14 research outputs found

    Influence of exhaustion on metabolism and visual motor performance of professional cricket players

    No full text
    No Abstract. African Journal for Physical, Health Education, Recreation and Dance Vol. 12(1) 2006: 50-5

    A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis.

    No full text
    The Hippo pathway is a central regulator of tissue development and homeostasis, and has been reported to have a role during vascular development. Here we develop a bioluminescence-based biosensor that monitors the activity of the Hippo core component LATS kinase. Using this biosensor and a library of small molecule kinase inhibitors, we perform a screen for kinases modulating LATS activity and identify VEGFR as an upstream regulator of the Hippo pathway. We find that VEGFR activation by VEGF triggers PI3K/MAPK signaling, which subsequently inhibits LATS and activates the Hippo effectors YAP and TAZ. We further show that the Hippo pathway is a critical mediator of VEGF-induced angiogenesis and tumor vasculogenic mimicry. Thus, our work offers a biosensor tool for the study of the Hippo pathway and suggests a role for Hippo signaling in regulating blood vessel formation in physiological and pathological settings

    A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis

    No full text
    The Hippo pathway is a major orchestrator of organ development and homeostasis. Here Azad and colleagues develop a biosensor to monitor the activity of the Hippo pathway component LATS and identify VEGF signalling as an upstream regulator of LATS, supporting a role for Hippo signalling during angiogenesis
    corecore