Structure of d(TGCGCA)(2) and a comparison with other DNA Hexamers

The X-ray crystal structure of d(TGCGCA)(2) has been determined at 120 K to a resolution of 1.3 Angstrom. Hexamer duplexes, in the Z-DNA conformation, pack in an arrangement similar to the 'pure spermine form' [Egli et al. (1991). Biochemistry, 30, 11388-11402] but with significantly different cell dimensions. The phosphate backbone exists in two equally populated discrete conformations at one nucleotide step, around phosphate 11. The structure contains two ordered cobalt hexammine molecules which have roles in stabilization of both the Z-DNA conformation of the duplex and in crystal packing. A comparison of d(TGCGCA)(2) with other Z-DNA hexamer structures available in the Nucleic Acid Database illustrates the elusive nature of crystal packing. A review of the interactions with the metal cations Na+, Mg2+ and Co3+ reveals a relatively small proportion of phosphate binding and that close contacts between metal ions are common. A prediction of the water structure is compared with the observed pattern in the reported structure

Integrability and explicit solutions in some Bianchi cosmological dynamical systems

The Einstein field equations for several cosmological models reduce to polynomial systems of ordinary differential equations. In this paper we shall concentrate our attention to the spatially homogeneous diagonal G_2 cosmologies. By using Darboux's theory in order to study ordinary differential equations in the complex projective plane CP^2 we solve the Bianchi V models totally. Moreover, we carry out a study of Bianchi VI models and first integrals are given in particular cases

Entanglement without nonlocality

We consider the characterization of entanglement from the perspective of a Heisenberg formalism. We derive an original two-party generalized separability criteria, and from this describe a novel physical understanding of entanglement. We find that entanglement may be considered as fundamentally a local effect, and therefore as a separable computational resource from nonlocality. We show how entanglement differs from correlation physically, and explore the implications of this new conception of entanglement for the notion of classicality. We find that this understanding of entanglement extends naturally to multipartite cases.Comment: 9 pages. Expanded introduction and sections on physical entanglement and localit

A dynamical systems approach to the tilted Bianchi models of solvable type

We use a dynamical systems approach to analyse the tilting spatially homogeneous Bianchi models of solvable type (e.g., types VI$_h$ and VII$_h$) with a perfect fluid and a linear barotropic $\gamma$-law equation of state. In particular, we study the late-time behaviour of tilted Bianchi models, with an emphasis on the existence of equilibrium points and their stability properties. We briefly discuss the tilting Bianchi type V models and the late-time asymptotic behaviour of irrotational Bianchi VII$_0$ models. We prove the important result that for non-inflationary Bianchi type VII$_h$ models vacuum plane-wave solutions are the only future attracting equilibrium points in the Bianchi type VII$_h$ invariant set. We then investigate the dynamics close to the plane-wave solutions in more detail, and discover some new features that arise in the dynamical behaviour of Bianchi cosmologies with the inclusion of tilt. We point out that in a tiny open set of parameter space in the type IV model (the loophole) there exists closed curves which act as attracting limit cycles. More interestingly, in the Bianchi type VII$_h$ models there is a bifurcation in which a set of equilibrium points turn into closed orbits. There is a region in which both sets of closed curves coexist, and it appears that for the type VII$_h$ models in this region the solution curves approach a compact surface which is topologically a torus.Comment: 29 page

A Survey for Transient Astronomical Radio Emission at 611 MHz

We have constructed and operated the Survey for Transient Astronomical Radio Emission (STARE) to detect transient astronomical radio emission at 611 MHz originating from the sky over the northeastern United States. The system is sensitive to transient events on timescales of 0.125 s to a few minutes, with a typical zenith flux density detection threshold of approximately 27 kJy. During 18 months of around-the-clock observing with three geographically separated instruments, we detected a total of 4,318,486 radio bursts. 99.9% of these events were rejected as locally generated interference, determined by requiring the simultaneous observation of an event at all three sites for it to be identified as having an astronomical origin. The remaining 3,898 events have been found to be associated with 99 solar radio bursts. These results demonstrate the remarkably effective RFI rejection achieved by a coincidence technique using precision timing (such as GPS clocks) at geographically separated sites. The non-detection of extra-solar bursting or flaring radio sources has improved the flux density sensitivity and timescale sensitivity limits set by several similar experiments in the 1970s. We discuss the consequences of these limits for the immediate solar neighborhood and the discovery of previously unknown classes of sources. We also discuss other possible uses for the large collection of 611 MHz monitoring data assembled by STARE.Comment: 24 pages, 6 figures; to appear in PAS

Self-similar Bianchi models: II. Class B models

In a companion article (referred hearafter as paper I) a detailed study of the simply transitive Spatially Homogeneous (SH) models of class A concerning the existence of a simply transitive similarity group has been given. The present work (paper II) continues and completes the above study by considering the remaining set of class B models. Following the procedure of paper I we find all SH models of class B subjected only to the minimal geometric assumption to admit a proper Homothetic Vector Field (HVF). The physical implications of the obtained geometric results are studied by specialising our considerations to the case of vacuum and $\gamma -$law perfect fluid models. As a result we regain all the known exact solutions regarding vacuum and non-tilted perfect fluid models. In the case of tilted fluids we find the \emph{general }self-similar solution for the exceptional type VI$_{-1/9}$ model and we identify it as equilibrium point in the corresponding dynamical state space. It is found that this \emph{new} exact solution belongs to the subclass of models $n_\alpha ^\alpha =0$, is defined for $\gamma \in (\frac 43,\frac 32)$ and although has a five dimensional stable manifold there exist always two unstable modes in the restricted state space. Furthermore the analysis of the remaining types, guarantees that tilted perfect fluid models of types III, IV, V and VII$_h$ cannot admit a proper HVF strongly suggesting that these models either may not be asymptotically self-similar (type V) or may be extreme tilted at late times. Finally for each Bianchi type, we give the extreme tilted equilibrium points of their state space.Comment: Latex, 15 pages, no figures; to appear in Classical Quantum Gravity (uses iopart style/class files); (v2) minor corrections to match published versio

The Asymptotic Behaviour of Tilted Bianchi type VI0_0 Universes

We study the asymptotic behaviour of the Bianchi type VI$_0$ universes with a tilted $\gamma$-law perfect fluid. The late-time attractors are found for the full 7-dimensional state space and for several interesting invariant subspaces. In particular, it is found that for the particular value of the equation of state parameter, $\gamma=6/5$, there exists a bifurcation line which signals a transition of stability between a non-tilted equilibrium point to an extremely tilted equilibrium point. The initial singular regime is also discussed and we argue that the initial behaviour is chaotic for $\gamma<2$.Comment: 22 pages, 4 figures, to appear in CQ

Ames collaborative study of cosmic-ray neutrons. 2: Low- and mid-latitude flights

Progress of the study of cosmic ray neutrons is described. Data obtained aboard flights from Hawaii at altitudes of 41,000 and 45,000 feet, and in the range of geomagnetic latitude 17 N less than or equal to lambda less than or equal to 21 N are reported. Preliminary estimates of neutron spectra are made

A critique of the evidence for active host defence against cancer, based on personal studies of 27 murine tumours of spontaneous origin.

Extensive experience with isotransplants of 27 different tumours (leukaemias, sarcomata, carcinomata), all of strictly spontaneous origin in laboratory bred mice of low cancer strains CBA/Ht and WHT/Ht, has revealed no evidence of tumour immunogenicity. Of approximately 20,000 maintenance transplants, none failed and none regressed; of almost 10,000 carefully observed tumours arising from small or minimal inocula of tumour cells, none spontaneously regressed. The number of injected viable tumour cells required to give a 50% probability of successful transplantation (the TD50) ranged from approximately 1 cell to greater than 10,000 cells among the 27 tumours; high TD50 values, which were dramatically reduced by various procedures having no immunological significance, did not signify active "resistance" of the hosts. In the case of all of 7 randomly selected tumours, prior "immunization" of recipients with homologous lethally irradiated cells increased their tumour receptivity. Several experiments using various tumours failed to give evidence that immunity could be non-specifically induced or that a massive preponderance of lymphocytes from specifically sensitized mice could inhibit tumour transplantation or growth in vivo; no trace of "resistance" to tumour was adopted by isogeneic recipients of lymphocytes from regional nodes of tumour bearers. A limited review of the recent literature on tumour immunity shows that practically all the animal data presented in support of a general theory of tumour immunogenicity or to provide a basis for active clinical immunotherapy have been obtained from transplanted tumour systems which entail artefactual immunity associated with viral or chemical induction of the tumours or their allogeneic transplantation. It is suggested that isotransplants of spontaneously arising tumours are the only appropriate models of human cancer and that any genuine rapport between the animal laboratory and the clinic requires their exclusive use