The CD100 Receptor Interacts with Its Plexin B2 Ligand to Regulate Epidermal γδ T Cell Function

Summaryγδ T cells respond rapidly to keratinocyte damage, providing essential contributions to the skin wound healing process. The molecular interactions regulating their response are unknown. Here, we identify a role for interaction of plexin B2 with the CD100 receptor in epithelial repair. In vitro blocking of plexin B2 or CD100 inhibited γδ T cell activation. Furthermore, CD100 deficiency in vivo resulted in delayed repair of cutaneous wounds due to a disrupted γδ T cell response to keratinocyte damage. Ligation of CD100 in γδ T cells induced cellular rounding via signals through ERK kinase and cofilin. Defects in this rounding process were evident in the absence of CD100-mediated signals, thereby providing a mechanistic explanation for the defective wound healing in CD100-deficient animals. The discovery of immune functions for plexin B2 and CD100 provides insight into the complex cell-cell interactions between epithelial resident γδ T cells and the neighboring cells they support

Observation of the DsJ(2317) and DsJ(2457) in B decays

We report the first observation of the B --> Dbar DsJ(2317) and B --> Dbar DsJ(2457) decays based on 123.8 10^6 BBar events collected with the Belle detector at KEKB. We observe the DsJ(2317) decay to Ds pi0 and DsJ(2457) decay to the Ds* pi0 and Ds gamma final states. We also set 90% CL upper limits for the decays DsJ(2317) --> Ds* gamma, DsJ(2457) --> Ds* gamma, DsJ(2457) --> Ds pi0 and DsJ(2457) --> Ds pi+ pi-.Comment: 6 pages, 3 figures. A few minor corrections. Replaced by version accepted to publication in Phys. Rev. Let

Evidence of the Purely Leptonic Decay B- --> tau- nu_tau-bar

We present the first evidence of the decay B- --> tau- nu_tau-bar using 414 fb^-1 of data collected at the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider. Events are tagged by fully reconstructing one of the B mesons in hadronic modes. We detect the signal with a significance of 3.5 standard deviations including systematics, and measure the branching fraction to be Br(B- --> tau- nu_tau-bar) = (1.79 +0.56-0.49(stat) +0.46-0.51(syst))*10^-4. This implies that f_B = 0.229 +0.036-0.031(stat) +0.034-0.037(syst) GeV and is the first direct measurement of this quantity.Comment: 6 pages, 3 figures, to appear in Physical Review Letter

An Upper Bound on the Decay tau -> mu gamma from Belle

We have performed a search for the lepton-flavor-violating decay tau -> mu gamma using a data sample of 86.3fb^{-1} accumulated by the Belle detector at KEK. No evidence for a signal is seen, and we set an upper limit for the branching fraction of B(tau -> mu gamma) < 3.1 x 10^{-7} at the 90% confidence level.Comment: 6 pages, 4 figuresm, submitted to Phys. Rev. Let