A Study of the Effects of Tornado Translation on Wind Loading Using a Potential Flow Model

This paper investigates the effects of tornado translation on pressure and overall force experienced by an airfoil subjected to tornado loading and presents a framework to reproduce the flow conditions and effects of a moving tornado. A thin symmetrical airfoil was used to explore the effects of tornado translation on a body. A panel method was used to compute the flow around an airfoil and an idealised tornado is represented using a moving vortex via unsteady potential flow. Analysis showed that the maximum overall pressure at a point was found to increase by up to 20% when the normalised translating velocity was 10% of the tangential velocity, but increases up to 60% when the normalised translating velocity is 30% of the tangential velocity. Investigation on the impact of varying airfoil thickness (Case 2) revealed that the location of the tornado has significant effect on the overall lift force. However, the overall lift force appeared to be largely insensitive to the tornado translation velocity due gross changes in pressure on either side of the airfoil cancelling each other out. Further comparison with varying airfoil sizes and distance to tornado translating path (Case 3) showed that the relative inflow and outflow angle is the primary factor affecting the lift on the airfoil. Additionally, the maximum forces on a body subjected to a moving tornado can be predicted using uniform flow providing that the appropriate range of inflow angles are known. Based on the analysis on the database of National Oceanic and Atmospheric Administration (NOAA), the normalised translation speed of the recorded tornadoes across the EF scales, appears to vary from 0.25 to 0.37, with an average of 0.32 (∼18.8 m/s). Finally, the framework using uniform flow to reproduce the flow conditions which are comparable to those generated by a translating vortex simulator is proposed and discussed in detail

Targeted Next-Generation Sequencing Analysis of 1,000 Individuals with Intellectual Disability.

To identify genetic causes of intellectual disability (ID), we screened a cohort of 986 individuals with moderate to severe ID for variants in 565 known or candidate ID-associated genes using targeted next-generation sequencing. Likely pathogenic rare variants were found in ∼11% of the cases (113 variants in 107/986 individuals: ∼8% of the individuals had a likely pathogenic loss-of-function [LoF] variant, whereas ∼3% had a known pathogenic missense variant). Variants in SETD5, ATRX, CUL4B, MECP2, and ARID1B were the most common causes of ID. This study assessed the value of sequencing a cohort of probands to provide a molecular diagnosis of ID, without the availability of DNA from both parents for de novo sequence analysis. This modeling is clinically relevant as 28% of all UK families with dependent children are single parent households. In conclusion, to diagnose patients with ID in the absence of parental DNA, we recommend investigation of all LoF variants in known genes that cause ID and assessment of a limited list of proven pathogenic missense variants in these genes. This will provide 11% additional diagnostic yield beyond the 10%-15% yield from array CGH alone.Action Medical Research (SP4640); the Birth Defect Foundation (RG45448); the Cambridge National Institute for Health Research Biomedical Research Centre (RG64219); the NIHR Rare Diseases BioResource (RBAG163); Wellcome Trust award WT091310; The Cell lines and DNA bank of Rett Syndrome, X-linked mental retardation and other genetic diseases (member of the Telethon Network of Genetic Biobanks (project no. GTB12001); the Genetic Origins of Congenital Heart Disease Study (GO-CHD)- funded by British Heart Foundation (BHF)This is the final version of the article. It first appeared from Wiley via http://dx.doi.org/10.1002/humu.2290

Measurement of Z0 decays to hadrons, and a precise determination of the number of neutrino species

We have made a precise measurement of the cross section for e+e--->Z0-->hadrons with the L3 detector at LEP, covering the range from 88.28 to 95.04 GeV. From a fit to the Z0 mass, total width, and the hadronic cross section to be MZ0=91.160 +/- 0.024 (experiment) +/-0.030(LEP) GeV, [Gamma]Z0=2.539+/-0.054 GeV, and [sigma]h(MZ0)=29.5+/-0.7 nb. We also used the fit to the Z0 peak cross section and the width todetermine [Gamma]invisible=0.548+/-0.029 GeV, which corresponds to 3.29+/-0.17 species of light neutrinos. The possibility of four or more neutrino flavors is thus ruled out at the 4[sigma] confidence level.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/28683/3/0000500.pd

A measurement of the Z0 leptonic partial widths and the vector and axial vector coupling constants

We have measured the partial widths of the Z0 into lepton pairs, and the forward-backward charge asymmetry for the process e+e--->[mu]+[mu]- using the L3 detector at LEP. We obtain an average [Gamma]ll of 83.0+/-2.1+/-1.1 MeV.From this result and the asymmetry measurement, we extract the values of the vector and axial vector couplings of the Z0 to leptons: grmv=-0.066-0.027+0.046 and grmA= -0.495-0.007+0.007.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/28666/3/0000483.pd