H.S.), R01ES006272 (M.E.H.),
P42ES007381 (M.E.H. and D.H.S.
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