2,145 research outputs found
Polarization Effects on the process with Large Extra Dimensions
We study large extra dimension effects on the polarizations of the pair
and electron beam at the process. It is shown that the
measurements of the cross section for transversely polarized pair with the
right-handed electron beam remarkably enhance the possibilities to see the low
scale quantum gravity effects. Higher Linear Collider bounds on the string
scale in this model can be obtained by using the left-handed electron beam.Comment: Final version to appear in Phys.Lett.B. More references are adde
Alteration patterns of trabecular bone microarchitectural characteristics induced by osteoarthritis over time
10.2147/CIA.S32513Clinical Interventions in Aging7303-31
TeV-scale seesaw from a multi-Higgs model
We suggest new simple model of generating tiny neutrino masses through a
TeV-scale seesaw mechanism without requiring tiny Yukawa couplings. This model
is a simple extension of the standard model by introducing extra one Higgs
singlet, and one Higgs doublet with a tiny vacuum expectation value.
Experimental constraints, electroweak precision data and no large flavor
changing neutral currents, are satisfied since the extra doublet only has a
Yukawa interaction with lepton doublets and right-handed neutrinos, and their
masses are heavy of order a TeV-scale. Since active light neutrinos are
Majorana particles, this model predicts a neutrinoless double beta decay.Comment: 21 pages, 8 figure
Pair production of charged Higgs bosons in the Left-Right Twin Higgs model at the ILC and LHC
Left-Right twin Higgs(LRTH) model predicts the existence of a pair of charged
Higgs . In this paper, we study the production of the charged Higgs
bosons pair via the process at
the International Linear Collider(ILC). The numerical results show that the
production rates are at the level of several tens fb, this process can produce
the adequate distinct multi-jet final states and the SM background can be
efficiently reduced. We also discuss the charged Higgs boson pair production
via the process at the Large Hadron
Collider(LHC) and estimate there production rates. We find that, as long as the
charged Higgs bosons are not too heavy, they can be abundantly produced at the
LHC. The possible signatures of these new particles might be detected at the
ILC and LHC experiments.Comment: 15 pages, 5 figures, discussion extended, reference added, typos
fixed, revised version to be published in Eur.Phys.J.
Distribution of graph-distances in Boltzmann ensembles of RNA secondary structures
Large RNA molecules often carry multiple functional domains whose spatial
arrangement is an important determinant of their function. Pre-mRNA splicing,
furthermore, relies on the spatial proximity of the splice junctions that can
be separated by very long introns. Similar effects appear in the processing of
RNA virus genomes. Albeit a crude measure, the distribution of spatial
distances in thermodynamic equilibrium therefore provides useful information on
the overall shape of the molecule can provide insights into the interplay of
its functional domains. Spatial distance can be approximated by the
graph-distance in RNA secondary structure. We show here that the equilibrium
distribution of graph-distances between arbitrary nucleotides can be computed
in polynomial time by means of dynamic programming. A naive implementation
would yield recursions with a very high time complexity of O(n^11). Although we
were able to reduce this to O(n^6) for many practical applications a further
reduction seems difficult. We conclude, therefore, that sampling approaches,
which are much easier to implement, are also theoretically favorable for most
real-life applications, in particular since these primarily concern long-range
interactions in very large RNA molecules.Comment: Peer-reviewed and presented as part of the 13th Workshop on
Algorithms in Bioinformatics (WABI2013
Enhanced expression of fibroblast growth factors and receptor FGFR-1 during vascular remodeling in chronic obstructive pulmonary disease
Important characteristics of chronic obstructive pulmonary disease (COPD)
include airway and vascular remodeling, the molecular mechanisms of which
are poorly understood. We assessed the role of fibroblast growth factors
(FGF) in pulmonary vascular remodeling by examining the expression pattern
of FGF-1, FGF-2, and the FGF receptor (FGFR-1) in peripheral area of lung
tissues from patients with COPD (FEV(1) < or = 75%; n = 15) and without
COPD (FEV(1) > or = 85%; n = 13). Immunohistochemical staining results
were evaluated by digital video image analysis as well as by manual
scoring. FGF-1 and FGFR-1 were detected in vascular smooth muscle (VSM),
airway smooth muscle, and airway epithelial cells. FGF-2 was localized in
the cytoplasm of airway epithelium and in the nuclei of airway smooth
muscle, VSM, and endothelial cells. In COPD cases, an unequivocal increase
in FGF-2 expression was observed in VSM (3-fold, P = 0.001) and
endothelium (2-fold, P = 0.007) of small pulmonary vessels with a luminal
diameter under 200 micro m. In addition, FGFR-1 levels were elevated in
the intima (1.5-fold, P = 0.05). VSM cells of large (> 200 micro m)
pulmonary vessels showed increased staining for FGF-1 (1.6-fold, P < 0.03)
and FGFR-1 (1.4-fold, P < 0.04) in COPD. Pulmonary vascular remodeling,
assessed as the ratio of alpha-smooth muscle actin staining and vascular
wall area with the lumen diameter, was increased in large vessels of
patients with COPD (P = 0.007) and was inversely correlated with FEV(1)
values (P < 0.007). Our results suggest an autocrine role of the
FGF-FGFR-1 system in the pathogenesis of COPD-associated vascular
remodeling
Cardiac involvement in patients recovered from COVID-2019 identified using magnetic resonance imaging
OBJECTIVES This study evaluated cardiac involvement in patients recovered from coronavirus disease-2019 (COVID-19) using cardiac magnetic resonance (CMR).BACKGROUND Myocardial injury caused by COVID-19 was previously reported in hospitalized patients. It is unknown if there is sustained cardiac involvement after patients' recovery from COVID-19.METHODS Twenty-six patients recovered from COVID-19 who reported cardiac symptoms and underwent CMR examinations were retrospectively included. CMR protocols consisted of conventional sequences (cine, T2-weighted imaging, and late gadolinium enhancement [LGE]) and quantitative mapping sequences (T1, T2, and extracellular volume [ECV] mapping). Edema ratio and LGE were assessed in post-COVID-19 patients. Cardiac function, native T1/T2, and ECV were quantitatively evaluated and compared with controls.RESULTS Fifteen patients (58%) had abnormal CMR findings on conventional CMR sequences: myocardial edema was found in 14 (54%) patients and LGE was found in 8 (31%) patients. Decreased right ventricle functional parameters including ejection fraction, cardiac index, and stroke volume/body surface area were found in patients with positive conventional CMR findings. Using quantitative mapping, global native T1, T2, and ECV were all found to be significantly elevated in patients with positive conventional CMR findings, compared with patients without positive findings and controls (median [interquartile range]: native T1 1,271 ms [1,243 to 1,298 ms] vs. 1,237 ms [1,216 to 1,262 ms] vs. 1,224 ms [1,217 to 1,245 ms]; mean +/- SD: T2 42.7 +/- 3.1 ms vs. 38.1 ms +/- 2.4 vs. 39.1 ms +/- 3.1; median [interquartile range]: 28.2% [24.8% to 36.2%] vs. 24.8% [23.1% to 25.4%] vs. 23.7% [22.2% to 25.2%]; p = 0.002; p < 0.001, and p =0.002, respectively).CONCLUSIONS Cardiac involvement was found in a proportion of patients recovered from COVID-19. CMR manifestation included myocardial edema, fibrosis, and impaired right ventricle function. Attention should be paid to the possible myocardial involvement in patients recovered from COVID-19 with cardiac symptoms. (C) 2020 by the American College of Cardiology Foundation.Cardiovascular Aspects of Radiolog
Partial Wave Analysis of
BES data on are presented. The
contribution peaks strongly near threshold. It is fitted with a
broad resonance with mass MeV, width MeV. A broad resonance peaking at 2020 MeV is also required
with width MeV. There is further evidence for a component
peaking at 2.55 GeV. The non- contribution is close to phase
space; it peaks at 2.6 GeV and is very different from .Comment: 15 pages, 6 figures, 1 table, Submitted to PL
Identification of bioactive metabolites against adenosine A1 receptor using NMR-based metabolomics
Plant science
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